DK1881984T3 - Inhibitorer af nukleosidphosphorylaser og nukleosidaser - Google Patents

Inhibitorer af nukleosidphosphorylaser og nukleosidaser

Info

Publication number: DK1881984T3
Authority: DK; Denmark
Prior art keywords: nucleoside; inhibitors; compounds; nucleosidases; phosphoryphlases
Prior art date: 2005-05-20

Application number

DK06747700.0T

Other languages

English (en)

Inventor

Gary Brian Evans

Richard Hubert Furneaux

Vern L Schramm

Peter Charles Tyler

Simon Peter Harold Mee

Olga Vladimirovna Zubkova

Original Assignee

Einstein Coll Med

Ind Res Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-05-20

Filing date

2006-05-22

Publication date

2012-06-25

2006-05-22 Application filed by Einstein Coll Med, Ind Res Ltd filed Critical Einstein Coll Med

2012-06-25 Application granted granted Critical

2012-06-25 Publication of DK1881984T3 publication Critical patent/DK1881984T3/da

Links

102000010722 N-Glycosyl Hydrolases Human genes 0.000 title abstract 3
108010063372 N-Glycosyl Hydrolases Proteins 0.000 title abstract 3
239000003112 inhibitor Substances 0.000 title abstract 2
239000002777 nucleoside Substances 0.000 title 1
150000003833 nucleoside derivatives Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
101710185027 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Proteins 0.000 abstract 2
102000030764 Purine-nucleoside phosphorylase Human genes 0.000 abstract 2
108700006317 Purine-nucleoside phosphorylases Proteins 0.000 abstract 2
102100034187 S-methyl-5'-thioadenosine phosphorylase Human genes 0.000 abstract 2
201000010099 disease Diseases 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
101710111176 5'-methylthioadenosine nucleosidase Proteins 0.000 abstract 1
108010034457 5'-methylthioadenosine phosphorylase Proteins 0.000 abstract 1
101710081557 Aminodeoxyfutalosine nucleosidase Proteins 0.000 abstract 1
208000035143 Bacterial infection Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
206010037075 Protozoal infections Diseases 0.000 abstract 1
101710136206 S-methyl-5'-thioadenosine phosphorylase Proteins 0.000 abstract 1
210000001744 T-lymphocyte Anatomy 0.000 abstract 1
208000022362 bacterial infectious disease Diseases 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
108010091901 purine phosphoribosyltransferase Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Physical Education & Sports Medicine (AREA)
Tropical Medicine & Parasitology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Transplantation (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)

DK06747700.0T 2005-05-20 2006-05-22 Inhibitorer af nukleosidphosphorylaser og nukleosidaser DK1881984T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
NZ540160A NZ540160A (en)	2005-05-20	2005-05-20	Inhibitors of nucleoside phosphorylases
PCT/NZ2006/000123 WO2006123953A1 (en)	2005-05-20	2006-05-22	Inhibitors of nucleoside phosphorylases and nucleosidases

Publications (1)

Publication Number	Publication Date
DK1881984T3 true DK1881984T3 (da)	2012-06-25

Family

ID=37431479

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK06747700.0T DK1881984T3 (da)	2005-05-20	2006-05-22	Inhibitorer af nukleosidphosphorylaser og nukleosidaser

Country Status (11)

Country	Link
US (1)	US20090233948A1 (da)
EP (1)	EP1881984B1 (da)
JP (1)	JP2008540642A (da)
AT (1)	ATE552259T1 (da)
AU (1)	AU2006248199B2 (da)
CY (1)	CY1113354T1 (da)
DK (1)	DK1881984T3 (da)
ES (1)	ES2385352T3 (da)
NZ (1)	NZ540160A (da)
PT (1)	PT1881984E (da)
WO (1)	WO2006123953A1 (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5985848A (en)	1997-10-14	1999-11-16	Albert Einstein College Of Medicine Of Yeshiva University	Inhibitors of nucleoside metabolism
SI1165564T1 (sl)	1999-04-08	2009-08-31	Ind Res Ltd	Postopek priprave inhibitorjev metabolizma nukleozidov
EP1539783B1 (en)	2002-08-21	2011-04-13	Albert Einstein College Of Medicine Of Yeshiva University	Inhibitors of nucleoside phosphorylases and nucleosidases
NZ523970A (en)	2003-02-04	2005-02-25	Ind Res Ltd	Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
NZ533360A (en)	2004-06-04	2007-02-23	Ind Res Ltd	Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
US8541567B2 (en) *	2005-07-27	2013-09-24	Albert Einstein College Of Medicine Of Yeshiva University	Transition state structure of 5′-methylthioadenosine/s-adenosylhomocysteine nucleosidases
NZ544187A (en) *	2005-12-15	2008-07-31	Ind Res Ltd	Deazapurine analogs of 1'-aza-l-nucleosides
US8394950B2 (en)	2006-02-22	2013-03-12	Industrial Research Limited	Analogues of coformycin and their use for treating protozoan parasite infections
JP2009528996A (ja) *	2006-02-24	2009-08-13	インダストリアルリサーチリミテッド	ヌクレオシドホスホリラーゼ及びヌクレオシダーゼの阻害剤を用いて疾患を処置する方法
JP2009527550A (ja)	2006-02-24	2009-07-30	アルバートアインシュタインカレッジオブメディシンオブイエシバユニバーシティ	癌を処置する方法
NZ575365A (en)	2006-09-07	2012-02-24	Ind Res Ltd	Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases
CA2662626C (en) *	2006-09-07	2016-07-26	Industrial Research Limited	Acyclic amine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
WO2008079028A1 (en) *	2006-12-22	2008-07-03	Industrial Research Limited	Azetidine analogues of nucleosidase and phosphorylase inhibitors
EP2173738A1 (en) *	2007-02-22	2010-04-14	Nanodream S.r.l. Unipersonale	Nucleoside analogues for the treatment of viral infections and methods for preparing them
UA103195C2 (uk)	2008-08-11	2013-09-25	Глаксосмитклайн Ллк	Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань
US20110190265A1 (en) *	2008-09-22	2011-08-04	Schramm Vern L	Methods and compositions for treating bacterial infections by inhibiting quorum sensing
EP2454263B1 (en)	2009-07-17	2018-06-13	Albert Einstein College of Medicine, Inc.	3-hydroxypyrrolidine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
US9290501B2 (en)	2010-11-29	2016-03-22	Albert Einstein College Of Medicine, Inc.	Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase
HRP20181667T1 (hr)	2011-07-22	2018-12-14	Glaxosmithkline Llc	Pripravak
EA026354B1 (ru)	2012-08-24	2017-03-31	ГЛАКСОСМИТКЛАЙН ЭлЭлСи	Пиразолопиримидиновые соединения
MX361933B (es) *	2012-11-12	2018-12-19	Victoria Link Ltd	Sal y formas polimorficas de (3r,4s)-l-((4-amino-5h-pirrolo [3,2-d]pirimidin-7-il)metil)-4 (metiltiometil)pirodin-3-ol(mtdia).
EA028480B1 (ru) *	2012-11-20	2017-11-30	ГЛАКСОСМИТКЛАЙН ЭлЭлСи	Новые соединения
BR112015011439A2 (pt)	2012-11-20	2017-07-11	Glaxosmithkline Llc	composto, composição farmacêutica, composição de vacina, e, uso de um composto
AU2013348217B2 (en) *	2012-11-20	2016-10-06	Glaxosmithkline Llc	Novel compounds
KR20160124157A (ko) *	2014-02-20	2016-10-26	글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드	인간 인터페론의 유도인자로서의 피롤로[3,2]피리미딘 유도체

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE60433B1 (en) *	1986-08-26	1994-07-13	Warner Lambert Co	Novel 9-deazaguanines
US5236926A (en) *	1992-02-03	1993-08-17	Warner-Lambert Company	9-substituted-8-halo or -8-hydroxy-9-deazaguanines as inhibitors or PNP for pharmaceutical compositions
SI1165564T1 (sl) *	1999-04-08	2009-08-31	Ind Res Ltd	Postopek priprave inhibitorjev metabolizma nukleozidov
US7109331B2 (en) *	2000-08-29	2006-09-19	Industrial Research Limited	5H-pyrrolo[3,2-d]pyrimidine nucleoside metabolism inhibitors
US7098334B2 (en) *	2002-03-25	2006-08-29	Industrial Research Limited	4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
EP1539783B1 (en) *	2002-08-21	2011-04-13	Albert Einstein College Of Medicine Of Yeshiva University	Inhibitors of nucleoside phosphorylases and nucleosidases
NZ523970A (en) *	2003-02-04	2005-02-25	Ind Res Ltd	Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
CA2538169A1 (en) *	2003-09-09	2005-03-17	Albert Einstein College Of Medicine Of Yeshiva University	Transition state analog inhibitors of ricin a-chain
NZ544187A (en) *	2005-12-15	2008-07-31	Ind Res Ltd	Deazapurine analogs of 1'-aza-l-nucleosides
JP2009527550A (ja) *	2006-02-24	2009-07-30	アルバートアインシュタインカレッジオブメディシンオブイエシバユニバーシティ	癌を処置する方法
CA2662626C (en) *	2006-09-07	2016-07-26	Industrial Research Limited	Acyclic amine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
EP2066671A1 (en) *	2006-09-26	2009-06-10	Albert Einstein College Of Medicine Of Yeshiva University	Transition state structure of human 5'-methylthioadenosine phosphorylase

2005
- 2005-05-20 NZ NZ540160A patent/NZ540160A/en not_active IP Right Cessation
2006
- 2006-05-22 AT AT06747700T patent/ATE552259T1/de active
- 2006-05-22 DK DK06747700.0T patent/DK1881984T3/da active
- 2006-05-22 WO PCT/NZ2006/000123 patent/WO2006123953A1/en not_active Ceased
- 2006-05-22 JP JP2008512236A patent/JP2008540642A/ja active Pending
- 2006-05-22 AU AU2006248199A patent/AU2006248199B2/en not_active Ceased
- 2006-05-22 PT PT06747700T patent/PT1881984E/pt unknown
- 2006-05-22 US US11/920,097 patent/US20090233948A1/en not_active Abandoned
- 2006-05-22 EP EP06747700A patent/EP1881984B1/en not_active Not-in-force
- 2006-05-22 ES ES06747700T patent/ES2385352T3/es active Active
2012
- 2012-06-26 CY CY20121100563T patent/CY1113354T1/el unknown

Also Published As

Publication number	Publication date
CY1113354T1 (el)	2016-06-22
EP1881984A1 (en)	2008-01-30
JP2008540642A (ja)	2008-11-20
EP1881984A4 (en)	2010-03-03
AU2006248199A1 (en)	2006-11-23
NZ540160A (en)	2008-03-28
AU2006248199B2 (en)	2012-11-01
ATE552259T1 (de)	2012-04-15
ES2385352T3 (es)	2012-07-23
EP1881984B1 (en)	2012-04-04
US20090233948A1 (en)	2009-09-17
WO2006123953A1 (en)	2006-11-23
PT1881984E (pt)	2012-05-07

Publication	Publication Date	Title
DK1539783T3 (da)	2011-06-20	Inhibitorer af nucleosidphosphorylaser og nucleosidaser
DK1881984T3 (da)	2012-06-25	Inhibitorer af nukleosidphosphorylaser og nukleosidaser
EP2057165A4 (en)	2009-09-02	AZYCLIC AMININHIBITORS OF NUCLEOSIDE PHOSPHOLE LASES AND HYDROLASES
CY1117180T1 (el)	2017-04-05	Ενωσεις φαινυλ amino πυριμιδινης και χρησεις αυτων
CR20220675A (es)	2023-02-15	Análogos de nucleósido de 1´- ciano y usos de los mismos
PL2201840T3 (pl)	2012-03-30	Inhibitory kinazy tyrozynowej Brutona
MEP36208A (en)	2011-02-10	Aryl urea compounds in combination with other cytostatic or cytotoxic agents for treating human cancers
EA200601100A1 (ru)	2006-10-27	6-замещённые 2-хинолиноны и 2-хиноксалиноны как ингибиторы поли(адф-рибоза)полимеразы
IL186104A (en)	2013-06-27	Phosphoramidate History of Nucleoside Compounds
CY1106476T1 (el)	2012-01-25	Υποκατεστημενες διυδροκιναζολινες με αντι-ιικες ιδιοτητες
MXPA05012606A (es)	2006-02-08	Fosforamidatos de nucleosidos como agentes anticancerigenos.
NO20035524D0 (no)	2003-12-11	4'-substituerte nukleosider
MX2009005011A (es)	2009-05-20	Imidazopirazinas como inhibidores de proteina quinasa.
DK1819227T3 (da)	2011-05-30	Farmaceutisk formulering af decitabin
UA85559C2 (en)	2009-02-10	Aminobenzophenone compounds
EA201000614A1 (ru)	2010-10-29	Производные пурина как лиганды аденозинового рецептора а
MX2015009006A (es)	2016-02-11	Oligonucleotidos inhibitorios y su uso en terapia.
UA90698C2 (en)	2010-05-25	Triazole substituted aminobenzophenone compounds
WO2006014913A3 (en)	2006-12-14	Inhibitors of 5'-methylthioadenosine phosphorylase and 5'methylthioadenosine/s-adenosylhomocysteine nucleosidase
NO20074780L (no)	2007-11-01	Heterocyklylamidsubstituerte imidazoler
TW200740816A (en)	2007-11-01	P38 MAP kinase inhibitors and methods for using the same
NO20053903L (no)	2005-12-19	Nukleotidlipidesterderivater.
PA8590801A1 (es)	2004-11-26	Derivados de nucleosido antivirales
DE602004007284D1 (de)	2007-08-09	Pyrimidine als inhibitoren von phosphoinositid-3-kinasen (pi3k)
ATE393768T1 (de)	2008-05-15	Nukleosidanaloga mit antiviraler wirkung