DK188486A - Glycopeptid-derivater og fremgangsmaade til fremstilling deraf - Google Patents

Glycopeptid-derivater og fremgangsmaade til fremstilling deraf Download PDF

Info

Publication number: DK188486A
Authority: DK; Denmark
Prior art keywords: procedures; preparing; glycopeptide derivatives; glycopeptide; derivatives
Prior art date: 1985-04-25

Application number

DK188486A

Other languages

English (en)

Other versions

DK188486D0 (da

Inventor

Ramakrishnan Nagarajan

Amelia Apolinaria Schabel

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-04-25

Filing date

1986-04-24

Publication date

1986-10-26

1986-04-24 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1986-04-24 Publication of DK188486D0 publication Critical patent/DK188486D0/da

1986-10-26 Publication of DK188486A publication Critical patent/DK188486A/da

Links

DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical class NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 title 1
238000000034 method Methods 0.000 title 1
241000894006 Bacteria Species 0.000 description 2
MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 2
108010059993 Vancomycin Proteins 0.000 description 1
150000001299 aldehydes Chemical class 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
210000004884 grey matter Anatomy 0.000 description 1
150000002576 ketones Chemical class 0.000 description 1
239000003910 polypeptide antibiotic agent Substances 0.000 description 1
229960003165 vancomycin Drugs 0.000 description 1
MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K9/00—Tenebrescent materials, i.e. materials for which the range of wavelengths for energy absorption is changed as a result of excitation by some form of energy

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Materials Engineering (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

hvori R, Rj. Rj. R3 og Rt| kan have an række forskellige betydninger, fremstilles ud fra et glycopeptid-antibio-ticum valgt blandt vancomycin, A515B8A. A515BBB, MM3A ag MM3B ved omsætning med et aldehyd eller en keton, eventuelt efterfulgt af en reduktion.

Forbindelserne (1) inhiberer væksten af en lang række bakterier, især gr em-pos iti ve bakterier.

DK188486A 1985-04-25 1986-04-24 Glycopeptid-derivater og fremgangsmaade til fremstilling deraf DK188486A (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US72673185A	1985-04-25	1985-04-25
US72673185		1985-04-25

Publications (2)

Publication Number	Publication Date
DK188486D0 DK188486D0 (da)	1986-04-24
DK188486A true DK188486A (da)	1986-10-26

Family

ID=24919774

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK188486A DK188486A (da)	1985-04-25	1986-04-24	Glycopeptid-derivater og fremgangsmaade til fremstilling deraf

Country Status (15)

Country	Link
EP (1)	EP0201251A3 (da)
JP (1)	JPS61251699A (da)
KR (1)	KR870001282B1 (da)
CN (1)	CN86103330A (da)
AU (1)	AU587615B2 (da)
DK (1)	DK188486A (da)
ES (1)	ES8706725A1 (da)
GR (1)	GR861071B (da)
HU (1)	HU204854B (da)
IL (1)	IL78597A0 (da)
NZ (1)	NZ215947A (da)
PH (1)	PH23900A (da)
PT (1)	PT82445B (da)
SU (1)	SU1586521A3 (da)
ZA (1)	ZA863091B (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8701872D0 (en) *	1987-01-28	1987-03-04	Lepetit Spa	N15-alkyl & n15,n15-dialkyl derivatives
US5071749A (en) *	1987-04-16	1991-12-10	Shionogi & Co., Ltd.	Glycopetide antibiotic pa-45052-b
GB8711066D0 (en) *	1987-05-11	1987-06-17	Lepetit Spa	Teicoplanin derivatives
GB8817053D0 (en) *	1988-07-18	1988-08-24	Lepetit Spa	Process for preparing n15 n15-dialkyl derivatives of teicoplanin compounds
US5840684A (en) *	1994-01-28	1998-11-24	Eli Lilly And Company	Glycopeptide antibiotic derivatives
NZ270387A (en) *	1994-01-28	1996-11-26	Lilly Co Eli	Glycopeptide antibiotic, its production and compositions thereof
AU701463B2 (en) *	1995-07-05	1999-01-28	Sanofi Aventis S.P.A.	Purification of dalbaheptide antibiotics by isoelectric focusing
EP1276759B1 (en)	2000-05-02	2008-07-30	Theravance, Inc.	Reductive alkylation process on glycopeptides
TWI275594B (en)	2001-08-24	2007-03-11	Theravance Inc	Process for preparing vancomycin phosphonate derivatives
TWI312785B (en)	2001-08-24	2009-08-01	Theravance Inc	Process for preparing vancomycin derivatives
WO2006057303A1 (ja)	2004-11-29	2006-06-01	National University Corporation Nagoya University	グリコペプチド抗生物質モノマー誘導体
TW200808818A (en)	2006-05-26	2008-02-16	Shionogi & Co	Glycopeptide antibiotic derivatives
AU2008342149A1 (en)	2007-12-26	2009-07-02	Shionogi & Co., Ltd.	Glycosylated glycopeptide antibiotic derivative
WO2016007855A1 (en) *	2014-07-10	2016-01-14	The Scripps Research Institute	N- (hydrophobe-substituted) vancosaminyl [ψ[c(=nh) nh] tpg4] vancomycin and [ψ[ch2nh]tpg4] vancomycin
CN105985412A (zh) *	2015-02-28	2016-10-05	爱斯医药科技(南京)有限公司	万古霉素衍生物、制备方法及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4462942A (en) *	1982-07-30	1984-07-31	Eli Lilly And Company	A47934 Antibiotic and process for production thereof
ZA839269B (en) *	1982-12-20	1985-07-31	Lilly Co Eli	Antibiotic a51568 factors a and b
DE3572178D1 (en) *	1984-04-16	1989-09-14	Lilly Co Eli	Improvements in and relating to antibiotics m43a, m43b, m43c and m43d

1986
- 1986-04-22 IL IL78597A patent/IL78597A0/xx unknown
- 1986-04-23 ES ES554286A patent/ES8706725A1/es not_active Expired
- 1986-04-23 PT PT82445A patent/PT82445B/pt not_active IP Right Cessation
- 1986-04-23 KR KR1019860003127A patent/KR870001282B1/ko not_active Expired
- 1986-04-23 GR GR861071A patent/GR861071B/el unknown
- 1986-04-23 JP JP61095826A patent/JPS61251699A/ja active Pending
- 1986-04-24 ZA ZA863091A patent/ZA863091B/xx unknown
- 1986-04-24 DK DK188486A patent/DK188486A/da not_active Application Discontinuation
- 1986-04-24 NZ NZ215947A patent/NZ215947A/xx unknown
- 1986-04-24 AU AU56598/86A patent/AU587615B2/en not_active Ceased
- 1986-04-24 HU HU861707A patent/HU204854B/hu not_active IP Right Cessation
- 1986-04-24 PH PH33701A patent/PH23900A/en unknown
- 1986-04-24 SU SU864027368A patent/SU1586521A3/ru active
- 1986-04-25 CN CN198686103330A patent/CN86103330A/zh active Pending
- 1986-04-25 EP EP86303158A patent/EP0201251A3/en not_active Withdrawn

Also Published As

Publication number	Publication date
DK188486D0 (da)	1986-04-24
NZ215947A (en)	1988-10-28
SU1586521A3 (ru)	1990-08-15
KR870001282B1 (ko)	1987-06-30
EP0201251A3 (en)	1987-12-16
PT82445B (pt)	1988-11-30
EP0201251A2 (en)	1986-11-12
CN86103330A (zh)	1986-10-29
KR860008210A (ko)	1986-11-14
ES554286A0 (es)	1987-07-01
JPS61251699A (ja)	1986-11-08
IL78597A0 (en)	1986-08-31
PH23900A (en)	1989-12-18
AU5659886A (en)	1986-10-30
HUT40683A (en)	1987-01-28
ZA863091B (en)	1987-12-30
AU587615B2 (en)	1989-08-24
HU204854B (en)	1992-02-28
GR861071B (en)	1986-08-21
ES8706725A1 (es)	1987-07-01
PT82445A (en)	1986-05-01

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Legal Events

Date	Code	Title	Description
1992-12-28	AHB	Application shelved due to non-payment