DK1885707T3 - Fremgangsmåde til oprensning af 10-deacetylbaccatin III fra 10-deacetyl-2-debenzoyl-2-pentenoylbaccatin III - Google Patents

Fremgangsmåde til oprensning af 10-deacetylbaccatin III fra 10-deacetyl-2-debenzoyl-2-pentenoylbaccatin III

Info

Publication number
DK1885707T3
DK1885707T3 DK06724105T DK06724105T DK1885707T3 DK 1885707 T3 DK1885707 T3 DK 1885707T3 DK 06724105 T DK06724105 T DK 06724105T DK 06724105 T DK06724105 T DK 06724105T DK 1885707 T3 DK1885707 T3 DK 1885707T3
Authority
DK
Denmark
Prior art keywords
iii
deacetyl
debenzoyl
pentenoylbaccatin
purifying
Prior art date
Application number
DK06724105T
Other languages
English (en)
Inventor
Bruno Gabetta
Andrea Gambini
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Application granted granted Critical
Publication of DK1885707T3 publication Critical patent/DK1885707T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK06724105T 2005-04-12 2006-04-07 Fremgangsmåde til oprensning af 10-deacetylbaccatin III fra 10-deacetyl-2-debenzoyl-2-pentenoylbaccatin III DK1885707T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI20050614 ITMI20050614A1 (it) 2005-04-12 2005-04-12 Processo per la purificazione della 10-deacetilbaccatina iii dalla 10-deacetil-2-debenzoil-2-pentenoilbaccatina iii
PCT/EP2006/003162 WO2006108561A1 (en) 2005-04-12 2006-04-07 A process for the purification of 10-deacetylbaccatine iii from 10-de acet yl-2- debenzoyl-2-pentenoylbaccatine iii

Publications (1)

Publication Number Publication Date
DK1885707T3 true DK1885707T3 (da) 2011-05-16

Family

ID=36572461

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06724105T DK1885707T3 (da) 2005-04-12 2006-04-07 Fremgangsmåde til oprensning af 10-deacetylbaccatin III fra 10-deacetyl-2-debenzoyl-2-pentenoylbaccatin III

Country Status (18)

Country Link
US (1) US9133152B2 (da)
EP (1) EP1885707B1 (da)
JP (1) JP5068743B2 (da)
KR (1) KR101329902B1 (da)
CN (1) CN101163688B (da)
AT (1) ATE499354T1 (da)
AU (1) AU2006233609B2 (da)
CA (1) CA2604193C (da)
DE (1) DE602006020268D1 (da)
DK (1) DK1885707T3 (da)
ES (1) ES2358872T3 (da)
IL (1) IL186593A (da)
IT (1) ITMI20050614A1 (da)
NO (1) NO340618B1 (da)
PL (1) PL1885707T3 (da)
RU (1) RU2409571C2 (da)
SI (1) SI1885707T1 (da)
WO (1) WO2006108561A1 (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5824511B2 (ja) 2010-05-03 2015-11-25 テイコク ファーマ ユーエスエー インコーポレーテッド 非水タキサンプロエマルジョン配合物ならびにそれを調製および使用する方法
CN103254187B (zh) * 2012-02-15 2016-05-25 浙江大学宁波理工学院 一种紫杉烷衍生物的制备方法
JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
CN111533714B (zh) * 2020-05-22 2023-04-11 无锡紫杉药业有限公司 一种巴卡亭iii衍生物及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1254517B (it) * 1992-03-06 1995-09-25 Indena Spa 14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico
US5380751A (en) * 1992-12-04 1995-01-10 Bristol-Myers Squibb Company 6,7-modified paclitaxels
TW354293B (en) * 1995-06-06 1999-03-11 Bristol Myers Squibb Co Prodrugs of paclitaxel derivatives
US5917062A (en) * 1997-11-21 1999-06-29 Indena S.P.A Intermediates and methods useful in the semisynthesis of paclitaxel and analogs
IT1308636B1 (it) * 1999-03-02 2002-01-09 Indena Spa Procedimento per la preparazione di tassani da 10-desacetilbaccatinaiii.
IT1318678B1 (it) 2000-08-10 2003-08-27 Indena Spa Procedimento per la preparazione di derivati della baccatina iii.
IT1320107B1 (it) 2000-11-28 2003-11-18 Indena Spa Procedimento per la preparazione di derivati tassanici.
IT1319682B1 (it) * 2000-12-06 2003-10-23 Indena Spa Procedimento di sintesi del paclitaxel.
ITMI20020782A1 (it) * 2002-04-12 2003-10-13 Indena Spa Processo semisintetico per la preparazione di n-debenzoilpaclitaxel
US7446126B2 (en) * 2004-10-08 2008-11-04 Indena S.P.A. Semisynthesis process for the preparation of 10-deacetyl-N-debenzoyl-paclitaxel

Also Published As

Publication number Publication date
ES2358872T3 (es) 2011-05-16
CN101163688B (zh) 2010-12-15
AU2006233609B2 (en) 2011-07-07
EP1885707B1 (en) 2011-02-23
JP5068743B2 (ja) 2012-11-07
AU2006233609A1 (en) 2006-10-19
KR20080002810A (ko) 2008-01-04
DE602006020268D1 (de) 2011-04-07
NO20075195L (no) 2007-10-11
SI1885707T1 (sl) 2011-05-31
HK1119166A1 (en) 2009-02-27
US20090298926A1 (en) 2009-12-03
ITMI20050614A1 (it) 2006-10-13
PL1885707T3 (pl) 2011-07-29
RU2007137695A (ru) 2009-04-20
ATE499354T1 (de) 2011-03-15
US9133152B2 (en) 2015-09-15
IL186593A (en) 2013-09-30
CA2604193A1 (en) 2006-10-19
KR101329902B1 (ko) 2013-11-14
JP2008535879A (ja) 2008-09-04
RU2409571C2 (ru) 2011-01-20
IL186593A0 (en) 2008-01-20
NO340618B1 (no) 2017-05-15
WO2006108561A1 (en) 2006-10-19
EP1885707A1 (en) 2008-02-13
CA2604193C (en) 2013-09-17
CN101163688A (zh) 2008-04-16

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