DK1886704T3 - Absorberingsmiddel og søjle til ekstrakorporal cirkulation - Google Patents

Absorberingsmiddel og søjle til ekstrakorporal cirkulation Download PDF

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Publication number
DK1886704T3
DK1886704T3 DK06730892.4T DK06730892T DK1886704T3 DK 1886704 T3 DK1886704 T3 DK 1886704T3 DK 06730892 T DK06730892 T DK 06730892T DK 1886704 T3 DK1886704 T3 DK 1886704T3
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absorbent
blood
column
fiber
granulocytes
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DK06730892.4T
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English (en)
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Masaaki Shimagaki
Yasufumi Yamamura
Katsuhisa Sato
Kazuo Teramoto
Takeshige Oozeki
Shigehisa Wada
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Toray Industries
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0081—After-treatment of organic or inorganic membranes
    • B01D67/0093—Chemical modification
    • B01D67/00931—Chemical modification by introduction of specific groups after membrane formation, e.g. by grafting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/265—Synthetic macromolecular compounds modified or post-treated polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
    • B01J20/28004—Sorbent size or size distribution, e.g. particle size
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28016—Particle form
    • B01J20/28021—Hollow particles, e.g. hollow spheres, microspheres or cenospheres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28023—Fibres or filaments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28033—Membrane, sheet, cloth, pad, lamellar or mat
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28069—Pore volume, e.g. total pore volume, mesopore volume, micropore volume
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28078—Pore diameter
    • B01J20/28085—Pore diameter being more than 50 nm, i.e. macropores
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
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  • Inorganic Chemistry (AREA)
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  • Manufacturing & Machinery (AREA)
  • Water Supply & Treatment (AREA)
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Claims (27)

1. Absorberingsmiddel, som kan absorbere granulocytter, monocytter og cy-tokin i blod, kendetegnet ved, at absorberingsmidlet har et zetapotential på -20 mV eller mere, hvilket absorberingsmiddel omfatter en vanduopløselig bærer med en funktionel gruppe bundet dertil, og den vanduopløselige bærer har et kvaternært ammoniumsalt og/eller en ligekædet aminogruppe bundet dertil.
2. Absorberingsmiddel ifølge krav 1, hvor formen af absorberingsmidlet er en form udvalgt fra en fiber, en membran, en hul fiber og en kugle.
3. Absorberingsmiddel ifølge krav 2, hvor formen af den vanduopløselige bærer er udvalgt fra en fiber eller en hul fiber med en fiberdiameter på mere end 3 pm og en kugle med et fremspring med en diameter på mere end 3 pm på overfladen.
4. Absorberingsmiddel ifølge krav 2, hvor formen af den vanduopløselige bærer er udvalgt fra en fiber eller en hul fiber med en fiberdiameter på 4 til 8 pm og en kugle med et fremspring med en diameter på 4 til 8 pm på overfladen.
5. Absorberingsmiddel ifølge krav 2, hvor formen af den vanduopløselige bærer er udvalgt fra en fiber eller en hul fiber med en fiberdiameter på 4,5 til 8 pm og en kugle med et fremspring med en diameter på 4,5 til 8 pm på overfladen.
6. Absorberingsmiddel ifølge et af kravene 3 til 5, hvor den vanduopløselige bærer endvidere omfatter en fiber eller en hul fiber med en fiberdiameter på 10 til 50 pm.
7. Absorberingsmiddel ifølge et af kravene 1 til 6, hvor det kvarternære ammoniumsalt er en gruppe, som kan tilvejebringes ved immobilisering af mindst en gruppe udvalgt fra Ν,Ν-dimethylhexylamin, N,N-dimethyloctylamin og Ν,Ν-dimethyllaurylamin til den vanduopløselige bærer.
8. Absorberingsmiddel ifølge et af kravene 1 til 6, hvor den ligekædede ami-nogruppe kan tilvejebringes ved immobilisering af tetraethylenepentamin til den vanduopløselige bærer.
9. Absorberingsmiddel ifølge et af kravene 1 til 8, hvor en absorptionsrate for lymfocytter er 40 % eller mindre, hvilken absorptionsrate måles ved passage af blod én gang gennem en søjle, som er fyldt med absorberingsmidlet, optælling af antallet af blodcellerne før og efter passagen og beregning af raten i henhold til formlen: Absorptionsrate (%) = [ (antal af lymfocytter i blod før passage gennem søjlen) - (antal af lymfocytter i blod efter passage gennem søjlen)] / (antal af lymfocytter i blod før passage gennem søjlen) x 100.
10. Absorberingsmiddel ifølge et af kravene 1 til 9, hvor cytokinet er mindst et udvalgt fra gruppen bestående af interleukin-1 (IL-1), interleukin-6 (IL-6), in-terleukin-8 (IL-8), interleukin-10 (IL-10), TNF-α, transformerende vækstfaktorbeta (TGF-β), vaskulær endotelial vækstfaktor (VEGF) og immunsuppressivt surt protein (IAP).
11. Absorberingsmiddel ifølge et af kravene 1 til 10, hvor absorptionsraten for koaguleringsfaktor XIII er 30 % eller mindre.
12. Absorberingsmiddel ifølge et af kravene 1 til 11 med zetapotentialet på -15 mV eller mere og med en kapacitet til at absorbere 90 % eller mere lipopolysaccharid (LPS) i salin indeholdende 1 volumenprocent føtalt kalveserum (FCS).
13. Absorberingsmiddel til kræftbehandling omfattende en vanduopløselig polymer, som er absorberingsmidlet ifølge krav 1, hvor absorberingsmidlet har en kapacitet til absorbering af latent transformerende vækstfaktor-β.
14. Absorberingsmiddel til kræftbehandling ifølge krav 13, hvor en absorptionsrate for granulocytter er 35 % eller mere, og en absorptionsrate for mono-cytter er 35 % eller mere, hvilken absorptionsrate måles ved passage af blod én gang gennem en søjle, som er fyldt med absorberingsmidlet, optælling af antallet af blodcellerne før og efter passagen og beregning af raten i henhold til formlerne: Absorptionsrate for granulocytter (%) = [ (antal af granulocytter i blod før passage gennem søjlen) - (antal af granulocytter i blod efter passage gennem søjlen) ] / (antal af granulocytter i blod før passage gennem søjlen) x 100; Absorptionsrate for monocytter (%) = [ (antal af monocytter i blod før passage gennem søjlen) - (antal af monocytter i blod efter passage gennem søjlen) ] / (antal af monocytter i blod før passage gennem søjlen) x 100.
15. Absorberingsmiddel til kræftbehandling ifølge krav 13 eller 14, hvor formen af den vanduopløselige polymer, som har den hydrofile aminrest bundet dertil, er en membran, en fiber eller et granulatmateriale.
16. Absorberingsmiddel ifølge et af kravene 1 til 15, hvor absorptionsraten for granulocytter er 50 % eller mere, og absorptionsraten for monocytter er 50 % eller mere, hvilken absorptionsrate måles ved passage af blod én gang gennem en søjle, som er fyldt med absorberingsmidlet, optælling af antallet af blodcellerne før og efter passagen og beregning af raten i henhold til formlerne: Absorptionsrate for granulocytter (%) = [ (antal af granulocytter i blod før passage gennem søjlen) - (antal af granulocytter i blod efter passage gennem søjlen) ] / (antal af granulocytter i blod før passage gennem søjlen) x 100; Absorptionsrate for monocytter (%) = [ (antal af monocytter i blod før passage gennem søjlen) - (antal af monocytter i blod efter passage gennem søjlen) ] / (antal af monocytter i blod før passage gennem søjlen) x 100.
17. Absorberingsmiddel ifølge et af kravene 1 til 16 med mindst en dobbeltlagsstruktur af et net og et ikke-vævet tekstil.
18. Absorberingsmiddel ifølge krav 17, hvor nettet er et net med 10 mm2 eller flere hulrum per 100 mm2.
19. Absorberingsmiddel ifølge krav 17 eller 18, hvor en hulrumsform af nettet er en firkant.
20. Absorberingsmiddel ifølge et af kravene 17 til 19, hvor en komponent af nettet er anbragt i en retning af en vinkel 90° ± 10° mod en hovedakse eller en lilleakse af det ikke-vævede tekstil i dobbeltlagsstrukturen.
21. Absorberingsmiddel ifølge et af kravene 17 til 20, hvilket absorberingsmiddel kan absorbere et fysiologisk aktivt stof og/eller celler.
22. Absorberingsmiddel ifølge et af kravene 17 til 21, hvor nettet består af et monofilament.
23. Absorberingsmiddel ifølge et af kravene 17 til 21, hvor der i nettet er sammenføjet portioner, hvor dets komponenter krydser hinanden.
24. Absorberingsmiddel ifølge et af kravene 17 til 23, hvor en bulkdensitet er 0,02 g/cm3 eller mere.
25. Blodbehandlingssøjle omfattende en beholder og absorberingsmidlet ifølge et af kravene 1 til 24 fyldt deri.
26. Blodbehandlingssøjle omfattende en cylindrisk beholder og absorberingsmidlet ifølge et af kravene 1 til 24 fyldt deri.
27. Ekstrakorporal cirkulationssøjle til kræftbehandling omfattende absorberingsmidlet til kræftbehandling ifølge et af kravene 13 til 15.
DK06730892.4T 2005-03-31 2006-03-31 Absorberingsmiddel og søjle til ekstrakorporal cirkulation DK1886704T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2005101466 2005-03-31
JP2005111652A JP2006288571A (ja) 2005-04-08 2005-04-08 癌治療用吸着材および体外循環カラム
JP2005111651 2005-04-08
PCT/JP2006/306944 WO2006106972A1 (ja) 2005-03-31 2006-03-31 吸着材および体外循環用カラム

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DK1886704T3 true DK1886704T3 (da) 2017-01-16

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US (1) US8584869B2 (da)
EP (1) EP1886704B1 (da)
KR (1) KR100972702B1 (da)
CN (1) CN101151056B (da)
CA (1) CA2603073C (da)
DK (1) DK1886704T3 (da)
ES (1) ES2608854T3 (da)
WO (1) WO2006106972A1 (da)

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CN101151056B (zh) 2012-07-04
EP1886704B1 (en) 2016-09-28
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US8584869B2 (en) 2013-11-19
CN101151056A (zh) 2008-03-26
US20090275874A1 (en) 2009-11-05
EP1886704A1 (en) 2008-02-13
ES2608854T3 (es) 2017-04-17
KR20070116667A (ko) 2007-12-10

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