DK1888537T3 - Fremgangsmåde til fremstilling af 4[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino]benzonitril - Google Patents

Fremgangsmåde til fremstilling af 4[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino]benzonitril

Info

Publication number: DK1888537T3
Authority: DK; Denmark
Prior art keywords: dihydro; oxo; benzonitrile; pyrimidinyl; amino
Prior art date: 2005-05-26

Application number

DK06755299.2T

Other languages

English (en)

Inventor

Didier Philippe Robert Schils

Alfred Elisabeth Stappers

Original Assignee

Janssen R & D Ireland

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-05-26

Filing date

2006-05-24

Publication date

2013-12-09

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35822492&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1888537(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-05-24 Application filed by Janssen R & D Ireland filed Critical Janssen R & D Ireland

2013-12-09 Application granted granted Critical

2013-12-09 Publication of DK1888537T3 publication Critical patent/DK1888537T3/da

Links

238000000034 method Methods 0.000 title abstract 2
LFVYGBSCJBMMQV-UHFFFAOYSA-N 2-[(6-oxo-1H-pyrimidin-2-yl)amino]benzonitrile Chemical compound OC1=NC(=NC=C1)NC1=C(C#N)C=CC=C1 LFVYGBSCJBMMQV-UHFFFAOYSA-N 0.000 title 1
-1 4-oxo-1,6-dihydro-pyrimidinylcarboxylic acid ester Chemical class 0.000 abstract 3
BBNOJNASJQRRSH-UHFFFAOYSA-N 4-[(6-oxo-1h-pyrimidin-2-yl)amino]benzonitrile Chemical compound N1C(=O)C=CN=C1NC1=CC=C(C#N)C=C1 BBNOJNASJQRRSH-UHFFFAOYSA-N 0.000 abstract 1
OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
150000002357 guanidines Chemical class 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000005580 one pot reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DK06755299.2T 2005-05-26 2006-05-24 Fremgangsmåde til fremstilling af 4[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino]benzonitril DK1888537T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP05104531		2005-05-26
US68599305P	2005-05-31	2005-05-31
PCT/EP2006/062606 WO2006125809A1 (en)	2005-05-26	2006-05-24	Process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino benzonitrile

Publications (1)

Publication Number	Publication Date
DK1888537T3 true DK1888537T3 (da)	2013-12-09

Family

ID=35822492

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK06755299.2T DK1888537T3 (da)	2005-05-26	2006-05-24	Fremgangsmåde til fremstilling af 4[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino]benzonitril

Country Status (19)

Country	Link
US (2)	US8101752B2 (da)
EP (1)	EP1888537B1 (da)
JP (2)	JP5148483B2 (da)
CN (1)	CN101248051B (da)
AU (1)	AU2006251163C1 (da)
BR (1)	BRPI0611038B8 (da)
CA (1)	CA2609716C (da)
DK (1)	DK1888537T3 (da)
ES (1)	ES2437202T3 (da)
HR (1)	HRP20131133T1 (da)
IN (1)	IN2014DN04588A (da)
ME (1)	ME01612B (da)
MX (1)	MX2007014881A (da)
PL (1)	PL1888537T3 (da)
PT (1)	PT1888537E (da)
RS (1)	RS53062B (da)
RU (1)	RU2458056C2 (da)
SI (1)	SI1888537T1 (da)
WO (1)	WO2006125809A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2437202T3 (es) *	2005-05-26	2014-01-09	Janssen R&D Ireland	Procedimiento para preparar 4-[(1,6-dihidro-6-oxo-2-pirimidinil)-amino]benzonitrilo
WO2012125993A1 (en)	2011-03-17	2012-09-20	Teva Pharmaceutical Industries Ltd.	Solid state forms of rilpivirine base, and rilipivirine salts
US10112972B2 (en)	2012-03-13	2018-10-30	Octapharma Ag	Process for production of fibrinogen and fibrinogen produced thereby
CN103058936B (zh) *	2013-01-23	2016-01-06	宁波九胜创新医药科技有限公司	4-[(4-氯-2-嘧啶基)氨基]苯腈的制备方法
CN103193719B (zh) *	2013-04-08	2015-07-22	宁波九胜创新医药科技有限公司	一种4-[(4-羟基-2-嘧啶基)氨基]苯腈的制备方法
CN114933567B (zh) *	2022-04-29	2023-07-11	武汉工程大学	一种2-甲硫基-4-嘧啶酮的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE63502B1 (en) *	1989-04-21	1995-05-03	Zeneca Ltd	Aminopyrimidine derivatives useful for treating cardiovascular disorders
RU2037483C1 (ru) *	1989-07-20	1995-06-19	Мерк Патент Гмбх	Способ получения замещенных ароматических нитрилов
DE3923979A1 (de)	1989-07-20	1991-01-24	Merck Patent Gmbh	Verfahren zur herstellung von aromatischen nitrilen
AU751573C (en) *	1998-03-27	2003-10-09	Janssen Pharmaceutica N.V.	HIV inhibiting pyrimidine derivatives
JP3635238B2 (ja) *	1998-11-10	2005-04-06	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	Ｈｉｖの複製を阻害するピリミジン類
DE60025837T2 (de) *	1999-09-24	2006-11-02	Janssen Pharmaceutica N.V.	Antivirale feste dispersionen
US7034019B2 (en) *	2000-05-08	2006-04-25	Janssen Pharmaceutica N.V.	Prodrugs of HIV replication inhibiting pyrimidines
JO3429B1 (ar) *	2001-08-13	2019-10-20	Janssen Pharmaceutica Nv	مشتقات برميدينات مثبطة فيروس الايدز
MXPA04004178A (es) *	2001-11-01	2004-09-06	Janssen Pharmaceutica Nv	Heteroarilaminas como inhibidores de glucogeno cintasa cinasa 3beta.
CN102702111B (zh) *	2002-08-09	2014-12-17	詹森药业有限公司	制备4-[[4-[[4-(2-氰基乙烯基)-2,6-二甲基苯基]氨基]-2-嘧啶基]氨基]苄腈的方法
NZ546259A (en) *	2003-09-30	2009-05-31	Janssen Pharmaceutica Nv	Benzoimidazole compounds
ES2437202T3 (es) *	2005-05-26	2014-01-09	Janssen R&D Ireland	Procedimiento para preparar 4-[(1,6-dihidro-6-oxo-2-pirimidinil)-amino]benzonitrilo

2006
- 2006-05-24 ES ES06755299.2T patent/ES2437202T3/es active Active
- 2006-05-24 PL PL06755299T patent/PL1888537T3/pl unknown
- 2006-05-24 US US11/913,200 patent/US8101752B2/en active Active
- 2006-05-24 CA CA2609716A patent/CA2609716C/en active Active
- 2006-05-24 RS RS20130528A patent/RS53062B/sr unknown
- 2006-05-24 DK DK06755299.2T patent/DK1888537T3/da active
- 2006-05-24 MX MX2007014881A patent/MX2007014881A/es active IP Right Grant
- 2006-05-24 CN CN2006800178794A patent/CN101248051B/zh active Active
- 2006-05-24 PT PT67552992T patent/PT1888537E/pt unknown
- 2006-05-24 JP JP2008512841A patent/JP5148483B2/ja active Active
- 2006-05-24 HR HRP20131133TT patent/HRP20131133T1/hr unknown
- 2006-05-24 IN IN4588DEN2014 patent/IN2014DN04588A/en unknown
- 2006-05-24 WO PCT/EP2006/062606 patent/WO2006125809A1/en not_active Ceased
- 2006-05-24 EP EP06755299.2A patent/EP1888537B1/en active Active
- 2006-05-24 AU AU2006251163A patent/AU2006251163C1/en active Active
- 2006-05-24 ME MEP-2013-136A patent/ME01612B/me unknown
- 2006-05-24 BR BRPI0611038A patent/BRPI0611038B8/pt active IP Right Grant
- 2006-05-24 RU RU2007148968/04A patent/RU2458056C2/ru active
- 2006-05-24 SI SI200631704T patent/SI1888537T1/sl unknown
2011
- 2011-12-14 US US13/325,621 patent/US8618291B2/en active Active
2012
- 2012-10-17 JP JP2012229897A patent/JP5580385B2/ja active Active

Also Published As

Publication number	Publication date
ME01612B (me)	2014-09-20
JP5580385B2 (ja)	2014-08-27
BRPI0611038B8 (pt)	2022-10-25
US8618291B2 (en)	2013-12-31
JP5148483B2 (ja)	2013-02-20
CA2609716A1 (en)	2006-11-30
ES2437202T3 (es)	2014-01-09
RU2007148968A (ru)	2009-07-10
AU2006251163C1 (en)	2012-07-12
HK1123551A1 (en)	2009-06-19
EP1888537B1 (en)	2013-09-11
US20120083606A1 (en)	2012-04-05
PL1888537T3 (pl)	2014-02-28
RU2458056C2 (ru)	2012-08-10
JP2008545680A (ja)	2008-12-18
JP2013040194A (ja)	2013-02-28
IN2014DN04588A (da)	2015-07-10
BRPI0611038A2 (pt)	2010-08-10
RS53062B (sr)	2014-04-30
SI1888537T1 (sl)	2014-01-31
AU2006251163A1 (en)	2006-11-30
BRPI0611038B1 (pt)	2022-02-08
US20080171878A1 (en)	2008-07-17
US8101752B2 (en)	2012-01-24
CN101248051B (zh)	2013-07-17
CA2609716C (en)	2014-10-14
CN101248051A (zh)	2008-08-20
AU2006251163B2 (en)	2012-03-08
MX2007014881A (es)	2008-02-15
PT1888537E (pt)	2013-11-26
HRP20131133T1 (hr)	2014-01-03
WO2006125809A1 (en)	2006-11-30
EP1888537A1 (en)	2008-02-20

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