DK190683A - Fremgangsmaade til fremstilling af fluoralkylderivater - Google Patents

Fremgangsmaade til fremstilling af fluoralkylderivater Download PDF

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Publication number
DK190683A
DK190683A DK190683A DK190683A DK190683A DK 190683 A DK190683 A DK 190683A DK 190683 A DK190683 A DK 190683A DK 190683 A DK190683 A DK 190683A DK 190683 A DK190683 A DK 190683A
Authority
DK
Denmark
Prior art keywords
derivatives
fluoral
cooler
preparing
procedure
Prior art date
Application number
DK190683A
Other languages
English (en)
Other versions
DK190683D0 (da
Inventor
David Robert Brittain
David Brown
Robin Wood
Original Assignee
Ici Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ici Plc filed Critical Ici Plc
Publication of DK190683D0 publication Critical patent/DK190683D0/da
Publication of DK190683A publication Critical patent/DK190683A/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Description

acyl eller tri-[(1-4C)alkyl]silyl med ammoniumcarbonat eller -carbamat, hvorpå/ når en ikke-toksisk bionedbrydelig forløber ønskes, en forbindelse med formlen I omsættes med et egnet akoxy-carbonyl-, aralkoxycarbonyl-, alkoxyoxalyl- eller l-(alkano-yloxy)alkylhalogenid, og når en optisk aktiv form ønskes, en racemisk form af en forbindelse med formel I omsættes med en optisk aktiv form af en egnet organisk base efterfulgt af separation af den således opnåede diastereoisomere blanding af salte, og den optisk aktive form af nævnte forbindelse frigøres ved behandling med syre, og når et salt ønskes, en forbindelse med formel I i fri baseform omsættes med en passende base, der tilvejebringer en farmaceutisk acceptabel kation.
Derivaterne er virksomme inhibitorer af enzymet aldosereduc-tase og er nyttige til behandling eller forhindring af visse diabeteskomplikationer.
DK190683A 1982-05-11 1983-04-28 Fremgangsmaade til fremstilling af fluoralkylderivater DK190683A (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8213651 1982-05-11
GB8213651 1982-05-11
GB8231129 1982-11-01
GB8231129 1982-11-01

Publications (2)

Publication Number Publication Date
DK190683D0 DK190683D0 (da) 1983-04-28
DK190683A true DK190683A (da) 1983-11-12

Family

ID=26282800

Family Applications (1)

Application Number Title Priority Date Filing Date
DK190683A DK190683A (da) 1982-05-11 1983-04-28 Fremgangsmaade til fremstilling af fluoralkylderivater

Country Status (12)

Country Link
US (1) US4539329A (da)
EP (1) EP0101149A1 (da)
AU (1) AU566869B2 (da)
CA (1) CA1201124A (da)
DK (1) DK190683A (da)
ES (1) ES522295A0 (da)
FI (1) FI831439A7 (da)
GR (1) GR78145B (da)
IL (1) IL68572A (da)
NO (1) NO831654L (da)
NZ (1) NZ204189A (da)
PT (1) PT76652B (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63132889A (ja) * 1986-11-21 1988-06-04 Tanabe Seiyaku Co Ltd キナゾリノン誘導体
US20030014951A1 (en) * 2001-07-20 2003-01-23 Ingersoll-Rand Company Horizontal separator tank for oil-flooded air compressor
WO2007091948A2 (en) * 2006-02-07 2007-08-16 Astrazeneca Ab Novel spiro [imidazolidine-4, 3´-indole] 2, 2´,5´(1h) triones for treatment of conditions associated with vanilloid receptor 1

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3767653A (en) * 1971-06-28 1973-10-23 Squibb & Sons Inc Thiazines
US4053613A (en) * 1975-09-17 1977-10-11 E. R. Squibb & Sons, Inc. 1,3,thiazolinyl and 1,3 thiazinyl substituted indolinones
US4490381A (en) * 1979-11-13 1984-12-25 Imperial Chemical Industries Plc 1'-Substituted spiro[imidazolidine-4,3'-indoline]2,2',5-triones
GB2098212B (en) * 1981-05-12 1984-11-14 Ici Plc Process for preparing 1'-substituted-spiro(imidazolidine)-4,3'-indoline-2,2',5-triones
IE53102B1 (en) * 1981-05-12 1988-06-22 Ici Plc Pharmaceutical spiro-succinimide derivatives
IE52879B1 (en) * 1981-05-12 1988-03-30 Ici Plc Pharmaceutical spiro-hydantoin derivatives
GB8312379D0 (en) * 1983-05-05 1983-06-08 Ici Plc Heterocyclic compounds

Also Published As

Publication number Publication date
IL68572A (en) 1986-01-31
NZ204189A (en) 1985-08-30
DK190683D0 (da) 1983-04-28
NO831654L (no) 1983-11-14
GR78145B (da) 1984-09-26
PT76652B (en) 1986-02-04
CA1201124A (en) 1986-02-25
FI831439L (fi) 1983-11-12
AU566869B2 (en) 1987-11-05
FI831439A7 (fi) 1983-11-12
AU1383883A (en) 1983-11-17
ES8407050A1 (es) 1984-08-16
ES522295A0 (es) 1984-08-16
FI831439A0 (fi) 1983-04-27
IL68572A0 (en) 1983-09-30
EP0101149A1 (en) 1984-02-22
PT76652A (en) 1983-06-01
US4539329A (en) 1985-09-03

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