DK1921077T3 - Middel til behandling og/eller forebyggelse af søvnforstyrrelse - Google Patents

Middel til behandling og/eller forebyggelse af søvnforstyrrelse Download PDF

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Publication number
DK1921077T3
DK1921077T3 DK06782197.5T DK06782197T DK1921077T3 DK 1921077 T3 DK1921077 T3 DK 1921077T3 DK 06782197 T DK06782197 T DK 06782197T DK 1921077 T3 DK1921077 T3 DK 1921077T3
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compound
nmr
ppm
furyl
thiazol
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DK06782197.5T
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English (en)
Inventor
Noriaki Uesaka
Shunji Ichikawa
Takao Nakajima
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Kyowa Hakko Kirin Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Claims (16)

1. Thiazolderivat gengivet ved en hvilken som helst af følgende formler (1), (5), (7), (8), (11), (78), (95), (99), (114), (136), (142), (157), (336), (360), (361), (365), (367), (373), (376), (407), (409), (416), (420), (463) og (508):
eller et farmaceutisk acceptabelt salt deraf, til anvendelse i behandling og/eller forebyggelse af hypersomni og/eller en søvnforstyrrelse forbundet med søvnighed i dagtimerne.
2. Thiazolderivat eller farmaceutisk acceptabelt salt deraf til anvendelse i behandling og/eller forebyggelse af hypersomni og/eller en søvnforstyrrelse forbundet med søvnighed i dagtimerne ifølge krav 1, hvor thiazolderivatet er som gengivet ved en hvilken som helst af de følgende formler (78), (95), (99), (114), (136), (142), (157), (336), (360), (361), (365), (367), (373), (376), (407), (409), (416), (420), (463), og (508).
3. Thiazolderivat eller farmaceutisk acceptabelt salt deraf til anvendelse i behandling og/eller forebyggelse af hypersomni og/eller en søvnforstyrrelse forbundet med søvnighed i dagtimerne ifølge krav 1, hvor thiazolderivatet er som gengivet ved en hvilken som helst af de følgende formler (95), (99), (114), (136), (142), og (157).
4. Thiazolderivat eller farmaceutisk acceptabelt salt deraf til anvendelse i behandling og/eller forebyggelse af hypersomni og/eller en søvnforstyrrelse forbundet med søvnighed i dagtimerne ifølge krav 1, hvor thiazolderivatet er som gengivet ved en hvilken som helst af de følgende formler (360), (361), (365), (367), (373), (376), (407), (409), (416), (420), og (463).
5. Thiazolderivat eller farmaceutisk acceptabelt salt deraf til anvendelse i behandling og/eller forebyggelse af hypersomni og/eller en søvnforstyrrelse forbundet med søvnighed i dagtimerne ifølge krav 1, hvor thiazolderivatet er som gengivet ved følgende formel (136).
6. Thiazolderivat eller farmaceutisk acceptabelt salt deraf til anvendelse i behandling og/eller forebyggelse af hypersomni og/eller en søvnforstyrrelse forbundet med søvnighed i dagtimerne ifølge krav 1, hvor thiazolderivatet er som gengivet ved følgende formel (409).
7. Thiazolderivat eller farmaceutisk acceptabelt salt deraf til anvendelse i behandling og/eller forebyggelse af hypersomni og/eller en søvnforstyrrelse forbundet med søvnighed i dagtimerne ifølge krav 1, hvor thiazolderivatet er som gengivet ved følgende formel (463).
8. Thiazolderivat eller farmaceutisk acceptabelt salt deraf til anvendelse i behandling og/eller forebyggelse af hypersomni og/eller en søvnforstyrrelse forbundet med søvnighed i dagtimerne ifølge et hvilket som helst af kravene 1 til 7, hvor hypersomnien og/eller søvnforstyrrelsen forbundet med søvnighed i dagtimerne er hypersomni.
9. Thiazolderivat eller farmaceutisk acceptabelt salt deraf til anvendelse i behandling og/eller forebyggelse af hypersomni og/eller en søvnforstyrrelse forbundet med søvnighed i dagtimerne ifølge et hvilket som helst af kravene 1 til 7, hvor hypersomnien og/eller søvnforstyrrelsen forbundet med søvnighed i dagtimerne er narkolepsi, tilbagevendende hypersomni (periodisk hypersomni), idiopatisk hypersomni eller posttraumatisk hypersomni.
10. Thiazolderivat eller farmaceutisk acceptabelt salt deraf til anvendelse i behandling og/eller forebyggelse af hypersomni og/eller en søvnforstyrrelse forbundet med søvnighed i dagtimerne ifølge et hvilket som helst af kravene 1 til 7, hvor hypersomnien og/eller søvnforstyrrelsen forbundet med søvnighed i dagtimerne er døgnrytme-søvnforstyrrelse.
11. Thiazolderivat eller farmaceutisk acceptabelt salt deraf til anvendelse i behandling og/eller forebyggelse af hypersomni og/eller en søvnforstyrrelse forbundet med søvnighed i dagtimerne ifølge et hvilket som helst af kravene 1 til 7, hvor behandlingen og/eller forebyggelsen af hypersomni og/eller en søvnforstyrrelse forbundet med søvnighed i dagtimerne forbedrer søvnighedstilstanden i dagtimerne.
12. Anvendelse af thiazolderivatet gengivet ved en hvilken som helst af følgende formler (1), (5), (7), (8), (11), (78), (95), (99), (114), (136), (142), (157), (336), (360), (361), (365), (367), (373), (376), (407), (409), (416), (420), (463) og (508):
eller et farmaceutisk acceptabelt salt deraf til fremstilling af et terapeutisk eller og/eller forebyggende middel mod hypersomni og/eller en søvnforstyrrelse forbundet med søvnighed i dagtimerne.
13. Anvendelse ifølge krav 12, hvor hypersomnien og/eller søvnforstyrrelsen forbundet med søvnighed i dagtimerne er hypersomni.
14. Anvendelse ifølge krav 12, hvor hypersomnien og/eller søvnforstyrrelsen forbundet med søvnighed i dagtimerne er narkolepsi, tilbagevendende hypersomni (periodisk hypersomni), idiopatisk hypersomni eller posttraumatisk hypersomni.
15. Anvendelse ifølge krav 12, hvor hypersomnien og/eller søvnforstyrrelsen forbundet med søvnighed i dagtimerne er forbundet med døgnrytme-søvnforstyrrelse.
16. Anvendelse ifølge krav 12, hvor det terapeutiske og/eller forebyggende middel mod hypersomni og/eller en søvnforstyrrelse forbundet med søvnighed i dagtimerne er til forbedring af søvnighedstilstanden i dagtimerne.
DK06782197.5T 2005-08-02 2006-08-02 Middel til behandling og/eller forebyggelse af søvnforstyrrelse DK1921077T3 (da)

Applications Claiming Priority (2)

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JP2005223547 2005-08-02
PCT/JP2006/315328 WO2007015528A1 (ja) 2005-08-02 2006-08-02 睡眠障害の治療および／または予防剤

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DK06782197.5T DK1921077T3 (da) 2005-08-02 2006-08-02 Middel til behandling og/eller forebyggelse af søvnforstyrrelse

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US (1) US7928098B2 (da)
EP (1) EP1921077B1 (da)
JP (1) JP5121453B2 (da)
CA (1) CA2617817C (da)
CY (1) CY1119488T1 (da)
DK (1) DK1921077T3 (da)
ES (1) ES2643340T3 (da)
HU (1) HUE034666T2 (da)
LT (1) LT1921077T (da)
PL (1) PL1921077T3 (da)
PT (1) PT1921077T (da)
SI (1) SI1921077T1 (da)
TW (1) TWI457125B (da)
WO (1) WO2007015528A1 (da)

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Also Published As

Publication number Publication date
SI1921077T1 (sl) 2017-11-30
US7928098B2 (en) 2011-04-19
HUE034666T2 (hu) 2018-02-28
TWI457125B (zh) 2014-10-21
CA2617817C (en) 2014-05-27
LT1921077T (lt) 2017-09-25
PT1921077T (pt) 2017-10-26
CA2617817A1 (en) 2007-02-08
JP5121453B2 (ja) 2013-01-16
EP1921077A4 (en) 2009-01-28
JPWO2007015528A1 (ja) 2009-02-19
EP1921077B1 (en) 2017-07-26
CY1119488T1 (el) 2018-03-07
EP1921077A1 (en) 2008-05-14
WO2007015528A1 (ja) 2007-02-08
PL1921077T3 (pl) 2018-01-31
US20100152162A1 (en) 2010-06-17
TW200740434A (en) 2007-11-01
ES2643340T3 (es) 2017-11-22

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