DK196185A - Fremgangsmaade til fremstilling af 7-halogen-7-desoxy-lincomycin og dermed analoge forbindelser - Google Patents

Fremgangsmaade til fremstilling af 7-halogen-7-desoxy-lincomycin og dermed analoge forbindelser Download PDF

Info

Publication number: DK196185A
Authority: DK; Denmark
Prior art keywords: adduct; halo; halogen; lincomycine; desoxy
Prior art date: 1984-05-15

Application number

DK196185A

Other languages

English (en)

Other versions

DK166390C (da

DK166390B (da

DK196185D0 (da

Inventor

Douglas Alan Livingston

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-05-15

Filing date

1985-05-01

Publication date

1985-11-16

1985-05-01 Application filed by Upjohn Co filed Critical Upjohn Co

1985-05-01 Publication of DK196185D0 publication Critical patent/DK196185D0/da

1985-11-16 Publication of DK196185A publication Critical patent/DK196185A/da

1993-05-10 Publication of DK166390B publication Critical patent/DK166390B/da

1993-09-27 Application granted granted Critical

1993-09-27 Publication of DK166390C publication Critical patent/DK166390C/da

Links

150000001875 compounds Chemical class 0.000 title 1
230000003301 hydrolyzing effect Effects 0.000 abstract description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
OJMMVQQUTAEWLP-UHFFFAOYSA-N Lincomycin Natural products CN1CC(CCC)CC1C(=O)NC(C(C)O)C1C(O)C(O)C(O)C(SC)O1 OJMMVQQUTAEWLP-UHFFFAOYSA-N 0.000 abstract 1
-1 amide halide Chemical class 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
238000010438 heat treatment Methods 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
OJMMVQQUTAEWLP-KIDUDLJLSA-N lincomycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@@H](C)O)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 OJMMVQQUTAEWLP-KIDUDLJLSA-N 0.000 abstract 1
229960005287 lincomycin Drugs 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000006413 ring segment Chemical group 0.000 abstract 1
239000007858 starting material Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/067—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
- C07H15/16—Lincomycin; Derivatives thereof

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Crystallography & Structural Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Cephalosporin Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Description

(c) hydrolyserer det i trin (b) dannede 7-halogen-7-desoxy--addukt med en vandig base og (d) isolerer den dannede 7-halogen-7-desoxy-lincomycinfor-bindelse, som fås i højt udbytte og med høj renhed.

DK196185A 1984-05-15 1985-05-01 Fremgangsmaade til fremstilling af 7-halogen-7-desoxy-lincomyciner DK166390C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/610,364 US4568741A (en)	1984-05-15	1984-05-15	Synthesis of 7-halo-7-deoxylincomycins
US61036484		1984-05-15

Publications (4)

Publication Number	Publication Date
DK196185D0 DK196185D0 (da)	1985-05-01
DK196185A true DK196185A (da)	1985-11-16
DK166390B DK166390B (da)	1993-05-10
DK166390C DK166390C (da)	1993-09-27

Family

ID=24444721

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK196185A DK166390C (da)	1984-05-15	1985-05-01	Fremgangsmaade til fremstilling af 7-halogen-7-desoxy-lincomyciner

Country Status (18)

Country	Link
US (1)	US4568741A (da)
EP (1)	EP0161794B1 (da)
JP (1)	JPS60260591A (da)
KR (1)	KR910002224B1 (da)
AT (1)	ATE54150T1 (da)
AU (1)	AU574453B2 (da)
CA (1)	CA1229592A (da)
DE (1)	DE3578425D1 (da)
DK (1)	DK166390C (da)
ES (1)	ES8606877A1 (da)
FI (1)	FI78108C (da)
GR (1)	GR851150B (da)
HK (1)	HK59293A (da)
HU (1)	HU196820B (da)
IL (2)	IL74971A (da)
MX (1)	MX163480B (da)
PT (1)	PT80463B (da)
ZA (1)	ZA852592B (da)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1004002B (zh) *	1984-11-29	1989-04-26	厄普约翰公司	制备7-卤-7-去氧林可霉素及其类似化合物的改进方法
TW282399B (da) *	1990-05-25	1996-08-01	Takeda Pharm Industry Co Ltd
DE4039750A1 (de) *	1990-12-13	1992-06-17	Basf Ag	Verfahren zur entfernung von phosgen aus abgasen
JP3202960B2 (ja)	1998-02-17	2001-08-27	大塚化学株式会社	ハロゲン化剤及び水酸基のハロゲン化方法
US6544555B2 (en)	2000-02-24	2003-04-08	Advancis Pharmaceutical Corp.	Antibiotic product, use and formulation thereof
US6565882B2 (en) *	2000-02-24	2003-05-20	Advancis Pharmaceutical Corp	Antibiotic composition with inhibitor
US6541014B2 (en) *	2000-10-13	2003-04-01	Advancis Pharmaceutical Corp.	Antiviral product, use and formulation thereof
US20020068078A1 (en) *	2000-10-13	2002-06-06	Rudnic Edward M.	Antifungal product, use and formulation thereof
US20020197314A1 (en) *	2001-02-23	2002-12-26	Rudnic Edward M.	Anti-fungal composition
ATE298758T1 (de) *	2001-08-28	2005-07-15	Pharmacia Corp	Kristalline freie base von clindamycin
MXPA05001689A (es) *	2002-08-15	2005-05-27	Vicuron Pharm Inc	Derivados de lincomicina que poseen actividad antibacteriana.
US7199105B2 (en) *	2002-08-15	2007-04-03	Vicuron Pharmaceuticals, Inc.	Lincomycin derivatives possessing antibacterial activity
GB0222522D0 (en)	2002-09-27	2002-11-06	Controlled Therapeutics Sct	Water-swellable polymers
EA009031B1 (ru)	2003-01-24	2007-10-26	Стифел Рисерч Оустрэйлиа Пти Лтд.	Пена на основе фосфата клиндамицина
US7256177B2 (en)	2003-06-17	2007-08-14	Vicuron Pharmaceuticals, Inc.	Lincomycin derivatives possessing antibacterial activity
US7199106B2 (en)	2003-06-17	2007-04-03	Vicuron Pharmaceuticals, Inc.	Lincomycin derivatives possessing antimicrobial activity
AU2004258949B2 (en) *	2003-07-21	2011-02-10	Shionogi, Inc.	Antibiotic product, use and formulation thereof
JP2006528190A (ja) *	2003-07-21	2006-12-14	アドバンシスファーマスーティカルコーポレイション	抗生物質製剤、その使用法及び作成方法
JP2006528185A (ja) *	2003-07-21	2006-12-14	アドバンシスファーマスーティカルコーポレイション	抗生物質製剤、その使用法及び作成方法
EP1653925A1 (en)	2003-08-11	2006-05-10	Advancis Pharmaceutical Corporation	Robust pellet
WO2005016278A2 (en)	2003-08-12	2005-02-24	Advancis Pharmaceuticals Corporation	Antibiotic product, use and formulation thereof
WO2005023184A2 (en) *	2003-08-29	2005-03-17	Advancis Pharmaceuticals Corporation	Antibiotic product, use and formulation thereof
US8460710B2 (en) *	2003-09-15	2013-06-11	Shionogi, Inc.	Antibiotic product, use and formulation thereof
CA2550983C (en) *	2003-12-24	2013-09-17	Advancis Pharmaceutical Corporation	Enhanced absorption of modified release dosage forms
US7361743B2 (en) *	2004-02-11	2008-04-22	Pfizer Inc	Lincomycin derivatives possessing antibacterial activity
AU2005269981A1 (en) *	2004-07-02	2006-02-09	Bonck, John A	Tablet for pulsed delivery
GB0417401D0 (en) *	2004-08-05	2004-09-08	Controlled Therapeutics Sct	Stabilised prostaglandin composition
US8778924B2 (en) *	2006-12-04	2014-07-15	Shionogi Inc.	Modified release amoxicillin products
US8357394B2 (en)	2005-12-08	2013-01-22	Shionogi Inc.	Compositions and methods for improved efficacy of penicillin-type antibiotics
PL2206494T3 (pl)	2006-03-31	2016-06-30	Stiefel Res Australia Pty Ltd	Spienialny żel zawiesinowy
US8299052B2 (en) *	2006-05-05	2012-10-30	Shionogi Inc.	Pharmaceutical compositions and methods for improved bacterial eradication
GB0613333D0 (en)	2006-07-05	2006-08-16	Controlled Therapeutics Sct	Hydrophilic polyurethane compositions
GB0613638D0 (en)	2006-07-08	2006-08-16	Controlled Therapeutics Sct	Polyurethane elastomers
GB0620685D0 (en) *	2006-10-18	2006-11-29	Controlled Therapeutics Sct	Bioresorbable polymers
CN101205245B (zh) *	2007-12-06	2011-04-06	河南天方药业股份有限公司	盐酸克林霉素的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3496163A (en) *	1965-02-08	1970-02-17	Upjohn Co	7-halo-7-deoxylincomycins and process for preparing the same
US3435025A (en) *	1966-03-18	1969-03-25	Upjohn Co	7-deoxylincomycin and analogs and isomers thereof and process for making the same
US3475407A (en) *	1967-12-22	1969-10-28	Upjohn Co	Process for preparing 7(r)- and 7(s)-halolincomycins
US3509127A (en) *	1968-04-30	1970-04-28	Upjohn Co	Isologs of lincomycins and process for preparing the same
US3574186A (en) *	1969-10-08	1971-04-06	Upjohn Co	Process for making 7-chloro-7-deoxylincomycin and related compounds and novel intermediates produced therein
US3714141A (en) *	1970-05-26	1973-01-30	Upjohn Co	Process for making 7-halolincomycins
CA1138443A (en) *	1979-03-09	1982-12-28	Tate & Lyle Patent Holdings Limited	Process for the preparation of chloro-deoxysugars
CN1004002B (zh) *	1984-11-29	1989-04-26	厄普约翰公司	制备7-卤-7-去氧林可霉素及其类似化合物的改进方法

1984
- 1984-05-15 US US06/610,364 patent/US4568741A/en not_active Expired - Lifetime
1985
- 1985-04-03 CA CA000478286A patent/CA1229592A/en not_active Expired
- 1985-04-04 ZA ZA852592A patent/ZA852592B/xx unknown
- 1985-04-09 EP EP85302494A patent/EP0161794B1/en not_active Expired - Lifetime
- 1985-04-09 AT AT85302494T patent/ATE54150T1/de not_active IP Right Cessation
- 1985-04-09 AU AU40950/85A patent/AU574453B2/en not_active Expired
- 1985-04-09 DE DE8585302494T patent/DE3578425D1/de not_active Expired - Lifetime
- 1985-04-19 IL IL74971A patent/IL74971A/xx not_active IP Right Cessation
- 1985-04-22 MX MX205050A patent/MX163480B/es unknown
- 1985-05-01 DK DK196185A patent/DK166390C/da not_active IP Right Cessation
- 1985-05-08 ES ES542940A patent/ES8606877A1/es not_active Expired
- 1985-05-13 IL IL75175A patent/IL75175A0/xx unknown
- 1985-05-13 GR GR851150A patent/GR851150B/el unknown
- 1985-05-14 PT PT80463A patent/PT80463B/pt unknown
- 1985-05-14 KR KR1019850003279A patent/KR910002224B1/ko not_active Expired
- 1985-05-14 HU HU851821A patent/HU196820B/hu unknown
- 1985-05-14 JP JP60103616A patent/JPS60260591A/ja active Granted
- 1985-05-15 FI FI851941A patent/FI78108C/fi not_active IP Right Cessation
1993
- 1993-06-17 HK HK592/93A patent/HK59293A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
PT80463A (en)	1985-06-01
KR850008349A (ko)	1985-12-16
FI78108B (fi)	1989-02-28
DK166390C (da)	1993-09-27
IL74971A0 (en)	1985-08-30
KR910002224B1 (ko)	1991-04-08
HUT40805A (en)	1987-02-27
DK166390B (da)	1993-05-10
ES542940A0 (es)	1986-05-16
ES8606877A1 (es)	1986-05-16
EP0161794A2 (en)	1985-11-21
EP0161794A3 (en)	1987-07-29
FI851941L (fi)	1985-11-16
AU574453B2 (en)	1988-07-07
DE3578425D1 (de)	1990-08-02
MX163480B (es)	1992-05-19
CA1229592A (en)	1987-11-24
FI78108C (fi)	1989-06-12
ATE54150T1 (de)	1990-07-15
IL74971A (en)	1991-07-18
IL75175A0 (en)	1985-09-29
AU4095085A (en)	1985-11-21
HK59293A (en)	1993-06-25
GR851150B (da)	1985-11-25
ZA852592B (en)	1985-11-27
JPH0533711B2 (da)	1993-05-20
PT80463B (pt)	1987-08-19
HU196820B (en)	1989-01-30
US4568741A (en)	1986-02-04
EP0161794B1 (en)	1990-06-27
DK196185D0 (da)	1985-05-01
FI851941A0 (fi)	1985-05-15
JPS60260591A (ja)	1985-12-23

Legal Events

Date	Code	Title	Description
2005-05-17	PUP	Patent expired

Publication	Publication Date	Title
DK196185A (da)	1985-11-16	Fremgangsmaade til fremstilling af 7-halogen-7-desoxy-lincomycin og dermed analoge forbindelser
ATE188707T1 (de)	2000-01-15	Verfahren zur herstellung von alanylglutamin
ATE35417T1 (de)	1988-07-15	Verfahren zur herstellung von phosphorhaltigen cyanhydrinderivaten.
ES2000604A6 (es)	1988-03-01	Un procedimiento para preparar aril-piperidin esteres
ATE98253T1 (de)	1993-12-15	Synthese von 6-methylenandrosta-1,4-dien-3,17dion-derivate.
ATE117297T1 (de)	1995-02-15	Verfahren zur herstellung von hochreinem ebselen.
DK160310C (da)	1991-07-29	Analogifremgangsmaade til fremstilling af 6-oe(cyclisk amino)ethylaminoaatetrahydrotriazolooe3,4-aaaphthalaziner eller farmaceutisk acceptable syreadditionssalte deraf
AU563050B2 (en)	1987-06-25	Synthesis of azetidin-3-ols
DK0492350T3 (da)	1998-01-26	Fremgangsmåde til fremstilling af (S)-vinyl- og (S)-allenyl-GABA
DK452984A (da)	1985-03-23	Fremgangsmaade til fremstilling af quinolin-4-oner
DK193180A (da)	1980-11-04	Fremgangsmaade til fremstilling af 2-aminoalkyl5-pyridinoler deres syreadditionssalte samt praeparater indeholdende disse forbindelser
DK452684D0 (da)	1984-09-21	Fremgangsmaade til fremstilling af quinolin-4-oner
FI863897L (fi)	1988-03-27	Kemiskt foerfarande.
DK437186D0 (da)	1986-09-12	Fremgangsmaade til fremstilling af bromfluoreddikesyrer