DK197586A - Fremgangsmaade til fremstilling af 17alfa-ethynyl-17beta-hydroxy-18-methyl-4,15-oestradien-3-on og udgangsforbindelser til denne fremgangsmaade - Google Patents

Fremgangsmaade til fremstilling af 17alfa-ethynyl-17beta-hydroxy-18-methyl-4,15-oestradien-3-on og udgangsforbindelser til denne fremgangsmaade Download PDF

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Publication number
DK197586A
DK197586A DK197586A DK197586A DK197586A DK 197586 A DK197586 A DK 197586A DK 197586 A DK197586 A DK 197586A DK 197586 A DK197586 A DK 197586A DK 197586 A DK197586 A DK 197586A
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DK
Denmark
Prior art keywords
procedure
preparation
oestradia
17alfa
17beta
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DK197586A
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English (en)
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DK171578B1 (da
DK197586D0 (da
Inventor
Helmut Hofmeister
Henry Laurent
Hans-Peter Lorenz
Rudolf Wiechert
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Schering Ag filed Critical Schering Ag
Publication of DK197586D0 publication Critical patent/DK197586D0/da
Publication of DK197586A publication Critical patent/DK197586A/da
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Publication of DK171578B1 publication Critical patent/DK171578B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0096—Alkynyl derivatives

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

Figure DK197586AD00021
(II), hvori R betegner en alkylgruppe »ed 1 til 3 carbonatomer og
Figure DK197586AD00022
grupperingen
Figure DK197586AD00023
eller
Figure DK197586AD00024
hvor R' er en acylgruppe »ed indtil 10 carbonatoier. Udgangs-forbindelserne »ed den almene formel II er hidtil ukendte.
DK197586A 1985-05-10 1986-04-30 Fremgangsmåde til fremstilling af 17alfa-ethynyl-17beta-hydroxy-18-methyl-4,15-østradien-3-on og mellemprodukter til anvendelse ved fremgangsmåden DK171578B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3517466 1985-05-10
DE3517466 1985-05-10

Publications (3)

Publication Number Publication Date
DK197586D0 DK197586D0 (da) 1986-04-30
DK197586A true DK197586A (da) 1986-11-11
DK171578B1 DK171578B1 (da) 1997-01-27

Family

ID=6270766

Family Applications (1)

Application Number Title Priority Date Filing Date
DK197586A DK171578B1 (da) 1985-05-10 1986-04-30 Fremgangsmåde til fremstilling af 17alfa-ethynyl-17beta-hydroxy-18-methyl-4,15-østradien-3-on og mellemprodukter til anvendelse ved fremgangsmåden

Country Status (16)

Country Link
US (2) US4751329A (da)
EP (1) EP0201452B1 (da)
JP (2) JPH0776231B2 (da)
CN (1) CN1008820B (da)
AT (1) ATE45363T1 (da)
AU (1) AU581138B2 (da)
CA (1) CA1250570A (da)
CS (1) CS268817B2 (da)
DD (1) DD251356B3 (da)
DE (1) DE3664916D1 (da)
DK (1) DK171578B1 (da)
ES (1) ES8704510A1 (da)
GR (1) GR861126B (da)
HU (2) HU197755B (da)
IE (1) IE58798B1 (da)
PT (1) PT82536B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3710728A1 (de) * 1987-03-31 1988-10-13 Schering Ag Verfahren zur herstellung von 17(alpha)-ethinyl-17ss-hydroxy-18-methyl-4,15-estradien-3-on und die neuen zwischenprodukte fuer dieses verfahren
FR2647452A1 (fr) * 1989-05-24 1990-11-30 Theramex Nouveaux 19-nor steroides 6-methyles leurs procedes d'obtention, les compositions pharmaceutiques en renfermant et leur conversion en 19-nor pregnadienes 17-substitues
IT1271004B (it) * 1994-09-09 1997-05-26 Ind Chimica Srl Processo per la preparazione del gestodene
EP2354150A1 (en) 2010-02-09 2011-08-10 Laboratoire Theramex Process for the preparation of gestodene
WO2012110947A1 (en) * 2011-02-17 2012-08-23 Lupin Limited An improved process for preparation of levonorgestrel
CN103319558B (zh) * 2012-03-22 2016-01-20 华润紫竹药业有限公司 甾体化合物及其制备方法和用途
CN119751531B (zh) * 2024-12-26 2025-10-17 浙江仙琚制药股份有限公司 一种左旋乙基甾烯二酮的制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3214448A (en) * 1962-07-27 1965-10-26 American Cyanamid Co 14alpha-hydroxyestrone and ester thereof
PH18332A (en) * 1972-01-27 1985-05-31 Ishihara Sangyo Kaisha Herbicide
DE2223894C3 (de) * 1972-05-17 1981-07-23 Hoechst Ag, 6000 Frankfurt Herbizide Mittel auf Basis von Phenoxycarbonsäurederivaten
DE2433067B2 (de) * 1974-07-10 1977-11-24 a- [4-(4" Trifluormethylphenoxy)-phenoxy] -propionsäuren und deren Derivate, Verfahren zu ihrer Herstellung und diese enthaltende herbizide Mittel Hoechst AG, 6000 Frankfurt Alpha- eckige klammer auf 4-(4' trifluormethylphenoxy)-phenoxy eckige klammer zu -propionsaeuren und deren derivate, verfahren zu ihrer herstellung und diese enthaltende herbizide mittel
CS185694B2 (en) * 1974-07-17 1978-10-31 Ishihara Sangyo Kaisha Herbicidal agent
DE2456068A1 (de) * 1974-11-23 1976-08-12 Schering Ag Verfahren zur herstellung von oestren3,17-dion-derivaten
GB1560416A (en) * 1975-09-03 1980-02-06 Rohm & Haas Trifluoromethylphenyl derivatives
DE2546062A1 (de) * 1975-10-10 1977-04-21 Schering Ag Delta hoch 15 -steroide
US4081537A (en) * 1975-10-10 1978-03-28 Schering Aktiengesellschaft Δ15 -Steroids and pharmaceutical compositions thereof
DE2601548C2 (de) * 1976-01-16 1984-01-26 Hoechst Ag, 6230 Frankfurt 2-[4-(2'-Chlor-4'-bromphenoxy)-phenoxy]-propionsäure und Derivate sowie diese enthaltende herbizide Mittel
DE2617804C2 (de) * 1976-04-23 1985-01-24 Hoechst Ag, 6230 Frankfurt 2-(4-Phenoxy phenoxy)-propionsäurederivate und ihre Verwendung als Herbizide
DE2749104C2 (de) * 1977-10-31 1982-03-25 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von δ↑15↑ -Steroiden
US4375981A (en) * 1979-05-14 1983-03-08 Ppg Industries, Inc. Method for controlling weed growth using herbicidally 5-(2-chloro-4-trifluoromethyl)-, or (4-trifluoromethyl or 2,6-dichloro-4-trifluoromethylphenoxy)-2-nitro-substituted carbonyl oxime-O-alkyl ethers
DE3068101D1 (en) * 1979-07-18 1984-07-12 Ici Plc Diphenyl ether compounds, and herbicidal compositions and processes utilising them
US4388472A (en) * 1979-07-18 1983-06-14 Imperial Chemical Industries Plc Substituted diphenyl ethers
US4353736A (en) * 1980-01-17 1982-10-12 Ciba-Geigy Corporation Method of selectively controlling weeds and herbicidal diphenyl ether oxime derivatives
DE3165721D1 (en) * 1980-02-05 1984-10-04 Ici Plc Method of preparing fluorine-substituted diphenyl ether derivatives and fluorine-substituted halogeno benzene derivatives for use therein
US4402727A (en) * 1981-06-04 1983-09-06 Bayer Aktiengesellschaft Substituted azolylalkyl phenoxyphenoxyalkane-carboxylates as herbicides and plant growth regulators
DE3122174A1 (de) * 1981-06-04 1982-12-30 Bayer Ag, 5090 Leverkusen Substituierte phenoxyphenyl-azolylalkylether, verfahren zu ihrer herstellung sowie ihre verwendung als herbizide und pflanzenwuchsregulatoren

Also Published As

Publication number Publication date
HU196430B (en) 1988-11-28
ES8704510A1 (es) 1987-04-16
EP0201452B1 (de) 1989-08-09
JPH0776231B2 (ja) 1995-08-16
DD251356B3 (de) 1993-04-01
DE3664916D1 (en) 1989-09-14
DK171578B1 (da) 1997-01-27
GR861126B (en) 1986-09-30
DD251356A5 (de) 1987-11-11
US4751329A (en) 1988-06-14
PT82536A (de) 1986-06-01
EP0201452A3 (en) 1987-07-01
US4719054A (en) 1988-01-12
JPH07316184A (ja) 1995-12-05
JPS61260096A (ja) 1986-11-18
CN86102560A (zh) 1987-01-21
CS326486A2 (en) 1989-08-14
ATE45363T1 (de) 1989-08-15
CA1250570A (en) 1989-02-28
PT82536B (pt) 1988-07-01
JP2509467B2 (ja) 1996-06-19
IE861233L (en) 1986-11-10
AU5715586A (en) 1986-11-13
IE58798B1 (en) 1993-11-17
CS268817B2 (en) 1990-04-11
EP0201452A2 (de) 1986-11-12
DK197586D0 (da) 1986-04-30
ES554711A0 (es) 1987-04-16
CN1008820B (zh) 1990-07-18
AU581138B2 (en) 1989-02-09
HUT40679A (en) 1987-01-28
HU197755B (en) 1989-05-29

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CTFF Application for supplementary protection certificate (spc) filed

Free format text: PRODUCT NAME: GESTODEN + ETHINYLESTRADIOL; REGISTRATION NO/DATE: 31255 20000726

Spc suppl protection certif: CA 2001 00002

Filing date: 20010126

PUP Patent expired
CTFW Supplementary protection certificate (spc) withdrawn, refused or deemed withdrawn

Spc suppl protection certif: CA 2001 00002