DK1984007T3 - Anvendelse af lavdoseret lokal immunsuppression til forstærkning af onkolytisk viral terapi - Google Patents
Anvendelse af lavdoseret lokal immunsuppression til forstærkning af onkolytisk viral terapi Download PDFInfo
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- DK1984007T3 DK1984007T3 DK07701775.4T DK07701775T DK1984007T3 DK 1984007 T3 DK1984007 T3 DK 1984007T3 DK 07701775 T DK07701775 T DK 07701775T DK 1984007 T3 DK1984007 T3 DK 1984007T3
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- reovirus
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- oncolytic virus
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/765—Reovirus; Rotavirus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
- A61N2005/1098—Enhancing the effect of the particle by an injected agent or implanted device
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Mycology (AREA)
- Pathology (AREA)
- Transplantation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Radiation-Therapy Devices (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Claims (9)
1. Onkolytisk virus til anvendelse ved en fremgangsmåde til behandling eller bedring af en fast tumor hos en patient, hvilken fremgangsmåde omfatter: (a) injektion af en virksom mængde af et onkolytisk virus i eller nær ved den faste tumor, hvor det onkolytiske virus er i stand til selektivt at dræbe celler i den faste tumor, hvor det onkolytiske virus er et reovirus; og (b) undertrykkelse af lokale immunreaktioner ved eller nær ved den faste tumor ved bestråling af den faste tumor med en virksom mængde af et bestrålingsmiddel, hvor mængden af bestrålingsmidlet er fra 1 til 25 Gy.
2. Onkolytisk virus til anvendelse ifølge krav 1, hvor det bestrålingsmidlet er valgt fra gruppen bestående af elektroner, røntgenstråler og gammastråler.
3. Onkolytisk virus til anvendelse ifølge krav 1 eller 2, hvor mængden af bestrålingsmidlet er 5 Gy.
4. Onkolytisk virus til anvendelse ifølge ethvert af kravene 1 til 3, hvor bestrålingsmidlet tilføres i én dosis eller i fraktioner over tid.
5. Onkolytisk virus til anvendelse ifølge ethvert af kravene 1 til 4, hvor reoviru-set er et pattedyrsreovirus eller et humant reovirus.
6. Onkolytisk virus til anvendelse ifølge krav 5, hvor det humane reovirus er valgt fra gruppen bestående af serotype 1 reovirus, serotype 2 reovirus og serotype 3 reovirus.
7. Onkolytisk virus til anvendelse ifølge krav 6, hvor det humane reovirus er serotype 3 reovirus.
8. Onkolytisk virus til anvendelse ifølge ethvert af kravene 1 til 7, hvor patienten er valgt fra gruppen bestående af hunde, katte, gnavere, får, geder, kvæg, heste, grise, menneskelige og ikke-menneskelige primater.
9. Onkolytisk virus til anvendelse ifølge ethvert af kravene 1 til 8, hvor trin (a) udføres før trin (b).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77306806P | 2006-02-13 | 2006-02-13 | |
| US78889806P | 2006-04-03 | 2006-04-03 | |
| PCT/CA2007/000187 WO2007093036A1 (en) | 2006-02-13 | 2007-02-09 | Use of local immune suppression to enhance oncolytic viral therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1984007T3 true DK1984007T3 (da) | 2015-12-07 |
Family
ID=38371138
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07701775.4T DK1984007T3 (da) | 2006-02-13 | 2007-02-09 | Anvendelse af lavdoseret lokal immunsuppression til forstærkning af onkolytisk viral terapi |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20070190032A1 (da) |
| EP (1) | EP1984007B1 (da) |
| JP (1) | JP2009525989A (da) |
| AR (1) | AR059482A1 (da) |
| AU (1) | AU2007215328A1 (da) |
| BR (1) | BRPI0707654A2 (da) |
| CA (1) | CA2640286C (da) |
| DK (1) | DK1984007T3 (da) |
| ES (1) | ES2551306T3 (da) |
| IL (1) | IL192211A0 (da) |
| TW (1) | TW200744618A (da) |
| WO (1) | WO2007093036A1 (da) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008316276A1 (en) * | 2007-10-22 | 2009-04-30 | Oncolytics Biotech Inc. | Treatment regime for proliferative disorders |
| WO2009135614A2 (en) * | 2008-05-09 | 2009-11-12 | Bayer Schering Pharma Aktiengesellschaft | Use of a virus regimen for the treatment of diseases |
| TW200950777A (en) * | 2008-05-27 | 2009-12-16 | Oncolytics Biotech Inc | Abrogating proinflammatory cytokine production during oncolytic reovirus therapy |
| US20110086005A1 (en) * | 2008-05-27 | 2011-04-14 | Oncolytics Biotech Inc. | Modulating interstitial pressure and oncolytic viral delivery and distribution |
| US10603351B2 (en) * | 2008-08-21 | 2020-03-31 | Turnstone Limited Partnership | Engineered synergistic oncolytic viral symbiosis |
| FI20100329A0 (fi) * | 2010-09-24 | 2010-09-24 | Antti Alitalo | Immunomodulatorinen adjuvanttihoito |
| CN107320734A (zh) | 2011-04-29 | 2017-11-07 | 西莱克塔生物科技公司 | 从合成纳米载体中控制释放免疫抑制剂 |
| AU2013204555A1 (en) * | 2012-04-30 | 2013-11-14 | Oncolytics Biotech Inc. | Protecting modified viruses from neutralizing antibodies using the reovirus sigma 1 protein |
| EP3461491B1 (en) * | 2013-04-18 | 2024-11-13 | TILT Biotherapeutics Oy | Enhanced adoptive cell therapy |
| US12421502B2 (en) | 2013-04-18 | 2025-09-23 | Tilt Biotherapeutics Oy | Enhanced adoptive cell therapy |
| CN105307641A (zh) | 2013-05-03 | 2016-02-03 | 西莱克塔生物科技公司 | 用于降低不期望体液免疫应答的给药组合 |
| EA201790551A1 (ru) | 2014-09-07 | 2017-07-31 | Селекта Байосайенсиз, Инк. | Способы и композиции для ослабления иммунных ответов к пропускающему экзон вирусному трансферному вектору |
| KR20180027516A (ko) * | 2015-06-11 | 2018-03-14 | 유니버시티 오브 마이애미 | 암 치료 및 진단 |
| EP4599848A3 (en) | 2017-03-11 | 2025-12-03 | Cartesian Therapeutics, Inc. | Methods and compositions related to combined treatment with anti-inflammatories and synthetic nanocarriers comprising an immunosuppressant |
| JP2022524979A (ja) | 2019-03-01 | 2022-05-11 | ランパート ヘルス リミテッド ライアビリティー カンパニー | 癌治療のための免疫学的方法及び化学療法を併用する医薬組成物 |
| US12553041B2 (en) | 2019-06-04 | 2026-02-17 | Cartesian Therapeutics Inc. | Formulations and doses of pegylated uricase |
| WO2022136057A1 (en) * | 2020-12-21 | 2022-06-30 | Probiogen Ag | Use of a birnavirus alone or in combination therapy for the treatment of cancer |
| IL305126A (en) | 2021-02-12 | 2023-10-01 | Rampart Health L L C | A therapeutic preparation and a method that combines immunotherapy with a cancer vaccine for the treatment of cancer |
| WO2023078574A1 (en) * | 2021-11-08 | 2023-05-11 | Sveuciliste U Zagrebu | A pharmaceutical kit for oncolytic virotherapy of breast cancer, its preparation and use |
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| US4108983A (en) * | 1976-06-01 | 1978-08-22 | The Wistar Institute | Viral oncolysate vaccine for stimulating the immune mechanism of mammals to species-specific tumors |
| SE445466B (sv) * | 1977-12-01 | 1986-06-23 | Wellcome Found | Sett att foroka rotavirus in vitro |
| NL7812359A (nl) * | 1978-12-20 | 1980-06-24 | Gist Brocades Nv | Vaccins tegen door reo virus veroorzaakte ziektever- schijnselen en werkwijze voor het bereiden van deze vaccins. |
| US5023252A (en) * | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US5525342A (en) * | 1994-05-20 | 1996-06-11 | Akzo Nobel, N.V. | Reovirus strain 2177 and vaccine containing same |
| US5614403A (en) * | 1994-06-01 | 1997-03-25 | Baylor College Of Medicine | In vitro replication system capable of rescuing cloned and manipulated rotavirus genes |
| US5776743A (en) * | 1994-09-06 | 1998-07-07 | La Jolla Cancer Research Foundation | Method of sensitizing tumor cells with adenovirus E1A |
| US5874531A (en) * | 1995-03-07 | 1999-02-23 | President And Fellows Of Harvard College | Identification of self and non-self antigens implicated autoimmune disease |
| WO1998043702A2 (en) * | 1997-04-03 | 1998-10-08 | Iacob Mathiesen | Method for introducing pharmaceutical drugs and nucleic acids into skeletal muscle |
| US6565831B1 (en) * | 1999-02-24 | 2003-05-20 | Oncolytics Biotech Inc. | Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders |
| US6136307A (en) * | 1997-08-13 | 2000-10-24 | Oncolytics Biotech Inc. | Reovirus for the treatment of cellular proliferative disorders |
| US6110461A (en) * | 1997-08-13 | 2000-08-29 | Oncolytics Biotech Inc. | Reovirus for the treatment of neoplasia |
| WO2000029033A2 (en) * | 1998-11-17 | 2000-05-25 | The General Hospital Corporation | A method of genetic vector delivery |
| BR0015491A (pt) * | 1999-11-12 | 2002-10-15 | Oncolytics Biotech Inc | Métodos para tratar um distúrbio proliferativo celular mediado por ras em um mamìfero, para tratar um neoplasma tendo uma via-ras ativada em um humano, para inibir metástase de um neoplasma tendo uma via-ras ativada em um mamìfero, e para tratar um neoplasma suspeito de ter uma via-ras ativada em um mamìfero, composição farmacêutica, kit, e, método para tratar uma população de células compreendendo um neoplasma suspeito de ter uma via-ras ativada in vitro |
| US20020187465A1 (en) * | 1999-11-12 | 2002-12-12 | Oncolytics Biotech, Inc. | Viruses for the treatment of cellular proliferative disorders |
| US6911200B2 (en) * | 2000-03-24 | 2005-06-28 | Cell Genesys, Inc. | Methods of treating neoplasia with combination of target-cell specific adenovirus, chemotherapy and radiation |
| US7306902B2 (en) * | 2002-06-28 | 2007-12-11 | Oncolyties Biotech Inc. | Oncolytic viruses as phenotyping agents for neoplasms |
| TWI289158B (en) * | 2000-08-10 | 2007-11-01 | Oncolytics Biotech Inc | Method of producing infectious reovirus |
| US6943245B2 (en) * | 2000-08-10 | 2005-09-13 | Board Of Regents, The University Of Texas System | Tumor suppressor CAR-1 |
| ES2445704T3 (es) * | 2000-11-09 | 2014-03-04 | Oncolytics Biotech Inc. | Métodos para el tratamiento de trastornos celulares proliferativos |
| PT1505993E (pt) * | 2002-05-10 | 2012-05-15 | Oncolytics Biotech Inc | Sensibilização de células neoplásicas a terapia de radiação com vírus oncolíticos |
| US7163678B2 (en) * | 2002-11-07 | 2007-01-16 | Oncolytics Biotech Inc. | Reovirus for the treatment of ral-mediated cellular proliferative disorders |
| US20070017123A1 (en) * | 2005-07-25 | 2007-01-25 | Rogue Outdoor Brands, Llc | Insert for footwear midsole |
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2007
- 2007-02-09 DK DK07701775.4T patent/DK1984007T3/da active
- 2007-02-09 WO PCT/CA2007/000187 patent/WO2007093036A1/en not_active Ceased
- 2007-02-09 ES ES07701775.4T patent/ES2551306T3/es active Active
- 2007-02-09 EP EP07701775.4A patent/EP1984007B1/en active Active
- 2007-02-09 US US11/673,201 patent/US20070190032A1/en not_active Abandoned
- 2007-02-09 CA CA2640286A patent/CA2640286C/en active Active
- 2007-02-09 AU AU2007215328A patent/AU2007215328A1/en not_active Abandoned
- 2007-02-09 BR BRPI0707654-1A patent/BRPI0707654A2/pt not_active Application Discontinuation
- 2007-02-09 JP JP2008553585A patent/JP2009525989A/ja active Pending
- 2007-02-12 TW TW096104995A patent/TW200744618A/zh unknown
- 2007-02-13 AR ARP070100608A patent/AR059482A1/es unknown
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2008
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| EP1984007B1 (en) | 2015-08-19 |
| US20070190032A1 (en) | 2007-08-16 |
| BRPI0707654A2 (pt) | 2011-05-10 |
| CA2640286C (en) | 2018-01-02 |
| TW200744618A (en) | 2007-12-16 |
| WO2007093036A1 (en) | 2007-08-23 |
| CA2640286A1 (en) | 2007-08-23 |
| AU2007215328A1 (en) | 2007-08-23 |
| EP1984007A4 (en) | 2012-03-07 |
| JP2009525989A (ja) | 2009-07-16 |
| IL192211A0 (en) | 2008-12-29 |
| AU2007215328A2 (en) | 2008-07-31 |
| HK1117424A1 (en) | 2009-01-16 |
| AR059482A1 (es) | 2008-04-09 |
| EP1984007A1 (en) | 2008-10-29 |
| ES2551306T3 (es) | 2015-11-17 |
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