DK1984012T3 - Anvendelse af peptidisk vasopressin-receptor-agonister - Google Patents
Anvendelse af peptidisk vasopressin-receptor-agonister Download PDFInfo
- Publication number
- DK1984012T3 DK1984012T3 DK07804708.1T DK07804708T DK1984012T3 DK 1984012 T3 DK1984012 T3 DK 1984012T3 DK 07804708 T DK07804708 T DK 07804708T DK 1984012 T3 DK1984012 T3 DK 1984012T3
- Authority
- DK
- Denmark
- Prior art keywords
- induced
- syndrome
- shock
- hypotension
- syncope
- Prior art date
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- 230000002829 reductive effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 238000013222 sprague-dawley male rat Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- XSROQCDVUIHRSI-UHFFFAOYSA-N thietane Chemical compound C1CSC1 XSROQCDVUIHRSI-UHFFFAOYSA-N 0.000 description 1
- VOVUARRWDCVURC-UHFFFAOYSA-N thiirane Chemical compound C1CS1 VOVUARRWDCVURC-UHFFFAOYSA-N 0.000 description 1
- 230000002537 thrombolytic effect Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- ZGYICYBLPGRURT-UHFFFAOYSA-N tri(propan-2-yl)silicon Chemical compound CC(C)[Si](C(C)C)C(C)C ZGYICYBLPGRURT-UHFFFAOYSA-N 0.000 description 1
- 125000004306 triazinyl group Chemical group 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 229960003726 vasopressin Drugs 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/16—Oxytocins; Vasopressins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/095—Oxytocins; Vasopressins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Claims (2)
1. Forbindelse valgt blandt en gruppe bestående af:
til anvendelse i behandling af hypertensiv gastropati-blødning, sepsis, svær sepsis, septisk chok, længerevarende og svær hypotension, intradialytisk hypotension, hjertestop, traume-betinget blodtab, vasodilatorisk chok induceret af kardio-pulmonal bypass, milrino-ne-induceret vasodilatorisk chok i kongestivt hjertesvigt, hepatorenalt syndrom type I, anafylaktisk chok, cardiovaskulær ustabilitet induceret af hjernedød, til anvendelse i behandling af hypotension i svær sepsis, akut respiratorisk distresssyndrom eller akut lungeskade, eller til anvendelse i behandling af utilstrækkelig vævsoxygenering, chok induceret af metformin-intoksikation, mitokondrie-sygdom eller cyanidforgiftning, vaskulær lækagesyndrom induceret af interleukin-2 eller andre cytokiner, denileukindiftitox eller andre immuntoksiner eller ovariehyperstimuleringssyndrom, hypertension induceret af nyresygdom i slutstadium, svære forbrændinger, termisk skade, reperfusionsskade, ascites, vasodepressor synkope omfattende vasovagal synkope, postural hypotension med synkope eller neu-rocardiogenisk synkope, toksisk choksyndrom eller idiopatisk systemisk kapillær lækagesyndrom (Clarkson's sygdom).
2. Forbindelse valgt blandt en gruppe bestående af:
til anvendelse til fremstilling af et lægemiddel til behandling af hypertensiv gastropa-ti- blødning, sepsis, svær sepsis, septisk chok, længerevarende og svær hypotension, in-tradialytisk hypotension, hjertestop, traumebetinget blodtab, vasodilatorisk chok induceret af kardio-pulmonal bypass, milrinone-induceret vasodilatorisk chok i kongestivt hjertesvigt, hepatorenalt syndrom type I, anafylaktisk chok, cardiovaskulær ustabilitet induceret af hjernedød, til anvendelse til fremstilling af et lægemiddel til behandling af hypotension i svær sepsis, akut respiratorisk distress-syndrom eller akut lungeskade eller til anvendelse til fremstilling af et lægemiddel til behandling af utilstrækkelig vævoxygenering, chok induceret af metformin-intoksikation, mitokondrie-sygdom eller cyanidforgiftning, vaskulær lækage-syndrom induceret af interleukin-2 eller andre cytokiner, denileukindiftitox eller andre immuntoksiner eller ovariehyperstimuleringssyndrom, hypertension induceret af nyresygdom i slutstadium, svære forbrændinger, termisk skade, reperfusionsskade, ascites, vasodepressor synkope, omfatter vasovagal synkope, postural hypotension med synkope eller neurokardiogen synkope, toksisk choksyndrom eller idiopatisk systemisk kapil-lær lækagesyndrom (Clarkson's sygdom).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77252806P | 2006-02-13 | 2006-02-13 | |
| PCT/IB2007/002248 WO2007144768A2 (en) | 2006-02-13 | 2007-02-12 | Use of peptidic vasopressin receptor agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1984012T3 true DK1984012T3 (da) | 2016-03-29 |
Family
ID=38832172
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07804708.1T DK1984012T3 (da) | 2006-02-13 | 2007-02-12 | Anvendelse af peptidisk vasopressin-receptor-agonister |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8222202B2 (da) |
| EP (1) | EP1984012B1 (da) |
| DK (1) | DK1984012T3 (da) |
| ES (1) | ES2566143T3 (da) |
| HU (1) | HUE027174T2 (da) |
| PL (1) | PL1984012T3 (da) |
| SI (1) | SI1984012T1 (da) |
| WO (1) | WO2007144768A2 (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2937B1 (en) * | 2004-08-11 | 2016-03-15 | فيرينغ.بي.في | Tight muscles of the peptide vascular tensioner receptor |
| KR101194586B1 (ko) | 2006-02-10 | 2012-10-25 | 훼링 비.브이. | 신규 화합물 |
| WO2009037586A2 (en) * | 2007-08-14 | 2009-03-26 | Ferring B.V. | Use of peptidic vasopressin receptor agonists |
| JO3109B1 (ar) * | 2012-05-10 | 2017-09-20 | Ferring Bv | منبهات لمستقبلات v1a |
| JP2017014206A (ja) * | 2015-06-30 | 2017-01-19 | ナノアンティバイオティクス，インコーポレイテッド | 腹水の治療 |
| US11033601B2 (en) | 2017-09-14 | 2021-06-15 | The Regents Of The University Of Colorado, A Body Corporate | Selective inhibition of V1b for treating fatty liver |
| JP2022507380A (ja) * | 2018-11-15 | 2022-01-18 | フェリング ベスローテン フェンノートシャップ | 敗血症を治療するための化合物、組成物及び方法 |
| AU2020279395B2 (en) | 2019-05-22 | 2025-08-28 | Biovie Inc. | Formulations of terlipressin |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1076984A (en) * | 1963-04-05 | 1967-07-26 | Sandoz Ltd | Improvements in or relating to local anaesthetics containing orn-vasopressin |
| US4829051A (en) * | 1983-04-05 | 1989-05-09 | Vega Laboratories, Inc. | N-substituted derivatives of 1-desaminovasopressin |
| GB9617021D0 (en) * | 1996-08-13 | 1996-09-25 | Salpep Biotechnology Inc | Novel peptides for treatment of inflammation and shock |
| NZ506839A (en) | 1998-03-09 | 2003-05-30 | Zealand Pharma As | Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis |
| WO2003082334A1 (fr) * | 2002-03-29 | 2003-10-09 | Wakamoto Pharmaceutical Co.,Ltd. | Medicaments pour augmenter la quantite de fluide lacrymal |
| US7183255B2 (en) | 2003-02-26 | 2007-02-27 | Intradialytic Pharmaceuticals | Method for stabilizing blood pressure in hemodialysis subjects |
| JO2937B1 (en) * | 2004-08-11 | 2016-03-15 | فيرينغ.بي.في | Tight muscles of the peptide vascular tensioner receptor |
-
2007
- 2007-02-12 DK DK07804708.1T patent/DK1984012T3/da active
- 2007-02-12 SI SI200731755A patent/SI1984012T1/sl unknown
- 2007-02-12 HU HUE07804708A patent/HUE027174T2/en unknown
- 2007-02-12 WO PCT/IB2007/002248 patent/WO2007144768A2/en not_active Ceased
- 2007-02-12 EP EP07804708.1A patent/EP1984012B1/en active Active
- 2007-02-12 US US12/223,673 patent/US8222202B2/en not_active Expired - Fee Related
- 2007-02-12 ES ES07804708.1T patent/ES2566143T3/es active Active
- 2007-02-12 PL PL07804708T patent/PL1984012T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007144768A2 (en) | 2007-12-21 |
| PL1984012T3 (pl) | 2016-07-29 |
| EP1984012B1 (en) | 2015-12-30 |
| EP1984012A2 (en) | 2008-10-29 |
| US20090305959A1 (en) | 2009-12-10 |
| WO2007144768A3 (en) | 2008-05-15 |
| ES2566143T3 (es) | 2016-04-11 |
| HUE027174T2 (en) | 2016-10-28 |
| HK1117071A1 (zh) | 2009-01-09 |
| SI1984012T1 (sl) | 2016-05-31 |
| US8222202B2 (en) | 2012-07-17 |
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