DK1987137T3 - Syntese af sialinsyre i planter - Google Patents

Syntese af sialinsyre i planter

Info

Publication number: DK1987137T3
Authority: DK; Denmark
Prior art keywords: sialic acid; plants; neu5ac; plant; nucleotide sequence
Prior art date: 2006-02-09

Application number

DK07710612.8T

Other languages

English (en)

Inventor

Stephanie Aquin

Thomas Paccalet

Christophe Rihouey

Aoust Marc-Andre D

Veronique Gomord

Loic Faye

Patrice Lerouge

Louis-Philippe Vezina

Muriel Bardor

Original Assignee

Medicago Inc

Centre Nat Rech Scient

Univ Rouen

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-02-09

Filing date

2007-02-09

Publication date

2011-10-10

2007-02-09 Application filed by Medicago Inc, Centre Nat Rech Scient, Univ Rouen filed Critical Medicago Inc

2011-10-10 Application granted granted Critical

2011-10-10 Publication of DK1987137T3 publication Critical patent/DK1987137T3/da

Links

SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 title abstract 6
SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 title abstract 5
230000015572 biosynthetic process Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
239000002773 nucleotide Substances 0.000 abstract 3
125000003729 nucleotide group Chemical group 0.000 abstract 3
230000002194 synthesizing effect Effects 0.000 abstract 3
TXCIAUNLDRJGJZ-UHFFFAOYSA-N CMP-N-acetyl neuraminic acid Natural products O1C(C(O)C(O)CO)C(NC(=O)C)C(O)CC1(C(O)=O)OP(O)(=O)OCC1C(O)C(O)C(N2C(N=C(N)C=C2)=O)O1 TXCIAUNLDRJGJZ-UHFFFAOYSA-N 0.000 abstract 2
TXCIAUNLDRJGJZ-BILDWYJOSA-N CMP-N-acetyl-beta-neuraminic acid Chemical compound O1[C@@H]([C@H](O)[C@H](O)CO)[C@H](NC(=O)C)[C@@H](O)C[C@]1(C(O)=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=C(N)C=C2)=O)O1 TXCIAUNLDRJGJZ-BILDWYJOSA-N 0.000 abstract 2
CERZMXAJYMMUDR-QBTAGHCHSA-N 5-amino-3,5-dideoxy-D-glycero-D-galacto-non-2-ulopyranosonic acid Chemical compound N[C@@H]1[C@@H](O)CC(O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO CERZMXAJYMMUDR-QBTAGHCHSA-N 0.000 abstract 1
SQVRNKJHWKZAKO-PFQGKNLYSA-N N-acetyl-beta-neuraminic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-PFQGKNLYSA-N 0.000 abstract 1
102000048245 N-acetylneuraminate lyases Human genes 0.000 abstract 1
108700023220 N-acetylneuraminate lyases Proteins 0.000 abstract 1
102000003838 Sialyltransferases Human genes 0.000 abstract 1
108090000141 Sialyltransferases Proteins 0.000 abstract 1
CERZMXAJYMMUDR-UHFFFAOYSA-N neuraminic acid Natural products NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO CERZMXAJYMMUDR-UHFFFAOYSA-N 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H1/00—Processes for modifying genotypes ; Plants characterised by associated natural traits
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8245—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified carbohydrate or sugar alcohol metabolism, e.g. starch biosynthesis
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/14—Plant cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
- C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
- C12Y205/01057—N-Acylneuraminate-9-phosphate synthase (2.5.1.57)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/03—Oxo-acid-lyases (4.1.3)
- C12Y401/03003—N-Acetylneuraminate lyase (4.1.3.3)

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Microbiology (AREA)
Medicinal Chemistry (AREA)
Cell Biology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nutrition Science (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Pharmacology & Pharmacy (AREA)
Botany (AREA)
Developmental Biology & Embryology (AREA)
Environmental Sciences (AREA)
Enzymes And Modification Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Saccharide Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines Containing Plant Substances (AREA)

DK07710612.8T 2006-02-09 2007-02-09 Syntese af sialinsyre i planter DK1987137T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US74326706P	2006-02-09	2006-02-09
PCT/CA2007/000197 WO2007090290A1 (en)	2006-02-09	2007-02-09	Synthesis of sialic acid in plants

Publications (1)

Publication Number	Publication Date
DK1987137T3 true DK1987137T3 (da)	2011-10-10

Family

ID=38344843

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK10166705.3T DK2224009T3 (da)	2006-02-09	2007-02-09	Syntese af sialinsyre i planter
DK07710612.8T DK1987137T3 (da)	2006-02-09	2007-02-09	Syntese af sialinsyre i planter

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK10166705.3T DK2224009T3 (da)	2006-02-09	2007-02-09	Syntese af sialinsyre i planter

Country Status (15)

Country	Link
US (3)	US9212372B2 (da)
EP (2)	EP1987137B1 (da)
JP (2)	JP5502328B2 (da)
KR (1)	KR101385051B1 (da)
CN (2)	CN102586319A (da)
AT (1)	ATE513918T1 (da)
AU (1)	AU2007214227B2 (da)
BR (1)	BRPI0707598A2 (da)
CA (2)	CA2649134C (da)
DK (2)	DK2224009T3 (da)
ES (2)	ES2368657T3 (da)
IL (1)	IL193333A (da)
NZ (2)	NZ570455A (da)
PT (2)	PT1987137E (da)
WO (1)	WO2007090290A1 (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2012150504A1 (en) *	2011-05-05	2012-11-08	Life Science Nutrition As	Performance enhancing compositions and methods of use
CN103060301A (zh) *	2011-10-20	2013-04-24	中国科学院微生物研究所	乳酸片球菌的n-乙酰神经氨酸醛缩酶及其基因与应用
DE102017117291A1 (de)	2017-07-31	2019-01-31	Rolls-Royce Deutschland Ltd & Co Kg	Luftführungsvorrichtung in einem Flugzeugtriebwerk

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5428147A (en)	1983-04-15	1995-06-27	Mycogen Plant Science, Inc.	Octopine T-DNA promoters
US4945050A (en)	1984-11-13	1990-07-31	Cornell Research Foundation, Inc.	Method for transporting substances into living cells and tissues and apparatus therefor
US5100792A (en)	1984-11-13	1992-03-31	Cornell Research Foundation, Inc.	Method for transporting substances into living cells and tissues
US5036006A (en)	1984-11-13	1991-07-30	Cornell Research Foundation, Inc.	Method for transporting substances into living cells and tissues and apparatus therefor
IL99245A0 (en) *	1990-09-04	1992-07-15	Taiyo Kagaku Kk	Method for production of sialic acid
JP3131655B2 (ja) *	1992-02-03	2001-02-05	マルキン忠勇株式会社	Ｎ−アセチルノイラミン酸の製造法
US6204431B1 (en) *	1994-03-09	2001-03-20	Abbott Laboratories	Transgenic non-human mammals expressing heterologous glycosyltransferase DNA sequences produce oligosaccharides and glycoproteins in their milk
US6949372B2 (en) *	1999-03-02	2005-09-27	The Johns Hopkins University	Engineering intracellular sialylation pathways
FR2791358B1 (fr)	1999-03-22	2003-05-16	Meristem Therapeutics	Promoteurs chimeriques d'expression, cassettes d'expression, plasmides, vecteurs, plantes et semences transgeniques les contenant et leurs methodes d'obtention
US6846656B1 (en) *	1999-08-30	2005-01-25	Kyowa Hakko Kogyo Co., Ltd.	Process for producing N-acetylneuraminic acid
DE60044858D1 (de) *	1999-10-26	2010-09-30	Stichting Dienst Landbouwkundi	Säugetierartige Glykosylierung in Pflanzen
JPWO2002033070A1 (ja)	2000-10-16	2004-02-26	協和醗酵工業株式会社	Ｎ−アセチルノイラミン酸合成酵素および該酵素をコードするｄｎａ
WO2002036786A2 (en)	2000-10-31	2002-05-10	Medicago Inc.	Method of selecting plant promoters to control transgene expression
JP4318549B2 (ja)	2002-02-28	2009-08-26	協和発酵バイオ株式会社	Ｎ−アセチルノイラミン酸の製造法
CN101613705A (zh) *	2002-03-19	2009-12-30	国际植物研究所	在植物中优化聚糖生成
CN1301330C (zh) *	2002-07-18	2007-02-21	雅玛山酱油株式会社	Cmp－n－乙酰神经氨酸的制造方法
JP2006333701A (ja)	2003-01-15	2006-12-14	Kazuhito Fujiyama	動物型糖鎖をもつ糖タンパク質の生産方法
WO2004071177A2 (en) *	2003-02-11	2004-08-26	Arizona Board Of Regents, Acting For And On Behalf Of, Arizona State University	Sialylation of glycoproteins in plants
EP1730293A2 (en) *	2004-03-17	2006-12-13	Glycofi, Inc.	Method of engineering a cytidine monophosphate-sialic acid synthetic pathway in fungi and yeast
DE602006015195D1 (de)	2005-07-12	2010-08-12	Greenovation Biotech Gmbh	Verbesserungen der proteinproduktion oder in zusammenhang damit
EP1915453B1 (en)	2005-07-27	2010-12-01	J.R. Simplot Company	Marker-free plant transformation
JP2010529845A (ja)	2007-06-15	2010-09-02	メディカゴインコーポレイテッド	植物でのタンパク質の製造

2007
- 2007-02-09 CA CA2649134A patent/CA2649134C/en active Active
- 2007-02-09 PT PT07710612T patent/PT1987137E/pt unknown
- 2007-02-09 NZ NZ570455A patent/NZ570455A/en unknown
- 2007-02-09 DK DK10166705.3T patent/DK2224009T3/da active
- 2007-02-09 US US12/278,677 patent/US9212372B2/en not_active Expired - Fee Related
- 2007-02-09 PT PT101667053T patent/PT2224009E/pt unknown
- 2007-02-09 CA CA2813435A patent/CA2813435C/en not_active Expired - Fee Related
- 2007-02-09 BR BRPI0707598-7A patent/BRPI0707598A2/pt not_active Application Discontinuation
- 2007-02-09 ES ES07710612T patent/ES2368657T3/es active Active
- 2007-02-09 AU AU2007214227A patent/AU2007214227B2/en not_active Ceased
- 2007-02-09 DK DK07710612.8T patent/DK1987137T3/da active
- 2007-02-09 CN CN2012100273796A patent/CN102586319A/zh active Pending
- 2007-02-09 KR KR1020087022025A patent/KR101385051B1/ko not_active Expired - Fee Related
- 2007-02-09 AT AT07710612T patent/ATE513918T1/de active
- 2007-02-09 WO PCT/CA2007/000197 patent/WO2007090290A1/en not_active Ceased
- 2007-02-09 JP JP2008553589A patent/JP5502328B2/ja not_active Expired - Fee Related
- 2007-02-09 NZ NZ596626A patent/NZ596626A/xx unknown
- 2007-02-09 EP EP07710612A patent/EP1987137B1/en active Active
- 2007-02-09 CN CN2007800111939A patent/CN101466829B/zh not_active Expired - Fee Related
- 2007-02-09 EP EP10166705A patent/EP2224009B1/en not_active Not-in-force
- 2007-02-09 ES ES10166705T patent/ES2399681T3/es active Active
2008
- 2008-08-07 IL IL193333A patent/IL193333A/en active IP Right Grant
2013
- 2013-03-25 JP JP2013062326A patent/JP2013126424A/ja not_active Withdrawn
2015
- 2015-11-04 US US14/932,326 patent/US9657305B2/en not_active Expired - Fee Related
2017
- 2017-03-30 US US15/474,853 patent/US20170247714A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CA2813435A1 (en)	2007-08-16
BRPI0707598A2 (pt)	2011-05-10
CN101466829A (zh)	2009-06-24
ES2399681T3 (es)	2013-04-02
US20160145664A1 (en)	2016-05-26
US9657305B2 (en)	2017-05-23
EP1987137B1 (en)	2011-06-22
IL193333A (en)	2012-05-31
AU2007214227A1 (en)	2007-08-16
NZ596626A (en)	2013-04-26
ATE513918T1 (de)	2011-07-15
KR101385051B1 (ko)	2014-04-24
IL193333A0 (en)	2011-08-01
JP2013126424A (ja)	2013-06-27
WO2007090290A1 (en)	2007-08-16
CA2649134C (en)	2013-07-02
CN101466829B (zh)	2012-03-14
US20170247714A1 (en)	2017-08-31
PT1987137E (pt)	2011-09-28
EP1987137A1 (en)	2008-11-05
JP2009525729A (ja)	2009-07-16
ES2368657T3 (es)	2011-11-21
NZ570455A (en)	2011-12-22
KR20080113367A (ko)	2008-12-30
JP5502328B2 (ja)	2014-05-28
CA2813435C (en)	2014-04-29
HK1146487A1 (en)	2011-06-10
CA2649134A1 (en)	2007-08-16
EP2224009A1 (en)	2010-09-01
AU2007214227B2 (en)	2012-09-27
EP1987137A4 (en)	2009-09-16
CN102586319A (zh)	2012-07-18
US9212372B2 (en)	2015-12-15
US20090312240A1 (en)	2009-12-17
DK2224009T3 (da)	2013-02-11
PT2224009E (pt)	2012-12-10
EP2224009B1 (en)	2012-10-31

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