DK199783A - Immunoglobulin-halvmolekyler og fremgangsmaade til fremstilling af hybrid-antistoffer - Google Patents

Immunoglobulin-halvmolekyler og fremgangsmaade til fremstilling af hybrid-antistoffer Download PDF

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Publication number
DK199783A
DK199783A DK199783A DK199783A DK199783A DK 199783 A DK199783 A DK 199783A DK 199783 A DK199783 A DK 199783A DK 199783 A DK199783 A DK 199783A DK 199783 A DK199783 A DK 199783A
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DK
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Prior art keywords
procedures
preparation
hybrid antibodies
half molecules
immunoglobulin
Prior art date
Application number
DK199783A
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English (en)
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DK199783D0 (da
Inventor
Karen Auditore-Hargreaves
Frederick Miesowicz
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/374,970 external-priority patent/US4446233A/en
Priority claimed from US06/374,971 external-priority patent/US4479895A/en
Application filed by Du Pont filed Critical Du Pont
Publication of DK199783D0 publication Critical patent/DK199783D0/da
Publication of DK199783A publication Critical patent/DK199783A/da

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Description

kyle tilvejebringer et bindingssted for et første antigen, og det andet halvmolekyle tilvejebringer et kemisk forskelligt bindingssted for det første eller et andet antigen.
Til immunoprøvning for analyter, såsom antigener eller haptener, anvendes det ovenfor fremstillede covalente hybrid-antistof til modulering af aktiviteten af indikatorer. Hybrid-antistoffet har i dette tilfælde bindingssteder for analyten og indikatoren. Slutaktiviteten af indikatoren er proportional med analytkoncentrationen.
·>
DK199783A 1982-05-05 1983-05-04 Immunoglobulin-halvmolekyler og fremgangsmaade til fremstilling af hybrid-antistoffer DK199783A (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US06/374,970 US4446233A (en) 1982-05-05 1982-05-05 Homogeneous immunoassay using covalent hybrid antibodies
US06/374,971 US4479895A (en) 1982-05-05 1982-05-05 Immunoglobulin half-molecules and process for producing hybrid antibodies
US37497182 1982-05-05
US37497082 1982-05-05

Publications (2)

Publication Number Publication Date
DK199783D0 DK199783D0 (da) 1983-05-04
DK199783A true DK199783A (da) 1983-11-06

Family

ID=27006845

Family Applications (1)

Application Number Title Priority Date Filing Date
DK199783A DK199783A (da) 1982-05-05 1983-05-04 Immunoglobulin-halvmolekyler og fremgangsmaade til fremstilling af hybrid-antistoffer

Country Status (5)

Country Link
EP (1) EP0096463B1 (da)
JP (1) JPH05295000A (da)
CA (1) CA1194415A (da)
DE (1) DE3368064D1 (da)
DK (1) DK199783A (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3583278D1 (de) * 1984-04-23 1991-07-25 Boston Biomed Res Inst Doppelspezifische antikoerper-determinanten.
NL8501219A (nl) * 1985-04-29 1986-11-17 Stichting Vrienden Van De Stic Immunologisch complex, de bereiding en toepassing daarvan.
US4954617A (en) * 1986-07-07 1990-09-04 Trustees Of Dartmouth College Monoclonal antibodies to FC receptors for immunoglobulin G on human mononuclear phagocytes
GB8626767D0 (en) * 1986-11-10 1986-12-10 Unilever Plc Assays
US5086002A (en) * 1987-09-07 1992-02-04 Agen Biomedical, Ltd. Erythrocyte agglutination assay
NZ226202A (en) * 1987-09-17 1992-01-29 Agen Ltd Erythrocyte agglutination assay
IT1235349B (it) * 1988-12-23 1992-06-30 Biodata Spa Saggio immunologico per determinazioni in fase omogenea
CA2108451A1 (en) * 1991-04-26 1992-10-27 Beverley J. Randle Novel antibodies, and methods for their use
US5447846A (en) * 1992-07-17 1995-09-05 Fuji Photo Film C., Ltd. Homogeneous Immunoassay process using covalent conjugate of enzyme and plural monoclonal antibodies for different epitopes on analyte
GB9316369D0 (en) * 1993-08-06 1993-09-22 Surface Active Ltd Diagnostic method
JP2005172694A (ja) * 2003-12-12 2005-06-30 Fuji Photo Film Co Ltd タンパク質の検出方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2508132C3 (de) * 1974-03-08 1980-10-16 Teijin Ltd., Osaka (Japan) Verfahren zur Herstellung von Humanimmunglobulin-Derivaten und parenteral applizierbare Lösung hiervon
US4156081A (en) * 1977-04-15 1979-05-22 Syva Company Theophylline antigens and antibodies
AU556548B2 (en) * 1980-03-03 1986-11-06 Milton David Goldenberg Tumor localization and therapy with labeled antibodies and antibody fragments specific to tumor-associated markers
DE3134361A1 (de) * 1981-08-31 1983-03-10 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur enzymimmuno-bestimmung in homogener phase

Also Published As

Publication number Publication date
DK199783D0 (da) 1983-05-04
DE3368064D1 (en) 1987-01-15
JPH05295000A (ja) 1993-11-09
CA1194415A (en) 1985-10-01
EP0096463B1 (en) 1986-12-03
EP0096463A1 (en) 1983-12-21

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