DK199986A - Fremgangsmaade til fremstilling af et baerestof til styret langsom afgivelse af et aktivt middel, samt et ved fremgangsmaaden fremstillet baerestof - Google Patents
Fremgangsmaade til fremstilling af et baerestof til styret langsom afgivelse af et aktivt middel, samt et ved fremgangsmaaden fremstillet baerestof Download PDFInfo
- Publication number
- DK199986A DK199986A DK199986A DK199986A DK199986A DK 199986 A DK199986 A DK 199986A DK 199986 A DK199986 A DK 199986A DK 199986 A DK199986 A DK 199986A DK 199986 A DK199986 A DK 199986A
- Authority
- DK
- Denmark
- Prior art keywords
- procedure
- sec
- macromer
- water
- government
- Prior art date
Links
- 239000013543 active substance Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000178 monomer Substances 0.000 abstract description 3
- 150000001875 compounds Chemical class 0.000 abstract description 2
- 229920001451 polypropylene glycol Polymers 0.000 abstract description 2
- 239000000017 hydrogel Substances 0.000 abstract 2
- 229920001577 copolymer Polymers 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- -1 polytetramethylene Polymers 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 description 8
- 229910052739 hydrogen Inorganic materials 0.000 description 7
- 239000001257 hydrogen Substances 0.000 description 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 150000002431 hydrogen Chemical class 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 125000002947 alkylene group Chemical group 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 1
- 125000004423 acyloxy group Chemical group 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000001589 carboacyl group Chemical group 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Medicinal Preparation (AREA)
- Macromonomer-Based Addition Polymer (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Compounds Of Unknown Constitution (AREA)
- Polyethers (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Polymerisation Methods In General (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Description
hvori R1 er en polykondensatkæde med en molekylvægt fra ca. 200 til ca. 8000, dér er resten af en poly-(propylenoxid)-eller poly~(tetramethylenoxid)-glycol med etherbindinger, R2 er hydrogen, methyl eller -CH2COOR4, hvori R4 er hydrogen eller en alkylgruppe med op til 10 carbonatomer, R3 er hydrogen eller COOR4, forudsat at mindst én af R2 og R3 er hydrogen, X er oxygen, —COO— eller -CONR^, hvori R5 er hydrogen eller alkyl med op til 5 carbonatomer, og Y er en direkte binding eller radikalet -R^-zi-CO-NH-R7-NH-CO-Z2-, hvor R5 er bundet til X og repræsenterer et forgrenet eller lineært alkylen med op til 7 carbonatomer, Z1 og Z2 er oxygen eller NR5, og R7 er diradikalet af et aliphatisk, herunder cycloaliphatisk, eller aromatisk diisocyanat, forudsat at dersom X er oxygen, er Y ikke en direkte binding, og R2 og R3 er hydrogen, fremstilles ved udførelse af følgende trin i) og il): i) den nævnte monomer (A) og den nævnte makromer (B) copolymeriseres i nærværelse af et udløsestof (en initiator) for frie radikaler ved en reaktionstemperatur mellem ca. 20 og ca. 150°C i nærværelse eller fraværelse af et i alt inaktivt opløsningsmiddel og i nærværelse af en makromerekspanderende virksom mængde af en opløselig forbindelse af makromeren (B) med formlen
(II) hvori R* er hydroxy, alkoxy med op til 8 carbonatomer eller alkanoyloxy med op til 8 carbonatomer, R" er en ligekædet eller forgrenet alkylen med fra 2 til 6 c arbonatomer, R"' er hydrogen, alkyl med op til 18 carbonatomer eller alkanoyl med op til 18 carbonatomer, og
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72982185A | 1985-05-02 | 1985-05-02 | |
| US72982185 | 1985-05-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK199986D0 DK199986D0 (da) | 1986-05-01 |
| DK199986A true DK199986A (da) | 1986-11-03 |
Family
ID=24932776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK199986A DK199986A (da) | 1985-05-02 | 1986-05-01 | Fremgangsmaade til fremstilling af et baerestof til styret langsom afgivelse af et aktivt middel, samt et ved fremgangsmaaden fremstillet baerestof |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0200213B1 (da) |
| JP (1) | JPS61254615A (da) |
| AT (1) | ATE78404T1 (da) |
| AU (1) | AU590758B2 (da) |
| CA (1) | CA1296459C (da) |
| DE (1) | DE3686085T2 (da) |
| DK (1) | DK199986A (da) |
| ES (1) | ES8801120A1 (da) |
| IE (1) | IE57864B1 (da) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL86211A (en) * | 1987-05-04 | 1992-03-29 | Ciba Geigy Ag | Oral forms of administration for carbamazepine in the forms of stable aqueous suspension with delayed release and their preparation |
| DE68928089T2 (de) * | 1988-02-26 | 1997-12-18 | Ciba Geigy Ag | Benetzbares, biegsames, sauerstoffdurchlässiges, quellbares Polymer mit Polyoxyalkyleneinheiten in der Hauptkette und Kontaktlinse |
| US6312724B1 (en) | 1997-04-04 | 2001-11-06 | Isa Odidi | Sustained release pharmaceutical matrix tablet of pharmaceutically acceptable salts of diclofenac and process for preparation thereof |
| US6572889B1 (en) * | 2002-03-07 | 2003-06-03 | Noveon Ip Holdings Corp. | Controlled release solid dosage carbamazepine formulations |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4177056A (en) * | 1974-06-27 | 1979-12-04 | Ciba-Geigy Corporation | Water-insoluble hydrophilic copolymers used as carriers for medicaments and pesticides |
| US4127127A (en) * | 1977-05-23 | 1978-11-28 | Alza Corporation | Therapeutic systems made from certain segmented copolyesters |
| US4548990A (en) * | 1983-08-15 | 1985-10-22 | Ciba-Geigy Corporation | Crosslinked, porous polymers for controlled drug delivery |
-
1986
- 1986-04-29 AT AT86105925T patent/ATE78404T1/de not_active IP Right Cessation
- 1986-04-29 EP EP86105925A patent/EP0200213B1/en not_active Expired
- 1986-04-29 DE DE8686105925T patent/DE3686085T2/de not_active Expired - Fee Related
- 1986-04-30 ES ES554593A patent/ES8801120A1/es not_active Expired
- 1986-04-30 CA CA000508013A patent/CA1296459C/en not_active Expired - Lifetime
- 1986-05-01 JP JP61099532A patent/JPS61254615A/ja active Pending
- 1986-05-01 DK DK199986A patent/DK199986A/da not_active Application Discontinuation
- 1986-05-01 AU AU57012/86A patent/AU590758B2/en not_active Ceased
- 1986-05-01 IE IE1158/86A patent/IE57864B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE3686085D1 (de) | 1992-08-27 |
| AU590758B2 (en) | 1989-11-16 |
| EP0200213A3 (en) | 1988-02-10 |
| ES554593A0 (es) | 1988-01-01 |
| IE57864B1 (en) | 1993-05-05 |
| EP0200213A2 (en) | 1986-11-05 |
| ATE78404T1 (de) | 1992-08-15 |
| EP0200213B1 (en) | 1992-07-22 |
| JPS61254615A (ja) | 1986-11-12 |
| AU5701286A (en) | 1986-11-06 |
| CA1296459C (en) | 1992-02-25 |
| DK199986D0 (da) | 1986-05-01 |
| DE3686085T2 (de) | 1993-01-07 |
| IE861158L (en) | 1986-11-02 |
| ES8801120A1 (es) | 1988-01-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHB | Application shelved due to non-payment |