DK200000792A - Lindring af Peyronie's sygdom - Google Patents
Lindring af Peyronie's sygdom Download PDFInfo
- Publication number
- DK200000792A DK200000792A DK200000792A DKPA200000792A DK200000792A DK 200000792 A DK200000792 A DK 200000792A DK 200000792 A DK200000792 A DK 200000792A DK PA200000792 A DKPA200000792 A DK PA200000792A DK 200000792 A DK200000792 A DK 200000792A
- Authority
- DK
- Denmark
- Prior art keywords
- collagenase
- approx
- pharmaceutical composition
- peyronie
- disease
- Prior art date
Links
- 208000004362 Penile Induration Diseases 0.000 title description 4
- 208000020758 Peyronie disease Diseases 0.000 title description 4
- 102000029816 Collagenase Human genes 0.000 description 16
- 108060005980 Collagenase Proteins 0.000 description 16
- 229960002424 collagenase Drugs 0.000 description 16
- 239000008194 pharmaceutical composition Substances 0.000 description 12
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 239000003937 drug carrier Substances 0.000 description 3
- 239000008365 aqueous carrier Substances 0.000 description 2
- 238000005452 bending Methods 0.000 description 2
- 210000003899 penis Anatomy 0.000 description 2
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000003100 immobilizing effect Effects 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Description
PATENTKRAV 1. Anvendelse af collagenase til fremstilling af et farmaceutisk præparat til behandling af Peyronie's sygdom ved injektion af det farmaceutiske præparat i en fibrøs Peyronie's plak i penisen på et individ, som lider af sygdommen, hvorved det farmaceutiske præparat injiceres på en sådan måde, at det tilvejebringer en collagenase-mængde og -koncentration, som er i stand til at blødgøre og/eller bryde hul på plakken, idet penisen immobiliseres umiddelbart efter injektionen og fastholdes immobil i adskillige timer, hvorved den penile bøjning, der er forårsaget af plakken, tindres. 2. Anvendelse ifølge krav 1, ved hvilken det farmaceutiske præparat indeholder collagenase i en koncentration på ca. 20.000 til ca. 40.000 ABC-enheder pr. ml i en farmaceutisk acceptabel bærer, og den injicerede mængde indeholder mindst ca. 20.000 ABC-enheder collagenase. 3. Anvendelse ifølge krav 2, ved hvilken den maksimale akkumulerede samlede dosis ikke overstiger ca. 60.000 ABC-enheder collagenase. 4. Anvendelse ifølge et hvilket som helst af kravene 1 til 3, ved hvilken immobiliseringsperioden er fra ca. 4 til ca. 12 timer. 5. Anvendelse ifølge et hvilket som helst af kravene 1-4, ved hvilken det farmaceutiske præparat omfatter collagenase i en vandig bærer. 6. Farmaceutisk præparat til behandlingen af Peyronie's sygdom omfattende en farmaceutisk virkningsfuld collagenase-mængde og -koncentration og en farmaceutisk acceptabel bærer. 7. Farmaceutisk præparat til behandling af et individ, der lider af Peyronie's sygdom, omfattende en virkningsfuld collagenase-mængde og -koncentration af til en serie på mindst to injektioner på hver mindst 10.000 ABC-enheder collagenase, som indgives med mindst én dags mellemrum, og tilvejebringer en samlet mængde på mindst ca. 20.000 ABC-enheder collagenase, hvor omtalte mængde og koncentration er i stand til at blødgøre og/eller bryde hul på plakken, hvorved den penile bøjning, der er forårsaget af plakken, lindres. 8. Farmaceutisk præparat ifølge krav 7, omfattende ca. 10.000 til ca. 20.000 ABC-enheder collagenase til hver injektion. 9. Farmaceutisk præparat ifølge et hvilket som helst af krav 7 eller 8 omfattende collagenase i en koncentration på ca. 20.000 til ca. 40.000 ABC-enheder pr. ml i en farmaceutisk acceptabel bærer. 10. Farmaceutisk præparat ifølge et hvilket som helst af kravene 7 til 9 til en serie på ca. ugentlige injektioner hver omfattende ca. 10.000 til ca. 20.000 ABC-enheder collagenase, og ikke overskridende en maksimal akkumuleret samlet dosis på ca. 60.000 ABC-enheder collagenase. 11. Farmaceutisk præparat ifølge et hvilket som helst af kravene 7 til 10 omfattende collagenase og en vandig bærer. 12. Farmaceutisk præparat ifølge et hvilket som helst af kravene 6 til 11, hvori omtalte collagenase er på en enhedsdosisform.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/325,224 US6022539A (en) | 1999-06-03 | 1999-06-03 | Amelioration of peyronie's disease |
| US32522499 | 1999-06-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK200000792A true DK200000792A (da) | 2000-12-04 |
| DK177177B1 DK177177B1 (da) | 2012-04-30 |
Family
ID=23266961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DKPA200000792A DK177177B1 (da) | 1999-06-03 | 2000-05-16 | Lindring af Peyronie's sygdom |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6022539A (da) |
| AU (1) | AU3532900A (da) |
| CA (1) | CA2308842C (da) |
| DE (1) | DE10027521A1 (da) |
| DK (1) | DK177177B1 (da) |
| FR (1) | FR2794369B1 (da) |
| GB (1) | GB2352173B (da) |
| NO (1) | NO333945B1 (da) |
| SE (1) | SE0001914L (da) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2197018B1 (es) * | 2002-06-06 | 2005-10-01 | Especialidades Farmaceuticas Centrum Sa | Nuevo uso terapeutico de los extractos de polypodium. |
| US20070224184A1 (en) * | 2006-02-22 | 2007-09-27 | The Research Foundation Of The State University Of New York | Method for treating cellulite |
| KR100989267B1 (ko) * | 2005-01-21 | 2010-10-20 | 더 리서치 파운데이션 오브 스테이트 유니버시티 오브 뉴욕 | 유착 관절낭염을 치료하는 방법 |
| US7811560B2 (en) | 2006-01-30 | 2010-10-12 | Auxilium Us Holdings, Llc | Compositions and methods for treating collagen-mediated diseases |
| US8323642B2 (en) * | 2006-12-13 | 2012-12-04 | Depuy Mitek, Inc. | Tissue fusion method using collagenase for repair of soft tissue |
| WO2008100833A2 (en) * | 2007-02-13 | 2008-08-21 | Auxilium International Holdings, Inc. | Production of recombinant collagenases colg and colh in escherichia coli |
| US10071143B1 (en) | 2007-05-03 | 2018-09-11 | The Research Foundation For The State University Of New York | Methods for non-surgical treatment of carpal tunnel syndrome |
| US20100159564A1 (en) * | 2007-11-30 | 2010-06-24 | Dwulet Francis E | Protease resistant recombinant bacterial collagenases |
| TWI395593B (zh) | 2008-03-06 | 2013-05-11 | Halozyme Inc | 可活化的基質降解酵素之活體內暫時性控制 |
| US20100061972A1 (en) * | 2008-08-19 | 2010-03-11 | Auxilium US Holdings,LLC | Method of Treating Peyronie's Disease |
| EP2403523A1 (en) * | 2009-03-06 | 2012-01-11 | Halozyme, Inc. | Temperature sensitive mutants of matrix metalloprotease 1 und uses thereof |
| US8465413B2 (en) | 2010-11-25 | 2013-06-18 | Coloplast A/S | Method of treating Peyronie's disease |
| US9180172B2 (en) | 2010-12-15 | 2015-11-10 | Ams Research Corporation | Treatment of Peyronies disease |
| WO2012125948A1 (en) | 2011-03-16 | 2012-09-20 | Biospecifics Technologies Corp. | Compositions and methods for producing clostridial collagenases |
| AU2012285378B2 (en) | 2011-07-20 | 2017-03-02 | Mediwound Ltd. | Proteolytic extract from bromelain for the treatment of connective tissue disorders |
| AU2013208028B2 (en) | 2012-01-12 | 2016-04-28 | Auxilium International Holdings, Inc. | Clostridium histolyticum enzymes and methods for the use thereof |
| US20180028575A1 (en) | 2012-01-30 | 2018-02-01 | Michael Zahalsky | Methods and compositions for treatment of penile defects |
| WO2013116327A1 (en) * | 2012-01-30 | 2013-08-08 | Zahalsky Michael P | Methods and compositions for treatment of penile defects |
| WO2014107745A1 (en) | 2013-01-07 | 2014-07-10 | Halozyme, Inc. | Metal sensitive mutants of matrix metalloproteases and uses thereof |
| WO2014144859A1 (en) | 2013-03-15 | 2014-09-18 | Biospecifics Technologies Corporation | Treatment method and product for uterine fibroids using purified collagenase |
| CN103751102A (zh) | 2014-01-15 | 2014-04-30 | 上海交通大学 | 一种胶原酶温敏水凝胶及其制备方法和应用 |
| BR112019018277A2 (pt) | 2017-03-01 | 2020-06-30 | Endo Ventures Limited | aparelho e método para avaliar e tratar celulite |
| KR20250171475A (ko) | 2017-03-28 | 2025-12-08 | 엔도 오퍼레이션즈 리미티드 | 개선된 콜라게나제 생성 방법 |
| US11872267B2 (en) | 2019-10-15 | 2024-01-16 | The Johns Hopkins University | Treatment of uterine fibroids using purified collagenase |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4338300A (en) * | 1981-02-05 | 1982-07-06 | The Regents Of The University Of California | Use of purified clostridial collangenase in the treatment of Peyronie's disease |
| HK1003981A1 (en) * | 1989-01-27 | 1998-11-13 | Immunolytics, Inc. | Composition and method for treating benign prostatic hypertrophy |
| US6086872A (en) * | 1997-03-27 | 2000-07-11 | Advance Biofactures Of Curacao, Nv | Amelioration of dupuytren's disease |
-
1999
- 1999-06-03 US US09/325,224 patent/US6022539A/en not_active Expired - Lifetime
-
2000
- 2000-05-16 AU AU35329/00A patent/AU3532900A/en not_active Abandoned
- 2000-05-16 DK DKPA200000792A patent/DK177177B1/da not_active IP Right Cessation
- 2000-05-19 CA CA2308842A patent/CA2308842C/en not_active Expired - Lifetime
- 2000-05-19 GB GB0011969A patent/GB2352173B/en not_active Expired - Lifetime
- 2000-05-23 SE SE0001914A patent/SE0001914L/ not_active Application Discontinuation
- 2000-05-25 NO NO20002686A patent/NO333945B1/no not_active IP Right Cessation
- 2000-05-29 FR FR0006863A patent/FR2794369B1/fr not_active Expired - Lifetime
- 2000-06-02 DE DE10027521A patent/DE10027521A1/de not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CA2308842A1 (en) | 2000-12-03 |
| IE20000402A1 (en) | 2001-01-10 |
| FR2794369A1 (fr) | 2000-12-08 |
| GB0011969D0 (en) | 2000-07-05 |
| NO20002686L (no) | 2000-12-04 |
| AU3532900A (en) | 2000-12-07 |
| FR2794369B1 (fr) | 2003-11-21 |
| DE10027521A1 (de) | 2000-12-07 |
| CA2308842C (en) | 2013-02-12 |
| NO20002686D0 (no) | 2000-05-25 |
| GB2352173B (en) | 2004-11-10 |
| GB2352173A (en) | 2001-01-24 |
| SE0001914L (sv) | 2000-12-04 |
| NO333945B1 (no) | 2013-10-28 |
| DK177177B1 (da) | 2012-04-30 |
| US6022539A (en) | 2000-02-08 |
| SE0001914D0 (sv) | 2000-05-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUP | Patent expired |
Expiry date: 20200516 |