DK2003104T3 - Reagens til organisk syntese og fremgangsmåde til organisk syntesereaktion med reagenset - Google Patents

Reagens til organisk syntese og fremgangsmåde til organisk syntesereaktion med reagenset Download PDF

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DK2003104T3
DK2003104T3 DK07714522.5T DK07714522T DK2003104T3 DK 2003104 T3 DK2003104 T3 DK 2003104T3 DK 07714522 T DK07714522 T DK 07714522T DK 2003104 T3 DK2003104 T3 DK 2003104T3
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reagent
organic synthesis
reaction
compound
solvent
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DK07714522.5T
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Kazuhiro Chiba
Shokaku Kim
Yusuke Kono
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Jitsubo Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/96—Esters of carbonic or haloformic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C265/00—Derivatives of isocyanic acid
    • C07C265/12—Derivatives of isocyanic acid having isocyanate groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/20—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group the two nitrogen atoms of the functional groups being doubly-bound to each other, e.g. azoformamide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/5022—Aromatic phosphines (P-C aromatic linkage)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)

Claims (5)

1. Reagens til organisk syntese, som kan anvendes til organiske syntesereaktioner, vist i den følgende kemiske formel (1), og med den egenskab, at det kan ændre sig reversibelt fra en flydende fasetilstand til en fast fasetilstand i henhold til ændringer i mindst en udvalgt fra gruppen bestående af opløsningssammensætning og opløsningstemperatur:
- (1 ) hvor R2 og R* er en docosyloxygruppe (C22H45O-), R1; R3 og R5 er hydrogen og X repræsenterer et aktivt reagenssted vist ved de følgende formler (A), (B), (E), (F), (G), (K), (L), (M) eller (M1):
(A) , (B)
(G),
· · * * (fvf ?,
· · · (M’l hvor Y er en alkylengruppe med et carbonantal på 1 til 10, m og n uafhængigt er 0 eller 1, Za er et chlorinatom eller et brominatom, og Zb er en hy-droxylgruppe, et chlorinatom eller et brominatom.
2. Reagens til organisk syntese ifølge krav 1 udvalgt fra gruppen bestående af de følgende kemiske formler (3), (4), (5), (6), (7), (8) og (9):
(3)
(4)
(5)
(6)
(7)
(S)
(9).
3. Reagens til organisk syntese, som kan anvendes til organiske syntesereaktioner, vist i den følgende Kemisk Formel 2 eller Kemisk Formel 10, og med den egenskab, at det kan ændre sig reversibelt fra en flydende fasetilstand til en fast fasetilstand i henhold til ændringer i mindst en udvalgt fra gruppen bestående af opløsningssammensætning og opløsningstemperatur.
• · · (2)
(10)
4. Fremgangsmåde til organisk syntesereaktion under anvendelse af reagenset til organisk syntese ifølge et af kravene 1 til 3, omfattende et reaktionstrin, hvor der udføres en reaktion, hvor reagenset til organisk syntese opløses i et reaktionssystem, hvor det aktive reagenssted X med Kemisk Formel (1), hydroxymethylgruppen med Kemisk Formel (2) eller det aktive reagenssted med Kemisk Formel (3) til (10) deltager i reaktionen, og efter dette, et separationstrin, hvor reagenset til organisk syntese og et reageret reagens til organisk syntese separeres.
5. Anvendelse af reagenset til organisk syntese ifølge et af kravene 1 til 3 til en organisk syntesereaktion.
DK07714522.5T 2006-03-24 2007-02-19 Reagens til organisk syntese og fremgangsmåde til organisk syntesereaktion med reagenset DK2003104T3 (da)

Applications Claiming Priority (2)

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JP2006084019 2006-03-24
PCT/JP2007/052996 WO2007122847A1 (ja) 2006-03-24 2007-02-19 有機合成用試薬、及び当該試薬を用いた有機合成反応方法

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US (2) US8093435B2 (da)
EP (1) EP2003104B1 (da)
JP (2) JPWO2007122847A1 (da)
CN (1) CN101405240B (da)
AU (1) AU2007242276A1 (da)
DK (1) DK2003104T3 (da)
ES (1) ES2546808T3 (da)
WO (1) WO2007122847A1 (da)

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JP5113118B2 (ja) 2013-01-09
EP2003104A2 (en) 2008-12-17
US20120108788A1 (en) 2012-05-03
AU2007242276A1 (en) 2007-11-01
JPWO2007122847A1 (ja) 2009-09-03
WO2007122847A1 (ja) 2007-11-01
EP2003104B1 (en) 2015-07-01
EP2003104A9 (en) 2009-04-15
EP2003104A4 (en) 2010-01-06
US8093435B2 (en) 2012-01-10
US8293948B2 (en) 2012-10-23
ES2546808T3 (es) 2015-09-28
JP2009185063A (ja) 2009-08-20
CN101405240B (zh) 2012-07-25
CN101405240A (zh) 2009-04-08
US20090299103A1 (en) 2009-12-03

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