DK2013336T3 - Ny gruppe af esteraser til fremstilling af fin- og specialkemikalier - Google Patents
Ny gruppe af esteraser til fremstilling af fin- og specialkemikalier Download PDFInfo
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- DK2013336T3 DK2013336T3 DK07724699.9T DK07724699T DK2013336T3 DK 2013336 T3 DK2013336 T3 DK 2013336T3 DK 07724699 T DK07724699 T DK 07724699T DK 2013336 T3 DK2013336 T3 DK 2013336T3
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- polynucleotide
- ala
- gly
- leu
- polypeptide
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Claims (17)
1. Polynukleotid, som koder for et enzym med carboxylesterase E.C. 3.1.1.1 aktivitet, hvor kodningssekvensen er valgt fra gruppen bestående af (a) et polynukleotid, som koder for en aminosyresekvens som skitseret i SEQ ID NO: 2; (b) et polynukleotid, som har eller omfatter en nukleotidsekvens, som vist i SEQ ID NO: 1; (c) et polynukleotid, som har eller omfatter en nukleotidsekvens, som koder for et fragment eller derivat af et enzym, som er kodet for af et polynukleotid ifølge (a) eller (b), hvor, i det nævnte derivat, én eller flere aminosyrerester er konservativt substitueret i sammenligning med aminosyresekvensen ifølge (a); (d) et polynukleotid, som er i det mindste 90% identisk med et polynukleotid, som koder for et enzym som vist i SEQ ID NO: 2; og (e) et polynukleotid, som har eller omfatter en nukleotidsekvens, som er degenereret til nukleotidsekvensen for polynukleotidet ifølge (d).
2. Polynukleotid ifølge krav 1, hvor kodningssekvensen er sammensmeltet med et heterologt eller homologt polynukleotid.
3. Polynukleotid ifølge krav 2, hvor det heterologe eller homologe polynukleotid koder for et polypeptid.
4. Vektor indeholdende polynukleotidet ifølge ethvert af kravene 1 til 3.
5. Ikke-human vært, som er genetisk manipuleret med polynukleotidet ifølge ethvert af kravene 1 til 3 eller vektoren ifølge krav 4.
6. Vært ifølge krav 5, som er en prokaryotisk vært valgt fra gruppen bestående af E. coli, Bacillus sp., Pseudomonas sp., Streptomyces sp., Mycobacterium sp., Caulobactersp., Rhodobacter sp., Lactococcus sp., Burkholderia sp, Rhizobium sp., Sinorhizobium sp. og Ralstonia sp.
7. Vært ifølge krav 5 eller 6, som eksprimerer polypeptidet, som er kodet for af polynukleotidet ifølge ethvert af kravene 1 til 3 eller vektoren ifølge krav 4 og ét eller flere yderligere enzymer, hvor enzymerne samlet katalyserer en flertrinskonvertering af et substrat eller bidrager dertil.
8. Fremgangsmåde til fremstilling af et polypeptid, som har carboxylesterase E.C. 3.1.1.1 aktivitet, omfattende dyrkning af værtscellen ifølge krav 5 eller 6 og udvinding af polypeptidet med carboxylesterase E.C. 3.1.1.1 aktivitet, som er fremstillet af værtscellen.
9. Fremgangsmåde til fremstilling af bakterier eller eukaryote celler, som er i stand til at eksprimere et polypeptid med carboxylesterase E.C. 3.1.1.1 aktivitet, hvilken fremgangsmåde omfatter genetisk manipulering af bakterier eller eukaryotiske celler med vektoren ifølge krav 4, hvor de eukaryotiske celler er ikke-humane embryoniske celler.
10. Polypeptid omfattende aminosyresekvensen, som kodes for af et polynukleotid ifølge ethvert af kravene 1 til 3 eller som kan tilvejebringes ved fremgangsmåden ifølge krav 8, og som har carboxylesterase E.C. 3.1.1.1 aktivitet.
11. Antistof, som specifikt binder til polypeptidet, som kodes for af polynukleotidet ifølge krav 1.
12. Komplementær streng af polynukleotidet ifølge krav 1(a) til (e).
13. Primer eller probe, som omfatter i det mindste 15 efter hinanden følgende nukleotider i den komplementære streng ifølge krav 12, og hybridiserer til polynukleotidet ifølge krav 1(a) til (e).
14. Sammensætning omfattende polynukleotidet ifølge ethvert af kravene 1 til 3, vektoren ifølge krav 4, værtscellen ifølge ethvert af kravene 5 til 7, polypeptidet ifølge krav 10, antistoffet ifølge krav 11 og/eller én eller flere primere ifølge krav 13.
15. Fremgangsmåde til fremstilling af en optisk aktiv forbindelse omfattende tilladelse af den enantioselektive konvertering af et racemisk udgangsmateriale med et polypeptid ifølge krav 10.
16. Fremgangsmåde ifølge krav 15, hvor (i) den optisk aktive forbindelse er (+) mentol og det racemiske udgangsmateriale er rac-menthylacetat.
17. Fremgangsmåde ifølge krav 15 eller 16, hvor det racemiske udgangsmateriale (educt) er fremstillet ved en katalyse af en konvertering ved hjælp af ét eller flere forskellige enzymer og/eller den optisk aktive forbindelse (produkt) er udgangsmaterialet (educt) for en yderligere konvertering ved hjælp af ét eller flere forskellige enzymer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06008953 | 2006-04-28 | ||
| PCT/EP2007/003772 WO2007128441A2 (en) | 2006-04-28 | 2007-04-27 | A novel group of esterases for the production of fine and speciality chemicals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2013336T3 true DK2013336T3 (da) | 2016-09-05 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07724699.9T DK2013336T3 (da) | 2006-04-28 | 2007-04-27 | Ny gruppe af esteraser til fremstilling af fin- og specialkemikalier |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8956838B2 (da) |
| EP (1) | EP2013336B1 (da) |
| CA (1) | CA2650608C (da) |
| DK (1) | DK2013336T3 (da) |
| WO (1) | WO2007128441A2 (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CO7020177A1 (es) * | 2014-04-30 | 2014-08-11 | Corporacion Corpogen | Enzima esterasa modificada enantioselectiva y proceso para la obtención de la misma |
| CN105779410B (zh) * | 2014-12-22 | 2020-08-14 | 丰益(上海)生物技术研发中心有限公司 | 一种酯酶及其编码基因 |
| JP2021506252A (ja) * | 2017-12-13 | 2021-02-22 | コデクシス， インコーポレイテッド | アミドカップリングのためのカルボキシエステラーゼポリペプチド |
| CN108753805A (zh) * | 2018-05-29 | 2018-11-06 | 安徽师范大学 | 一种耐热的酯酶编码基因、载体、工程菌及其编码蛋白的用途 |
| CN114540456B (zh) * | 2020-11-25 | 2025-04-22 | 弈柯莱生物科技(集团)股份有限公司 | 拆分2-(苄氧基羰基氨基)-2-(氧杂环丁烷-3-基)乙酸甲酯的方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5939534A (en) * | 1993-12-29 | 1999-08-17 | Sumitomo Pharmaceuticals Company, Limited | Factors mutated in the D1 cap region |
-
2007
- 2007-04-27 EP EP07724699.9A patent/EP2013336B1/en not_active Not-in-force
- 2007-04-27 WO PCT/EP2007/003772 patent/WO2007128441A2/en not_active Ceased
- 2007-04-27 US US12/298,874 patent/US8956838B2/en not_active Expired - Fee Related
- 2007-04-27 DK DK07724699.9T patent/DK2013336T3/da active
- 2007-04-27 CA CA2650608A patent/CA2650608C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2650608C (en) | 2017-02-14 |
| CA2650608A1 (en) | 2007-11-15 |
| US8956838B2 (en) | 2015-02-17 |
| EP2013336A2 (en) | 2009-01-14 |
| WO2007128441A2 (en) | 2007-11-15 |
| US20090221031A1 (en) | 2009-09-03 |
| EP2013336B1 (en) | 2016-06-22 |
| WO2007128441A3 (en) | 2008-02-28 |
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