DK203588A - Fremgangsmaade til fremstilling af proteiner - Google Patents
Fremgangsmaade til fremstilling af proteinerInfo
- Publication number
- DK203588A DK203588A DK203588A DK203588A DK203588A DK 203588 A DK203588 A DK 203588A DK 203588 A DK203588 A DK 203588A DK 203588 A DK203588 A DK 203588A DK 203588 A DK203588 A DK 203588A
- Authority
- DK
- Denmark
- Prior art keywords
- production
- proteins
- procedure
- human plasminogen
- novel
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 239000013598 vector Substances 0.000 abstract 3
- 101000605403 Homo sapiens Plasminogen Proteins 0.000 abstract 2
- 102000001938 Plasminogen Activators Human genes 0.000 abstract 2
- 229940127126 plasminogen activator Drugs 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 abstract 1
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 abstract 1
- 229960005356 urokinase Drugs 0.000 abstract 1
- 210000005253 yeast cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878709081A GB8709081D0 (en) | 1987-04-15 | 1987-04-15 | Production of proteins |
| GB878714059A GB8714059D0 (en) | 1987-04-15 | 1987-06-16 | Production of proteins |
| IE329987A IE81116B1 (en) | 1986-12-05 | 1987-12-04 | Hybrid plasminogen activators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK203588D0 DK203588D0 (da) | 1988-04-14 |
| DK203588A true DK203588A (da) | 1988-10-16 |
Family
ID=27263391
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK203588A DK203588A (da) | 1987-04-15 | 1988-04-14 | Fremgangsmaade til fremstilling af proteiner |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5175105A (da) |
| EP (1) | EP0288435B1 (da) |
| JP (1) | JP2894696B2 (da) |
| AT (1) | ATE102994T1 (da) |
| AU (1) | AU604305B2 (da) |
| CA (1) | CA1341306C (da) |
| DD (1) | DD274053A5 (da) |
| DE (1) | DE3888386T2 (da) |
| DK (1) | DK203588A (da) |
| ES (1) | ES2061719T3 (da) |
| FI (1) | FI98219C (da) |
| HU (1) | HU204557B (da) |
| IL (1) | IL86058A (da) |
| MX (1) | MX168507B (da) |
| MY (1) | MY103358A (da) |
| NO (1) | NO179046C (da) |
| NZ (1) | NZ224243A (da) |
| PT (1) | PT87230B (da) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2634495B1 (fr) * | 1988-07-01 | 1990-10-26 | Chambon Pierre | Procede de preparation d'une proteine par des levures utilisant un systeme inductible, vecteurs et souches transformees correspondantes |
| DK0462207T3 (da) * | 1989-03-06 | 2001-06-18 | Univ Texas | t-Pa mutanter resistente mod deres respektive inhibitorer |
| US5866413A (en) * | 1989-03-06 | 1999-02-02 | Board Of Regents Of The University Of Texas System | Pai-1 mutants |
| EP0387380A1 (en) * | 1989-03-17 | 1990-09-19 | BEHRINGWERKE Aktiengesellschaft | Mutants of urinary plasminogen activator, their production and use |
| US5268273A (en) * | 1990-12-14 | 1993-12-07 | Phillips Petroleum Company | Pichia pastoris acid phosphatase gene, gene regions, signal sequence and expression vectors comprising same |
| GB2256197B (en) * | 1991-05-31 | 1995-11-22 | Ciba Geigy Ag | Yeast as host for expression of heterologous glycosyl transferase enzymes |
| SE9201544L (sv) * | 1991-05-31 | 1992-12-01 | Ciba Geigy Ag | Saett att framstaella glykosyltransferaser |
| JPH0823995A (ja) * | 1994-07-14 | 1996-01-30 | Green Cross Corp:The | 宿主細胞由来のプロテアーゼで低分子化され得る蛋白質の製造方法 |
| US20030113271A1 (en) * | 1997-01-29 | 2003-06-19 | University Technology Corporation | Formulations for pulmonary delivery |
| US6207442B1 (en) * | 1997-10-16 | 2001-03-27 | Zymogenetics, Inc. | Plasmid construction by homologous recombination |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4245051A (en) * | 1978-03-30 | 1981-01-13 | Rockefeller University | Human serum plasminogen activator |
| US4370417A (en) * | 1980-04-03 | 1983-01-25 | Abbott Laboratories | Recombinant deoxyribonucleic acid which codes for plasminogen activator |
| US4558010A (en) * | 1980-04-03 | 1985-12-10 | Abbott Laboratories | Recombinant deoxyribonucleic acid which codes for plasminogen activator and method of making plasminogen activator protein therefrom |
| NL8003402A (nl) * | 1980-06-11 | 1982-01-04 | Leuven Res & Dev Vzw | Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking. |
| US4775622A (en) * | 1982-03-08 | 1988-10-04 | Genentech, Inc. | Expression, processing and secretion of heterologous protein by yeast |
| GR78180B (da) * | 1982-04-15 | 1984-09-26 | Genentech Inc | |
| AR241654A1 (es) * | 1982-05-05 | 1992-10-30 | Genentech Inc | Procedimiento para producir activador de plasminogeno de tejido humano. |
| US5010003A (en) * | 1983-04-25 | 1991-04-23 | Genentech, Inc. | Use of yeast homologous signals to secrete heterologous proteins |
| NZ207926A (en) * | 1983-04-25 | 1988-04-29 | Genentech Inc | Use of yeast #a#-factor to assist in expression of proteins heterologus to yeast |
| DE3585097D1 (de) * | 1984-02-27 | 1992-02-20 | Green Cross Corp | Herstellung menschlicher urokinase. |
| JPS60256385A (ja) * | 1984-05-18 | 1985-12-18 | イーライ・リリー・アンド・カンパニー | 酵母においてヘテロローガスポリペプチドを効率よく発現するための方法、ベクターおよび形質転換体 |
| JPS60248181A (ja) * | 1984-05-23 | 1985-12-07 | Shiseido Co Ltd | 酵母発現ベクタ− |
| EP0174835A1 (en) * | 1984-09-11 | 1986-03-19 | The Upjohn Company | Human tissue plasminogen activator and recombinant DNA compounds |
| EP0210279B1 (en) * | 1985-01-25 | 1991-08-14 | Sagami Chemical Research Center | Stabilized human prourokinase |
| US5219569A (en) * | 1985-04-22 | 1993-06-15 | Genentech, Inc. | Protease resistant urokinase |
| AU596356B2 (en) * | 1985-04-22 | 1990-05-03 | Genentech Inc. | Novel human tissue plasminogen activator mutants |
| FI100106B (fi) * | 1986-12-05 | 1997-09-30 | Novartis Ag | Menetelmä plasminogeenin yksisäikeisen yhdistelmäaktivaattorin valmist amiseksi |
| DE19736137C1 (de) * | 1997-08-20 | 1998-10-01 | Daimler Benz Ag | Verfahren zum Starten eines Verbrennungsmotors |
-
1988
- 1988-03-30 MY MYPI88000322A patent/MY103358A/en unknown
- 1988-04-08 US US07/179,345 patent/US5175105A/en not_active Expired - Fee Related
- 1988-04-11 AT AT88810234T patent/ATE102994T1/de active
- 1988-04-11 EP EP88810234A patent/EP0288435B1/en not_active Expired - Lifetime
- 1988-04-11 DE DE3888386T patent/DE3888386T2/de not_active Expired - Fee Related
- 1988-04-11 ES ES88810234T patent/ES2061719T3/es not_active Expired - Lifetime
- 1988-04-13 CA CA000563968A patent/CA1341306C/en not_active Expired - Fee Related
- 1988-04-13 PT PT87230A patent/PT87230B/pt active IP Right Grant
- 1988-04-13 NZ NZ224243A patent/NZ224243A/xx unknown
- 1988-04-13 FI FI881713A patent/FI98219C/fi not_active IP Right Cessation
- 1988-04-13 IL IL86058A patent/IL86058A/xx not_active IP Right Cessation
- 1988-04-14 HU HU881922A patent/HU204557B/hu not_active IP Right Cessation
- 1988-04-14 NO NO881615A patent/NO179046C/no not_active IP Right Cessation
- 1988-04-14 AU AU14626/88A patent/AU604305B2/en not_active Ceased
- 1988-04-14 DK DK203588A patent/DK203588A/da not_active Application Discontinuation
- 1988-04-14 JP JP63090433A patent/JP2894696B2/ja not_active Expired - Lifetime
- 1988-04-14 MX MX011116A patent/MX168507B/es unknown
- 1988-04-15 DD DD31480088A patent/DD274053A5/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2894696B2 (ja) | 1999-05-24 |
| ATE102994T1 (de) | 1994-04-15 |
| EP0288435A1 (en) | 1988-10-26 |
| CA1341306C (en) | 2001-10-23 |
| FI881713L (fi) | 1988-10-16 |
| AU1462688A (en) | 1988-10-20 |
| NO179046B (no) | 1996-04-15 |
| DK203588D0 (da) | 1988-04-14 |
| NZ224243A (en) | 1991-02-26 |
| FI98219B (fi) | 1997-01-31 |
| HU204557B (en) | 1992-01-28 |
| NO881615D0 (no) | 1988-04-14 |
| AU604305B2 (en) | 1990-12-13 |
| PT87230A (pt) | 1988-05-01 |
| PT87230B (pt) | 1992-08-31 |
| JPS63296689A (ja) | 1988-12-02 |
| MX168507B (es) | 1993-05-27 |
| DE3888386T2 (de) | 1994-07-14 |
| ES2061719T3 (es) | 1994-12-16 |
| FI881713A0 (fi) | 1988-04-13 |
| HUT46360A (en) | 1988-10-28 |
| DE3888386D1 (de) | 1994-04-21 |
| FI98219C (fi) | 1997-05-12 |
| MY103358A (en) | 1993-06-30 |
| IL86058A0 (en) | 1988-09-30 |
| IL86058A (en) | 1993-07-08 |
| NO881615L (no) | 1988-10-17 |
| EP0288435B1 (en) | 1994-03-16 |
| DD274053A5 (de) | 1989-12-06 |
| US5175105A (en) | 1992-12-29 |
| NO179046C (no) | 1996-07-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHB | Application shelved due to non-payment |