DK203882A - Fremgangsmaade til fremstilling af hidtil ukendte 1'-substituerede spiro(pyrrolidin-3,3'-indolin)-2,2',5-trioner - Google Patents

Fremgangsmaade til fremstilling af hidtil ukendte 1'-substituerede spiro(pyrrolidin-3,3'-indolin)-2,2',5-trioner Download PDF

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Publication number
DK203882A
DK203882A DK203882A DK203882A DK203882A DK 203882 A DK203882 A DK 203882A DK 203882 A DK203882 A DK 203882A DK 203882 A DK203882 A DK 203882A DK 203882 A DK203882 A DK 203882A
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DK
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Prior art keywords
indoline
formula
trioner
pyrrolidin
unknown
Prior art date
Application number
DK203882A
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Danish (da)
English (en)
Inventor
D R Brittain
R Wood
Original Assignee
Ici Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ici Plc filed Critical Ici Plc
Publication of DK203882A publication Critical patent/DK203882A/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DK203882A 1981-05-12 1982-05-06 Fremgangsmaade til fremstilling af hidtil ukendte 1'-substituerede spiro(pyrrolidin-3,3'-indolin)-2,2',5-trioner DK203882A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8114397 1981-05-12

Publications (1)

Publication Number Publication Date
DK203882A true DK203882A (da) 1982-11-13

Family

ID=10521723

Family Applications (1)

Application Number Title Priority Date Filing Date
DK203882A DK203882A (da) 1981-05-12 1982-05-06 Fremgangsmaade til fremstilling af hidtil ukendte 1'-substituerede spiro(pyrrolidin-3,3'-indolin)-2,2',5-trioner

Country Status (25)

Country Link
US (2) US4478847A (de)
EP (1) EP0065407B1 (de)
JP (1) JPS57192314A (de)
KR (1) KR830009775A (de)
AT (1) ATE12113T1 (de)
AU (1) AU561390B2 (de)
CA (1) CA1182823A (de)
DD (1) DD202576A5 (de)
DE (1) DE3262529D1 (de)
DK (1) DK203882A (de)
ES (2) ES8306485A1 (de)
FI (1) FI821579A7 (de)
GR (1) GR75871B (de)
HU (1) HU186016B (de)
IE (1) IE53102B1 (de)
IL (1) IL65604A (de)
MW (1) MW1982A1 (de)
NO (1) NO821557L (de)
NZ (1) NZ200576A (de)
PH (1) PH18101A (de)
PL (1) PL236283A1 (de)
PT (1) PT74876B (de)
ZA (1) ZA822797B (de)
ZM (1) ZM3282A1 (de)
ZW (1) ZW7882A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU566869B2 (en) * 1982-05-11 1987-11-05 Imperial Chemical Industries Plc Spiro (imidazolidine-4,3'-indoline) 2,2',5-triones
GB8331194D0 (en) * 1982-12-20 1983-12-29 Ici Plc Chemical process
JPS60142984A (ja) * 1983-12-28 1985-07-29 Kyorin Pharmaceut Co Ltd 新規なスピロピロリジン−２，５−ジオン誘導体およびその製造法
US4567278A (en) * 1984-03-26 1986-01-28 Imperial Chemical Industries Plc Process for racemizing certain spiro compounds
GB8415635D0 (en) * 1984-06-19 1984-07-25 Ici Plc Cyclic amides
MX18021A (es) * 1988-10-18 1993-11-01 Pfizer Pro-farmacos de la 3-acil-2-oxindol-1-carboxamidasanti-inflamatorias
US4900739A (en) * 1988-10-20 1990-02-13 American Home Products Corp. Novel spirosuccinimides as aldose reductase inhibitors and antihyperglycemic agents
US4946858A (en) * 1988-10-20 1990-08-07 American Home Products Corporation Novel spirosuccinimides as aldose reductase inhibitors and antihyperglycemic agents
FR2708606B1 (fr) * 1993-07-30 1995-10-27 Sanofi Sa Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
CA2461616A1 (en) * 2001-09-28 2003-04-03 Mcneil-Ppc, Inc. Composite dosage forms having an inlaid portion
US6837696B2 (en) * 2001-09-28 2005-01-04 Mcneil-Ppc, Inc. Apparatus for manufacturing dosage forms
RU2238272C1 (ru) * 2003-05-19 2004-10-20 Пермский государственный университет Способ получения 1-алкил-6,6-диметил-2,4-диоксо-2,3,4,5,6,7-гексагидро-1h-индол-3-спиро-2-( 1-арил-3-ароил-4-гидрокси-5-оксо-2,5-дигидропирролов)
NZ562772A (en) * 2005-05-24 2010-01-29 Serono Lab Tricyclic spiro derivatives as CRTH2 modulators
US20080057023A1 (en) * 2006-08-29 2008-03-06 Chynn Emil W Oxygenated ophthalmic composition
RU2316557C1 (ru) * 2006-10-06 2008-02-10 Государственное образовательное учреждение высшего профессионального образования "Пермский государственный университет" 6,6-диметил-8-оксо-5,6,8,9-тетрагидробензо[f]-пирроло[2,1-альфа]изохинолин-9-спиро-2-(3-ароил-4-гидрокси-1-о-гидроксифенил-5-оксо-2,5-дигидро-1н-пирролы), 6,6-диметил-8-оксо-5,6,8,9-тетрагидробензо[f]пирроло[2,1-альфа]изохинолин-9-спиро-2-(3-бензоил-4-гидрокси-1-о-гидроксифенил-5-оксо-2,5-дигидро-1н-пиррол), проявляющий анальгетическую активность и способ их получения
US8512581B2 (en) * 2006-10-09 2013-08-20 Solexel, Inc. Methods for liquid transfer coating of three-dimensional substrates

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4117230A (en) * 1976-10-18 1978-09-26 Pfizer Inc. Hydantoin derivatives as therapeutic agents
US4177230A (en) * 1978-06-02 1979-12-04 The United States Of America As Represented By The Secretary Of The Air Force Process for producing reaction sintered silicon nitride of increased density
US4307108A (en) * 1979-12-26 1981-12-22 Pfizer Inc. Method for lowering sorbitol levels using spiro-imides

Also Published As

Publication number Publication date
NO821557L (no) 1982-11-15
KR830009775A (ko) 1983-12-23
ES519780A0 (es) 1984-03-01
ES512093A0 (es) 1983-06-01
US4523021A (en) 1985-06-11
NZ200576A (en) 1984-11-09
GR75871B (de) 1984-08-02
AU561390B2 (en) 1987-05-07
IL65604A (en) 1986-12-31
PH18101A (en) 1985-03-20
PL236283A1 (en) 1983-09-12
US4478847A (en) 1984-10-23
HU186016B (en) 1985-05-28
EP0065407A3 (en) 1983-03-16
ATE12113T1 (de) 1985-03-15
FI821579L (fi) 1982-11-13
EP0065407B1 (de) 1985-03-13
DE3262529D1 (en) 1985-04-18
CA1182823A (en) 1985-02-19
ES8402840A1 (es) 1984-03-01
AU8299482A (en) 1982-11-18
ES8306485A1 (es) 1983-06-01
MW1982A1 (en) 1984-02-08
PT74876A (en) 1982-06-01
FI821579A7 (fi) 1982-11-13
IE53102B1 (en) 1988-06-22
IE820928L (en) 1982-11-12
EP0065407A2 (de) 1982-11-24
DD202576A5 (de) 1983-09-21
ZA822797B (en) 1983-07-27
JPS57192314A (en) 1982-11-26
ZW7882A1 (en) 1983-11-30
PT74876B (en) 1983-12-07
ZM3282A1 (en) 1982-12-21
FI821579A0 (fi) 1982-05-05

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DK203882A (da) Fremgangsmaade til fremstilling af hidtil ukendte 1'-substituerede spiro(pyrrolidin-3,3'-indolin)-2,2',5-trioner
NO154842C (no) Analogifremgangsmaate for fremstilling av farmasoeytisk aktive 1'-substituerte spiro-(imidazolidin-4,3'-indolin)-2,2', 5-trioner.
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AHB Application shelved due to non-payment