DK2066680T3 - Triphenylphosphoniumthionitrit-nitrogenoxiddonorer - Google Patents

Triphenylphosphoniumthionitrit-nitrogenoxiddonorer

Info

Publication number
DK2066680T3
DK2066680T3 DK07834884.4T DK07834884T DK2066680T3 DK 2066680 T3 DK2066680 T3 DK 2066680T3 DK 07834884 T DK07834884 T DK 07834884T DK 2066680 T3 DK2066680 T3 DK 2066680T3
Authority
DK
Denmark
Prior art keywords
triphenylphosphoniumthionitrit
nitric oxide
oxide donors
donors
nitric
Prior art date
Application number
DK07834884.4T
Other languages
English (en)
Inventor
Robin Andrew James Smith
Michael Patrick Murphy
Original Assignee
Medical Res Council
Univ Otago
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical Res Council, Univ Otago filed Critical Medical Res Council
Application granted granted Critical
Publication of DK2066680T3 publication Critical patent/DK2066680T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5407—Acyclic saturated phosphonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5456—Arylalkanephosphonium compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK07834884.4T 2006-09-28 2007-09-26 Triphenylphosphoniumthionitrit-nitrogenoxiddonorer DK2066680T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84768606P 2006-09-28 2006-09-28
PCT/NZ2007/000282 WO2008039085A1 (en) 2006-09-28 2007-09-26 Triphenylphosphonium thionitrite nitric oxide donors

Publications (1)

Publication Number Publication Date
DK2066680T3 true DK2066680T3 (da) 2012-10-22

Family

ID=39230415

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07834884.4T DK2066680T3 (da) 2006-09-28 2007-09-26 Triphenylphosphoniumthionitrit-nitrogenoxiddonorer

Country Status (8)

Country Link
US (1) US20090233873A1 (da)
EP (1) EP2066680B1 (da)
AU (1) AU2007300782B2 (da)
CA (1) CA2664744C (da)
DK (1) DK2066680T3 (da)
ES (1) ES2391662T3 (da)
NZ (1) NZ575904A (da)
WO (1) WO2008039085A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9045505B2 (en) 2006-09-28 2015-06-02 University Of Otago Nitric oxide donors
KR101560844B1 (ko) * 2007-06-04 2015-10-15 벤-구리온 유니버시티 오브 더 네게브 리서치 앤드 디벨럽먼트 어쏘러티 트라이-아릴계 화합물 및 이를 포함하는 조성물
WO2010110684A1 (en) * 2009-03-27 2010-09-30 Robin Andrew James Smith Nitric oxide donors
WO2013043580A2 (en) * 2011-09-19 2013-03-28 Gencia Corporation Modified creatine compounds
WO2014046671A1 (en) * 2012-09-21 2014-03-27 Michigan Technological University No-releasing polymers and uses thereof
GB201411937D0 (en) 2014-07-03 2014-08-20 Medical Res Council Succinate dehydrogenase inhibitors (SDH's)
US11814519B2 (en) * 2020-03-26 2023-11-14 Virginia Commonwealth University Nitric oxide-releasing 3D-printing compositions and uses thereof
CA3248935A1 (en) * 2022-04-14 2023-10-19 W. L. Gore & Associates, Inc. CHEMICAL ENTITIES

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331532B1 (en) * 1998-11-25 2001-12-18 University Of Otago Mitochondrially targeted antioxidants
US20030069208A1 (en) * 1997-11-25 2003-04-10 University Of Otago Mitochondrially targeted antioxidants
US20080275005A1 (en) * 1998-11-25 2008-11-06 Murphy Michael P Mitochondrially targeted antioxidants
US20060229278A1 (en) * 1998-11-25 2006-10-12 Antipodean Pharmaceuticals, Inc. Mitoquinone derivatives used as mitochondrially targeted antioxidants
ATE244318T1 (de) * 1999-12-22 2003-07-15 Sidmar Nv Ultraniedriggekohlte stahlzusammensetzung, verfahren zur herstellung dieses einbrennhärtbaren stahls, und das hergestellte produkt
US20040038947A1 (en) * 2002-06-14 2004-02-26 The Gov. Of The U.S. Of America As Represented By The Sec. Of The Dept. Of Health & Human Services Method of treating ischemia/reperfusion injury with nitroxyl donors
CA2397684A1 (en) * 2002-08-12 2004-02-12 Michael P. Murphy Mitochondrially targeted antioxidants
US6936639B2 (en) * 2002-08-21 2005-08-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitroxyl progenitors in the treatment of heart failure
US7888334B2 (en) * 2003-08-22 2011-02-15 Antipodean Pharmaceuticals, Inc. Mitoquinone derivatives used as mitochondrially targeted antioxidants
JP4648319B2 (ja) * 2003-08-22 2011-03-09 アンティポディーン ファーマシューティカルズ インコーポレイティド ミトコンドリアを標的とする抗酸化剤として使用されるミトキノン誘導体
NZ528966A (en) * 2003-10-17 2006-11-30 Otago Innovation Ltd Peptide nucleic acid conjugates and uses thereof
US20060122267A1 (en) * 2003-11-25 2006-06-08 Brookes Paul S Compositions and methods for attenuating mitochondria-mediated cell injury
RU2318500C2 (ru) * 2005-10-18 2008-03-10 Общество С Ограниченной Ответственностью "Митотехнология" Способ воздействия на организм путем адресной доставки биологически активных веществ в митохондрии, фармацевтическая композиция для его осуществления и соединение, применяемое для этой цели
US20070161609A1 (en) * 2006-01-10 2007-07-12 Charles Buck Use of mitochondrially targeted antioxidant in treatment and prevention of drug-induced liver disease
US20080032940A1 (en) * 2006-08-07 2008-02-07 Balaraman Kalyanaraman Methods for reducing anthracycline-induced toxicity

Also Published As

Publication number Publication date
AU2007300782B2 (en) 2013-08-29
CA2664744A1 (en) 2008-04-03
AU2007300782A1 (en) 2008-04-03
EP2066680A1 (en) 2009-06-10
CA2664744C (en) 2015-02-17
EP2066680B1 (en) 2012-08-08
ES2391662T3 (es) 2012-11-28
NZ575904A (en) 2011-11-25
US20090233873A1 (en) 2009-09-17
EP2066680A4 (en) 2011-05-25
WO2008039085A1 (en) 2008-04-03

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DK2066680T3 (da) Triphenylphosphoniumthionitrit-nitrogenoxiddonorer