DK2076132T3 - P-toluensulfonsyresalt af 5-amino-3-(2´-o-acetyl-3´desoxy-beta-d-ribofuranosyl)-3h-thiazol[4,5-d]pyrimidin-2-on og fremgangsmåder til fremstilling deraf - Google Patents

P-toluensulfonsyresalt af 5-amino-3-(2´-o-acetyl-3´desoxy-beta-d-ribofuranosyl)-3h-thiazol[4,5-d]pyrimidin-2-on og fremgangsmåder til fremstilling deraf

Info

Publication number: DK2076132T3
Authority: DK; Denmark
Prior art keywords: desoxy; ribofuranosyl; pyrimidin; thiazole; acetyl
Prior art date: 2006-10-17

Application number

DK07873546.1T

Other languages

English (en)

Inventor

David Kucera

Gregory J Haley

Erik J Rueden

Tingman Wang

Martin Viertelhaus

Fritz Blatter

Original Assignee

Anadys Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-10-17

Filing date

2007-10-16

Publication date

2012-09-10

2007-10-16 Application filed by Anadys Pharmaceuticals Inc filed Critical Anadys Pharmaceuticals Inc

2012-09-10 Application granted granted Critical

2012-09-10 Publication of DK2076132T3 publication Critical patent/DK2076132T3/da

Links

238000000034 method Methods 0.000 title 1
VTGOHKSTWXHQJK-UHFFFAOYSA-N pyrimidin-2-ol Chemical compound OC1=NC=CC=N1 VTGOHKSTWXHQJK-UHFFFAOYSA-N 0.000 title 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical class CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Virology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK07873546.1T 2006-10-17 2007-10-16 P-toluensulfonsyresalt af 5-amino-3-(2´-o-acetyl-3´desoxy-beta-d-ribofuranosyl)-3h-thiazol[4,5-d]pyrimidin-2-on og fremgangsmåder til fremstilling deraf DK2076132T3 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US85200206P	2006-10-17	2006-10-17
US89940507P	2007-02-05	2007-02-05
US95359707P	2007-08-02	2007-08-02
PCT/US2007/081526 WO2008140549A1 (en)	2006-10-17	2007-10-16	P-TOLUENE SULFONIC ACID SALT OF 5-AMINO-3-(2'-O-ACETYL-3'-DEOXY-β-D-RIBOFURANOSYL)-3H-THIAZOLE [4, 5-D] PYRIMIDINE-2-ONE AND METHODS FOR PREPARATION

Publications (1)

Publication Number	Publication Date
DK2076132T3 true DK2076132T3 (da)	2012-09-10

Family

ID=39472747

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK07873546.1T DK2076132T3 (da)	2006-10-17	2007-10-16	P-toluensulfonsyresalt af 5-amino-3-(2´-o-acetyl-3´desoxy-beta-d-ribofuranosyl)-3h-thiazol[4,5-d]pyrimidin-2-on og fremgangsmåder til fremstilling deraf

Country Status (24)

Country	Link
US (2)	US7928085B2 (da)
EP (1)	EP2076132B1 (da)
JP (2)	JP5279715B2 (da)
KR (2)	KR101515077B1 (da)
AR (1)	AR063484A1 (da)
AU (1)	AU2007353381B2 (da)
BR (1)	BRPI0717741A2 (da)
CA (2)	CA2898225A1 (da)
CY (1)	CY1113368T1 (da)
DK (1)	DK2076132T3 (da)
DO (1)	DOP2007000131A (da)
EA (1)	EA017005B1 (da)
ES (1)	ES2390930T3 (da)
IL (2)	IL198180A (da)
MX (1)	MX2009004028A (da)
MY (1)	MY150408A (da)
NO (1)	NO20091598L (da)
NZ (1)	NZ576408A (da)
PE (1)	PE20081105A1 (da)
PL (1)	PL2076132T3 (da)
PT (1)	PT2076132E (da)
TW (1)	TWI415854B (da)
UY (1)	UY30650A1 (da)
WO (1)	WO2008140549A1 (da)

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CA2655904C (en)	2006-06-22	2014-11-18	Anadys Pharmaceuticals, Inc.	Prodrugs of 5-amino-3-(3'-deoxy-.beta.-d-ribofuranosyl)-thiazolo[4,5-d]pyrimidin-2,7-dione
WO2009026292A1 (en)	2007-08-20	2009-02-26	Anadys Pharmaceuticals, Inc.	Dosing methods for treating disease
HUE053704T2 (hu)	2014-12-08	2021-07-28	Hoffmann La Roche	3-szubsztitutált 5-amino-6H-tiazolo[4,5-d]pirimidin-2,7-dion vegyületek vírusfertõzések kezelésére és megelõzésére
US9676793B2 (en)	2014-12-23	2017-06-13	Hoffmann-Laroche Inc.	Co-crystals of 5-amino-2-oxothiazolo[4,5-d]pyrimidin-3(2H)-yl-5-hydroxymethyl tetrahydrofuran-3-yl acetate and methods for preparing and using the same
CN107427514B (zh)	2015-03-16	2021-07-13	豪夫迈·罗氏有限公司	使用tlr7激动剂和hbv衣壳装配抑制剂的组合治疗
EP3294745B1 (en)	2015-05-08	2020-01-01	H. Hoffnabb-La Roche Ag	Novel oxathiolane carboxylic acids and derivatives for the treatment and prophylaxis of virus infection
CN107592864B (zh)	2015-05-12	2021-04-16	豪夫迈·罗氏有限公司	用于治疗和预防病毒感染的新的取代的氨基噻唑并嘧啶二酮
CN107820498B (zh)	2015-06-30	2020-06-19	豪夫迈·罗氏有限公司	用于治疗和预防病毒感染的取代的氨基噻唑并嘧啶二酮
WO2018127525A1 (en) *	2017-01-06	2018-07-12	F. Hoffmann-La Roche Ag	PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED 5-AMINO-6H-THIAZOLO[4,5-d]PYRIMIDINE-2,7-DIONE COMPOUNDS
CN110007010A (zh) *	2018-01-05	2019-07-12	大鹏药品工业株式会社	源自曲氟尿苷的类似物质的检测方法

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JPH07224081A (ja) *	1994-02-10	1995-08-22	Kobayashi Koryo Kk	デオキシリボフラノシルハライド誘導体の製造方法
US5532374A (en)	1995-06-06	1996-07-02	Hitachi Chemical Company, Ltd.	Method of preparation of bis-quinolines
JP4067226B2 (ja) *	1999-04-01	2008-03-26	三井化学株式会社	１―ハロゲノ−２−デオキシリボフラノース誘導体の製造方法
JP2000327693A (ja) *	1999-05-21	2000-11-28	Mitsui Chemicals Inc	２’−デオキシ−β−シチジン誘導体の製造方法
US6649761B2 (en) *	2001-05-30	2003-11-18	Merck & Co., Inc.	Process for preparing piperazinepentaneamide HIV protease inhibitors
WO2003045968A1 (en) *	2001-11-27	2003-06-05	Anadys Pharmaceuticals, Inc.	3-β-D-RIBOFURANOSYLTHIAZOLO[4,5-d]PYRIDIMINE NUCLEOSIDES AND USES THEREOF
US20060229322A1 (en) *	2002-12-09	2006-10-12	Pau Cid	Anhydrous crystalline form of valacyclovir hydrochloride
EP1667694B1 (en) *	2003-09-05	2010-04-28	Anadys Pharmaceuticals, Inc.	Tlr7 ligands for the treatment of hepatitis c
AU2004320625B2 (en) *	2004-06-07	2009-08-27	Anadys Pharmaceuticals, Inc.	3-beta-D-ribofuranosylthiazolo[4,5-d]pyrimidine nucleosides and uses thereof
ES2459368T3 (es)	2004-12-17	2014-05-09	Anadys Pharmaceuticals, Inc.	Compuestos de 3H-oxazolo y 3H-tiazolo[4,5-d]pirimidin-2-ona 3,5-disustituidos y 3,5,7-trisustituidos y profármacos de los mismos
US7501526B2 (en) *	2005-01-20	2009-03-10	Taigen Biotechnology	Synthesis of polyamine compounds
CA2655904C (en) *	2006-06-22	2014-11-18	Anadys Pharmaceuticals, Inc.	Prodrugs of 5-amino-3-(3'-deoxy-.beta.-d-ribofuranosyl)-thiazolo[4,5-d]pyrimidin-2,7-dione
CN101595117B (zh) *	2006-12-08	2014-01-22	株式会社Api	呋喃糖衍生物的制造方法

2007
- 2007-10-06 BR BRPI0717741-0A2A patent/BRPI0717741A2/pt not_active Application Discontinuation
- 2007-10-16 WO PCT/US2007/081526 patent/WO2008140549A1/en not_active Ceased
- 2007-10-16 CA CA2898225A patent/CA2898225A1/en not_active Abandoned
- 2007-10-16 AU AU2007353381A patent/AU2007353381B2/en not_active Ceased
- 2007-10-16 CA CA2666537A patent/CA2666537C/en not_active Expired - Fee Related
- 2007-10-16 DK DK07873546.1T patent/DK2076132T3/da active
- 2007-10-16 JP JP2009533481A patent/JP5279715B2/ja not_active Expired - Fee Related
- 2007-10-16 EA EA200970387A patent/EA017005B1/ru not_active IP Right Cessation
- 2007-10-16 TW TW096138583A patent/TWI415854B/zh not_active IP Right Cessation
- 2007-10-16 PE PE2007001399A patent/PE20081105A1/es not_active Application Discontinuation
- 2007-10-16 US US11/873,202 patent/US7928085B2/en not_active Expired - Fee Related
- 2007-10-16 KR KR1020147026217A patent/KR101515077B1/ko not_active Expired - Fee Related
- 2007-10-16 PL PL07873546T patent/PL2076132T3/pl unknown
- 2007-10-16 PT PT07873546T patent/PT2076132E/pt unknown
- 2007-10-16 MX MX2009004028A patent/MX2009004028A/es active IP Right Grant
- 2007-10-16 EP EP07873546A patent/EP2076132B1/en not_active Not-in-force
- 2007-10-16 ES ES07873546T patent/ES2390930T3/es active Active
- 2007-10-16 NZ NZ576408A patent/NZ576408A/en not_active IP Right Cessation
- 2007-10-16 MY MYPI20091559 patent/MY150408A/en unknown
- 2007-10-16 KR KR1020097010038A patent/KR101486444B1/ko not_active Expired - Fee Related
- 2007-10-17 AR ARP070104611A patent/AR063484A1/es unknown
- 2007-10-17 DO DO2007000131A patent/DOP2007000131A/es unknown
- 2007-10-17 UY UY30650A patent/UY30650A1/es not_active Application Discontinuation
2009
- 2009-04-16 IL IL198180A patent/IL198180A/en active IP Right Grant
- 2009-04-22 NO NO20091598A patent/NO20091598L/no not_active Application Discontinuation
2011
- 2011-03-23 US US13/069,426 patent/US8193342B2/en not_active Expired - Fee Related
2012
- 2012-09-28 CY CY20121100897T patent/CY1113368T1/el unknown
- 2012-11-19 IL IL223126A patent/IL223126A/en active IP Right Grant
2013
- 2013-05-21 JP JP2013107302A patent/JP5703334B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IL223126A (en)	2016-08-31
TW200833699A (en)	2008-08-16
EP2076132B1 (en)	2012-07-11
ES2390930T3 (es)	2012-11-19
US20110172447A1 (en)	2011-07-14
TWI415854B (zh)	2013-11-21
JP2010506947A (ja)	2010-03-04
UY30650A1 (es)	2008-05-31
PT2076132E (pt)	2012-10-03
EP2076132A1 (en)	2009-07-08
CA2666537A1 (en)	2008-11-20
NO20091598L (no)	2009-07-10
AR063484A1 (es)	2009-01-28
DOP2007000131A (es)	2008-09-15
EP2076132A4 (en)	2011-05-04
KR20090074237A (ko)	2009-07-06
AU2007353381A1 (en)	2008-11-20
US7928085B2 (en)	2011-04-19
CA2898225A1 (en)	2008-11-20
CA2666537C (en)	2015-12-08
KR20140119203A (ko)	2014-10-08
NZ576408A (en)	2012-04-27
EA017005B1 (ru)	2012-09-28
KR101486444B1 (ko)	2015-01-26
JP2013166782A (ja)	2013-08-29
JP5703334B2 (ja)	2015-04-15
EA200970387A1 (ru)	2009-10-30
CY1113368T1 (el)	2016-06-22
PE20081105A1 (es)	2008-08-15
IL198180A (en)	2015-06-30
WO2008140549A1 (en)	2008-11-20
PL2076132T3 (pl)	2013-01-31
IL223126A0 (en)	2012-12-31
MX2009004028A (es)	2009-05-11
JP5279715B2 (ja)	2013-09-04
AU2007353381B2 (en)	2013-07-04
MY150408A (en)	2014-01-15
US8193342B2 (en)	2012-06-05
HK1132429A1 (en)	2010-02-26
KR101515077B1 (ko)	2015-04-24
IL198180A0 (en)	2009-12-24
US20090197826A1 (en)	2009-08-06
BRPI0717741A2 (pt)	2014-04-08

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