DK2079706T3 - Fremgangsmåde til fremstilling af medetomidin og saltene deraf - Google Patents

Fremgangsmåde til fremstilling af medetomidin og saltene deraf

Info

Publication number: DK2079706T3
Authority: DK; Denmark
Prior art keywords: salts; medetomidine; preparation; transmetalation; dimethylbenzaldehyde
Prior art date: 2006-11-06

Application number

DK07822154.6T

Other languages

English (en)

Inventor

Inese Reine

Armands Zandersons

Original Assignee

Grindeks Jsc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-11-06

Filing date

2007-11-02

Publication date

2011-10-03

2007-11-02 Application filed by Grindeks Jsc filed Critical Grindeks Jsc

2011-10-03 Application granted granted Critical

2011-10-03 Publication of DK2079706T3 publication Critical patent/DK2079706T3/da

Links

238000000034 method Methods 0.000 title abstract 3
150000003839 salts Chemical class 0.000 title abstract 3
HRLIOXLXPOHXTA-UHFFFAOYSA-N medetomidine Chemical compound C=1C=CC(C)=C(C)C=1C(C)C1=CN=C[N]1 HRLIOXLXPOHXTA-UHFFFAOYSA-N 0.000 title abstract 2
229960002140 medetomidine Drugs 0.000 title abstract 2
UIFVCPMLQXKEEU-UHFFFAOYSA-N 2,3-dimethylbenzaldehyde Chemical compound CC1=CC=CC(C=O)=C1C UIFVCPMLQXKEEU-UHFFFAOYSA-N 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
150000004795 grignard reagents Chemical class 0.000 abstract 1
150000002460 imidazoles Chemical class 0.000 abstract 1
230000009257 reactivity Effects 0.000 abstract 1
238000006478 transmetalation reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DK07822154.6T 2006-11-06 2007-11-02 Fremgangsmåde til fremstilling af medetomidin og saltene deraf DK2079706T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP06123548A EP1918282A1 (en)	2006-11-06	2006-11-06	Method for preparing medetomidine and its salts
PCT/EP2007/061822 WO2008055852A1 (en)	2006-11-06	2007-11-02	Method for preparing medetomidine and its salts

Publications (1)

Publication Number	Publication Date
DK2079706T3 true DK2079706T3 (da)	2011-10-03

Family

ID=37770375

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK07822154.6T DK2079706T3 (da)	2006-11-06	2007-11-02	Fremgangsmåde til fremstilling af medetomidin og saltene deraf

Country Status (19)

Country	Link
US (1)	US7902377B2 (da)
EP (2)	EP1918282A1 (da)
JP (1)	JP2010508332A (da)
KR (1)	KR20090052398A (da)
CN (1)	CN101535272B (da)
AT (1)	ATE517094T1 (da)
AU (1)	AU2007316693B2 (da)
BR (1)	BRPI0714992A2 (da)
CA (1)	CA2660365C (da)
DK (1)	DK2079706T3 (da)
EA (1)	EA200900355A1 (da)
ES (1)	ES2369746T3 (da)
MX (1)	MX2009004649A (da)
NZ (1)	NZ575125A (da)
PL (1)	PL2079706T3 (da)
PT (1)	PT2079706E (da)
SI (1)	SI2079706T1 (da)
WO (1)	WO2008055852A1 (da)
ZA (1)	ZA200902607B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2011070069A1 (en)	2009-12-09	2011-06-16	I-Tech Ab	Process for preparation of medetomidine
CN102452984B (zh) *	2010-10-21	2013-10-23	桑迪亚医药技术（上海）有限责任公司	4-[1-(2,3-二甲基苯基)乙烯基]-1-r1-2-r2咪唑的合成方法
KR101932206B1 (ko)	2011-07-22	2018-12-24	캠브렉스 칼스코가 아베	4-치환 이미다졸의 신규 제조방법
US9045433B2 (en)	2012-05-08	2015-06-02	Lonza Ltd.	Method for preparation of medetomidine
KR101537204B1 (ko) *	2012-05-08	2015-07-22	론자 아게 (론자 엘티디.)	2-(2,3-디메틸페닐)-1-프로파날의 제조 방법
WO2012172119A2 (en)	2012-05-08	2012-12-20	Lonza Ltd	Method for the preparation of medetomidine
WO2012172122A2 (en)	2012-06-28	2012-12-20	Lonza Ltd	Method for the preparation of 2-(2,3-dimethylphenyl)-1-propanal
CA2866441C (en)	2012-06-28	2017-01-17	Lonza Ltd.	Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal with chloroacetone
WO2012172121A1 (en) *	2012-06-28	2012-12-20	Lonza Ltd	Method for the preparation of medetomidine with chloroacetone
WO2013011157A1 (en)	2012-06-28	2013-01-24	Lonza Ltd	Method for preparation of medetomidine with chloroacetone
CN103588711B (zh) *	2013-11-27	2015-04-08	天津炜捷制药有限公司	一种美托咪定中间体的制备方法
CN103664788B (zh) *	2013-12-04	2015-11-25	湖北生物医药产业技术研究院有限公司	制备美托咪啶的方法
CN104447562A (zh) *	2014-03-27	2015-03-25	宁波天衡药业股份有限公司	一种制备盐酸右美托咪定关键中间体的新方法
CN106083724B (zh) *	2016-08-02	2018-06-26	江苏恒瑞医药股份有限公司	一种右美托咪定的制备方法
CN111269192A (zh) *	2020-02-25	2020-06-12	成都睿智化学研究有限公司	一种5-羟甲基四氮唑及其衍生物的合成方法
CN114671811A (zh) *	2022-04-14	2022-06-28	南京正科医药股份有限公司	一种右美托咪定拆分副产物的外消旋化回收方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2069481B (en)	1980-02-13	1983-07-27	Farmos Oy	Substituted imidazole derivatives
GB2101114B (en) *	1981-07-10	1985-05-22	Farmos Group Ltd	Substituted imidazole derivatives and their preparation and use
WO2006036497A2 (en) *	2004-09-24	2006-04-06	Allergan, Inc.	4-(condensed cyclicmethyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists
WO2006036480A1 (en) *	2004-09-24	2006-04-06	Allergan, Inc.	4-(phenylmethyl and substituted phenylmethyl)-imidazole-2-thiones acting as specific alpha2 adrenergic agonists

2006
- 2006-11-06 EP EP06123548A patent/EP1918282A1/en not_active Withdrawn
2007
- 2007-11-02 AT AT07822154T patent/ATE517094T1/de active
- 2007-11-02 JP JP2009535083A patent/JP2010508332A/ja active Pending
- 2007-11-02 PL PL07822154T patent/PL2079706T3/pl unknown
- 2007-11-02 PT PT07822154T patent/PT2079706E/pt unknown
- 2007-11-02 BR BRPI0714992-1A patent/BRPI0714992A2/pt not_active IP Right Cessation
- 2007-11-02 CN CN2007800358734A patent/CN101535272B/zh not_active Expired - Fee Related
- 2007-11-02 DK DK07822154.6T patent/DK2079706T3/da active
- 2007-11-02 SI SI200730737T patent/SI2079706T1/sl unknown
- 2007-11-02 ES ES07822154T patent/ES2369746T3/es active Active
- 2007-11-02 AU AU2007316693A patent/AU2007316693B2/en not_active Ceased
- 2007-11-02 CA CA2660365A patent/CA2660365C/en active Active
- 2007-11-02 US US12/312,324 patent/US7902377B2/en active Active
- 2007-11-02 EP EP07822154A patent/EP2079706B1/en active Active
- 2007-11-02 WO PCT/EP2007/061822 patent/WO2008055852A1/en not_active Ceased
- 2007-11-02 EA EA200900355A patent/EA200900355A1/ru unknown
- 2007-11-02 KR KR1020097007913A patent/KR20090052398A/ko not_active Ceased
- 2007-11-02 NZ NZ575125A patent/NZ575125A/en not_active IP Right Cessation
- 2007-11-02 MX MX2009004649A patent/MX2009004649A/es not_active Application Discontinuation
2009
- 2009-04-16 ZA ZA200902607A patent/ZA200902607B/xx unknown

Also Published As

Publication number	Publication date
EP2079706A1 (en)	2009-07-22
US7902377B2 (en)	2011-03-08
PT2079706E (pt)	2011-10-19
EP1918282A1 (en)	2008-05-07
EA200900355A1 (ru)	2009-10-30
WO2008055852A8 (en)	2009-05-22
ES2369746T3 (es)	2011-12-05
CA2660365A1 (en)	2008-05-15
BRPI0714992A2 (pt)	2013-07-30
CN101535272B (zh)	2011-10-05
EP2079706B1 (en)	2011-07-20
CN101535272A (zh)	2009-09-16
WO2008055852A1 (en)	2008-05-15
KR20090052398A (ko)	2009-05-25
US20100048915A1 (en)	2010-02-25
ZA200902607B (en)	2010-04-28
JP2010508332A (ja)	2010-03-18
CA2660365C (en)	2014-03-25
NZ575125A (en)	2011-02-25
AU2007316693A1 (en)	2008-05-15
PL2079706T3 (pl)	2011-12-30
ATE517094T1 (de)	2011-08-15
MX2009004649A (es)	2009-05-21
SI2079706T1 (sl)	2011-11-30
AU2007316693B2 (en)	2012-02-02

Publication	Publication Date	Title
DK2079706T3 (da)	2011-10-03	Fremgangsmåde til fremstilling af medetomidin og saltene deraf
UA107443C2 (uk)	2015-01-12	Хімічний спосіб
HUE043249T2 (hu)	2019-08-28	Eljárás puzzolánok feldolgozására
SG166091A1 (en)	2010-11-29	Method for producing isocyanates
NO20082305L (no)	2008-07-24	Mikrobiologisk stabilisert ol
UA104438C2 (uk)	2014-02-10	Спосіб одержання дабігатрану і його проміжних сполук
EP1854219A4 (en)	2011-12-21	METHOD, APPARATUS AND SYSTEM FOR TRANSMITTING ENERGY
DK2376015T3 (da)	2019-08-19	Pneumopedisk-ortodontisk instrument, system og fremgangsmåde.
MX265618B (es)	2009-04-02	Metodo para preparar n-fenilpirazol-1-carboxamidas.
NO20083153L (no)	2008-09-22	Kjemiske forbindelser
PL2124381T3 (pl)	2013-11-29	Sposób, system i urządzenie do generowania klucza grupowego
EP2153302A4 (en)	2012-04-25	INTERFACE, METHOD AND SYSTEM FOR PROVIDING INLINE CONTEXTION AID AND SUPPORT
EA201070689A1 (ru)	2010-10-29	Композиция для личного ухода
TW200617019A (en)	2006-06-01	A process for the preparation of 7α-alkylated 19-norsteroids
EG23841A (en)	2007-10-16	Method, system and apparatus for exposing workbookranges as data sources
TW200833649A (en)	2008-08-16	Method for the preparation of hydroxyadamantanamine
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EP1797967A4 (en)	2013-04-10	ORGANIC THIN FILM PROCESSING, ORGANIC THIN FILM TRAINING AND SOLUTION FOR ORGANIC THIN FILM EDUCATION
TW200619206A (en)	2006-06-16	Chemokine-binding heterocyclic compound salts, and methods of use thereof
IL200000A (en)	2013-06-27	Process for Preparing 5- (1- Alkylthio) Alkylpyridines are Stored in Position 2 and Its Compounds
BRPI0814211A2 (pt)	2015-01-27	Método e aparelho para produção de gás misturado, e aparelho e método para produção de composto époxi.
TWI372439B (en)	2012-09-11	Semiconductor wafer positioning method, and apparatus using the same
GB0812662D0 (en)	2008-08-20	Data processing apparatus, for example using modes
WO2010148177A3 (en)	2011-04-28	Compounds, compositions, methods of synthesis, and methods of treatment
EA200901598A1 (ru)	2010-06-30	Способ получения триазолонов