DK2079706T3 - Fremgangsmåde til fremstilling af medetomidin og saltene deraf - Google Patents

Fremgangsmåde til fremstilling af medetomidin og saltene deraf

Info

Publication number: DK2079706T3
Authority: DK; Denmark
Prior art keywords: salts; medetomidine; preparation; transmetalation; dimethylbenzaldehyde
Prior art date: 2006-11-06

Application number

DK07822154.6T

Other languages

English (en)

Inventor

Inese Reine

Armands Zandersons

Original Assignee

Grindeks Jsc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-11-06

Filing date

2007-11-02

Publication date

2011-10-03

2007-11-02 Application filed by Grindeks Jsc filed Critical Grindeks Jsc

2011-10-03 Application granted granted Critical

2011-10-03 Publication of DK2079706T3 publication Critical patent/DK2079706T3/da

Links

238000000034 method Methods 0.000 title abstract 3
150000003839 salts Chemical class 0.000 title abstract 3
HRLIOXLXPOHXTA-UHFFFAOYSA-N medetomidine Chemical compound C=1C=CC(C)=C(C)C=1C(C)C1=CN=C[N]1 HRLIOXLXPOHXTA-UHFFFAOYSA-N 0.000 title abstract 2
229960002140 medetomidine Drugs 0.000 title abstract 2
UIFVCPMLQXKEEU-UHFFFAOYSA-N 2,3-dimethylbenzaldehyde Chemical compound CC1=CC=CC(C=O)=C1C UIFVCPMLQXKEEU-UHFFFAOYSA-N 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
150000004795 grignard reagents Chemical class 0.000 abstract 1
150000002460 imidazoles Chemical class 0.000 abstract 1
230000009257 reactivity Effects 0.000 abstract 1
238000006478 transmetalation reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DK07822154.6T 2006-11-06 2007-11-02 Fremgangsmåde til fremstilling af medetomidin og saltene deraf DK2079706T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP06123548A EP1918282A1 (en)	2006-11-06	2006-11-06	Method for preparing medetomidine and its salts
PCT/EP2007/061822 WO2008055852A1 (en)	2006-11-06	2007-11-02	Method for preparing medetomidine and its salts

Publications (1)

Publication Number	Publication Date
DK2079706T3 true DK2079706T3 (da)	2011-10-03

Family

ID=37770375

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK07822154.6T DK2079706T3 (da)	2006-11-06	2007-11-02	Fremgangsmåde til fremstilling af medetomidin og saltene deraf

Country Status (19)

Country	Link
US (1)	US7902377B2 (da)
EP (2)	EP1918282A1 (da)
JP (1)	JP2010508332A (da)
KR (1)	KR20090052398A (da)
CN (1)	CN101535272B (da)
AT (1)	ATE517094T1 (da)
AU (1)	AU2007316693B2 (da)
BR (1)	BRPI0714992A2 (da)
CA (1)	CA2660365C (da)
DK (1)	DK2079706T3 (da)
EA (1)	EA200900355A1 (da)
ES (1)	ES2369746T3 (da)
MX (1)	MX2009004649A (da)
NZ (1)	NZ575125A (da)
PL (1)	PL2079706T3 (da)
PT (1)	PT2079706E (da)
SI (1)	SI2079706T1 (da)
WO (1)	WO2008055852A1 (da)
ZA (1)	ZA200902607B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN102753532B (zh) *	2009-12-09	2015-05-13	I-技术有限公司	美托咪定的制备方法
CN102452984B (zh) *	2010-10-21	2013-10-23	桑迪亚医药技术（上海）有限责任公司	4-[1-(2,3-二甲基苯基)乙烯基]-1-r1-2-r2咪唑的合成方法
IN2014DN00144A (da)	2011-07-22	2015-05-22	Cambrex Karlskoga Ab
WO2012172119A2 (en)	2012-05-08	2012-12-20	Lonza Ltd	Method for the preparation of medetomidine
JP5777840B2 (ja) *	2012-05-08	2015-09-09	ロンザ・リミテッド	２−（２，３−ジメチルフェニル）−１−プロパナールを調製するための方法
IN2014DN07983A (da) *	2012-05-08	2015-05-01	Lonza Ag
IN2014DN08121A (da)	2012-06-28	2015-05-01	Lonza Ag
WO2012172121A1 (en) *	2012-06-28	2012-12-20	Lonza Ltd	Method for the preparation of medetomidine with chloroacetone
US9156793B2 (en) *	2012-06-28	2015-10-13	Lonza Ltd.	Method for preparation of medetomidine with chloroacetone
WO2012172122A2 (en)	2012-06-28	2012-12-20	Lonza Ltd	Method for the preparation of 2-(2,3-dimethylphenyl)-1-propanal
CN103588711B (zh)	2013-11-27	2015-04-08	天津炜捷制药有限公司	一种美托咪定中间体的制备方法
CN103664788B (zh) *	2013-12-04	2015-11-25	湖北生物医药产业技术研究院有限公司	制备美托咪啶的方法
CN104447562A (zh) *	2014-03-27	2015-03-25	宁波天衡药业股份有限公司	一种制备盐酸右美托咪定关键中间体的新方法
CN106083724B (zh) *	2016-08-02	2018-06-26	江苏恒瑞医药股份有限公司	一种右美托咪定的制备方法
CN111269192A (zh) *	2020-02-25	2020-06-12	成都睿智化学研究有限公司	一种5-羟甲基四氮唑及其衍生物的合成方法
CN114671811A (zh) *	2022-04-14	2022-06-28	南京正科医药股份有限公司	一种右美托咪定拆分副产物的外消旋化回收方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2069481B (en)	1980-02-13	1983-07-27	Farmos Oy	Substituted imidazole derivatives
GB2101114B (en) *	1981-07-10	1985-05-22	Farmos Group Ltd	Substituted imidazole derivatives and their preparation and use
WO2006036497A2 (en) *	2004-09-24	2006-04-06	Allergan, Inc.	4-(condensed cyclicmethyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists
WO2006036480A1 (en) *	2004-09-24	2006-04-06	Allergan, Inc.	4-(phenylmethyl and substituted phenylmethyl)-imidazole-2-thiones acting as specific alpha2 adrenergic agonists

2006
- 2006-11-06 EP EP06123548A patent/EP1918282A1/en not_active Withdrawn
2007
- 2007-11-02 BR BRPI0714992-1A patent/BRPI0714992A2/pt not_active IP Right Cessation
- 2007-11-02 CA CA2660365A patent/CA2660365C/en active Active
- 2007-11-02 DK DK07822154.6T patent/DK2079706T3/da active
- 2007-11-02 MX MX2009004649A patent/MX2009004649A/es not_active Application Discontinuation
- 2007-11-02 SI SI200730737T patent/SI2079706T1/sl unknown
- 2007-11-02 AT AT07822154T patent/ATE517094T1/de active
- 2007-11-02 CN CN2007800358734A patent/CN101535272B/zh not_active Expired - Fee Related
- 2007-11-02 WO PCT/EP2007/061822 patent/WO2008055852A1/en not_active Ceased
- 2007-11-02 NZ NZ575125A patent/NZ575125A/en not_active IP Right Cessation
- 2007-11-02 PT PT07822154T patent/PT2079706E/pt unknown
- 2007-11-02 JP JP2009535083A patent/JP2010508332A/ja active Pending
- 2007-11-02 PL PL07822154T patent/PL2079706T3/pl unknown
- 2007-11-02 ES ES07822154T patent/ES2369746T3/es active Active
- 2007-11-02 KR KR1020097007913A patent/KR20090052398A/ko not_active Ceased
- 2007-11-02 EP EP07822154A patent/EP2079706B1/en active Active
- 2007-11-02 EA EA200900355A patent/EA200900355A1/ru unknown
- 2007-11-02 US US12/312,324 patent/US7902377B2/en active Active
- 2007-11-02 AU AU2007316693A patent/AU2007316693B2/en not_active Ceased
2009
- 2009-04-16 ZA ZA200902607A patent/ZA200902607B/xx unknown

Also Published As

Publication number	Publication date
WO2008055852A8 (en)	2009-05-22
CA2660365C (en)	2014-03-25
BRPI0714992A2 (pt)	2013-07-30
EA200900355A1 (ru)	2009-10-30
KR20090052398A (ko)	2009-05-25
AU2007316693B2 (en)	2012-02-02
CN101535272A (zh)	2009-09-16
EP2079706A1 (en)	2009-07-22
ES2369746T3 (es)	2011-12-05
US20100048915A1 (en)	2010-02-25
EP1918282A1 (en)	2008-05-07
ZA200902607B (en)	2010-04-28
CN101535272B (zh)	2011-10-05
CA2660365A1 (en)	2008-05-15
PT2079706E (pt)	2011-10-19
MX2009004649A (es)	2009-05-21
JP2010508332A (ja)	2010-03-18
US7902377B2 (en)	2011-03-08
AU2007316693A1 (en)	2008-05-15
PL2079706T3 (pl)	2011-12-30
SI2079706T1 (sl)	2011-11-30
NZ575125A (en)	2011-02-25
WO2008055852A1 (en)	2008-05-15
ATE517094T1 (de)	2011-08-15
EP2079706B1 (en)	2011-07-20

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