DK210888A - Fremgangsmaade til fremstilling af en hoejresmeltende polymorf form af terfenadin - Google Patents

Fremgangsmaade til fremstilling af en hoejresmeltende polymorf form af terfenadin

Info

Publication number: DK210888A
Authority: DK; Denmark
Prior art keywords: terfenadine; preparing; procedure; polymorph form; approx
Prior art date: 1986-05-07

Application number

DK210888A

Other languages

English (en)

Other versions

DK210888D0 (da

DK173555B1 (da

Inventor

Timothy G Fawcett

Christian T Goralski

David W Ziettlow

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-05-07

Filing date

1988-04-18

Publication date

1989-10-19

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8198929&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK210888(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1988-04-18 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1988-04-18 Publication of DK210888D0 publication Critical patent/DK210888D0/da

1989-10-19 Publication of DK210888A publication Critical patent/DK210888A/da

2001-03-12 Application granted granted Critical

2001-03-12 Publication of DK173555B1 publication Critical patent/DK173555B1/da

Links

GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 title abstract 6
229960000351 terfenadine Drugs 0.000 title abstract 6
238000002844 melting Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
238000004519 manufacturing process Methods 0.000 abstract 2
239000000155 melt Substances 0.000 abstract 2
239000002904 solvent Substances 0.000 abstract 2
238000002425 crystallisation Methods 0.000 abstract 1
230000008025 crystallization Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
238000010992 reflux Methods 0.000 abstract 1
238000003756 stirring Methods 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK198802108A 1986-05-07 1988-04-18 Fremgangsmåde til fremstilling af en ren polymorf form af terfenadin DK173555B1 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US86061986A	1986-05-07	1986-05-07
US86061986		1986-05-07
EP88106898A EP0339118B1 (en)	1988-04-29	1988-04-29	Preparation of polymorphically pure terfenadine
EP88106898		1988-04-29

Publications (3)

Publication Number	Publication Date
DK210888D0 DK210888D0 (da)	1988-04-18
DK210888A true DK210888A (da)	1989-10-19
DK173555B1 DK173555B1 (da)	2001-03-12

Family

ID=8198929

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198802108A DK173555B1 (da)	1986-05-07	1988-04-18	Fremgangsmåde til fremstilling af en ren polymorf form af terfenadin

Country Status (8)

Country	Link
US (1)	US4742175A (da)
EP (1)	EP0339118B1 (da)
AR (1)	AR243612A1 (da)
AT (1)	ATE107283T1 (da)
CA (1)	CA1312610C (da)
DE (1)	DE3850244T2 (da)
DK (1)	DK173555B1 (da)
ES (1)	ES2056851T3 (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4742175A (en) *	1986-05-07	1988-05-03	Merrell Dow Pharmaceuticals Inc.	Preparation of polymorphically pure terfenadine
IT1217837B (it) *	1988-06-17	1990-03-30	Lepetit Spa	Procedimento per la preparazione del "alfa /4(1,1 dimetiletil)fenil/piperidinbutanolo"
ZA901360B (en) *	1989-02-28	1990-11-28	Merrell Dow Pharma	Preparation of the low-melting polymorphic form of terfenadine
CA2015390A1 (en) *	1989-05-01	1990-11-01	Frederick J. Mccarty	Process for the preparation of the high melting polymorphic of terfenadine
US5247092A (en) *	1989-12-29	1993-09-21	Erregierre Industria Chimica S.P.A.	Preparation of the high-melting polymorph of terfenadine
FR2681861B1 (fr) *	1991-10-01	1995-06-09	Isochem Sa	Procede de preparation d'une forme polymorphique de la terfenadine, a point de fusion eleve, d'une plus grande purete et produit obtenu.
US5347006A (en) *	1992-12-31	1994-09-13	Augusto Lavacchielli	Method of preparing a polymorph of terfenadine
US20020007068A1 (en) *	1999-07-16	2002-01-17	D'ambra Thomas E.	Piperidine derivatives and process for their production
HU226559B1 (en) *	1993-06-24	2009-03-30	Amr Technology	Process for the production of piperidine derivatives
US6147216A (en) *	1993-06-25	2000-11-14	Merrell Pharmaceuticals Inc.	Intermediates useful for the preparation of antihistaminic piperidine derivatives
EP1953142A1 (en)	1993-06-25	2008-08-06	Aventis Inc.	Process for the preparation of antihistaminic 4-diphenylmethyl piperidine derivatives
IT1270829B (it) *	1993-09-17	1997-05-13	Recordati Chem Pharm	Procedimento per la preparazione di polimorfo i della terfenadina con distribuzione granulometrica ottimale
US20030045722A1 (en) *	1994-05-18	2003-03-06	Henton Daniel R.	Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof
CA2449419C (en) *	1994-05-18	2011-09-06	Aventis Pharmaceuticals Inc.	Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof
US6153754A (en)	1995-12-21	2000-11-28	Albany Molecular Research, Inc.	Process for production of piperidine derivatives
US6201124B1 (en)	1995-12-21	2001-03-13	Albany Molecular Research, Inc.	Process for production of piperidine derivatives
US6194431B1 (en)	1998-04-14	2001-02-27	Paul D. Rubin	Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors
US6613907B2 (en)	2000-11-08	2003-09-02	Amr Technology, Inc.	Process for the production of piperidine derivatives with microorganisms
TW200517114A (en)	2003-10-15	2005-06-01	Combinatorx Inc	Methods and reagents for the treatment of immunoinflammatory disorders
ZA200804550B (en)	2005-11-09	2009-08-26	Combinatorx Inc	Methods, compositions, and kits for the treatment of medical conditions
WO2010021681A2 (en) *	2008-08-18	2010-02-25	Combinatorx (Singapore) Pte. Ltd.	Compositions and methods for treatment of viral diseases
US20110130711A1 (en) *	2009-11-19	2011-06-02	Follica, Inc.	Hair growth treatment

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3878217A (en) *	1972-01-28	1975-04-15	Richardson Merrell Inc	Alpha-aryl-4-substituted piperidinoalkanol derivatives
ZA728544B (en) *	1972-01-28	1974-02-27	Richardson Merrell Inc	Alpha-aryl-4-substituted piperidinoalkanol derivatives
US4742175A (en) *	1986-05-07	1988-05-03	Merrell Dow Pharmaceuticals Inc.	Preparation of polymorphically pure terfenadine

1987
- 1987-06-30 US US07/068,752 patent/US4742175A/en not_active Expired - Lifetime
1988
- 1988-04-14 CA CA000564174A patent/CA1312610C/en not_active Expired - Lifetime
- 1988-04-18 DK DK198802108A patent/DK173555B1/da not_active IP Right Cessation
- 1988-04-26 AR AR88310668A patent/AR243612A1/es active
- 1988-04-29 DE DE3850244T patent/DE3850244T2/de not_active Expired - Lifetime
- 1988-04-29 AT AT88106898T patent/ATE107283T1/de not_active IP Right Cessation
- 1988-04-29 EP EP88106898A patent/EP0339118B1/en not_active Expired - Lifetime
- 1988-04-29 ES ES88106898T patent/ES2056851T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DK210888D0 (da)	1988-04-18
AR243612A1 (es)	1993-08-31
DE3850244T2 (de)	1994-10-06
EP0339118B1 (en)	1994-06-15
DE3850244D1 (de)	1994-07-21
ES2056851T3 (es)	1994-10-16
DK173555B1 (da)	2001-03-12
CA1312610C (en)	1993-01-12
US4742175A (en)	1988-05-03
EP0339118A1 (en)	1989-11-02
ATE107283T1 (de)	1994-07-15

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Legal Events

Date	Code	Title	Description
2001-03-12	B1	Patent granted (law 1993)
2008-05-05	PUP	Patent expired