DK2114383T3 - Små-volumen orale transmukosale doseringsformer indeholdende sufentanil til behandling af smerte - Google Patents

Små-volumen orale transmukosale doseringsformer indeholdende sufentanil til behandling af smerte

Info

Publication number
DK2114383T3
DK2114383T3 DK07870025.9T DK07870025T DK2114383T3 DK 2114383 T3 DK2114383 T3 DK 2114383T3 DK 07870025 T DK07870025 T DK 07870025T DK 2114383 T3 DK2114383 T3 DK 2114383T3
Authority
DK
Denmark
Prior art keywords
pain
treatment
dosage forms
small
forms containing
Prior art date
Application number
DK07870025.9T
Other languages
English (en)
Inventor
Pamela Palmer
Thomas Schreck
Stelios Tzannis
Larry Hamel
Andrew I Poutiatine
Charles Rampersaud
Bruce Edwards
Original Assignee
Acelrx Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/650,174 external-priority patent/US8202535B2/en
Application filed by Acelrx Pharmaceuticals Inc filed Critical Acelrx Pharmaceuticals Inc
Application granted granted Critical
Publication of DK2114383T3 publication Critical patent/DK2114383T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Primary Health Care (AREA)
  • Pain & Pain Management (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK07870025.9T 2007-01-05 2007-12-28 Små-volumen orale transmukosale doseringsformer indeholdende sufentanil til behandling af smerte DK2114383T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/650,174 US8202535B2 (en) 2006-01-06 2007-01-05 Small-volume oral transmucosal dosage forms
US11/985,162 US8865743B2 (en) 2006-01-06 2007-11-14 Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
PCT/US2007/089018 WO2008085765A2 (en) 2007-01-05 2007-12-28 Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain

Publications (1)

Publication Number Publication Date
DK2114383T3 true DK2114383T3 (da) 2010-10-04

Family

ID=39609243

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07870025.9T DK2114383T3 (da) 2007-01-05 2007-12-28 Små-volumen orale transmukosale doseringsformer indeholdende sufentanil til behandling af smerte

Country Status (10)

Country Link
US (5) US8865743B2 (da)
EP (1) EP2114383B1 (da)
JP (1) JP2010532745A (da)
KR (1) KR101545754B1 (da)
AT (1) ATE474564T1 (da)
CA (1) CA2673856C (da)
DE (1) DE602007007991D1 (da)
DK (1) DK2114383T3 (da)
PT (1) PT2114383E (da)
WO (1) WO2008085765A2 (da)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8252328B2 (en) 2006-01-06 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US8252329B2 (en) 2007-01-05 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US9289583B2 (en) 2006-01-06 2016-03-22 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US8357114B2 (en) 2006-01-06 2013-01-22 Acelrx Pharmaceuticals, Inc. Drug dispensing device with flexible push rod
US8753308B2 (en) 2006-01-06 2014-06-17 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US8202535B2 (en) 2006-01-06 2012-06-19 Acelrx Pharmaceuticals, Inc. Small-volume oral transmucosal dosage forms
US9066847B2 (en) 2007-01-05 2015-06-30 Aceirx Pharmaceuticals, Inc. Storage and dispensing devices for administration of oral transmucosal dosage forms
US8535714B2 (en) 2006-01-06 2013-09-17 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US8865743B2 (en) 2006-01-06 2014-10-21 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
AU2008216867B2 (en) 2007-02-09 2014-01-30 Durect Corporation Transoral dosage forms comprising sufentanil and naloxone
CA2704929C (en) * 2007-08-07 2018-05-15 Pamela Palmer Compositions and methods for procedural sedation and analgesia using oral transmucosal dosage forms
US8945592B2 (en) * 2008-11-21 2015-02-03 Acelrx Pharmaceuticals, Inc. Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same
US8548623B2 (en) 2009-03-18 2013-10-01 Acelrx Pharmaceuticals, Inc. Storage and dispensing devices for administration of oral transmucosal dosage forms
US20110050412A1 (en) * 2009-08-18 2011-03-03 Cynthia Wittman Voice activated finding device
US20110091544A1 (en) * 2009-10-16 2011-04-21 Acelrx Pharmaceuticals, Inc. Compositions and Methods for Mild Sedation, Anxiolysis and Analgesia in the Procedural Setting
US20110218595A1 (en) * 2010-03-04 2011-09-08 Mcmillan William C Prescription device controller
US20110288128A1 (en) 2010-05-21 2011-11-24 Acelrx Pharmaceuticals, Inc. Oral Transmucosal Administration of Sufentanil
GB201014783D0 (en) * 2010-09-06 2010-10-20 St George S Hospital Medical School Apparatus and method for positioning a probe for observing microcirculation vessels
US20130020351A1 (en) * 2011-07-21 2013-01-24 Gojo Industries, Inc. Dispenser with optical keying system
TR201815935T4 (tr) 2012-05-02 2018-11-21 Orexo Ab Akut ağrının tedavisi için yeni alfentanil bileşimi.
CN115671064A (zh) * 2014-02-07 2023-02-03 讯唐制药公司 全天然无毒舌下药物递送系统
TWI689326B (zh) * 2014-08-06 2020-04-01 加拿大商複製細胞生命科學公司 注射裝置
US11058856B2 (en) 2014-12-23 2021-07-13 Acelrx Pharmaceuticals, Inc. Systems, devices and methods for dispensing oral transmucosal dosage forms
FR3032353B1 (fr) 2015-02-06 2017-03-10 Jacques Seguin Composition pharmaceutique et dispositif pour le traitement de la douleur
SE539111C2 (en) * 2015-06-03 2017-04-11 Iconovo Ab Single dose dry powder inhaler
PT3682915T (pt) 2015-10-30 2023-06-26 Acelrx Pharmaceuticals Inc Aparelho e métodos para dispensar formas de dosagem trasnmucosa oral
JP2017112241A (ja) * 2015-12-17 2017-06-22 ルネサスエレクトロニクス株式会社 半導体装置
US9731103B1 (en) 2017-01-13 2017-08-15 Berkshire Biomedical, LLC Computerized oral prescription administration devices and associated systems and methods
US10792226B2 (en) 2017-06-07 2020-10-06 Berkshire Biomedical, LLC Refill and dosage management devices and associated systems and methods for use with computerized oral prescription administration devices
US10441509B2 (en) 2018-03-16 2019-10-15 Berkshire Biomedical, LLC Computerized oral prescription administration with refillable medication dispensing devices and associated systems and methods
US10597206B2 (en) 2018-06-15 2020-03-24 Kenneth Corey Medicine container cover
US10729860B1 (en) 2019-05-22 2020-08-04 Berkshire Biomedical, LLC Computerized oral prescription administration for securely dispensing a medication and associated systems and methods

Family Cites Families (263)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2621655A (en) 1951-10-11 1952-12-16 Kenneth L Gothard Tablet dispensing gun
US3162322A (en) 1962-03-29 1964-12-22 John E Gilbertson Sanitary dispenser for cartridges holding fluid medicants
US3238941A (en) 1963-06-19 1966-03-08 Frost Eng Dev Balling gun
GB1142325A (en) * 1965-05-14 1969-02-05 Higham Stanley Russell Means for administering drugs
US3757781A (en) 1971-09-17 1973-09-11 R Smart Tool for administering pills to animals
US3780735A (en) 1972-02-03 1973-12-25 J Crouter Dose syringe
US3789845A (en) 1973-01-29 1974-02-05 J Long Capsule and tablet administration for animals
FR2278317A1 (fr) * 1974-07-19 1976-02-13 Commissariat Energie Atomique Implant buccal pour administrer des produits solubilisables
US4060083A (en) 1976-04-01 1977-11-29 Hanson Raymond L Pill gun
US4237884A (en) 1978-03-17 1980-12-09 Victor Erickson Medication dispenser
GB2042888B (en) * 1979-03-05 1983-09-28 Teijin Ltd Preparation for administration to the mucosa of the oral or nasal cavity
US4229447A (en) 1979-06-04 1980-10-21 American Home Products Corporation Intraoral methods of using benzodiazepines
US4465191A (en) 1982-06-14 1984-08-14 Darbo Rolf E Personal tablet dispenser
US4474308A (en) * 1982-09-30 1984-10-02 Michel Bergeron Tablet ejector
US4489853A (en) 1982-12-15 1984-12-25 Korte Jay S Pill dispensing device
GB8332556D0 (en) 1983-12-06 1984-01-11 Reckitt & Colmann Prod Ltd Analgesic compositions
US5288498A (en) 1985-05-01 1994-02-22 University Of Utah Research Foundation Compositions of oral nondissolvable matrixes for transmucosal administration of medicaments
US5855908A (en) 1984-05-01 1999-01-05 University Of Utah Research Foundation Non-dissolvable drug-containing dosage-forms for use in the transmucosal delivery of a drug to a patient
US4863737A (en) 1985-05-01 1989-09-05 University Of Utah Compositions and methods of manufacture of compressed powder medicaments
DE3421468A1 (de) 1984-06-08 1985-12-19 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim Lipidnanopellets als traegersystem fuer arzneimittel zur peroralen anwendung
EP0166315B1 (de) 1984-06-19 1989-08-23 BASF Aktiengesellschaft Magensaftresistent überzogene zylindrische Pankreatin-Mikrotabletten
US4671953A (en) * 1985-05-01 1987-06-09 University Of Utah Research Foundation Methods and compositions for noninvasive administration of sedatives, analgesics, and anesthetics
US5132114A (en) 1985-05-01 1992-07-21 University Of Utah Research Foundation Compositions and methods of manufacture of compressed powder medicaments
US5122127A (en) 1985-05-01 1992-06-16 University Of Utah Apparatus and methods for use in administering medicaments by direct medicament contact to mucosal tissues
US5785989A (en) 1985-05-01 1998-07-28 University Utah Research Foundation Compositions and methods of manufacturing of oral dissolvable medicaments
US5288497A (en) 1985-05-01 1994-02-22 The University Of Utah Compositions of oral dissolvable medicaments
US4764378A (en) * 1986-02-10 1988-08-16 Zetachron, Inc. Buccal drug dosage form
DE3632546A1 (de) 1986-09-25 1988-03-31 Knoll Ag Dosierspender
US4785969A (en) 1986-11-10 1988-11-22 Pyxis Corporation Medication dispensing system
CA1296231C (en) * 1987-05-26 1992-02-25 Keiji Fujioka Device for administering solid preparations
US4915948A (en) 1987-08-31 1990-04-10 Warner-Lambert Company Tablets having improved bioadhesion to mucous membranes
FR2619718B1 (fr) 1987-09-02 1991-07-12 Medibrevex Nouvelles formes galeniques de beta-2-mimetiques pour administration par voie per- et sublinguale
US4873076A (en) 1988-04-29 1989-10-10 Baker Cummins Pharmaceuticals, Inc. Method of safely providing anesthesia or conscious sedation
WO1989010127A1 (en) 1988-04-29 1989-11-02 Baker Cummins Pharmaceuticals, Inc. Method of safely providing anesthesia or conscious sedation
JPH02121039A (ja) 1988-10-31 1990-05-08 Toshiba Corp 計算機システムの負荷予測シミュレーション方式
US5236714A (en) 1988-11-01 1993-08-17 Alza Corporation Abusable substance dosage form having reduced abuse potential
US5112616A (en) * 1988-11-30 1992-05-12 Schering Corporation Fast dissolving buccal tablet
AT391300B (de) 1989-04-12 1990-09-10 Hinterreiter Ignaz Tablettenspender
US5223264A (en) 1989-10-02 1993-06-29 Cima Labs, Inc. Pediatric effervescent dosage form
US5178878A (en) 1989-10-02 1993-01-12 Cima Labs, Inc. Effervescent dosage form with microparticles
US5190185A (en) 1990-05-18 1993-03-02 Baxter International Inc. Medication transport and dispensing magazine
GB9015522D0 (en) * 1990-07-13 1990-08-29 Braithwaite Philip W Inhaler
WO1992016236A1 (en) * 1991-03-19 1992-10-01 Rajadhyaksha Vithal J Compositions and method comprising aminoalcohol derivatives as membrane penetration enhancers
US5296234A (en) 1991-10-11 1994-03-22 Abbott Laboratories Holder and packaging for a hardened medicated matrix
US5263596A (en) 1991-12-02 1993-11-23 Williams David R Medication dispenser station sub-assembly
US5348158A (en) 1991-12-19 1994-09-20 G. D. Searle & Co. Dispenser pack for the successive dispensing of a drug
NL9200844A (nl) 1992-05-13 1993-12-01 De Wijdeven Gijsbertus G P Van Inrichting en werkwijze voor het injecteren met een vaste stof.
US5352680A (en) * 1992-07-15 1994-10-04 Regents Of The University Of Minnesota Delta opioid receptor antagonists to block opioid agonist tolerance and dependence
US5292307A (en) 1992-09-16 1994-03-08 Dolzine Theodore W Dispensing package for unit dosage
US5507277A (en) 1993-01-29 1996-04-16 Aradigm Corporation Lockout device for controlled release of drug from patient-activateddispenser
US5694919A (en) 1993-01-29 1997-12-09 Aradigm Corporation Lockout device for controlled release of drug from patient-activated dispenser
US5724957A (en) 1993-01-29 1998-03-10 Aradigm Corporation Intrapulmonary delivery of narcotics
US5489689A (en) * 1993-09-30 1996-02-06 Mallinckrodt Chemical, Inc. Preparation of piperidine derivatives
US5366113A (en) 1993-12-13 1994-11-22 Kim David S Pill dispenser
US5489025A (en) * 1994-03-01 1996-02-06 Romick; Jerome M. Unit-dose medication dispenser and multiple-dispenser frame therefor
US5507807A (en) * 1994-03-01 1996-04-16 Shippert; Ronald D. Apparatus for the release of a substance within a patient
US5488953A (en) * 1994-04-15 1996-02-06 Ecocath, Inc. Diffracting doppler-transducer
US6328159B1 (en) 1994-07-13 2001-12-11 Centrix, Inc Single patient dose medicament dispenser with applicator
US6685013B2 (en) 1994-07-13 2004-02-03 Centrix, Inc. Single patient dose medicament dispenser with applicator
US5660273A (en) * 1994-07-13 1997-08-26 Centrix, Inc. Single patient dose medicament dispenser with applicator
WO1996008284A2 (en) 1994-09-16 1996-03-21 Laboratoire Glaxo Wellcome Inhalation device
US5584805A (en) 1995-03-17 1996-12-17 Sutton; Matthew R. Animal pill-dispenser gun
EP0836511B1 (en) 1995-06-05 2004-04-07 Alza Corporation Device for transdermal electrotransport delivery of fentanyl and sufentanil
US6216033B1 (en) 1996-05-22 2001-04-10 Alza Corporation Device for transdermal electrotransport delivery of fentanyl and sufentanil
US6881208B1 (en) * 1995-06-05 2005-04-19 Joseph B. Phipps Method and device for transdermal electrotransport delivery of fentanyl and sufentanil
US6425892B2 (en) * 1995-06-05 2002-07-30 Alza Corporation Device for transdermal electrotransport delivery of fentanyl and sufentanil
CN1122540C (zh) 1995-06-07 2003-10-01 亚历山大·乔治·布赖恩·奥尼尔 由病人控制的药物输送装置
US5984888A (en) 1995-06-07 1999-11-16 Kimberly-Clark Worldwide, Inc. Applicator and coating
US5710551A (en) 1995-07-26 1998-01-20 Ridgeway; Donald G. Self-medication monitoring system
CA2184316A1 (en) 1995-09-12 1997-03-13 Wei-Chi Liao Buccal delivery system for therapeutic agents
AUPN603895A0 (en) 1995-10-19 1995-11-09 University Of Queensland, The Production of analgesic synergy by co-administration of sub-analgesic doses of two strong opioids
GB2309966A (en) 1996-02-07 1997-08-13 Harwill Ind Pty Ltd Teat device for administering medicaments
US5995938A (en) 1996-02-27 1999-11-30 Whaley; Susan S. Medication compliance system
ATE240764T1 (de) 1996-07-05 2003-06-15 Novo Nordisk As Gerät zum einbringen eines zäpfchens
NL1003596C2 (nl) 1996-07-15 1997-05-27 Cons Health Entrepreneurs Bv Geneesmiddelafgifte-automaat.
US6248789B1 (en) 1996-08-29 2001-06-19 Stuart L. Weg Administration of ketamine to manage pain and to reduce drug dependency
US5800832A (en) 1996-10-18 1998-09-01 Virotex Corporation Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces
US5954641A (en) 1997-09-08 1999-09-21 Informedix, Inc. Method, apparatus and operating system for managing the administration of medication and medical treatment regimens
US5752620A (en) 1996-11-13 1998-05-19 Pearson Ventures, L.L.C. Medication dispenser
US6529446B1 (en) * 1996-12-20 2003-03-04 Telaric L.L.C. Interactive medication container
US5968547A (en) 1997-02-24 1999-10-19 Euro-Celtique, S.A. Method of providing sustained analgesia with buprenorphine
US5950632A (en) 1997-03-03 1999-09-14 Motorola, Inc. Medical communication apparatus, system, and method
US6024981A (en) 1997-04-16 2000-02-15 Cima Labs Inc. Rapidly dissolving robust dosage form
US5945651A (en) 1997-07-17 1999-08-31 Chorosinski; Leonard Remotely programmable medication dispensing system
JPH1147233A (ja) 1997-07-30 1999-02-23 Teikoku Seiyaku Co Ltd 貼付剤および貼付剤の保存方法
US5850937A (en) 1997-08-14 1998-12-22 Rauche; Stephen J. Dispenser with means for alerting a user
EA002806B1 (ru) * 1997-09-11 2002-10-31 Нюкомед Данмарк А/С Многоединичные композиции с модифицированным высвобождением нестероидных противовоспалительных лекарственных веществ (nsaid)
US6660295B2 (en) 1997-09-30 2003-12-09 Alza Corporation Transdermal drug delivery device package with improved drug stability
US20030185761A1 (en) * 1997-10-01 2003-10-02 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating pain
DK1019039T3 (da) 1997-10-03 2002-03-25 Warner Lambert Co Komprimeret nitroglycerintablet og fremgangsmåde til dens fremstilling
WO2000066458A1 (en) 1997-10-30 2000-11-09 HALLIN, Cristian under the firm of TELUM PRODUCTI N A tablet dispenser
US5997518A (en) 1998-01-14 1999-12-07 Laibovitz; Robert A. Apparatus and method for delivery of small volumes of liquid
WO1999037323A1 (en) * 1998-01-23 1999-07-29 Genencor International, Inc. Chemically modified mutant enzymes and methods for producing them and screening them
US5981552A (en) 1998-10-23 1999-11-09 Taylor Pharmaceuticals Sublingual and buccal compositions of droperidol and method for treating migraine
US6974590B2 (en) * 1998-03-27 2005-12-13 Cima Labs Inc. Sublingual buccal effervescent
US6200604B1 (en) 1998-03-27 2001-03-13 Cima Labs Inc. Sublingual buccal effervescent
US20030091629A1 (en) 1998-03-27 2003-05-15 Cima Labs Inc. Sublingual buccal effervescent
US6350470B1 (en) 1998-04-29 2002-02-26 Cima Labs Inc. Effervescent drug delivery system for oral administration
US6576250B1 (en) 1998-03-27 2003-06-10 Cima Labs Inc. Pharmaceutical compositions for rectal and vaginal administration
US6039251A (en) 1998-04-16 2000-03-21 Holowko; Paul L. Method and system for secure control of a medical device
US6651651B1 (en) 1998-08-28 2003-11-25 Smithkline Beecham Corporation Dispenser
SE9803239D0 (sv) 1998-09-24 1998-09-24 Diabact Ab Composition for the treatment of acute pain
SE9803240D0 (sv) 1998-09-24 1998-09-24 Diabact Ab A pharmaceutical composition having a rapid action
JP2000142841A (ja) 1998-11-17 2000-05-23 Lion Corp 小形物品用容器
JP3459882B2 (ja) 1998-11-30 2003-10-27 株式会社バンダイ 物品取出装置
GB9826192D0 (en) 1998-12-01 1999-01-20 Controlled Theraputics Scotlan Oral transmucosal delivery
US6131765A (en) 1999-01-08 2000-10-17 Barry; William Dean Device for storing and dispensing solid-form medication
WO2000047203A1 (en) 1999-02-12 2000-08-17 Mqs, Inc. Formulation and system for intra-oral delivery of pharmaceutical agents
US6680071B1 (en) 1999-03-03 2004-01-20 R. P. Scherer Technologies, Inc. Opioid agonist in a fast dispersing dosage form
US6835194B2 (en) * 1999-03-18 2004-12-28 Durect Corporation Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners
US6541021B1 (en) * 1999-03-18 2003-04-01 Durect Corporation Devices and methods for pain management
US6234343B1 (en) 1999-03-26 2001-05-22 Papp Enterprises, Llc Automated portable medication radial dispensing apparatus and method
US6601729B1 (en) * 1999-03-26 2003-08-05 Papp Enterprises, Llc Automated portable medication radial dispensing apparatus and method using a carrier tape
US6210699B1 (en) 1999-04-01 2001-04-03 Watson Pharmaceuticals, Inc. Oral transmucosal delivery of drugs or any other ingredients via the inner buccal cavity
US6762684B1 (en) 1999-04-19 2004-07-13 Accutrak Systems, Inc. Monitoring system
US6319510B1 (en) 1999-04-20 2001-11-20 Alayne Yates Gum pad for delivery of medication to mucosal tissues
US6190326B1 (en) 1999-04-23 2001-02-20 Medtrac Technologies, Inc. Method and apparatus for obtaining patient respiratory data
GB2369063B (en) 1999-04-29 2003-07-16 Peter James Brian Lamb Device for depositing a non-flowable object or a non-flowable medicament in a body cavity
GB9911388D0 (en) 1999-05-18 1999-07-14 Glaxo Group Ltd Dispenser
US6395300B1 (en) 1999-05-27 2002-05-28 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
US7919119B2 (en) 1999-05-27 2011-04-05 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
BR0013122A (pt) 1999-08-13 2002-04-30 Vela Pharmaceuticals Inc Ciclobenzaprina para tratamento de distúrbio de ansiedade generalizado e composições de ciclobenzaprina
US6264983B1 (en) * 1999-09-16 2001-07-24 Rhodia, Inc. Directly compressible, ultra fine acetaminophen compositions and process for producing same
FR2799124B1 (fr) 1999-10-01 2004-08-13 Sanofi Synthelabo Utilisation des antagonistes des recepteurs aux cannabinoides centraux pour la preparation de medicaments
US6382204B1 (en) 1999-10-14 2002-05-07 Becton Dickinson And Company Drug delivery system including holder and drug container
US6572891B1 (en) 1999-10-23 2003-06-03 Alkaloid Ad Sublingual oral dosage form
US6264981B1 (en) * 1999-10-27 2001-07-24 Anesta Corporation Oral transmucosal drug dosage using solid solution
EP1246801B1 (en) 1999-12-06 2006-09-20 Mallinckrodt Inc. Methods for the syntheses of alfentanil, sufentanil and remifentanil
PE20010720A1 (es) * 1999-12-11 2001-07-26 Glaxo Group Ltd Distribuidor de medicamento
AT408488B (de) * 1999-12-22 2001-12-27 Scan Messtechnik Gmbh Miniaturisiertes spektrometer
US6294999B1 (en) 1999-12-29 2001-09-25 Becton, Dickinson And Company Systems and methods for monitoring patient compliance with medication regimens
US6471645B1 (en) 1999-12-30 2002-10-29 Medtronic, Inc. Communications system for an implantable device and a drug dispenser
BR0108730A (pt) * 2000-02-28 2002-11-05 Vectura Ltd Sistema, dispositivo e método para administração de uma droga, bocal de um dispositivo de administração de droga, dispositivo para administração de doses unitárias múltiplas de uma droga, métodos para preparação de um sistema de administração de droga e de uma formulação de droga e para tratamento de um paciente que necessita de doses múltiplas de uma droga, formulação de droga e multiparticulados
US6364158B1 (en) 2000-03-24 2002-04-02 John Dimoulis Anesthetic dispensing station and method of using same
AU2001262992A1 (en) * 2000-05-10 2002-02-18 University Of Kentucky Research Foundation System and method for intranasal administration of opioids
DE10025946A1 (de) 2000-05-26 2001-11-29 Gruenenthal Gmbh Wirkstoffkombination
AT409366B (de) * 2000-06-20 2002-07-25 Haas Beteiligungsgesellschaft Magazin zur aufnahme und vereinzelten abgabe von tabletten
WO2001097780A2 (en) 2000-06-22 2001-12-27 Pharmasol Ltd Pharmaceutical compositions comprising an opioid analgesic
DE60133203T3 (de) * 2000-07-31 2012-02-23 Nycomed Danmark Aps Fentanyl Zusammensetzung für nasale Anwendung
EP1309315B1 (en) * 2000-08-18 2006-06-14 Pharmacia Corporation Rapidly disintegrating oral formulation of valdecoxib
US20020026330A1 (en) * 2000-08-23 2002-02-28 Klein Edward E. System and method for patient medication management and compliance using a portable computing device
US6417184B1 (en) 2000-09-19 2002-07-09 David M. Ockert Triple drug therapy for the treatment and prevention of acute or chronic pain
GB2368061B (en) 2000-10-20 2005-05-11 Gw Pharmaceuticals Ltd Dose dispensing apparatus
US20050054942A1 (en) * 2002-01-22 2005-03-10 Melker Richard J. System and method for therapeutic drug monitoring
US20020160043A1 (en) 2001-02-27 2002-10-31 Dennis Coleman Compositions and method of manufacture for oral dissolvable dosage forms
DE10109763A1 (de) * 2001-02-28 2002-09-05 Gruenenthal Gmbh Pharmazeutische Salze
US20050176790A1 (en) * 2001-02-28 2005-08-11 Johannes Bartholomaus Pharmaceutical salts
WO2002074372A2 (en) 2001-03-15 2002-09-26 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nebulizer having cooling chamber
JP4850346B2 (ja) * 2001-03-15 2012-01-11 救急薬品工業株式会社 粘膜貼付剤
EP1243524A3 (en) 2001-03-16 2004-04-07 Pfizer Products Inc. Pharmaceutical kit for oxygen-sensitive drugs
GB0108228D0 (en) 2001-04-02 2001-05-23 Glaxo Group Ltd Medicament dispenser
GB0108215D0 (en) * 2001-04-02 2001-05-23 Glaxo Group Ltd Medicament dispenser
AU2002339378A1 (en) * 2001-05-22 2002-12-03 Euro-Celtique Compartmentalized dosage form
JP2005503425A (ja) 2001-05-24 2005-02-03 アレックザ モレキュラー デリヴァリー コーポレイション 所定の吸入ルートによる薬剤エステルの送出
US7766013B2 (en) 2001-06-05 2010-08-03 Alexza Pharmaceuticals, Inc. Aerosol generating method and device
WO2002094218A2 (en) * 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route
US7090830B2 (en) 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US6564967B1 (en) 2001-06-29 2003-05-20 Brown & Williamson Tobacco Corporation Child resistant tablet dispenser
US20030017175A1 (en) 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
US20030022910A1 (en) 2001-07-05 2003-01-30 R.T. Alamo Ventures I, Inc. Compositions and methods for sublingual formulations of dihydroergotamine for the treatment of migraine
US20030008005A1 (en) 2001-07-05 2003-01-09 R.T. Alamo Ventures, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
US20030068356A1 (en) 2001-07-10 2003-04-10 Pather S. Indiran Sequential drug delivery systems
FR2827517B1 (fr) * 2001-07-23 2003-10-24 Bioalliance Pharma Systemes therapeutiques bioadhesifs a liberation prolongee
EP1421458B1 (en) * 2001-08-03 2010-04-07 Hill-Rom Services, Inc. Patient point-of-care computer system
US7144587B2 (en) * 2001-08-06 2006-12-05 Euro-Celtique S.A. Pharmaceutical formulation containing opioid agonist, opioid antagonist and bittering agent
US7044302B2 (en) * 2001-09-19 2006-05-16 Avancen, Inc. Patient controlled timed oral medication dispenser
US7896192B2 (en) * 2001-09-19 2011-03-01 Avancen MOD Corp. Patient controlled timed medication dispenser
US7743923B2 (en) 2001-09-19 2010-06-29 Avanced MOD Corporation Patient controlled timed medication dispenser
PL369298A1 (en) * 2001-09-26 2005-04-18 Pharmacia Corporation Intraorally disintegrating valdecoxib compositions
ATE364561T1 (de) 2001-10-22 2007-07-15 3M Innovative Properties Co Verpackung für transdermale/transmucosale pflaster
US6863901B2 (en) 2001-11-30 2005-03-08 Collegium Pharmaceutical, Inc. Pharmaceutical composition for compressed annular tablet with molded triturate tablet for both intraoral and oral administration
EP1455784A1 (en) 2001-12-17 2004-09-15 Aryx Therapeutics Analgesic delivery systems and methods of use
CA2366887C (en) * 2001-12-31 2011-11-01 Michael Petersen Replicate incorporating an electronic content monitoring system for use in form-fill-seal applications
US7537005B2 (en) * 2002-02-22 2009-05-26 Gw Pharma Limited Dose dispensing system and apparatus
US7204425B2 (en) * 2002-03-18 2007-04-17 Precision Dynamics Corporation Enhanced identification appliance
US7074426B2 (en) * 2002-03-27 2006-07-11 Frank Kochinke Methods and drug delivery systems for the treatment of orofacial diseases
GB0209782D0 (en) 2002-04-29 2002-06-05 Glaxo Group Ltd Medicament dispenser
US6961541B2 (en) 2002-05-24 2005-11-01 Aeroscout, Inc. Method and apparatus for enhancing security in a wireless network using distance measurement techniques
US6793075B1 (en) 2002-05-30 2004-09-21 Michael Jeter Container for dispensing a liquid and method of using the same
DE10226494A1 (de) 2002-06-14 2004-01-08 Lts Lohmann Therapie-Systeme Ag Filmförmige mucoadhäsive Darreichungsformen zur Verabreichung von Cannabis-Wirkstoffen
PT2058754E (pt) * 2002-06-21 2013-07-24 Glaxo Group Ltd Indicador de accionamento para um dispositivo de distribuição
JP2004051502A (ja) 2002-07-17 2004-02-19 Jcr Pharmaceuticals Co Ltd 成長ホルモン含有安定化粉末製剤
EP2080561A3 (en) * 2002-08-06 2016-11-16 Glaxo Group Limited A dispenser
US9486581B2 (en) 2002-09-11 2016-11-08 Becton, Dickinson And Company Injector device with force lock-out and injection rate limiting mechanisms
US7295890B2 (en) * 2002-09-26 2007-11-13 Stratamed Labs, Inc. Prescription drug compliance monitoring system
US6963289B2 (en) 2002-10-18 2005-11-08 Aeroscout, Ltd. Wireless local area network (WLAN) channel radio-frequency identification (RFID) tag system and method therefor
US6999092B2 (en) * 2002-10-25 2006-02-14 Fujitsu Limited Image display apparatus in which a specific area display attribute is modifiable
JP3447009B1 (ja) 2002-10-29 2003-09-16 實 平垣 構築物用構成体およびその製造方法
US6726053B1 (en) * 2002-10-29 2004-04-27 John E. Harrold Child resistant multiple dosage blister pack dispenser
GB0226022D0 (en) * 2002-11-07 2002-12-18 Corporate Intellectual Propert Device
CA2506615A1 (en) 2002-11-18 2004-06-03 Yaupon Therapeutics, Inc. Analgesic uses of norketamine and ketamine/norketamine prodrugs
JP5079981B2 (ja) 2002-12-13 2012-11-21 アルファバックス，インコーポレイティド アルファウイルス粒子及び調製方法
US7264139B2 (en) 2003-01-14 2007-09-04 Hypoguard Limited Sensor dispensing device
CA2512559A1 (en) 2003-01-31 2004-08-12 Orexo Ab A rapid-acting pharmaceutical composition
US20040253307A1 (en) 2003-02-04 2004-12-16 Brian Hague Sugar-free oral transmucosal solid dosage forms and uses thereof
KR101170844B1 (ko) * 2003-02-24 2012-08-02 파마슈티칼 프로덕션스, 인크. 경점막 약물 전달 시스템
US20060062812A1 (en) 2003-03-11 2006-03-23 Calvin Ross Novel compositions
GB0305581D0 (en) 2003-03-11 2003-04-16 Dallas Burston Ltd Dispensing devices
AU2004229551A1 (en) 2003-04-14 2004-10-28 Pain Therapeutics, Inc. Methods for the treatment of pain comprising opioid antagonists
US7276246B2 (en) 2003-05-09 2007-10-02 Cephalon, Inc. Dissolvable backing layer for use with a transmucosal delivery device
US7306812B2 (en) 2003-05-09 2007-12-11 Cephalon, Inc. Dissolvable backing layer for use with a transmucosal delivery device
US6914668B2 (en) 2003-05-14 2005-07-05 International Technologies (Laser) Ltd. Personal identification verification and controlled substance detection and identification system
BR0302017B1 (pt) * 2003-06-02 2014-10-29 Ems Sigma Pharma Ltda Composição farmacêutica sublingual a base de um agonista do receptor central de benzodiazepínicos
US7819847B2 (en) * 2003-06-10 2010-10-26 Hewlett-Packard Development Company, L.P. System and methods for administering bioactive compositions
US7118550B2 (en) 2003-07-10 2006-10-10 B. Braun Medical Side-delivery suppository dispenser
US20050049464A1 (en) 2003-08-29 2005-03-03 Lassers Harold Aaron Remote pharmaceutical administration device
US7248165B2 (en) 2003-09-09 2007-07-24 Motorola, Inc. Method and apparatus for multiple frequency RFID tag architecture
US20050065175A1 (en) * 2003-09-24 2005-03-24 Xanodyne Pharmacal, Inc. Oral transmucosal methadone
WO2005032556A1 (en) 2003-10-02 2005-04-14 Elan Pharmaceuticals, Inc. Method for reducing pain
US8157788B2 (en) * 2003-11-06 2012-04-17 Paolo L. Manfredi Multi-site drug delivery platform
US7540998B2 (en) 2003-11-19 2009-06-02 Biocompatibles Uk Limited Delivery system and prescription method for interstitial radiation therapy using enhanced parametric release sterilization techniques
US7780973B2 (en) 2003-12-15 2010-08-24 Ethicon Endo-Surgery, Inc. Method and device for minimally invasive implantation of biomaterial
US6999028B2 (en) 2003-12-23 2006-02-14 3M Innovative Properties Company Ultra high frequency radio frequency identification tag
US7858121B2 (en) 2003-12-31 2010-12-28 Cima Labs, Inc. Effervescent oral fentanyl dosage form and methods of administering fentanyl
EP1708686B1 (en) 2003-12-31 2011-02-16 Cima Labs Inc. Generally linear effervescent oral fentanyl dosage form and methods of administering
US20070036853A1 (en) 2003-12-31 2007-02-15 Cima Labs Inc. Generally linear effervescent oral fentanyl dosage form and methods of administering
DE602004031771D1 (de) 2003-12-31 2011-04-21 Cima Labs Inc Brauseformen von opiaten zur oralen anwendung und verfahren zur verabreichung von oxycodon
US20050150489A1 (en) 2004-01-12 2005-07-14 Steve Dunfield Dispensing medicaments based on rates of medicament action
CA2553392A1 (en) 2004-01-16 2005-08-11 Biodel Inc Sublingual drug delivery device
PL1729730T3 (pl) 2004-03-30 2009-06-30 Euro Celtique Sa Odporna na zniszczenie postać dawkowania zawierająca adsorbent i środek przeciwdziałający
US20050226923A1 (en) 2004-04-07 2005-10-13 Gassert Chad M Venlafaxine compositions in the form of microtablets
US7004111B2 (en) 2004-05-26 2006-02-28 Keryl Olson Treat dispenser
US20060026035A1 (en) 2004-07-28 2006-02-02 William Younkes Computer aided interactive medical management information and control system and method
US20060045865A1 (en) * 2004-08-27 2006-03-02 Spherics, Inc. Controlled regional oral delivery
GB0420016D0 (en) 2004-09-09 2004-10-13 Leuven K U Res & Dev Controlled release oral delivery system
US20060067978A1 (en) * 2004-09-29 2006-03-30 Bausch & Lomb Incorporated Process for preparing poly(vinyl alcohol) drug delivery devices
US7388493B2 (en) 2004-10-08 2008-06-17 Bartronics America, Inc. Method and system for preventing unauthorized removal and use of an RFID apparatus
US7119690B2 (en) 2004-10-08 2006-10-10 Proximities, Inc. Identification band using serpentine paths to detect tampering
RU2390023C2 (ru) 2004-10-21 2010-05-20 БАЙЕР ХЕЛТКЭА ЭлЭлСи Диспенсер датчиков и механизм для извлечения датчика
CN2776369Y (zh) 2004-10-22 2006-05-03 瓦索金爱尔兰有限公司 分配系统
US20060089858A1 (en) 2004-10-25 2006-04-27 Tun Ling Means and method of applying RFID and PKI technologies for patient safety
FR2883179B1 (fr) * 2005-03-18 2009-04-17 Ethypharm Sa Comprime enrobe
EP1863456A1 (en) 2005-03-28 2007-12-12 Orexo AB New pharmaceutical compositions useful in the treatment of pain
US20070020186A1 (en) 2005-07-22 2007-01-25 Alpex Pharma S.A. Solid dosage formulations of narcotic drugs having improved buccal adsorption
WO2007035913A2 (en) 2005-09-21 2007-03-29 Kurve Technology, Inc. Medicament delivery control, monitoring, and reporting system and method
US20070104763A1 (en) * 2005-11-10 2007-05-10 Navinta Llc Composition of fentanyl citrate oral solid transmucosal dosage form, excipient and binding material therefore, and methods of making
JP2009522288A (ja) * 2005-12-28 2009-06-11 アルザ コーポレイション 安定な治療剤形
US8202535B2 (en) * 2006-01-06 2012-06-19 Acelrx Pharmaceuticals, Inc. Small-volume oral transmucosal dosage forms
US8252328B2 (en) * 2006-01-06 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US8753308B2 (en) 2006-01-06 2014-06-17 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US8252329B2 (en) * 2007-01-05 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US8865743B2 (en) 2006-01-06 2014-10-21 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US9066847B2 (en) * 2007-01-05 2015-06-30 Aceirx Pharmaceuticals, Inc. Storage and dispensing devices for administration of oral transmucosal dosage forms
US9289583B2 (en) * 2006-01-06 2016-03-22 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US8357114B2 (en) 2006-01-06 2013-01-22 Acelrx Pharmaceuticals, Inc. Drug dispensing device with flexible push rod
US8535714B2 (en) * 2006-01-06 2013-09-17 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
WO2007084290A2 (en) 2006-01-12 2007-07-26 Orexigen Therapeutics, Inc. Compositions of an anticonvulsant and psychotherapeutic and methods of using the same for reversing weight gain
US20070190130A1 (en) 2006-02-16 2007-08-16 Mark William A Protein hydrolysate excipients
US20070260491A1 (en) 2006-05-08 2007-11-08 Pamela Palmer System for delivery and monitoring of administration of controlled substances
US7581657B2 (en) 2006-05-15 2009-09-01 Dickmann Alexander J Bandage dispenser
US20070286900A1 (en) 2006-06-09 2007-12-13 Catherine Herry Low dose tablets of opioid analgesics and preparation process
US20070299687A1 (en) 2006-06-23 2007-12-27 Pamela Palmer Inpatient system for patient-controlled delivery of oral transmucosal medications dosed as needed
JP5503292B2 (ja) 2007-01-05 2014-05-28 エーセルアールエックス ファーマシューティカルズ， インコーポレイテッド 経粘膜剤形の投与のための貯蔵および投与デバイス
US7744558B2 (en) 2007-06-06 2010-06-29 Maag R John Pill plunger
US20090010992A1 (en) * 2007-07-03 2009-01-08 Aceirx Pharmaceuticals, Inc. Drug formulations for oral transmucosal delivery to pediatric patients
CA2704929C (en) 2007-08-07 2018-05-15 Pamela Palmer Compositions and methods for procedural sedation and analgesia using oral transmucosal dosage forms
US8945592B2 (en) * 2008-11-21 2015-02-03 Acelrx Pharmaceuticals, Inc. Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same
US8548623B2 (en) 2009-03-18 2013-10-01 Acelrx Pharmaceuticals, Inc. Storage and dispensing devices for administration of oral transmucosal dosage forms
US8062248B2 (en) 2009-07-14 2011-11-22 Charles Edward Kindel Pill dispenser for pets
US20110091544A1 (en) * 2009-10-16 2011-04-21 Acelrx Pharmaceuticals, Inc. Compositions and Methods for Mild Sedation, Anxiolysis and Analgesia in the Procedural Setting
US20110288128A1 (en) 2010-05-21 2011-11-24 Acelrx Pharmaceuticals, Inc. Oral Transmucosal Administration of Sufentanil

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CA2673856A1 (en) 2008-07-17
US20160213606A1 (en) 2016-07-28
US8865743B2 (en) 2014-10-21
US20150105424A1 (en) 2015-04-16
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US20180161270A1 (en) 2018-06-14
US10245228B2 (en) 2019-04-02
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US20080268023A1 (en) 2008-10-30
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WO2008085765A3 (en) 2008-11-27
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