DK2114896T3 - Strålebeskyttende forbindelser og tilknyttede fremgangsmåder - Google Patents
Strålebeskyttende forbindelser og tilknyttede fremgangsmåder Download PDFInfo
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- DK2114896T3 DK2114896T3 DK07845428.7T DK07845428T DK2114896T3 DK 2114896 T3 DK2114896 T3 DK 2114896T3 DK 07845428 T DK07845428 T DK 07845428T DK 2114896 T3 DK2114896 T3 DK 2114896T3
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- radiation
- optionally substituted
- compound
- cells
- electron donating
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/10—Radicals substituted by halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (11)
1. Strålebeskyttende forbindelse, der er udvalgt blandt:
2. Strålebeskyttende forbindelse med formel (I)
Formula (I) hvor: X er alkylamino; Y og Z er N; og Ri til Ru kan være ens eller forskellige og er udvalgt blandt fluor, chlor, hydrogen og en elektrondonerende gruppe, eller hvilke som helst to af Ri til Ru og NH sammen med carbonatomerne, hvortil de er bundet, kan danne en eventuelt substitueret ring, der kan indeholde heteroatomer, forudsat at mindst en af Ri til Ru er fluor eller chlor; der yderligere er kendetegnet ved, at den ene eller begge af R2 og R3 er en elektrondonerende gruppe, hvor mindst en af Ri til R5 (hvis ikke det er en elektrondonerende gruppe) er fluor; hvor den elektrondonerende gruppe er udvalgt blandt eventuelt substitueret alkyl, eventuelt substitueret alkenyl, NHR', NR'2, OR' eller SR', hvor R' er hydrogen, eventuelt substitueret alkyl eller eventuelt substitueret alkenyl; og salte og/eller tautomerer deraf.
3. Forbindelse med formel (I) ifølge krav 2, hvor: X er alkylamino; Y og Z er N; R3 er N(R)2 eller NHR, hvor R er Ci til C4-alkyl; Ri er fluor; og R2 og R4 til Ru er hydrogen.
4. Forbindelse ifølge et hvilket som helst af kravene 1 til 3 til anvendelse som et medikament.
5. Farmaceutisk præparat, der omfatter en forbindelse ifølge et hvilket som helst af kravene 1 til 3 og et eller flere farmaceutisk acceptable bærematerialer og/eller fortyndingsmidler.
6. Strålebeskyttende forbindelse med formel (I)
Formula (I) hvor: X er eventuelt substitueret alkylamino eller eventuelt substitueret alkyl; Y og Z er ens eller forskellige og er udvalgt blandt N og C(R'), hvor R' er hydrogen, eventuelt substitueret alkyl eller eventuelt substitueret alkenyl; og Ri til Ru kan være ens eller forskellige og er udvalgt blandt fluor, chlor, hydrogen og en elektrondonerende gruppe, eller hvilke som helst to af Ri til Ru og NH sammen med carbonatomerne, hvortil de er bundet, kan danne en eventuelt substitueret ring, der kan indeholde heteroatomer, forudsat at mindst en af Ri til Ru er fluor eller chlor; hvor den elektrondonerende gruppe er udvalgt blandt eventuelt substitueret alkyl, eventuelt substitueret alkenyl, NHR', NR'2, OR' eller SR'; og salte og/eller tautomerer deraf; til anvendelse som en strålebeskytter.
7. Strålebeskyttende forbindelse til anvendelse ifølge krav 6, hvor den strålebeskyttende forbindelse er som defineret i et hvilket som helst af kravene 1-3.
8. Strålebeskyttende forbindelse til anvendelse ifølge enten krav 6 eller 7 til anvendelse som en strålebeskytter i forbindelse med cancerstrålebehandling.
9. Anvendelse af en strålebeskyttende forbindelse med formel m
hvor: X er eventuelt substitueret alkylamino eller eventuelt substitueret alkyl; Y og Z er ens eller forskellige og er udvalgt blandt N og C(R'), hvor R' er hydrogen, eventuelt substitueret alkyl eller eventuelt substitueret alkenyl; og Ri til Ru kan være ens eller forskellige og er udvalgt blandt fluor, chlor, hydrogen og en elektrondonerende gruppe, eller hvilke som helst to af Ri til Ru og NH sammen med carbonatomerne, hvortil de er bundet, kan danne en eventuelt substitueret ring, der kan indeholde heteroatomer, forudsat at mindst en af Ri til Ru er fluor eller chlor; hvor den elektrondonerende gruppe er udvalgt blandt eventuelt substitueret alkyl, eventuelt substitueret alkenyl, NHR', NR'2, OR' eller SR'; og salte og/eller tautomerer deraf; ved fremstilling af et medikament til anvendelse som en strålebeskytter.
10. Anvendelse af en strålebeskyttende forbindelse ifølge krav 9, hvor den strålebeskyttende forbindelse er som defineret i et hvilket som helst af kravene 1-3.
11. Anvendelse af en strålebeskyttende forbindelse ifølge enten krav 9 eller 10 ved fremstilling af et medikament til anvendelse som en strålebeskytter i forbindelse med cancerstrålebehandling.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2006907254A AU2006907254A0 (en) | 2006-12-21 | Novel Compounds and Methods | |
| PCT/AU2007/001990 WO2008074091A1 (en) | 2006-12-21 | 2007-12-21 | Radioprotector compounds and related methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2114896T3 true DK2114896T3 (da) | 2015-10-26 |
Family
ID=39535900
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07845428.7T DK2114896T3 (da) | 2006-12-21 | 2007-12-21 | Strålebeskyttende forbindelser og tilknyttede fremgangsmåder |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8796277B2 (da) |
| EP (1) | EP2114896B1 (da) |
| JP (1) | JP5639763B2 (da) |
| KR (1) | KR101518078B1 (da) |
| CN (1) | CN101605763B (da) |
| AU (1) | AU2007335185B2 (da) |
| CA (1) | CA2673417C (da) |
| DK (1) | DK2114896T3 (da) |
| ES (1) | ES2550589T3 (da) |
| IL (1) | IL199427A (da) |
| NZ (1) | NZ577845A (da) |
| PT (1) | PT2114896E (da) |
| WO (1) | WO2008074091A1 (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7906655B2 (en) * | 2008-08-07 | 2011-03-15 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| KR101792895B1 (ko) * | 2010-04-06 | 2017-11-02 | 피터 맥칼룸 캔서 인스티튜트 | 방사선 보호 화합물 및 방법 |
| GB201506660D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
| GB201506658D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
| KR102317644B1 (ko) * | 2020-04-13 | 2021-10-26 | 부산대학교 산학협력단 | 글리메피리드를 유효성분으로 함유하는 방사선 치료 민감제 조성물 |
| MX2023003357A (es) * | 2020-09-22 | 2023-06-30 | Rythera Therapeutics Inc | Composicion y metodo para la prevencion y el tratamiento de lesiones cutaneas por radiacion. |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1670684A1 (de) * | 1966-04-01 | 1970-12-03 | Hoechst Ag | Verfahren zur Herstellung von basisch substituierten Bis-benzimidazol-derivaten |
| AUPN449295A0 (en) * | 1995-07-28 | 1995-08-24 | Inner And Eastern Health Care Network, The | Radioprotectors |
-
2007
- 2007-12-21 DK DK07845428.7T patent/DK2114896T3/da active
- 2007-12-21 US US12/520,356 patent/US8796277B2/en not_active Expired - Fee Related
- 2007-12-21 EP EP07845428.7A patent/EP2114896B1/en not_active Not-in-force
- 2007-12-21 JP JP2009541697A patent/JP5639763B2/ja not_active Expired - Fee Related
- 2007-12-21 KR KR1020097015377A patent/KR101518078B1/ko not_active Expired - Fee Related
- 2007-12-21 NZ NZ577845A patent/NZ577845A/en not_active IP Right Cessation
- 2007-12-21 WO PCT/AU2007/001990 patent/WO2008074091A1/en not_active Ceased
- 2007-12-21 ES ES07845428.7T patent/ES2550589T3/es active Active
- 2007-12-21 PT PT78454287T patent/PT2114896E/pt unknown
- 2007-12-21 AU AU2007335185A patent/AU2007335185B2/en not_active Ceased
- 2007-12-21 CN CN200780049844.3A patent/CN101605763B/zh not_active Expired - Fee Related
- 2007-12-21 CA CA2673417A patent/CA2673417C/en not_active Expired - Fee Related
-
2009
- 2009-06-18 IL IL199427A patent/IL199427A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PT2114896E (pt) | 2015-11-04 |
| KR101518078B1 (ko) | 2015-05-06 |
| AU2007335185B2 (en) | 2013-06-27 |
| JP5639763B2 (ja) | 2014-12-10 |
| EP2114896A1 (en) | 2009-11-11 |
| AU2007335185A1 (en) | 2008-06-26 |
| US20100022557A1 (en) | 2010-01-28 |
| NZ577845A (en) | 2012-03-30 |
| JP2010513323A (ja) | 2010-04-30 |
| WO2008074091A1 (en) | 2008-06-26 |
| EP2114896B1 (en) | 2015-07-22 |
| ES2550589T3 (es) | 2015-11-10 |
| IL199427A (en) | 2017-03-30 |
| CN101605763A (zh) | 2009-12-16 |
| KR20090107039A (ko) | 2009-10-12 |
| US8796277B2 (en) | 2014-08-05 |
| CN101605763B (zh) | 2016-03-09 |
| CA2673417C (en) | 2015-09-15 |
| EP2114896A4 (en) | 2010-02-17 |
| CA2673417A1 (en) | 2008-06-26 |
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