DK212384A - Fremgangsmaade til fremstilling af 21-hydroxy-20-keto-delta16-steroider og mellemprodukter dannet ved denne fremgangsmaade - Google Patents

Fremgangsmaade til fremstilling af 21-hydroxy-20-keto-delta16-steroider og mellemprodukter dannet ved denne fremgangsmaade Download PDF

Info

Publication number: DK212384A
Authority: DK; Denmark
Prior art keywords: procedure; steroids; keto; hydroxy; delta16
Prior art date: 1983-04-29

Application number

DK212384A

Other languages

English (en)

Other versions

DK166544B1 (da

DK212384D0 (da

Inventor

Albert Mattheus Van Leusen

Adriaan Marinus Van Leusen

Original Assignee

Gist Brocades Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-04-29

Filing date

1984-04-27

Publication date

1984-10-30

1984-04-27 Application filed by Gist Brocades Nv filed Critical Gist Brocades Nv

1984-04-27 Publication of DK212384D0 publication Critical patent/DK212384D0/da

1984-10-30 Publication of DK212384A publication Critical patent/DK212384A/da

1993-06-07 Application granted granted Critical

1993-06-07 Publication of DK166544B1 publication Critical patent/DK166544B1/da

Links

238000000034 method Methods 0.000 title abstract 4
239000000543 intermediate Substances 0.000 title 1
150000003431 steroids Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
- C07J53/005—3 membered carbocyclic rings in position 12
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J33/005—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J33/005—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
- C07J33/007—Cyclic thioketals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK212384A 1983-04-29 1984-04-27 Fremgangsmaade til fremstilling af 21-hydroxy-20-keto-delta16-steroider DK166544B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP83200618		1983-04-29
EP83200618A EP0123736A1 (en)	1983-04-29	1983-04-29	New process for the preparation of 21-hydroxy-20-keto-delta 16-steroids and new intermediate compounds formed in this process

Publications (3)

Publication Number	Publication Date
DK212384D0 DK212384D0 (da)	1984-04-27
DK212384A true DK212384A (da)	1984-10-30
DK166544B1 DK166544B1 (da)	1993-06-07

Family

ID=8190951

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK212384A DK166544B1 (da)	1983-04-29	1984-04-27	Fremgangsmaade til fremstilling af 21-hydroxy-20-keto-delta16-steroider
DK022292A DK167443B1 (da)	1983-04-29	1992-02-21	17-(2-alkoxy-3-oxazolin-4-yl)-delta16-steroider og fremgangsmaade til fremstilling heraf

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK022292A DK167443B1 (da)	1983-04-29	1992-02-21	17-(2-alkoxy-3-oxazolin-4-yl)-delta16-steroider og fremgangsmaade til fremstilling heraf

Country Status (18)

Country	Link
US (1)	US4548749A (da)
EP (2)	EP0123736A1 (da)
JP (2)	JPS59206400A (da)
KR (1)	KR860001470B1 (da)
AT (1)	ATE71108T1 (da)
AU (1)	AU567934B2 (da)
CA (1)	CA1302401C (da)
DE (1)	DE3485399D1 (da)
DK (2)	DK166544B1 (da)
ES (2)	ES8608536A1 (da)
FI (1)	FI82059C (da)
GR (1)	GR81987B (da)
HU (2)	HU194906B (da)
IE (1)	IE57392B1 (da)
IL (1)	IL71659A (da)
NO (1)	NO167512C (da)
NZ (1)	NZ207986A (da)
PT (1)	PT78504B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0123735A1 (en) *	1983-04-29	1984-11-07	Gist-Brocades N.V.	New process for the preparation of 20-keto-delta-16-steroids and new intermediate compounds formed in this process
FR2677029B1 (fr) *	1991-05-23	1994-01-21	Roussel Uclaf	Nouveaux derives sterouides de l'andostra-4,9(11),16-trien-3-one.
FR2676740B1 (fr) *	1991-05-23	1993-11-05	Roussel Uclaf	Nouveaux derives sterouides du pregna-4,9(11),17(20)-trie-3-one, leur preparation, leur application a la preparation de composes sterouides de type pregna-4,9(11),16-triene-3,20-dione et nouveaux intermediaires.
FR2677028B1 (fr) *	1991-05-23	1994-01-21	Roussel Uclaf	Nouveaux derives sterouides du pregna-4,9(11),17(20)-trien-3-one.
WO2001005364A1 (en) *	1999-07-15	2001-01-25	The Procter & Gamble Company	Nitrogen-containing steroid compounds and their use to regulate hair growth
US8569275B2 (en)	2002-08-28	2013-10-29	Harbor Therapeutics, Inc.	Steroids having 7-oxgen and 17-heteroaryl substitution

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE927029C (de) *	1952-02-12	1955-04-28	Hoechst Ag	Verfahren zur Herstellung von 16, 17-Oxydo-20, 21-ketolen der Pregnanreihe
US2963496A (en) *	1957-06-05	1960-12-06	Olin Mathieson	9 alpha-halo-16-dehydro steroids of the pregnane series
US3056730A (en) *	1961-06-14	1962-10-02	Olin Mathieson	21-hydroxylation of steroids
US3281415A (en) *	1963-08-30	1966-10-25	Upjohn Co	Steroidal delta16-20 (alpha and beta)-hydroperoxides
NL6801762A (da) *	1967-02-20	1968-08-21
US3493563A (en) *	1968-02-23	1970-02-03	Squibb & Sons Inc	Process for the production of intermediates for triamcinolone and related compounds
FR2462445A1 (fr) *	1979-07-31	1981-02-13	Roussel Uclaf	Nouveaux derives 17-/(hydroxymethyl) (formamido) methylene/steroides, leur procede de preparation et leur application a l'introduction de la chaine laterale hydroxyacetyle
FR2493324B1 (da) *	1980-11-05	1983-01-21	Roussel Uclaf
FR2498607A1 (fr) *	1981-01-29	1982-07-30	Roussel Uclaf	Nouveau procede de preparation de 17a-hydroxy 17b-hydroxyacetyle steroides, produits intermediaires correspondants et produits finals obtenus
US4460509A (en) *	1981-08-19	1984-07-17	Beth Israel Medical Center	Chemical synthesis

1983
- 1983-04-29 EP EP83200618A patent/EP0123736A1/en not_active Withdrawn
1984
- 1984-04-19 AU AU27135/84A patent/AU567934B2/en not_active Ceased
- 1984-04-26 IL IL71659A patent/IL71659A/xx not_active IP Right Cessation
- 1984-04-27 CA CA000453027A patent/CA1302401C/en not_active Expired - Lifetime
- 1984-04-27 HU HU841662A patent/HU194906B/hu not_active IP Right Cessation
- 1984-04-27 NZ NZ207986A patent/NZ207986A/xx unknown
- 1984-04-27 DK DK212384A patent/DK166544B1/da not_active IP Right Cessation
- 1984-04-27 AT AT84200596T patent/ATE71108T1/de not_active IP Right Cessation
- 1984-04-27 KR KR1019840002248A patent/KR860001470B1/ko not_active Expired
- 1984-04-27 EP EP84200596A patent/EP0127216B1/en not_active Expired - Lifetime
- 1984-04-27 GR GR74530A patent/GR81987B/el unknown
- 1984-04-27 US US06/604,735 patent/US4548749A/en not_active Expired - Lifetime
- 1984-04-27 JP JP59086020A patent/JPS59206400A/ja active Granted
- 1984-04-27 FI FI841680A patent/FI82059C/fi not_active IP Right Cessation
- 1984-04-27 HU HU874319A patent/HU203767B/hu not_active IP Right Cessation
- 1984-04-27 PT PT78504A patent/PT78504B/pt not_active IP Right Cessation
- 1984-04-27 IE IE1039/84A patent/IE57392B1/en not_active IP Right Cessation
- 1984-04-27 DE DE8484200596T patent/DE3485399D1/de not_active Expired - Fee Related
- 1984-04-27 NO NO841701A patent/NO167512C/no unknown
- 1984-04-28 ES ES532031A patent/ES8608536A1/es not_active Expired
1986
- 1986-04-01 ES ES553608A patent/ES8800262A1/es not_active Expired
1992
- 1992-01-08 JP JP4001727A patent/JPH0699470B2/ja not_active Expired - Lifetime
- 1992-02-21 DK DK022292A patent/DK167443B1/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
ES8800262A1 (es)	1987-11-01
JPH0699470B2 (ja)	1994-12-07
FI841680A0 (fi)	1984-04-27
DK166544B1 (da)	1993-06-07
IL71659A (en)	1988-11-15
NO167512C (no)	1991-11-13
AU567934B2 (en)	1987-12-10
JPS59206400A (ja)	1984-11-22
IE841039L (en)	1984-10-29
ES8608536A1 (es)	1986-07-16
DK212384D0 (da)	1984-04-27
ES553608A0 (es)	1987-11-01
DK22292A (da)	1992-02-21
NZ207986A (en)	1986-11-12
PT78504B (en)	1986-05-20
JPH053479B2 (da)	1993-01-14
FI82059B (fi)	1990-09-28
ES532031A0 (es)	1986-07-16
HU203767B (en)	1991-09-30
DK22292D0 (da)	1992-02-21
IE57392B1 (en)	1992-08-26
CA1302401C (en)	1992-06-02
GR81987B (da)	1984-12-12
KR860001470B1 (ko)	1986-09-26
EP0127216A1 (en)	1984-12-05
FI82059C (fi)	1991-01-10
NO167512B (no)	1991-08-05
KR840008462A (ko)	1984-12-15
PT78504A (en)	1984-05-01
DE3485399D1 (de)	1992-02-13
DK167443B1 (da)	1993-11-01
NO841701L (no)	1984-10-30
JPH06287200A (ja)	1994-10-11
HUT34217A (en)	1985-02-28
EP0127216B1 (en)	1992-01-02
FI841680L (fi)	1984-10-30
HU194906B (en)	1988-03-28
IL71659A0 (en)	1984-07-31
US4548749A (en)	1985-10-22
EP0123736A1 (en)	1984-11-07
AU2713584A (en)	1984-11-01
ATE71108T1 (de)	1992-01-15

Legal Events

Date	Code	Title	Description
1993-06-07	B1	Patent granted (law 1993)
2000-12-04	PBP	Patent lapsed

Publication	Publication Date	Title
DK32684A (da)	1984-01-25	Fremgangsmaade til fremstilling af 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholesterol og mellemprodukter til brug herfor
ES8800263A1 (es)	1987-11-01	Procedimiento de preparacion de 17-(isociano-sulfonilmetileno)-esteroides
DE3481513D1 (de)	1990-04-12	Verfahren zur herstellung von erythro-bishydroxyalkensauere-derivaten.
DK212384D0 (da)	1984-04-27	Fremgangsmaade til fremstilling af 21-hydroxy-20-keto-delta16-steroider og mellemprodukter dannet ved denne fremgangsmaade
DK426881A (da)	1982-03-30	Fremgangsmaade til fremstilling af 4!-deoxydaunorubicin og 4!-deoxydoxorubicin
JPS5798300A (en)	1982-06-18	Manufacture of pregnane derivative
CA2115015A1 (fr)	1994-08-06	Procede de preparation de steroides 6alpha, 9alpha-difluores et nouveaux intermediaires obtenus
DE3161243D1 (en)	1983-11-24	22-arylsulfonyl-24,25-dihydroxycholestanes and process for preparing the same
DE3167016D1 (en)	1984-12-13	New 20-substituted 3-oxo-pregn-4-ene steroid compounds and process for their preparation
DK154433C (da)	1989-04-10	Fremgangsmaade til fremstilling af lactulose ud fra lactose
DK129491D0 (da)	1991-07-02	Fremgangsmaade til fremstilling af 17alfa-ethynyl-19-nortestosteron (net)
DK29280A (da)	1980-07-25	Praefabrikeret ligeloebet trappe fremgangsmaade til fremstilling af d-homosteroider
DK212284A (da)	1984-10-30	Fremgangsmaade til fremstilling af 20-keto-delta16-steroider og mellemprodukter dannet ved denne fremgangsmaade
JPS5536553A (en)	1980-03-14	Method of installing truss beam by pushinggout
JPS5465705A (en)	1979-05-26	Method of controlling mixing of byyproduct gas produced during iron making process
JPS5762300A (en)	1982-04-15	17alpha-cyanosteroid
DK93884D0 (da)	1984-02-23	Fremgangsmade til fremstilling af 1,5-dibeskyttede-1,5,10-triazadecaner, mellemprodukter derfor samt disses fremstilling
ES483895A3 (es)	1980-06-16	Procedimiento de obtencion de esteres de la 1-dehidro-6-me- tilcortisona y 1-dehidro-6-metilhidrocortisona
HUT36138A (en)	1985-08-28	Process for producing 4,9/11/-androstadione-3,17-dione
ATE150465T1 (de)	1997-04-15	Verfahren zur herstellung von 10-(2-propynyl)estr-4-en-3,17-dion