DK2135861T4 - Fremgangsmåde til syntese af 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on og dets anvendelse ved syntese af ivabradin såvel som dets additionssalte med en farmaceutisk acceptabel syre - Google Patents

Fremgangsmåde til syntese af 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on og dets anvendelse ved syntese af ivabradin såvel som dets additionssalte med en farmaceutisk acceptabel syre Download PDF

Info

Publication number: DK2135861T4
Authority: DK; Denmark
Prior art keywords: synthesis; ivabradine; benzazepin; dimethoxy; dihydro
Prior art date: 2008-06-20

Application number

DK09290466.3T

Other languages

English (en)

Other versions

DK2135861T3 (da

Inventor

Jean-Michel Lerestif

Jean-Pierre Lecouve

Daniel Brigot

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-06-20

Filing date

2009-06-19

Publication date

2021-03-22

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40347797&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2135861(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2009-06-19 Application filed by Servier Lab filed Critical Servier Lab

2014-10-20 Application granted granted Critical

2014-10-20 Publication of DK2135861T3 publication Critical patent/DK2135861T3/da

2021-03-22 Publication of DK2135861T4 publication Critical patent/DK2135861T4/da

Links

230000015572 biosynthetic process Effects 0.000 title 2
238000003786 synthesis reaction Methods 0.000 title 2
CPNZASIAJKSBBH-UHFFFAOYSA-N 7,8-dimethoxy-1,3-dihydro-3-benzazepin-2-one Chemical compound C1C(=O)NC=CC2=C1C=C(OC)C(OC)=C2 CPNZASIAJKSBBH-UHFFFAOYSA-N 0.000 title 1
239000002253 acid Substances 0.000 title 1
ACRHBAYQBXXRTO-OAQYLSRUSA-N ivabradine Chemical compound C1CC2=CC(OC)=C(OC)C=C2CC(=O)N1CCCN(C)C[C@H]1CC2=C1C=C(OC)C(OC)=C2 ACRHBAYQBXXRTO-OAQYLSRUSA-N 0.000 title 1
229960003825 ivabradine Drugs 0.000 title 1
238000000034 method Methods 0.000 title 1
150000003839 salts Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)

DK09290466.3T 2008-06-20 2009-06-19 Fremgangsmåde til syntese af 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on og dets anvendelse ved syntese af ivabradin såvel som dets additionssalte med en farmaceutisk acceptabel syre DK2135861T4 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0803452A FR2932800B1 (fr)	2008-06-20	2008-06-20	Nouveau procede de synthese de la 7,8-dimethoxy-1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Publications (2)

Publication Number	Publication Date
DK2135861T3 DK2135861T3 (da)	2014-10-20
DK2135861T4 true DK2135861T4 (da)	2021-03-22

Family

ID=40347797

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK09290466.3T DK2135861T4 (da)	2008-06-20	2009-06-19	Fremgangsmåde til syntese af 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on og dets anvendelse ved syntese af ivabradin såvel som dets additionssalte med en farmaceutisk acceptabel syre

Country Status (35)

Country	Link
US (1)	US7928223B2 (da)
EP (1)	EP2135861B2 (da)
JP (1)	JP5216697B2 (da)
KR (1)	KR101119296B1 (da)
CN (1)	CN101607939B (da)
AR (1)	AR072175A1 (da)
AU (1)	AU2009202314B2 (da)
BR (1)	BRPI0902105A2 (da)
CA (1)	CA2668524C (da)
CL (1)	CL2009001414A1 (da)
CY (1)	CY1115623T1 (da)
DK (1)	DK2135861T4 (da)
EA (1)	EA017333B1 (da)
ES (1)	ES2522625T5 (da)
FR (1)	FR2932800B1 (da)
GE (1)	GEP20125407B (da)
HR (1)	HRP20140928T4 (da)
JO (1)	JO3806B1 (da)
MA (1)	MA31071B1 (da)
ME (1)	ME00814B (da)
MX (1)	MX2009006288A (da)
MY (1)	MY146245A (da)
NZ (1)	NZ577540A (da)
PE (1)	PE20100051A1 (da)
PL (1)	PL2135861T5 (da)
PT (1)	PT2135861E (da)
RS (1)	RS53495B2 (da)
SA (1)	SA109300396B1 (da)
SG (1)	SG158026A1 (da)
SI (1)	SI2135861T2 (da)
TW (1)	TWI374134B (da)
UA (1)	UA107779C2 (da)
UY (1)	UY31883A (da)
WO (1)	WO2009153461A2 (da)
ZA (1)	ZA200904316B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2162438A4 (en) *	2007-05-30	2011-07-06	Ind Swift Lab Ltd	PROCESS FOR THE PREPARATION OF IVABRADINE HYDROCHLORIDE AND CORRESPONDING POLYMORPHIDE
CN101774969B (zh) *	2009-01-13	2012-07-04	江苏恒瑞医药股份有限公司	硫酸伊伐布雷定及其i型结晶的制备方法
SI23290A (sl)	2010-02-12	2011-08-31	Krka D.D., Novo Mesto	Nove oblike ivabradin hidroklorida
FR2956401B1 (fr)	2010-02-17	2012-02-03	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
WO2011104723A2 (en) *	2010-02-23	2011-09-01	Ind-Swift Laboratories Limited	Acid addition salts of ivabradine and preparation thereof
HUP1000245A2 (en) *	2010-05-07	2011-11-28	Richter Gedeon Nyrt	Industrial process for the production ivabradin salts
FR2984320B1 (fr) *	2011-12-20	2013-11-29	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR3003859B1 (fr)	2013-03-26	2015-03-13	Servier Lab	"procede de synthese de derives de la 7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one et application a la synthese de l'ivabradine"
HU230826B1 (hu) *	2014-11-19	2018-07-30	Richter Gedeon Nyrt.	Eljárás benzazepin származékok előállítására
EP3101010A1 (en)	2015-06-03	2016-12-07	Urquima S.A.	New method for the preparation of highly pure ivabradine base and salts thereof
CN108424389A (zh) *	2017-02-13	2018-08-21	浙江京新药业股份有限公司	一种伊伐布雷定杂质的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4490369A (en) *	1981-05-19	1984-12-25	Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung	Benzazepine derivatives, their pharmaceutical compositions and method of use
IL70854A0 (en) *	1983-02-04	1984-05-31	Lilly Co Eli	Improvements in or relating to benzazepine derivatives
DE3343801A1 (de) *	1983-12-03	1985-06-13	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue indolderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3418270A1 (de) *	1984-05-17	1985-11-21	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3418271A1 (de) *	1984-05-17	1985-11-21	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0204349A3 (de) *	1985-06-01	1990-01-03	Dr. Karl Thomae GmbH	Neue heteroaromatische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
FR2681862B1 (fr) *	1991-09-27	1993-11-12	Adir Cie	Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
UA77165C2 (en) *	2000-11-17	2006-11-15	Lilly Co Eli	(n)-((s)-2-hydroxy-3-methyl-butyryl)-1-(l-alaninyl)-(s)-1-amino-3-methyl-4,5,6,7-tetrahydro-2h-3-benzazepin-2-one dihydrate, processes for manufacturing and pharmaceutical composition
WO2002074746A1 (en) *	2001-03-16	2002-09-26	Yamanouchi Pharmaceutical Co., Ltd.	Benzazepine derivatives
ATE411027T1 (de) *	2003-10-23	2008-10-15	Hoffmann La Roche	Benzazepin-derivate als mao-b-hemmer
FR2868777B1 (fr) *	2004-04-13	2006-05-26	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
KR101594898B1 (ko) *	2005-07-15	2016-02-18	알바니 몰레큘라 리써치, 인크.	아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도

2008
- 2008-06-20 FR FR0803452A patent/FR2932800B1/fr active Active
2009
- 2009-06-08 SG SG200903913-2A patent/SG158026A1/en unknown
- 2009-06-09 PE PE2009000809A patent/PE20100051A1/es not_active Application Discontinuation
- 2009-06-09 NZ NZ577540A patent/NZ577540A/en unknown
- 2009-06-09 UY UY0001031883A patent/UY31883A/es unknown
- 2009-06-09 CA CA2668524A patent/CA2668524C/fr active Active
- 2009-06-10 AU AU2009202314A patent/AU2009202314B2/en active Active
- 2009-06-11 MY MYPI20092391A patent/MY146245A/en unknown
- 2009-06-12 MX MX2009006288A patent/MX2009006288A/es active IP Right Grant
- 2009-06-15 MA MA31996A patent/MA31071B1/fr unknown
- 2009-06-15 CL CL2009001414A patent/CL2009001414A1/es unknown
- 2009-06-17 US US12/456,437 patent/US7928223B2/en active Active
- 2009-06-17 GE GEAP200911317A patent/GEP20125407B/en unknown
- 2009-06-17 SA SA109300396A patent/SA109300396B1/ar unknown
- 2009-06-18 ME MEP-2009-230A patent/ME00814B/me unknown
- 2009-06-18 JO JOP/2009/0217A patent/JO3806B1/ar active
- 2009-06-18 UA UAA200906350A patent/UA107779C2/ru unknown
- 2009-06-18 AR ARP090102210A patent/AR072175A1/es active IP Right Grant
- 2009-06-19 RS RS20140439A patent/RS53495B2/sr unknown
- 2009-06-19 PL PL09290466.3T patent/PL2135861T5/pl unknown
- 2009-06-19 WO PCT/FR2009/000738 patent/WO2009153461A2/fr not_active Ceased
- 2009-06-19 SI SI200931020T patent/SI2135861T2/sl unknown
- 2009-06-19 ES ES09290466T patent/ES2522625T5/es active Active
- 2009-06-19 DK DK09290466.3T patent/DK2135861T4/da active
- 2009-06-19 EA EA200900707A patent/EA017333B1/ru unknown
- 2009-06-19 BR BRPI0902105-1A patent/BRPI0902105A2/pt not_active Application Discontinuation
- 2009-06-19 EP EP09290466.3A patent/EP2135861B2/fr active Active
- 2009-06-19 ZA ZA200904316A patent/ZA200904316B/xx unknown
- 2009-06-19 TW TW098120697A patent/TWI374134B/zh active
- 2009-06-19 KR KR1020090054857A patent/KR101119296B1/ko active Active
- 2009-06-19 PT PT92904663T patent/PT2135861E/pt unknown
- 2009-06-19 CN CN2009101504175A patent/CN101607939B/zh active Active
- 2009-06-19 JP JP2009145931A patent/JP5216697B2/ja active Active
2014
- 2014-09-29 HR HRP20140928TT patent/HRP20140928T4/hr unknown
- 2014-10-14 CY CY20141100834T patent/CY1115623T1/el unknown

Also Published As

Publication number	Publication date
CN101607939A (zh)	2009-12-23
GEP20125407B (en)	2012-02-27
AU2009202314B2 (en)	2013-01-24
AU2009202314A1 (en)	2010-01-14
ZA200904316B (en)	2010-05-26
PL2135861T5 (pl)	2022-07-18
DK2135861T3 (da)	2014-10-20
ES2522625T5 (es)	2021-07-29
FR2932800B1 (fr)	2015-02-20
CY1115623T1 (el)	2017-01-04
SI2135861T1 (sl)	2014-10-30
MX2009006288A (es)	2010-02-17
SG158026A1 (en)	2010-01-29
FR2932800A1 (fr)	2009-12-25
JP2010006807A (ja)	2010-01-14
KR20090132544A (ko)	2009-12-30
CL2009001414A1 (es)	2010-06-04
SA109300396B1 (ar)	2013-09-08
MY146245A (en)	2012-07-31
JP5216697B2 (ja)	2013-06-19
HRP20140928T4 (hr)	2021-03-05
TWI374134B (en)	2012-10-11
CA2668524C (fr)	2012-09-11
RS53495B2 (sr)	2021-02-26
PT2135861E (pt)	2014-09-02
EA017333B1 (ru)	2012-11-30
UA107779C2 (en)	2015-02-25
EA200900707A1 (ru)	2010-04-30
US20090318682A1 (en)	2009-12-24
MA31071B1 (fr)	2010-01-04
US7928223B2 (en)	2011-04-19
ME00814B (me)	2012-03-20
BRPI0902105A2 (pt)	2010-04-13
RS53495B1 (sr)	2015-02-27
WO2009153461A2 (fr)	2009-12-23
HK1140188A1 (en)	2010-10-08
CN101607939B (zh)	2012-05-02
SI2135861T2 (sl)	2021-04-30
UY31883A (es)	2010-01-29
KR101119296B1 (ko)	2012-03-15
PE20100051A1 (es)	2010-02-06
EP2135861A1 (fr)	2009-12-23
CA2668524A1 (fr)	2009-12-20
EP2135861B2 (fr)	2020-12-16
TW201002671A (en)	2010-01-16
ES2522625T3 (es)	2014-11-17
JO3806B1 (ar)	2021-01-31
EP2135861B1 (fr)	2014-07-30
WO2009153461A3 (fr)	2010-04-29
AR072175A1 (es)	2010-08-11
PL2135861T3 (pl)	2014-11-28
NZ577540A (en)	2010-10-29
HRP20140928T1 (en)	2014-11-21

Publication	Publication Date	Title
DK2135861T3 (da)	2014-10-20	Fremgangsmåde til syntese af 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on og dets anvendelse ved syntese af ivabradin såvel som dets additionssalte med en farmaceutisk acceptabel syre
DK2202225T3 (da)	2013-02-11	Ny fremgangsmåde til syntese af ivabradin og additionssalte heraf med en farmaceutisk acceptabel syre
DK1589005T3 (da)	2007-07-30	Fremgangsmåde til syntese af ivabradin og additionssalte heraf med en farmaceutisk acceptabel syre
DK1598333T3 (da)	2007-02-12	Fremgangsmåde til fremstilling af (1S)-4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutan og syreadditionssalte heraf samt anvendelse til syntese af ivabradin og syreadditionssalte heraf med farmaceutisk acceptable syrer
EP2189486A4 (en)	2012-11-21	MELT-LOW VISCOSITY POLYGLYCOLIC ACID, PROCESS FOR PRODUCTION THEREOF, AND USE OF MELT-LOW VISCOSITY POLYGLYCOLIC ACID
IL204556A (en)	2013-06-27	(Cyclopropyl - phenyl) - Phenyl - oxalamides, a method for their production, and their use as a drug
MA31149B1 (fr)	2010-02-01	Nouveau procede de preparation de benzocyclobutenes fonctionnalises, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutique acceptable
BRPI0722209A2 (pt)	2014-05-13	"solução estabilizada de peróxido de hidrogênio, solução de limpeza, processo para a preparação de uma solução de limpeza"
ZA201105172B (en)	2012-09-26	New process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
DK2241553T3 (da)	2011-10-31	Fremgangsmåde til fremstilling af ivabradin og dets farmaceutisk acceptable syreadditionssalte
BRPI1016109A2 (pt)	2016-05-17	"composto, composição farmacêutica, e, processo para preparar um composto"
ZA201201329B (en)	2013-05-29	New process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
BRPI0819543A2 (pt)	2015-05-26	"composição, método para produzir a composição e artigo"
DK2241554T3 (da)	2011-12-12	Ny fremgangsmåde til syntese af ivabradin og additionssalte heraf med en farmaceutisk acceptabel syre
DK1589014T3 (da)	2008-02-25	Fremgangsmåde til syntese af derivater af 1,3-dihydro-2H-3-benzazepin-2-on og anvendelse heraf ved syntese af ivabradin og additionssalte heraf med en farmaceutisk acceptabel syre
BRPI0907664A2 (pt)	2015-07-21	''composição farmacêutica anidra, uso de uma composição e processo de preparação de uma composição''
ZA201000159B (en)	2011-06-29	Process for the production of substituted 5-quinolyl-oxazoles and pharmaceutically acceptable salts thereof
PL385441A1 (pl)	2008-12-08	Sposób wytwarzania 3'-(3''-metylo-3''-hydroksybutylo)-2',4,4'-trihydroksy-6'-metoksychalkonu
SG117528A1 (en)	2005-12-29	New process for the synthesis of (1S)-4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutane and addition salts thereof, and application in the synthesis of ivabradine and addition salts thereof, with