DK213990A - Fremgangsmaade til 5-aroylering af 1,2-dihydro-3h-pyrrolo(1,2-a)pyrrol-1-carboxylsyrenitriler - Google Patents

Fremgangsmaade til 5-aroylering af 1,2-dihydro-3h-pyrrolo(1,2-a)pyrrol-1-carboxylsyrenitriler Download PDF

Info

Publication number: DK213990A
Authority: DK; Denmark
Prior art keywords: pyrrolo; aroylation; dihydro; nitrils; pyrrol
Prior art date: 1980-11-21

Application number

DK213990A

Other languages

English (en)

Other versions

DK213990D0 (da

DK161967B (da

DK161967C (da

Inventor

Timothy C Thurber

Derek Tegg

Original Assignee

Syntex Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-11-21

Filing date

1990-09-06

Publication date

1990-09-06

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22776597&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK213990(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1990-09-06 Application filed by Syntex Inc filed Critical Syntex Inc

1990-09-06 Publication of DK213990D0 publication Critical patent/DK213990D0/da

1990-09-06 Publication of DK213990A publication Critical patent/DK213990A/da

1991-09-02 Publication of DK161967B publication Critical patent/DK161967B/da

1992-02-03 Application granted granted Critical

1992-02-03 Publication of DK161967C publication Critical patent/DK161967C/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pain & Pain Management (AREA)
Pharmacology & Pharmacy (AREA)
Rheumatology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyrrole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DK213990A 1980-11-21 1990-09-06 Fremgangsmaade til 5-aroylering af 1,2-dihydro-3h-pyrrolooe1,2-aaapyrrol-1-nitriler DK161967C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US20892080		1980-11-21
US06/208,920 US4353829A (en)	1980-11-21	1980-11-21	Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters

Publications (4)

Publication Number	Publication Date
DK213990D0 DK213990D0 (da)	1990-09-06
DK213990A true DK213990A (da)	1990-09-06
DK161967B DK161967B (da)	1991-09-02
DK161967C DK161967C (da)	1992-02-03

Family

ID=22776597

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK516081A DK161966C (da)	1980-11-21	1981-11-20	Fremgangsmaade til fremstilling af 5-aroylerede 1,2-dihydro-3h-pyrrolooe1,2-aaapyrrol-1-carboxylsyrer eller estere eller farmaceutisk acceptable salte deraf
DK213990A DK161967C (da)	1980-11-21	1990-09-06	Fremgangsmaade til 5-aroylering af 1,2-dihydro-3h-pyrrolooe1,2-aaapyrrol-1-nitriler

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK516081A DK161966C (da)	1980-11-21	1981-11-20	Fremgangsmaade til fremstilling af 5-aroylerede 1,2-dihydro-3h-pyrrolooe1,2-aaapyrrol-1-carboxylsyrer eller estere eller farmaceutisk acceptable salte deraf

Country Status (20)

Country	Link
US (1)	US4353829A (da)
EP (1)	EP0053021B1 (da)
JP (3)	JPS57145878A (da)
KR (1)	KR880001658B1 (da)
AT (1)	ATE13059T1 (da)
AU (1)	AU545034B2 (da)
CA (1)	CA1168244A (da)
DE (1)	DE3170342D1 (da)
DK (2)	DK161966C (da)
ES (1)	ES8206527A1 (da)
FI (1)	FI813710L (da)
HK (1)	HK3488A (da)
HU (2)	HU191850B (da)
IE (1)	IE52217B1 (da)
IL (1)	IL64329A (da)
MY (1)	MY8700828A (da)
NO (1)	NO159598C (da)
NZ (1)	NZ199014A (da)
SG (1)	SG94587G (da)
ZA (1)	ZA818078B (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3368416D1 (en) *	1982-02-25	1987-01-29	Beecham Group Plc	Aroyl pyrrolizine compounds, process for their preparation and pharmaceutical compositions containing them
US4612325A (en) *	1982-06-08	1986-09-16	Syntex (U.S.A) Inc.	5-Aroyl-6-alkylthio-1,2-dihydro-3H-pyrrolo(1,2-A)pyrrole-1-carboxylic acids and use thereof as analgesics and anti-inflammatories
US4560699A (en) *	1983-01-17	1985-12-24	Syntex (U.S.A.) Inc.	5-(4-Vinylbenzoyl)-1,2-dihydro-3H-pyrrolo-[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof and use as analgesics and anti-inflammatories
US4873340A (en) *	1986-05-29	1989-10-10	Syntex (U.S.A.) Inc.	Process for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-A]pyrrole-1,1-dicarboxylates
US4988822A (en) *	1986-05-29	1991-01-29	Syntex (U.S.A.) Inc.	Intermediates for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo(1,2-A)pyrrole-1,1-dicarboxylates
HU198927B (en) *	1987-01-14	1989-12-28	Richter Gedeon Vegyeszet	Process for producing 1-/substituted aminomethyl/-octa-hydroindolo-(2,3-a)quinolizine derivatives, pharmaceutically applicable acid addition salts thereof, as well as pharmaceutical compositions comprising same
US4874872A (en) *	1987-01-14	1989-10-17	Syntex (U.S.A.) Inc.	Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates
US4835288A (en) *	1987-01-14	1989-05-30	Syntex Inc.	Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-a]pyrrole-1,7-dicarboxylates
US4849526A (en) *	1987-01-14	1989-07-18	Syntex (U.S.A.) Inc.	Process for preparing (±)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates
US4874871A (en) *	1987-03-25	1989-10-17	Syntex (U.S.A.) Inc.	Process for preparing (+)-2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds
JP2649168B2 (ja) *	1988-02-25	1997-09-03	久光製薬株式会社	新規な５，６−ジフェニル−１，２−ジヒドロ−３Ｈ−ピロロ［１，２−ａ］ピロール−１−カルボン酸誘導体
IT1241124B (it) *	1990-04-20	1993-12-29	Industriale Chimica	Processo per la preparazione di derivati di acidi 1,2-diidro 3h pirrol (1,2-a) pirrol-l-carbossilici e relativi intermedi
US5082950A (en) *	1990-10-12	1992-01-21	Syntex (U.S.A.) Inc.	Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (II) and intermediates therefor
US5082951A (en) *	1990-10-12	1992-01-21	Syntex (U.S.A.) Inc.	Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (I) and intermediates therefor
US5804214A (en) *	1993-07-08	1998-09-08	Cygnus, Inc.	Monolithic matrix transdermal delivery system for delivering ketorolac tromethamine
US5621115A (en) *	1996-02-21	1997-04-15	Ohmeda Pharmaceutical Products Division Inc.	Methods for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo-[1,2-A]pyrrole-1-carboxylic acids
US6191285B1 (en)	1997-07-03	2001-02-20	Abbott Laboratories	Process for the preparation of ketorolac tromethamine
US6197976B1 (en)	1998-12-14	2001-03-06	Syntex (U.S.A.) Llc	Preparation of ketorolac

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4089969A (en) *	1976-07-14	1978-05-16	Syntex (U.S.A.) Inc.	5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
JPS539788A (en) *	1976-07-14	1978-01-28	Syntex Inc	55aloyll122dihydroo3hh pyroro 122a pyroll11 carboxylic acid derivative
US4087539A (en) *	1976-07-14	1978-05-02	Syntex (U.S.A.) Inc.	5-(2-Furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl)- and 5-(3-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
JPS539789A (en) *	1976-07-14	1978-01-28	Syntex Inc	Production of 5522floyl* * 5522thenoyl* * 5533 floyl* and 5533thenoyl* 122dihydroo3hhpyroro 122apyrolee11carboxylic acid derivative
US4097579A (en) *	1977-03-31	1978-06-27	Syntex (U.S.A.) Inc.	5-(2-Pyrroyl)-1,2-dihydro-3H-pyrrolo 1,2-a!pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4140698A (en) *	1977-07-25	1979-02-20	Syntex (Usa) Inc.	1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles
US4232038A (en) *	1979-08-31	1980-11-04	Syntex (U.S.A.) Inc.	5-Alkylsulfinylbenzoyl- and 5-alkylsulfonylbenzoyl-1,2-dihydro-3H-pyrrolo[1,]pyrrole-1-carboxylic acids

1980
- 1980-11-21 US US06/208,920 patent/US4353829A/en not_active Expired - Lifetime
1981
- 1981-11-20 AT AT81305496T patent/ATE13059T1/de not_active IP Right Cessation
- 1981-11-20 KR KR1019810004496A patent/KR880001658B1/ko not_active Expired
- 1981-11-20 HU HU832033A patent/HU191850B/hu unknown
- 1981-11-20 FI FI813710A patent/FI813710L/fi not_active Application Discontinuation
- 1981-11-20 ZA ZA818078A patent/ZA818078B/xx unknown
- 1981-11-20 HU HU813476A patent/HU185982B/hu unknown
- 1981-11-20 ES ES507305A patent/ES8206527A1/es not_active Expired
- 1981-11-20 NZ NZ199014A patent/NZ199014A/en unknown
- 1981-11-20 EP EP81305496A patent/EP0053021B1/en not_active Expired
- 1981-11-20 IE IE2731/81A patent/IE52217B1/en not_active IP Right Cessation
- 1981-11-20 DE DE8181305496T patent/DE3170342D1/de not_active Expired
- 1981-11-20 DK DK516081A patent/DK161966C/da not_active IP Right Cessation
- 1981-11-20 IL IL64329A patent/IL64329A/xx not_active IP Right Cessation
- 1981-11-20 AU AU77707/81A patent/AU545034B2/en not_active Expired
- 1981-11-20 CA CA000390585A patent/CA1168244A/en not_active Expired
- 1981-11-20 NO NO813949A patent/NO159598C/no not_active IP Right Cessation
- 1981-11-20 JP JP56185571A patent/JPS57145878A/ja active Pending
1987
- 1987-10-29 SG SG945/87A patent/SG94587G/en unknown
- 1987-12-30 MY MY828/87A patent/MY8700828A/xx unknown
1988
- 1988-01-14 HK HK34/88A patent/HK3488A/en not_active IP Right Cessation
1990
- 1990-03-15 JP JP2062823A patent/JPH0660182B2/ja not_active Expired - Lifetime
- 1990-09-06 DK DK213990A patent/DK161967C/da not_active IP Right Cessation
1992
- 1992-07-28 JP JP4220702A patent/JPH0742290B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
NZ199014A (en)	1985-05-31
IE52217B1 (en)	1987-08-05
DE3170342D1 (en)	1985-06-05
JPH0742290B2 (ja)	1995-05-10
IE812731L (en)	1983-05-21
MY8700828A (en)	1987-12-31
FI813710A7 (fi)	1982-05-22
EP0053021A2 (en)	1982-06-02
KR830007654A (ko)	1983-11-04
JPS57145878A (en)	1982-09-09
JPH0660182B2 (ja)	1994-08-10
FI813710L (fi)	1982-05-22
DK213990D0 (da)	1990-09-06
IL64329A (en)	1985-09-29
HK3488A (en)	1988-01-22
EP0053021A3 (en)	1982-09-29
IL64329A0 (en)	1982-02-28
ES507305A0 (es)	1982-09-01
HU185982B (en)	1985-04-28
ATE13059T1 (de)	1985-05-15
AU545034B2 (en)	1985-06-27
NO159598B (no)	1988-10-10
NO159598C (no)	1989-01-18
DK161966B (da)	1991-09-02
DK161966C (da)	1992-02-03
JPH05208978A (ja)	1993-08-20
ES8206527A1 (es)	1982-09-01
DK516081A (da)	1982-05-22
SG94587G (en)	1988-05-06
KR880001658B1 (ko)	1988-09-05
DK161967B (da)	1991-09-02
DK161967C (da)	1992-02-03
ZA818078B (en)	1983-07-27
CA1168244A (en)	1984-05-29
US4353829A (en)	1982-10-12
HU191850B (en)	1987-04-28
AU7770781A (en)	1982-05-27
NO813949L (no)	1982-05-24
EP0053021B1 (en)	1985-05-02
JPH02288881A (ja)	1990-11-28

Legal Events

Date	Code	Title	Description
2001-12-03	PUP	Patent expired

Publication	Publication Date	Title
DK161967C (da)	1992-02-03	Fremgangsmaade til 5-aroylering af 1,2-dihydro-3h-pyrrolooe1,2-aaapyrrol-1-nitriler
ZA774238B (en)	1979-02-28	5-aroyl-1,2-dihydro-3h-pyrrolo(1,2-a)pyrrole-1-carboxylic acid derivatives and process for the production thereof
SE7411888L (da)	1975-03-24
GB1554075A (en)	1979-10-17	1,2-dihydro-3h-pyrrolo-(1,2-a)-pyrrole-1-carboxylic acid derivatives and process for the production thereof
IL55181A (en)	1981-12-31	Preparation of 5-substituted-1,2-dihydro-3h-pyrrolo(1,2-a)pyrrole-1-carboxylic acids and the corresponding novel nitrile starting materials
JPS5692289A (en)	1981-07-25	Manufacture of nitrogen heterocyclic compound
DK643189D0 (da)	1989-12-18	Fremstilling af 5-acylamino-1,2,4-triazol-3-sulfonamider samt mellemprodukter
DE69203856D1 (de)	1995-09-07	Verfahren zur Herstellung von 1,3A,8-Trimethyl-1,2,3,3A,8,8A-HEXAHYDROPYROLO(2,3-B)INDOL-5(3AS,8AR)-HEPTYLCARBAMAT.
DK0611751T3 (da)	1997-04-14
RU94004974A (ru)	1995-12-20	Способ получения натриевой соли 1-амино-1-цианамидо-2,2-дицианоэтилена
DK200000691A (da)	2000-04-27	Pyrrolderivater
IL89634A0 (en)	1989-09-28	Preparation of a pyrrole derivative
ES8307785A1 (es)	1983-08-01	"procedimiento para la preparacion de 3-metil-3(0-metoxifenoxi)-benzo-2,4-dioxaciclohexanona".
SU630853A1 (ru)	2016-09-10	Гидрохлориды эфиров 9-замещенных имидазо/1,2-а/бензимидазолил-2-уксусных кислот, обладающие антиаритмической активностью
HRP940490B1 (en)	1996-06-30	5-AROYL-1,2-DIHYDRO-3H-PYRROLO(1,2-a)PYRROLE-1-CARBOXYLIC ACID DERIVATIVES AND PROCESS FOR THE PRODUCTION THEREOF
ES8601126A1 (es)	1985-10-16	Procedimiento para la obtencion de n-(2-(diisopropilamino) etil-2-(2-oxi-1-pirrolidina) acetamida
JPS52156855A (en)	1977-12-27	Preparation of tetrahydro-t-oxo-2-furanacetic acid
DD135386A1 (de)	1979-05-02	Verfahren zur gewinnung von 3,4-dihydropyrrolo eckige klammer auf 1,2-a eckige klammer zu-pyrazin
JPS52106884A (en)	1977-09-07	Acylation of 6-aminopenicillanic acid
ES8301941A1 (es)	1983-01-16	"procedimiento para la preparacion del acido 1,2,3,6-tetrahidro 2 6 dioxo 4 pirimidin carboxilico"