DK2153227T3 - Reagenser og metoder til bestemmelse af PK/ADME-TOX egenskaber ved nye kemiske forbindelser og ved lægemiddelkandidater - Google Patents
Reagenser og metoder til bestemmelse af PK/ADME-TOX egenskaber ved nye kemiske forbindelser og ved lægemiddelkandidaterInfo
- Publication number
- DK2153227T3 DK2153227T3 DK08829343.6T DK08829343T DK2153227T3 DK 2153227 T3 DK2153227 T3 DK 2153227T3 DK 08829343 T DK08829343 T DK 08829343T DK 2153227 T3 DK2153227 T3 DK 2153227T3
- Authority
- DK
- Denmark
- Prior art keywords
- reagents
- methods
- adme
- new chemical
- determining
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 239000003153 chemical reaction reagent Substances 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title 1
- 229940000406 drug candidate Drugs 0.000 title 1
- 229920001940 conductive polymer Polymers 0.000 abstract 2
- 230000035495 ADMET Effects 0.000 abstract 1
- 150000005829 chemical entities Chemical class 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000000084 colloidal system Substances 0.000 abstract 1
- 239000002131 composite material Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 239000002082 metal nanoparticle Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910000510 noble metal Inorganic materials 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54346—Nanoparticles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Nanotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94064107P | 2007-05-29 | 2007-05-29 | |
| PCT/IB2008/003187 WO2009031049A2 (en) | 2007-05-29 | 2008-05-28 | Reagents and methods for the determination of pk/adme-tox characteristics of new chemical entities and of drug candidates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2153227T3 true DK2153227T3 (da) | 2011-04-04 |
Family
ID=40295743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08829343.6T DK2153227T3 (da) | 2007-05-29 | 2008-05-28 | Reagenser og metoder til bestemmelse af PK/ADME-TOX egenskaber ved nye kemiske forbindelser og ved lægemiddelkandidater |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20090029391A1 (da) |
| EP (1) | EP2153227B1 (da) |
| JP (1) | JP2010528311A (da) |
| CN (1) | CN101680882A (da) |
| AT (1) | ATE498839T1 (da) |
| AU (1) | AU2008294419A1 (da) |
| CA (1) | CA2685450A1 (da) |
| DE (1) | DE602008005013D1 (da) |
| DK (1) | DK2153227T3 (da) |
| EA (1) | EA200901641A1 (da) |
| TW (1) | TW200912312A (da) |
| WO (1) | WO2009031049A2 (da) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9002656B2 (en) * | 2011-10-17 | 2015-04-07 | Daxor Corporation | Automated total body albumin analyzer |
| GB201202631D0 (en) | 2012-02-16 | 2012-04-04 | Pharmadiagnostics Nv | Method of measuring interaction between molecules |
| GB201407303D0 (en) * | 2014-04-25 | 2014-06-11 | Pharmadiagnostics Nv | Competition assay |
| CN105758984B (zh) * | 2015-12-15 | 2017-07-14 | 中国药科大学 | 衍生化hplc‑dad法测定药物中小分子卤代羧酸的方法 |
| TWI614502B (zh) * | 2017-07-26 | 2018-02-11 | 國立成功大學 | 分析物濃度的檢測方法 |
| CN109970696B (zh) * | 2019-04-11 | 2022-12-23 | 江南大学 | 一种香豆素肟酯类光引发剂 |
| CN112763382B (zh) * | 2021-01-11 | 2022-03-15 | 南京信息工程大学 | 一种金属纳米粒子联合毒性的定量预测方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL125517A0 (en) * | 1996-01-26 | 1999-03-12 | Univ California | Polymeric film assay and method for direct colorimetric detection of analytes |
| CA2330937A1 (en) * | 1998-06-22 | 1999-12-29 | Regents Of The University Of California | Nucleic acid-coupled colorimetric analyte detectors |
| EP1207391A1 (en) * | 1999-06-30 | 2002-05-22 | Ajinomoto Co., Inc. | Method for screening targeting dds preparation |
| JP2004507718A (ja) * | 2000-07-28 | 2004-03-11 | ライオン バイオサイエンス アクチェンゲゼルシャフト | 化合物のadme/tox特性を予測するためのシステム及び方法 |
| CA2419544A1 (en) * | 2000-08-14 | 2002-02-21 | Surface Logix, Inc. | Pathways arrays |
| EP1256354A1 (en) * | 2001-05-11 | 2002-11-13 | Schering Corporation | Methods for treating cancer |
| US20030044992A1 (en) * | 2001-08-31 | 2003-03-06 | Chao Anthony C. | Cell-based multiplexing ADME analysis using focused fluid flow |
| JP3925701B2 (ja) * | 2002-01-15 | 2007-06-06 | 東洋紡績株式会社 | 生体組織を用いたインビトロ試験方法 |
| WO2003064704A1 (en) * | 2002-01-28 | 2003-08-07 | Mds Proteomics, Inc. | Chemical proteomics |
| JP2005530132A (ja) * | 2002-03-18 | 2005-10-06 | イーエスエイ,インク. | 製薬的発見および開発の改良 |
| US7288368B2 (en) * | 2002-06-17 | 2007-10-30 | Stephen Eliot Zweig | Membrane receptor reagent and assay |
| US20040115822A1 (en) * | 2002-09-12 | 2004-06-17 | Schapaugh Randal Lee | Methods of measuring the dissolution rate of an analyte in a non-aqueous liquid composition |
| US20040115837A1 (en) * | 2002-11-27 | 2004-06-17 | Schapaugh Randal Lee | Methods of measuring the dissolution rate of an analyte in a non-aqueous liquid composition |
| US20060046278A1 (en) * | 2004-08-26 | 2006-03-02 | Qualyst, Inc. | Methods and kits for determining metabolic stability of compounds |
| ZA200703604B (en) * | 2004-10-21 | 2009-10-28 | Pharma Diagnostics M V | Stable metal/conductive polymer composite colloids and methods for making and using the same |
-
2008
- 2008-05-28 CA CA002685450A patent/CA2685450A1/en not_active Abandoned
- 2008-05-28 AT AT08829343T patent/ATE498839T1/de not_active IP Right Cessation
- 2008-05-28 EA EA200901641A patent/EA200901641A1/ru unknown
- 2008-05-28 WO PCT/IB2008/003187 patent/WO2009031049A2/en not_active Ceased
- 2008-05-28 US US12/128,562 patent/US20090029391A1/en not_active Abandoned
- 2008-05-28 DE DE602008005013T patent/DE602008005013D1/de active Active
- 2008-05-28 JP JP2010509920A patent/JP2010528311A/ja active Pending
- 2008-05-28 EP EP08829343A patent/EP2153227B1/en not_active Not-in-force
- 2008-05-28 CN CN200880017704A patent/CN101680882A/zh active Pending
- 2008-05-28 AU AU2008294419A patent/AU2008294419A1/en not_active Abandoned
- 2008-05-28 DK DK08829343.6T patent/DK2153227T3/da active
- 2008-05-29 TW TW097119819A patent/TW200912312A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW200912312A (en) | 2009-03-16 |
| WO2009031049A2 (en) | 2009-03-12 |
| JP2010528311A (ja) | 2010-08-19 |
| EP2153227A2 (en) | 2010-02-17 |
| DE602008005013D1 (de) | 2011-03-31 |
| EP2153227B1 (en) | 2011-02-16 |
| WO2009031049A3 (en) | 2009-05-14 |
| CN101680882A (zh) | 2010-03-24 |
| AU2008294419A1 (en) | 2009-03-12 |
| AU2008294419A8 (en) | 2009-12-17 |
| US20090029391A1 (en) | 2009-01-29 |
| CA2685450A1 (en) | 2009-03-12 |
| ATE498839T1 (de) | 2011-03-15 |
| EA200901641A1 (ru) | 2010-04-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK2153227T3 (da) | Reagenser og metoder til bestemmelse af PK/ADME-TOX egenskaber ved nye kemiske forbindelser og ved lægemiddelkandidater | |
| Tabana et al. | Target identification of small molecules: an overview of the current applications in drug discovery | |
| Helm et al. | Limited antibody specificity compromises epitranscriptomic analyses | |
| Zheng et al. | Switching of macroscopic molecular recognition selectivity using a mixed solvent system | |
| Qing et al. | Visual and portable strategy for copper (II) detection based on a striplike poly (thymine)-caged and microwell-printed hydrogel | |
| Mattila et al. | Reactive oxygen species: reactions and detection from photosynthetic tissues | |
| ATE483825T1 (de) | Zusammensetzungen für die identifizierung von adenoviren | |
| WO2010135705A3 (en) | Biological bar code | |
| CY1119526T1 (el) | Εμπλουτισμος και ταυτοποιηση εμβρυϊκων κυτταρων σε μητρικο αιμα και προσδετες για τετοια χρηση | |
| WO2008036691A3 (en) | Biomarkers for prostate cancer and methods using the same | |
| Manshian et al. | High content analysis at single cell level identifies different cellular responses dependent on nanomaterial concentrations | |
| WO2009153774A3 (en) | Compositions and methods for prognosis of ovarian cancer | |
| BRPI0513308A (pt) | sistemas e métodos de análise de polìmeros de ácido nucléico e componentes relacionados | |
| Wang et al. | Coupling a DNA-based machine with glucometer readouts for amplified detection of telomerase activity in cancer cells | |
| BRPI0516227A (pt) | colóides compósitos de metal/polìmero condutor estáveis e métodos para fabricar e usar os mesmos | |
| Sekine et al. | A macroscopic reaction: Direct covalent bond formation between materials using a Suzuki-Miyaura cross-coupling reaction | |
| Zessin et al. | PCNA appears in two populations of slow and fast diffusion with a constant ratio throughout S-phase in replicating mammalian cells | |
| WO2007113575A3 (en) | Reagents and methods for cross-linking biological molecules | |
| SG10201610586QA (en) | Dynamic Light Scattering Nanoplatform For High-Throughput Transcription Factor-DNA Interaction Determination For Drug And/Or Disease Screening | |
| ATE507250T1 (de) | Probenlyse und beschichtung einer reaktionsoberfläche | |
| Li et al. | Proximity Ligation Assay: From a Foundational Principle to a Versatile Platform for Molecular and Translational Research | |
| WO2009047532A3 (en) | Cancer susceptibility loci | |
| Mirlohi et al. | Advances and Challenges in KRAS Mutation Detection and Clinical Implications | |
| WO2012068519A3 (en) | Markers associated with response to activated protein c administration, and uses thereof | |
| Liu et al. | A “Space-for-Time” Strategy Based on Single-Cell Dual-Isotope ICP-MS Analysis Enabling High-Throughput and Sensitive Quantification of miRNAs in Breast Cancer Cells for Therapeutic Assessment |