DK2155222T3 - Ekstrakt af Trigonella foenum-graecum - Google Patents

Ekstrakt af Trigonella foenum-graecum Download PDF

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Publication number
DK2155222T3
DK2155222T3 DK08715639.4T DK08715639T DK2155222T3 DK 2155222 T3 DK2155222 T3 DK 2155222T3 DK 08715639 T DK08715639 T DK 08715639T DK 2155222 T3 DK2155222 T3 DK 2155222T3
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DK
Denmark
Prior art keywords
extract
infection
mixture
treatment
pharmaceutical composition
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Application number
DK08715639.4T
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English (en)
Inventor
Jens Steen Olsen
Original Assignee
V-Biotek Holding Aps
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Publication of DK2155222T3 publication Critical patent/DK2155222T3/da

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08Magnoliopsida [dicotyledons]
    • A01N65/20Fabaceae or Leguminosae [Pea or Legume family], e.g. pea, lentil, soybean, clover, acacia, honey locust, derris or millettia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02Local antiseptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Extraction Or Liquid Replacement (AREA)

Claims (13)

1. Fremgangsmåde til opnåelse af et ekstrakt, hvilken fremgangsmåde omfatter trinnene, der går ud på a. at fremstille en blanding af frø opnået af Trigonella foenum-graecum og vand, b. at inkubere blandingen i mindst 3 timer ved en temperatur på mellem 10 og 45°C, c. at koge blandingen i 10 til 45 minutter for at frigøre kimene fra frøene, og d. at indvinde et flydende ekstrakt fra blandingen.
2. Fremgangsmåde ifølge krav 1, som omfatter det yderligere trin, der går ud på at fryse den inkuberede blanding forud for varmebehandlingen ifølge trin c eller at fryse den varmebehandlede blanding.
3. Fremgangsmåde ifølge krav 2, hvor det yderligere trin omfatter at fryse blandingen som defineret i krav 2 og at gentage trin c.
4. Fremgangsmåde til opnåelse af en ekstraktfraktion ved at udføre revers fasekromatografi af ekstraktet, der er opnået ifølge et hvilket som helst af kravene 1 til 3, på Lichroprep RP-18 (40-63 pm) af størrelse B (Merck) under anvendelse af følgende gradient: 0-1 min FhO/AcN 98:2, og derefter under anvendelse af en konstant gradient fra 1-40 min op til 100 % AcN og indsamling af fraktionen i tidsrummet mellem 5 og 10 min.
5. Fremgangsmåde til opnåelse af et ekstrakt eller en fraktion deraf ifølge et hvilket som helst af kravene 1 til 4, hvor ekstraktet eller fraktionen deraf opkoncentreres ved helt eller delvis at fjerne opløsningsmiddel ved en metode, der er valgt fra gruppen bestående af membranfiltrering, afdampning, udfældning, ekstraktion, azeotrop destillation, lyofilisering, spraytørring og kombinationer deraf.
6. Farmaceutisk sammensætning, der omfatter et ekstrakt eller en fraktion deraf, som er opnået ved en fremgangsmåde ifølge et hvilket som helst af kravene 1 til 5, til anvendelse ved behandling af en betændelses- eller infektionstilstand.
7. Farmaceutisk sammensætning ifølge krav 6, hvor betændelsestilstanden er valgt fra gruppen bestående af bledermatitis, akne, astma og en betændelsestilstand i mave-tarmkanalen.
8. Farmaceutisk sammensætning ifølge krav 6, hvor infektionstilstanden er herpes simplex.
9. Farmaceutisk sammensætning ifølge krav 6, hvor infektionstilstanden er valgt fra gruppen bestående af et betændt sår, et kirurgisk sår, impetigo, en stafylokok, såsom infektion med staphylococcus aureus, en infektion i mundhulen, periodontal sygdom, en infektion i øjet eller øjets hjælpeorganer, almindelig forkølelse, forkølelsessår, vorter og pharyngitis.
10. Farmaceutisk sammensætning ifølge krav 9, hvor den periodontale sygdom er valgt blandt gingivitis, periodontitis og halitosis.
11. Farmaceutisk sammensætning ifølge et hvilket som helst af kravene 6 til 10, hvor den farmaceutiske sammensætning er formuleret som en mundskyllevæske, tyggegummi, tandpasta, balsam, plaster, læbesalve, spray, salve, gel, kapsel, drop eller tablet.
12. Anvendelse af ekstraktet, der er opnået ved en fremgangsmåde ifølge et hvilket som helst af kravene 1 til 5, til fremstilling af en sammensætning til desinficering af hud; anlæg såsom køkkener, slagterier, toiletter og stalde; køkkenudstyr såsom køleskabe eller frysere; vand; vandbeholdere; boliger med lugt af syge personer, eller betonelementer.
13. Anvendelse af ekstraktet, der er opnået ved en fremgangsmåde ifølge et hvilket som helst af kravene 1 til 5, til fremstilling af en sammensætning til konservering af fødevarer såsom kød, fjerkræ og produkter deraf.
DK08715639.4T 2007-04-13 2008-04-14 Ekstrakt af Trigonella foenum-graecum DK2155222T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91165307P 2007-04-13 2007-04-13
PCT/DK2008/050086 WO2008125120A2 (en) 2007-04-13 2008-04-14 Extract of trigonella foenum-graecum

Publications (1)

Publication Number Publication Date
DK2155222T3 true DK2155222T3 (da) 2018-01-22

Family

ID=39739903

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08715639.4T DK2155222T3 (da) 2007-04-13 2008-04-14 Ekstrakt af Trigonella foenum-graecum

Country Status (16)

Country Link
US (2) US9107920B2 (da)
EP (1) EP2155222B1 (da)
JP (1) JP2010527326A (da)
KR (1) KR20090129490A (da)
CN (1) CN101687002B (da)
AU (1) AU2008238445B2 (da)
BR (1) BRPI0810532A2 (da)
CA (1) CA2682138A1 (da)
DK (1) DK2155222T3 (da)
EA (1) EA018425B1 (da)
ES (1) ES2655876T3 (da)
IL (1) IL201047A (da)
LT (1) LT2155222T (da)
NO (1) NO2155222T3 (da)
PL (1) PL2155222T3 (da)
WO (1) WO2008125120A2 (da)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022214671A1 (en) 2021-04-08 2022-10-13 Qur Medical Aps Pharmaceutical composition for prevention or treatment of virus-induced disease

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US8513203B2 (en) * 2011-05-02 2013-08-20 Indus Biotech Private Limited Composition and method thereof
CN102532248B (zh) * 2011-12-19 2013-09-04 四川省中医药科学院 制备胡芦巴皂苷b的方法
WO2013171764A2 (en) * 2012-04-30 2013-11-21 Rubicon Research Private Limited Ophthalmic formulations
WO2014075676A1 (en) * 2012-11-15 2014-05-22 V-Biotek Holding Aps Amines from trigonella foemum - graecum
MX2017014198A (es) * 2015-05-06 2018-06-28 Procter & Gamble Desintoxicacion de los factores de virulencia microbiana en la cavidad oral.
ITUB20152286A1 (it) * 2015-07-17 2017-01-17 Harven S A S Composizione anti herpes
EP3436041B1 (en) 2016-03-31 2023-05-24 Gojo Industries, Inc. Sanitizer composition with probiotic/prebiotic active ingredient
US10806769B2 (en) 2016-03-31 2020-10-20 Gojo Industries, Inc. Antimicrobial peptide stimulating cleansing composition
EP3435765A1 (en) 2016-03-31 2019-02-06 Gojo Industries, Inc. Antimicrobial peptide stimulating sanitizing composition
EP3463393A1 (en) 2016-06-03 2019-04-10 Jens Steen Olsen A composition comprising a mixture of an extract and bentonite
DE102016007774A1 (de) * 2016-06-24 2017-12-28 Hossam El Dakroury Antibiotikum - goldene Flüssigkeit -
DK178915B1 (en) * 2016-07-29 2017-05-22 Helge Vinther Christensen Composition and method for preventing algal growth on outdoor surfaces
JP2020500860A (ja) 2016-11-23 2020-01-16 ゴジョ・インダストリーズ・インコーポレイテッド プロバイオティック/プレバイオティックな有効成分を含む消毒薬組成物
CN106667785A (zh) * 2017-02-27 2017-05-17 宁波圆明工业设计有限公司 一种利用PericoannosinA作为抗菌组分的牙膏
US20200030226A1 (en) * 2018-07-27 2020-01-30 Johnson & Johnson Consumer Inc. Botanical and bacterial extracts displaying retinol-like activity
WO2020021477A2 (en) 2018-07-27 2020-01-30 Johnson & Johnson Vision Care, Inc. Compositions and methods for treating the eye
US10966948B2 (en) 2019-07-23 2021-04-06 Johnson & Johnson Surgical Vision, Inc. Compositions and methods for treating the eye
US11969454B2 (en) 2019-11-19 2024-04-30 Johnson & Johnson Surgical Vision, Inc. Compositions and methods for treating the eye
US20230405068A1 (en) 2020-11-06 2023-12-21 Handelsselskabet Af 20.10.2020 Aps Radiation-induced fibrosis treatment
TR2021015672A2 (tr) * 2021-10-07 2023-04-24 Elbasheer Omer Zona, yara ve ci̇lt enfeksi̇yonlarinin engellenmesi̇ne ve mi̇gren, artri̇t hastaliğinin tedavi̇si̇ne yöneli̇k bi̇tki̇sel bi̇leşenler i̇çeri̇kli̇ bi̇r krem
JP7705427B2 (ja) * 2022-05-19 2025-07-09 ルミスター バイオテクノロジー,インク. コロナウイルス感染抑制のための植物成分組成物及び生薬組成物
CN115336596A (zh) * 2022-09-01 2022-11-15 武汉安慧生物科技有限公司 杀线虫剂及其制备方法和应用
WO2025083459A1 (en) * 2023-10-21 2025-04-24 Carlos Alvarado A multifunctional vulnerary composition

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AU6141498A (en) * 1997-02-04 1998-08-25 John V. Kosbab Compositions and methods for prevention and treatment of vascular degenerative diseases
CN1313435C (zh) * 2003-10-27 2007-05-02 成都华高药业有限公司 一种从葫芦巴中提取4-羟基异亮氨酸制品的新方法
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022214671A1 (en) 2021-04-08 2022-10-13 Qur Medical Aps Pharmaceutical composition for prevention or treatment of virus-induced disease

Also Published As

Publication number Publication date
LT2155222T (lt) 2018-02-12
EA018425B1 (ru) 2013-07-30
CN101687002A (zh) 2010-03-31
CA2682138A1 (en) 2008-10-23
JP2010527326A (ja) 2010-08-12
US9107920B2 (en) 2015-08-18
PL2155222T3 (pl) 2018-06-29
ES2655876T3 (es) 2018-02-22
US10195239B2 (en) 2019-02-05
EP2155222A2 (en) 2010-02-24
KR20090129490A (ko) 2009-12-16
EA200970942A1 (ru) 2010-04-30
US20160000845A1 (en) 2016-01-07
AU2008238445A1 (en) 2008-10-23
BRPI0810532A2 (pt) 2014-10-21
EP2155222B1 (en) 2017-11-15
WO2008125120A3 (en) 2009-05-28
IL201047A (en) 2016-09-29
IL201047A0 (en) 2010-05-17
AU2008238445B2 (en) 2012-02-02
NO2155222T3 (da) 2018-04-14
WO2008125120A2 (en) 2008-10-23
CN101687002B (zh) 2014-03-26
US20100129296A1 (en) 2010-05-27

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