DK216883A - Fremgangsmaade til fremstilling af biotin og forbindelser til brug som mellemprodukter herved - Google Patents

Fremgangsmaade til fremstilling af biotin og forbindelser til brug som mellemprodukter herved Download PDF

Info

Publication number: DK216883A
Authority: DK; Denmark
Prior art keywords: biotin; preparation; intermediates; relationships; procedure
Prior art date: 1982-05-17

Application number

DK216883A

Other languages

Danish (da)

English (en)

Other versions

DK216883D0 (da

Inventor

Robert Alfred Volkmann

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-05-17

Filing date

1983-05-16

Publication date

1983-12-30

1983-05-16 Application filed by Pfizer filed Critical Pfizer

1983-05-16 Publication of DK216883D0 publication Critical patent/DK216883D0/da

1983-12-30 Publication of DK216883A publication Critical patent/DK216883A/da

Links

YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 title abstract 7
238000000034 method Methods 0.000 title abstract 5
229960002685 biotin Drugs 0.000 title abstract 3
235000020958 biotin Nutrition 0.000 title abstract 3
239000011616 biotin Substances 0.000 title abstract 3
239000000543 intermediate Substances 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title 1
WTEOIRVLGSZEPR-UHFFFAOYSA-N boron trifluoride Chemical compound FB(F)F WTEOIRVLGSZEPR-UHFFFAOYSA-N 0.000 abstract 2
150000002148 esters Chemical class 0.000 abstract 2
230000003301 hydrolyzing effect Effects 0.000 abstract 2
229910015900 BF3 Inorganic materials 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229940068840 d-biotin Drugs 0.000 abstract 1
230000001590 oxidative effect Effects 0.000 abstract 1
150000003557 thiazoles Chemical class 0.000 abstract 1
125000001984 thiazolidinyl group Chemical group 0.000 abstract 1
CBDKQYKMCICBOF-UHFFFAOYSA-N thiazoline Chemical compound C1CN=CS1 CBDKQYKMCICBOF-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/10—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK216883A 1982-05-17 1983-05-16 Fremgangsmaade til fremstilling af biotin og forbindelser til brug som mellemprodukter herved DK216883A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/379,247 US4468516A (en)	1982-05-17	1982-05-17	Process for the preparation of biotin

Publications (2)

Publication Number	Publication Date
DK216883D0 DK216883D0 (da)	1983-05-16
DK216883A true DK216883A (da)	1983-12-30

Family

ID=23496439

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK216883A DK216883A (da)	1982-05-17	1983-05-16	Fremgangsmaade til fremstilling af biotin og forbindelser til brug som mellemprodukter herved

Country Status (12)

Country	Link
US (1)	US4468516A (de)
EP (1)	EP0094776B1 (de)
JP (1)	JPS58210091A (de)
AT (1)	ATE35268T1 (de)
AU (1)	AU539264B2 (de)
CA (1)	CA1194879A (de)
DE (1)	DE3377131D1 (de)
DK (1)	DK216883A (de)
GR (1)	GR77500B (de)
IE (1)	IE55995B1 (de)
IN (1)	IN159855B (de)
ZA (1)	ZA833472B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4670564A (en) *	1985-03-14	1987-06-02	Pfizer Inc.	Preparation of thieno-imidazole derivatives
DE3776385D1 (de) *	1986-04-19	1992-03-12	Merck Patent Gmbh	Verfahren zur herstellung von d-(+)-biotin.
DE3926690A1 (de) *	1989-08-12	1991-02-14	Merck Patent Gmbh	Verfahren zur herstellung von d-(+)-biotin
DE3928263A1 (de) *	1989-08-26	1991-02-28	Merck Patent Gmbh	Verfahren zur herstellung von 7-cyan-7,7a-dihydro-1h,3h-imidazol(1,5-c) thiazol-5(6h)-onen
US9567346B2 (en)	2010-10-29	2017-02-14	Life Technologies Corporation	Biotin derivatives
WO2024250224A1 (en) *	2023-06-08	2024-12-12	Dsm Ip Assets B.V.	A process for producing a biotin intermediate

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2489236A (en) *	1947-07-24	1949-11-22	Hoffmann La Roche	Synthesis of biotin and related compounds
US2489235A (en) *	1947-07-24	1949-11-22	Hoffmann La Roche	Synthesis of biotin
US3978084A (en) *	1973-12-03	1976-08-31	Hoffmann-La Roche Inc.	Synthesis of biotin
US4029647A (en) *	1973-12-03	1977-06-14	Hoffmann-La Roche Inc.	Synthesis of biotin
US4044020A (en) *	1975-06-30	1977-08-23	Syntex (U.S.A.) Inc.	Process for preparing biotin
US4062868A (en) *	1977-02-23	1977-12-13	Hoffmann-La Roche Inc.	Synthesis of biotin
US4189586A (en) *	1977-08-05	1980-02-19	Hoffmann-La Roche Inc.	Preparation of biotin
DE3122562C1 (de) *	1981-06-06	1982-11-11	Merck Patent Gmbh, 6100 Darmstadt	Verfahren zur Herstellung von D-(+)-Biotin

1982
- 1982-05-17 US US06/379,247 patent/US4468516A/en not_active Expired - Lifetime
1983
- 1983-03-04 IN IN138/DEL/83A patent/IN159855B/en unknown
- 1983-05-09 DE DE8383302589T patent/DE3377131D1/de not_active Expired
- 1983-05-09 EP EP83302589A patent/EP0094776B1/de not_active Expired
- 1983-05-09 AT AT83302589T patent/ATE35268T1/de not_active IP Right Cessation
- 1983-05-13 CA CA000428090A patent/CA1194879A/en not_active Expired
- 1983-05-13 GR GR71348A patent/GR77500B/el unknown
- 1983-05-16 ZA ZA833472A patent/ZA833472B/xx unknown
- 1983-05-16 IE IE1133/83A patent/IE55995B1/en not_active IP Right Cessation
- 1983-05-16 DK DK216883A patent/DK216883A/da not_active Application Discontinuation
- 1983-05-16 AU AU14563/83A patent/AU539264B2/en not_active Ceased
- 1983-05-17 JP JP58086505A patent/JPS58210091A/ja active Granted

Also Published As

Publication number	Publication date
IN159855B (de)	1987-06-13
IE831133L (en)	1983-11-17
EP0094776A3 (en)	1985-06-19
US4468516A (en)	1984-08-28
DE3377131D1 (en)	1988-07-28
AU539264B2 (en)	1984-09-20
JPH0348916B2 (de)	1991-07-25
EP0094776B1 (de)	1988-06-22
GR77500B (de)	1984-09-24
ATE35268T1 (de)	1988-07-15
JPS58210091A (ja)	1983-12-07
IE55995B1 (en)	1991-03-13
EP0094776A2 (de)	1983-11-23
ZA833472B (en)	1984-12-24
AU1456383A (en)	1983-11-24
DK216883D0 (da)	1983-05-16
CA1194879A (en)	1985-10-08

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Legal Events

Date	Code	Title	Description
1993-01-25	AHB	Application shelved due to non-payment