DK2170384T3 - Fremgangsmåder og sammensætninger til fremstilling af en adenovirusvektor til anvendelse ved flere vaccinationer - Google Patents

Fremgangsmåder og sammensætninger til fremstilling af en adenovirusvektor til anvendelse ved flere vaccinationer Download PDF

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DK2170384T3
DK2170384T3 DK08781241.8T DK08781241T DK2170384T3 DK 2170384 T3 DK2170384 T3 DK 2170384T3 DK 08781241 T DK08781241 T DK 08781241T DK 2170384 T3 DK2170384 T3 DK 2170384T3
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protein
adenovirus vector
replication
virus
vol
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DK08781241.8T
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Joseph P Balint
Richard B Gayle Iii
Frank R Jones
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Etubics Corp
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Claims (9)

1. Repl i kationsdefekt adenovirusvektor, hvor E1-regionen erdeleteret, og DNA-polymerasegenet, og det præterminale protein (pTP) i E2b-regionen, er deleteret, hvor den replikationsdefekte adenovirusvektor ikke er en tømt (’’gutted”) vektor, og hvor adenovirusvektoren omfatter en nukleinsyre, der koder for et målantigen, til anvendelse i en fremgangsmåde til behandling af cancer, eller en infektionssygdom, eller vaccination mod cancer, eller en infektionssygdom hos et individ, ved fremkaldelse af et immunrespons hos individet mod det målantigen, som udtrykkes af den replikationsdefekte adenovirusvektor i individet, hvor fremgangsmåden omfatter (i) at administrere adenovirusvektoren til individet, og (ii) at gen-administrere adenovirusvektoren til individet for at fremkalde et immunrespons mod målantigenet.
2. Replikationsdefekt adenovirusvektor til anvendelse ifølge krav 1, hvor individet har allerede eksisterende immunitet mod adenovirus.
3. Replikationsdefekt adenovirusvektor til anvendelse ifølge krav 1 eller 2, hvor den replikationsdefekte adenovirusvektors målantigen omfatter et antigen valgt blandt et cancerprotein, eller et fragment deraf, som inducerer et immunrespons, et bakterielt antigen, og et viralt antigen.
4. Replikationsdefekt adenovirusvektor til anvendelse ifølge krav 1 eller 2, hvor den replikationsdefekte adenovirusvektors målantigen omfatter et protozoprotein, et svampeprotein, et skimmelsvampeprotein, et pattedyrprotein, og et fugleprotein, eller et fragment af et hvilket som helst af disse, som inducerer et immunrespons.
5. Replikationsdefekt adenovirusvektor til anvendelse ifølge krav 1 eller 2, hvor den replikationsdefekte adenovirusvektors målantigen omfatter: (i) et hiv-protein, herpes simplex-virusprotein, hepatitis C-virusprotein, malariaprotein, pestprotein, M. tuberculosis-prote'm, Streptococcus pneumonia-protein, Leishmania-protein, eller et immunogent fragment af et hvilket som helst af disse, eller (ii) et venezuelansk hesteencephalitis-virus (VEEV)-protein, vestlig hesteencephalitis-virusprotein, eller japansk encephalitis-virusprotein, eller et immunogent fragment af et hvilket som helst af disse.
6. Replikationsdefekt adenovirusvektor til anvendelse ifølge krav 1 eller 2, hvor den replikationsdefekte adenovirusvektors målantigen omfatter et influenzavirusprotein fra et influenzavirus valgt blandt H5N1, H3N2, H9N1, H1N1, H2N2, H7N7, H1N2, H9N2, H7N2, H7N3 og H10N7.
7. Replikationsdefekt adenovirusvektor til anvendelse ifølge krav 6, hvor influenzavirusproteinet er valgt blandt hæmagglutinin, neuraminidase og matrixprotein M1.
8. Replikationsdefekt adenovirusvektor til anvendelse ifølge krav 1 eller 2, hvor den replikationsdefekte adenovirusvektors målantigen omfatter et hiv-protein.
9. Replikationsdefekt adenovirusvektor til anvendelse ifølge krav 8, hvor hivproteinet er et hiv-gag-protein.
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EP3061462A1 (en) 2016-08-31
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US11826417B2 (en) 2023-11-28
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US20170065693A1 (en) 2017-03-09
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