DK2170435T3 - Automatisk indretning til afgivelse af et lægemiddel - Google Patents

Automatisk indretning til afgivelse af et lægemiddel Download PDF

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Publication number
DK2170435T3
DK2170435T3 DK08786273.6T DK08786273T DK2170435T3 DK 2170435 T3 DK2170435 T3 DK 2170435T3 DK 08786273 T DK08786273 T DK 08786273T DK 2170435 T3 DK2170435 T3 DK 2170435T3
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DK
Denmark
Prior art keywords
delivery
force
spring
container
medicament
Prior art date
Application number
DK08786273.6T
Other languages
English (en)
Inventor
Carlos Guillermo
Lucio Giambattista
David Desalvo
Original Assignee
Shl Group Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shl Group Ab filed Critical Shl Group Ab
Application granted granted Critical
Publication of DK2170435T3 publication Critical patent/DK2170435T3/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M5/31515—Connection of piston with piston rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16F—SPRINGS; SHOCK-ABSORBERS; MEANS FOR DAMPING VIBRATION
    • F16F1/00—Springs
    • F16F1/02—Springs made of steel or other material having low internal friction; Wound, torsion, leaf, cup, ring or the like springs, the material of the spring not being relevant
    • F16F1/025—Springs made of steel or other material having low internal friction; Wound, torsion, leaf, cup, ring or the like springs, the material of the spring not being relevant characterised by having a particular shape
    • F16F1/027—Planar, e.g. in sheet form; leaf springs
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16F—SPRINGS; SHOCK-ABSORBERS; MEANS FOR DAMPING VIBRATION
    • F16F1/00—Springs
    • F16F1/02—Springs made of steel or other material having low internal friction; Wound, torsion, leaf, cup, ring or the like springs, the material of the spring not being relevant
    • F16F1/04—Wound springs
    • F16F1/10—Spiral springs with turns lying substantially in plane surfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2006—Having specific accessories
    • A61M2005/2013—Having specific accessories triggering of discharging means by contact of injector with patient body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31563—Mechanically operated dose setting member interacting with a displaceable stop member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31591—Single dose, i.e. individually set dose administered only once from the same medicament reservoir, e.g. including single stroke limiting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Claims (4)

1. Indretning til afgivelse af et lægemiddel, omfattende: - et aflangt hus; - en beholder (4) med en kanyle og monteret i huset og indrettet til at indeholde et flydende lægemiddel; - en stopper, der er anbragt glidbart i beholderen; - aktiveringsorganer omfattende et elastisk legeme, en stødstang (50), der har en proximal ende i kontakt med stopperen, og en distal ende, der er funktionelt forbundet til det elastiske legeme; - en medbringer (30), som er fast anbragt på indersiden af huset; - et låseorgan (40) anbragt svingbart på medbringeren og omfattende et fremspring (41) indrettet til at være i kontakt med en rille (52) i stødstangen til løsbar fastholdelse af stødstangen i en første position, hvor det elastiske legeme har en akkumuleret energi; og - aktiveringsorganer (10), der er funktionsforbundne til låseorganet til frigørelse af stødstangen til en anden position efter aktivering ved en bruger, således at den akkumulerede energi overføres til stødstangen til fremdrivning af stopperen en forudbestemt strækning i beholderen, hvorved lægemidlet i beholderen afgives; kendetegnet ved, - at aktiveringsorganerne omfatter et på huset monteret, rørformet legeme (11) og mindst ét elastisk legeme (17), der er funktionelt forbundet til det rørformede legeme, hvilket rørformet legeme omfatter et endestykke indrettet til tilbagetrækning i forhold til huset mod kraften af det elastiske legeme (17), når endestykket presses mod et afgivelsessted, således at kanylen trænger ind i et afgivelsessted, og hvor det rørformede legeme er indrettet til at blive tvunget i retningen af endestykket i kraft af det mindst ene elastiske legeme, når endestykket fjernes fra afgivelsesstedet, - at det elastiske legeme er en fjeder (60) med variabel kraft, der har én ende fastgjort til medbringeren (30), og en anden ende, som er variabelt viklet, lagt som i en gaffel på den anden ende af stødstangen, og hvor fjederen med variabel kraft er indrettet til at frembringe en forudbestemt sekvens af mindst to forskellige kraftprofiler under lægemiddelafgivelsen, og hvor den sidste kraftprofil i sekvensen er en profil, hvor kraften stiger, efterhånden som fjederen afspændes, og - at fjederen (60) med variabel kraft er en spiralfjeder af båndmateriale, og hvor de forskellige kraftprofiler opnås ved egnet valg af materialet og/eller geometrien og/eller den naturlige radius og/eller elasticitetsmodulet af fjederen.
2. Indretning ifølge krav 1, kendetegnet ved, at det rørformede legeme (11) omfatter en udvendig ringformet kant (13), der har to tunger (14), der strækker sig i længderetningen mod indretningens distale ende, og hvor én af tungerne (14) omfatter en tungeforlængelse (16), således at når endestykket skubbes mod et afgivelsessted, vil tungeforlængelsen (16) skubbe og svinge låseorganet (40), hvorved fremspringet (41) kommer ud af rillen (52).
3. Indretning ifølge ethvert af kravene 1-2, kendetegnet ved, at indretningen omfatter dosisindstillingsorganer indrettet til betjening i forudbestemte trin, når indretningen er i en ikke-lægemiddelafgivende stilling, hvor betjeningen af dosisindstillingsorganet med ét trin øger dosis med et forudbestemt trin.
4. Indretning ifølge krav 3, kendetegnet ved, at dosisindstillingsorganerne omfatter mindst én i længderetningen trindelt dosisrille (51) med en endevæg (53) anbragt på drivorganet (50), hvor mindst én af de i længderetningen trindelte dosisriller (51) er funktionsforbundet til et indre fremspring (22) anbragt på et koaksialt, gennemgående hul på en periferioverflade (21) af en vælgerring (20), hvor drivorganet (50) er indrettet til at passere igennem, og hvor afstanden mellem hver endevæg (53) og fremspringet (22) svarer til en forudbestemt dosis, således at når indretningen er i en lægemiddelafgivende stilling, stopper drivorganets bevægelse, når fremspringet (22) af vælgerringen går i indgreb med endevæggen (53).
DK08786273.6T 2007-07-19 2008-07-19 Automatisk indretning til afgivelse af et lægemiddel DK2170435T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95077007P 2007-07-19 2007-07-19
SE0702720 2007-12-05
PCT/EP2008/059493 WO2009010591A2 (en) 2007-07-19 2008-07-19 Automatic device for delivering a medicament

Publications (1)

Publication Number Publication Date
DK2170435T3 true DK2170435T3 (da) 2018-02-12

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Application Number Title Priority Date Filing Date
DK08786273.6T DK2170435T3 (da) 2007-07-19 2008-07-19 Automatisk indretning til afgivelse af et lægemiddel

Country Status (7)

Country Link
US (3) US8460245B2 (da)
EP (1) EP2170435B1 (da)
JP (1) JP5311685B2 (da)
CN (1) CN101754778B (da)
AU (1) AU2008277608B2 (da)
DK (1) DK2170435T3 (da)
WO (1) WO2009010591A2 (da)

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Also Published As

Publication number Publication date
WO2009010591A2 (en) 2009-01-22
EP2170435A2 (en) 2010-04-07
JP2010533529A (ja) 2010-10-28
CN101754778A (zh) 2010-06-23
WO2009010591A3 (en) 2009-02-26
EP2170435B1 (en) 2017-12-06
AU2008277608B2 (en) 2011-03-03
US20100249721A1 (en) 2010-09-30
US20130190696A1 (en) 2013-07-25
US8460245B2 (en) 2013-06-11
US20160158444A1 (en) 2016-06-09
US10112013B2 (en) 2018-10-30
CN101754778B (zh) 2012-04-18
AU2008277608A1 (en) 2009-01-22
JP5311685B2 (ja) 2013-10-09

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