DK2178990T3 - Antimikrobiel fotostabil belægningssammensætning - Google Patents
Antimikrobiel fotostabil belægningssammensætning Download PDFInfo
- Publication number
- DK2178990T3 DK2178990T3 DK08783307.5T DK08783307T DK2178990T3 DK 2178990 T3 DK2178990 T3 DK 2178990T3 DK 08783307 T DK08783307 T DK 08783307T DK 2178990 T3 DK2178990 T3 DK 2178990T3
- Authority
- DK
- Denmark
- Prior art keywords
- silver
- group
- medical
- medical material
- polymeric
- Prior art date
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- 239000008199 coating composition Substances 0.000 title claims description 13
- 230000000845 anti-microbial effect Effects 0.000 title claims description 12
- 239000004332 silver Substances 0.000 claims description 27
- 229910052709 silver Inorganic materials 0.000 claims description 27
- 239000000463 material Substances 0.000 claims description 26
- 239000012567 medical material Substances 0.000 claims description 25
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 23
- 238000000576 coating method Methods 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 18
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 claims description 17
- 229940079889 pyrrolidonecarboxylic acid Drugs 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 16
- 239000011248 coating agent Substances 0.000 claims description 15
- GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 claims description 14
- 239000000178 monomer Substances 0.000 claims description 11
- 229920000642 polymer Polymers 0.000 claims description 11
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 claims description 8
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 claims description 6
- 239000004599 antimicrobial Substances 0.000 claims description 6
- 238000002845 discoloration Methods 0.000 claims description 6
- RQAKESSLMFZVMC-UHFFFAOYSA-N n-ethenylacetamide Chemical group CC(=O)NC=C RQAKESSLMFZVMC-UHFFFAOYSA-N 0.000 claims description 6
- 229920001296 polysiloxane Polymers 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 claims description 5
- 239000012965 benzophenone Substances 0.000 claims description 5
- 150000001720 carbohydrates Chemical class 0.000 claims description 5
- 235000014633 carbohydrates Nutrition 0.000 claims description 5
- CQLFBEKRDQMJLZ-UHFFFAOYSA-M silver acetate Chemical compound [Ag+].CC([O-])=O CQLFBEKRDQMJLZ-UHFFFAOYSA-M 0.000 claims description 5
- 229940071536 silver acetate Drugs 0.000 claims description 5
- GJBRNHKUVLOCEB-UHFFFAOYSA-N tert-butyl benzenecarboperoxoate Chemical compound CC(C)(C)OOC(=O)C1=CC=CC=C1 GJBRNHKUVLOCEB-UHFFFAOYSA-N 0.000 claims description 5
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 4
- 229960001506 brilliant green Drugs 0.000 claims description 4
- HXCILVUBKWANLN-UHFFFAOYSA-N brilliant green cation Chemical group C1=CC(N(CC)CC)=CC=C1C(C=1C=CC=CC=1)=C1C=CC(=[N+](CC)CC)C=C1 HXCILVUBKWANLN-UHFFFAOYSA-N 0.000 claims description 4
- 239000007943 implant Substances 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 229910001961 silver nitrate Inorganic materials 0.000 claims description 4
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 4
- 229920002554 vinyl polymer Polymers 0.000 claims description 4
- 238000001631 haemodialysis Methods 0.000 claims description 3
- 210000003709 heart valve Anatomy 0.000 claims description 3
- 230000000322 hemodialysis Effects 0.000 claims description 3
- PNLUGRYDUHRLOF-UHFFFAOYSA-N n-ethenyl-n-methylacetamide Chemical compound C=CN(C)C(C)=O PNLUGRYDUHRLOF-UHFFFAOYSA-N 0.000 claims description 3
- LMEWRZSPCQHBOB-UHFFFAOYSA-M silver;2-hydroxypropanoate Chemical compound [Ag+].CC(O)C([O-])=O LMEWRZSPCQHBOB-UHFFFAOYSA-M 0.000 claims description 3
- 238000006722 reduction reaction Methods 0.000 claims description 2
- 230000002485 urinary effect Effects 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims 2
- KWVGIHKZDCUPEU-UHFFFAOYSA-N 2,2-dimethoxy-2-phenylacetophenone Chemical compound C=1C=CC=CC=1C(OC)(OC)C(=O)C1=CC=CC=C1 KWVGIHKZDCUPEU-UHFFFAOYSA-N 0.000 claims 1
- JAHNSTQSQJOJLO-UHFFFAOYSA-N 2-(3-fluorophenyl)-1h-imidazole Chemical compound FC1=CC=CC(C=2NC=CN=2)=C1 JAHNSTQSQJOJLO-UHFFFAOYSA-N 0.000 claims 1
- CYUZOYPRAQASLN-UHFFFAOYSA-N 3-prop-2-enoyloxypropanoic acid Chemical compound OC(=O)CCOC(=O)C=C CYUZOYPRAQASLN-UHFFFAOYSA-N 0.000 claims 1
- IRQWEODKXLDORP-UHFFFAOYSA-N 4-ethenylbenzoic acid Chemical compound OC(=O)C1=CC=C(C=C)C=C1 IRQWEODKXLDORP-UHFFFAOYSA-N 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 1
- 235000000126 Styrax benzoin Nutrition 0.000 claims 1
- 244000028419 Styrax benzoin Species 0.000 claims 1
- 235000008411 Sumatra benzointree Nutrition 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 239000011888 foil Substances 0.000 claims 1
- 235000019382 gum benzoic Nutrition 0.000 claims 1
- LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
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- 239000000975 dye Substances 0.000 description 8
- 239000003999 initiator Substances 0.000 description 8
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- 229920000742 Cotton Polymers 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 4
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- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- CHHBLJMHCMIDIZ-UHFFFAOYSA-N 2-oxopyrrolidine-1-carboxylic acid;silver Chemical compound [Ag].OC(=O)N1CCCC1=O CHHBLJMHCMIDIZ-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- FFBHFFJDDLITSX-UHFFFAOYSA-N benzyl N-[2-hydroxy-4-(3-oxomorpholin-4-yl)phenyl]carbamate Chemical compound OC1=C(NC(=O)OCC2=CC=CC=C2)C=CC(=C1)N1CCOCC1=O FFBHFFJDDLITSX-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 125000002091 cationic group Chemical group 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 229910001873 dinitrogen Inorganic materials 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 239000001046 green dye Substances 0.000 description 2
- 230000002779 inactivation Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 238000007540 photo-reduction reaction Methods 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- NDVLTYZPCACLMA-UHFFFAOYSA-N silver oxide Chemical compound [O-2].[Ag+].[Ag+] NDVLTYZPCACLMA-UHFFFAOYSA-N 0.000 description 2
- 229910001923 silver oxide Inorganic materials 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- FTQLNOIQKWFTTA-UHFFFAOYSA-N 5-oxopyrrolidine-2-carboxylic acid;silver Chemical compound [Ag].OC(=O)C1CCC(=O)N1 FTQLNOIQKWFTTA-UHFFFAOYSA-N 0.000 description 1
- 229910001316 Ag alloy Inorganic materials 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 229920003043 Cellulose fiber Polymers 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- RRUDCFGSUDOHDG-UHFFFAOYSA-N acetohydroxamic acid Chemical compound CC(O)=NO RRUDCFGSUDOHDG-UHFFFAOYSA-N 0.000 description 1
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- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 235000011114 ammonium hydroxide Nutrition 0.000 description 1
- CKMXBZGNNVIXHC-UHFFFAOYSA-L ammonium magnesium phosphate hexahydrate Chemical compound [NH4+].O.O.O.O.O.O.[Mg+2].[O-]P([O-])([O-])=O CKMXBZGNNVIXHC-UHFFFAOYSA-L 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 150000001805 chlorine compounds Chemical class 0.000 description 1
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- 150000001875 compounds Chemical class 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
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- GXGAKHNRMVGRPK-UHFFFAOYSA-N dimagnesium;dioxido-bis[[oxido(oxo)silyl]oxy]silane Chemical compound [Mg+2].[Mg+2].[O-][Si](=O)O[Si]([O-])([O-])O[Si]([O-])=O GXGAKHNRMVGRPK-UHFFFAOYSA-N 0.000 description 1
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- 229920001971 elastomer Polymers 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- JVICFMRAVNKDOE-UHFFFAOYSA-M ethyl violet Chemical compound [Cl-].C1=CC(N(CC)CC)=CC=C1C(C=1C=CC(=CC=1)N(CC)CC)=C1C=CC(=[N+](CC)CC)C=C1 JVICFMRAVNKDOE-UHFFFAOYSA-M 0.000 description 1
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- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
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- 239000000017 hydrogel Substances 0.000 description 1
- 229920001480 hydrophilic copolymer Polymers 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- 239000000391 magnesium silicate Substances 0.000 description 1
- 229940099273 magnesium trisilicate Drugs 0.000 description 1
- 229910000386 magnesium trisilicate Inorganic materials 0.000 description 1
- 235000019793 magnesium trisilicate Nutrition 0.000 description 1
- FDZZZRQASAIRJF-UHFFFAOYSA-M malachite green Chemical compound [Cl-].C1=CC(N(C)C)=CC=C1C(C=1C=CC=CC=1)=C1C=CC(=[N+](C)C)C=C1 FDZZZRQASAIRJF-UHFFFAOYSA-M 0.000 description 1
- 229940107698 malachite green Drugs 0.000 description 1
- CXKWCBBOMKCUKX-UHFFFAOYSA-M methylene blue Chemical compound [Cl-].C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 CXKWCBBOMKCUKX-UHFFFAOYSA-M 0.000 description 1
- 229960000907 methylthioninium chloride Drugs 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- OTCVAHKKMMUFAY-UHFFFAOYSA-N oxosilver Chemical class [Ag]=O OTCVAHKKMMUFAY-UHFFFAOYSA-N 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 230000000176 photostabilization Effects 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
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- 239000002861 polymer material Substances 0.000 description 1
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- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
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- 150000003254 radicals Chemical class 0.000 description 1
- 125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 description 1
- 150000003378 silver Chemical class 0.000 description 1
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- 229960003600 silver sulfadiazine Drugs 0.000 description 1
- UEJSSZHHYBHCEL-UHFFFAOYSA-N silver(1+) sulfadiazinate Chemical compound [Ag+].C1=CC(N)=CC=C1S(=O)(=O)[N-]C1=NC=CC=N1 UEJSSZHHYBHCEL-UHFFFAOYSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 150000004764 thiosulfuric acid derivatives Chemical class 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 239000001003 triarylmethane dye Substances 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
Classifications
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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- A61L15/42—Use of materials characterised by their function or physical properties
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
- C08J7/04—Coating
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- C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
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- C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
- C08J7/12—Chemical modification
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B67/00—Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
- C09B67/0071—Process features in the making of dyestuff preparations; Dehydrating agents; Dispersing agents; Dustfree compositions
- C09B67/0083—Solutions of dyes
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- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
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- C09B67/00—Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
- C09B67/0071—Process features in the making of dyestuff preparations; Dehydrating agents; Dispersing agents; Dustfree compositions
- C09B67/0084—Dispersions of dyes
- C09B67/0085—Non common dispersing agents
- C09B67/0086—Non common dispersing agents anionic dispersing agents
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- C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
- C09D5/14—Paints containing biocides, e.g. fungicides, insecticides or pesticides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- C08J2383/00—Characterised by the use of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen, or carbon only; Derivatives of such polymers
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Claims (17)
1. Antimikrobiel fotostabil belægningssammensætning, som omfatter kompleksbundet sølv og farvestof, hvor det kompleksbundne sølv omfatter et sølvsalt, der er kompleksbundet til pyrrolidoncarboxylsyre (PCA) for at beskytte sølvet mod efterfølgende oxidations-/reduktionsreaktioner, hvor farvestoffet er brilliant-grøn, og hvor sammensætningen hindrer fotoinduceret misfarvning, ikke farver væv og kan påføres overfladen af en række medicinske materialer.
2. Sammensætning ifølge krav 1, hvor sølvsaltet er valgt fra gruppen bestående af sølvnitrat, sølvacetat, sølvlactat og kombinationer deraf.
3. Sammensætning ifølge et hvilket som helst af kravene 1-2, hvor sølvsaltet forefindes i en mængde på 1 til 20 mM, og PCA forefindes i en ca. dobbelt så stor mængde som sølvsaltet.
4. Sammensætning ifølge et hvilket som helst af kravene 1-3, hvor farvestoffet forefindes i en mængde på 0,02 til 2 mM.
5. Medicinsk materiale, som er belagt eller imprægneret med sammensætningen ifølge et hvilket som helst af kravene 1-4, hvor det medicinske materiale er valgt blandt et hydrofilt materiale og et polymert materiale.
6. Medicinsk materiale ifølge krav 5, hvor det polymere materiale er en anordning valgt fra gruppen bestående af implantater, katetre, stenter, sårforbindinger, hjerteklapper, slanger, stifter og klemmer.
7. Medicinsk materiale ifølge krav 5, hvor det hydrofile materiale er valgt fra gruppen bestående af gazebind, polymerslanger, sårdræn, kartransplantater, endotrakealtuber, hæmodialysekatetre og vævsafdækning sammensat af proteiner og carbohydrater.
8. Medicinsk materiale ifølge krav 6, hvor anordningen belægges med en hydrofil belægning, inden den belægges eller imprægneres med sammensætningen.
9. Polymer medicinsk anordning, som omfatter det medicinske materiale ifølge krav 8 med en hydrofil belægning frembragt ved fremgangsmåden, der omfatter: inkubering af et fotoinitiatorbelagt siliconemateriale, der er tilvejebragt som en anordning valgt fra gruppen bestående af implantater, katetre, stenter, sårforbindinger, hjerteklapper, slanger, stifter og klemmer, med en vandig co-monomer-opløsning, som er i stand til fri radikal-polymerisering og er valgt fra den primære gruppe bestående af acrylsyre, methacrylsyre, 2-carboxyethylacrylat, 4-vinylben-zoesyre, itaconsyre og blandinger deraf og en sekundær gruppe bestående af en hvilken som helst vinylmonomer, hvor fotoinitiatoren er valgt fra gruppen bestående af p-benzoyl-tert-butylperbenzoat, benzophenon, tert-butylperoxybenzoat, 2,2-dimethoxy-2-phenyl-acetophenon, benzilketaler, benzoiner og derivater og blandinger deraf; eksponering af materialet, der inkuberes, for ultraviolet lys, så der frembringes en modificeret overflade på materialet; og vask og tørring af materialet med den modificerede overflade, hvor anordningen endvidere belægges eller imprægneres med sammensætningen ifølge et hvilket som helst af kravene 1-4.
10. Anordning ifølge krav 9, hvor vinylmonomeren er N-vinylacetamid, N-methyl-vinylacetamid eller methylacrylat.
11. Fremgangsmåde til fremstilling af et antimikrobielt fotostabilt belagt medicinsk materiale, hvilken fremgangsmåde omfatter: (a) blanding af et sølvsalt med PCA og lyofilisering til dannelse af et tørt pulver; (b) tilsætning af (a) til en brilliantgrøn-opløsning; (c) nedsænkning af et medicinsk materiale i (b) i et ønsket tidsrum og (d) tørring af det medicinske materiale.
12. Fremgangsmåde ifølge krav 11, hvor sølvsaltet forefindes i en mængde på 1 til 20 mM, PCA forefindes i en ca. dobbelt så stor mængde som sølvsaltet, og brilliantgrøn forefindes i en mængde på 0,02 til 2 mM.
13. Fremgangsmåde ifølge krav 11 eller 12, hvor sølvsaltet er valgt fra gruppen bestående af sølvnitrat, sølvacetat, sølvlactat og kombinationer deraf.
14. Fremgangsmåde ifølge et hvilket som helst af kravene 11-13, hvor det medicinske materiale er valgt fra gruppen bestående af hydrofile materialer og polymere materialer.
15. Fremgangsmåde ifølge krav 14, hvor de hydrofile materialer er valgt fra gruppen bestående af gazebind, polymerslanger, sårdræn, kartransplantater, endotrakealtuber, hæmodialysekatetre og vævsafdækning sammensat af proteiner og carbohydrater.
16. Fremgangsmåde ifølge krav 15, hvor polymerslangen er et urinvejskateter.
17. Fremgangsmåde ifølge krav 2, hvor de polymere materialer er medicinske anordninger valgt fra gruppen bestående af katetre, sårdræn, endotrakealtuber og andre polymere væskestrømningskanaler og polymere foliematerialer.
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| US93525907P | 2007-08-02 | 2007-08-02 | |
| PCT/CA2008/001396 WO2009015476A1 (en) | 2007-08-02 | 2008-07-31 | Antimicrobial photo-stable coating composition |
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| DK2178990T3 true DK2178990T3 (da) | 2015-10-12 |
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| DE102007036685A1 (de) | 2007-08-03 | 2009-02-05 | Innora Gmbh | Verbesserte arzneimittelbeschichtete Medizinprodukte deren Herstellung und Verwendung |
| EP2373270B8 (en) | 2009-01-07 | 2023-04-12 | entrotech life sciences, inc. | Chlorhexidine-containing antimicrobial laminates |
| US8967077B2 (en) | 2009-09-29 | 2015-03-03 | Covalon Technologies, Inc. | System and method for coating medical devices |
| ES2831299T3 (es) | 2010-06-17 | 2021-06-08 | Covalon Tech Inc | Apósito para heridas a base de silicona antimicrobiano |
| WO2013006947A1 (en) | 2011-07-08 | 2013-01-17 | Covalon Technologies Inc. | Method for treating a surface with a coating comprising a therapeutic agent and device with treated surface |
| CN103857759B (zh) * | 2011-10-11 | 2016-12-14 | 罗门哈斯公司 | 水性聚合物分散体 |
| WO2015161302A1 (en) | 2014-04-18 | 2015-10-22 | Entrotech Life Sciences, Inc. | Methods of processing chlorhexidine-containing polymerizable compositions and antimicrobial articles formed thereby |
| AU2018241528A1 (en) * | 2017-03-29 | 2019-10-17 | Covalon Technologies Ltd. | Coating compositions, polymeric coatings, and methods |
| EP3983141A4 (en) | 2019-06-14 | 2023-07-19 | Covalon Technologies Inc. | COATED DEVICES AND RELATED PROCESSES |
| US11292921B2 (en) | 2019-08-01 | 2022-04-05 | Pison Stream Solutions Inc. | High performance antimicrobial coating composition |
| US20240081336A1 (en) * | 2019-09-16 | 2024-03-14 | Corning Incorporated | Color stabilization of biocidal coatings |
| CN112933301B (zh) * | 2019-11-26 | 2023-01-24 | 上海微创医疗器械（集团）有限公司 | 载药植入医疗器械及其制备方法 |
| CN115066292B (zh) | 2019-12-17 | 2025-09-26 | 科发龙技术公司 | 涂覆器件的反应器以及相关系统和方法 |
| PL4294880T3 (pl) * | 2021-02-22 | 2025-09-08 | Actega Terra Gmbh | Drukowana powłoka ze wskaźnikiem utwardzania |
| US20240358897A1 (en) * | 2023-04-27 | 2024-10-31 | Becton, Dickinson And Company | Antimicrobial catheter coatings with passive antifungal properties |
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|---|---|---|---|---|
| US4646730A (en) * | 1986-05-23 | 1987-03-03 | Johnson & Johnson Products, Inc. | Color stabilized hydrogel dressing and process |
| US5413788A (en) * | 1986-07-03 | 1995-05-09 | Johnson Matthey Public Limited Company | Antimicrobial compositions |
| GB8616294D0 (en) * | 1986-07-03 | 1986-08-13 | Johnson Matthey Plc | Antimicrobial compositions |
| US5788687A (en) * | 1994-02-01 | 1998-08-04 | Caphco, Inc | Compositions and devices for controlled release of active ingredients |
| CA2263473C (en) * | 1996-08-16 | 2003-04-22 | Christopher C. Capelli | Silver-based antimicrobial compositions |
| US6468521B1 (en) * | 1998-08-14 | 2002-10-22 | Coloplast A/S | Stabilized compositions having antibacterial activity |
| JP2000256365A (ja) | 1999-03-03 | 2000-09-19 | Meiji Milk Prod Co Ltd | 水溶性銀錯体 |
| JP2001335405A (ja) * | 2000-05-23 | 2001-12-04 | Meiji Milk Prod Co Ltd | 抗菌抗かび剤 |
| JP4782977B2 (ja) * | 2000-11-29 | 2011-09-28 | コンバテック・テクノロジーズ・インコーポレイテッド | 光安定させた抗菌材料 |
| AU2002235694B2 (en) | 2001-02-28 | 2007-06-14 | Covalon Technologies Inc. | Method of making anti-microbial polymeric surfaces |
| DE60321773D1 (de) * | 2002-03-14 | 2008-08-07 | Ash Access Technology Inc | Medizinische vorrichtungen mit antibakteriellen eigenschaften |
| GB2408206B (en) * | 2003-11-18 | 2007-11-28 | Johnson & Johnson Medical Ltd | Antioxidant and antimicrobial wound dressing materials |
| JP2007091501A (ja) * | 2005-09-27 | 2007-04-12 | Sinanen Zeomic Co Ltd | 抗菌性ゼオライト及び抗菌性樹脂組成物 |
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| WO2009015476A1 (en) | 2009-02-05 |
| CA2695659C (en) | 2014-04-01 |
| US8877256B2 (en) | 2014-11-04 |
| EP2178990A1 (en) | 2010-04-28 |
| HK1143390A1 (zh) | 2010-12-31 |
| CA2695659A1 (en) | 2009-02-05 |
| EP2178990A4 (en) | 2011-08-24 |
| ES2544336T3 (es) | 2015-08-28 |
| EP2178990B1 (en) | 2015-07-08 |
| CN101790568B (zh) | 2015-09-30 |
| AU2008281278A1 (en) | 2009-02-05 |
| US20090035388A1 (en) | 2009-02-05 |
| AU2008281278B2 (en) | 2012-08-09 |
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