DK2182902T3 - Sammensætninger omfattende sufentanil og triazolam til proceduresedering og analgesi under anvendelse af orale transmucosale doseringsformer - Google Patents
Sammensætninger omfattende sufentanil og triazolam til proceduresedering og analgesi under anvendelse af orale transmucosale doseringsformer Download PDFInfo
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- DK2182902T3 DK2182902T3 DK08797363.2T DK08797363T DK2182902T3 DK 2182902 T3 DK2182902 T3 DK 2182902T3 DK 08797363 T DK08797363 T DK 08797363T DK 2182902 T3 DK2182902 T3 DK 2182902T3
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- sufentanil
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Classifications
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- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
- A61J7/0015—Devices specially adapted for taking medicines
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- A—HUMAN NECESSITIES
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- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
- A61J7/0015—Devices specially adapted for taking medicines
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- A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
- A61J7/0076—Medicament distribution means
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
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- B65D25/2802—Handles fixed, i.e. non-swingable, handles
- B65D25/2805—Handles fixed, i.e. non-swingable, handles provided on a local area of the side walls
- B65D25/2811—Vertical, e.g. U-shaped
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/04—Containers or packages with special means for dispensing contents for dispensing annular, disc-shaped, spherical or like small articles, e.g. tablets or pills
- B65D83/0409—Containers or packages with special means for dispensing contents for dispensing annular, disc-shaped, spherical or like small articles, e.g. tablets or pills the dispensing means being adapted for delivering one article, or a single dose, upon each actuation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/08—Containers or packages with special means for dispensing contents for dispensing thin flat articles in succession
- B65D83/0847—Containers or packages with special means for dispensing contents for dispensing thin flat articles in succession through an aperture at the junction of two walls
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Mechanical Engineering (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Physiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Claims (6)
1. Fast enkeltdoseringsform med lille volumen til anvendelse ved proceduresede-ring og analgesi: - omfattende kombinationen af fra 5 pg til 50 pg af sufentanil og fra 100 pg til 500 pg triazolam, hvori den faste doseringsform er bioadhæsiv og indrettet til at hæfte til mundslimhinden, indtil det meste eller hele medikamentet er blevet tilført ved oral transmucosal indgivelse under medikamenttilførslen, hvori den faste doseringsform har et volumen mindre end 100 pi og en masse mindre end 100 mg.
2. Fast doseringsform til anvendelse ved proceduresedering og analgesi ifølge krav 1, hvori doseringsformen har en masse valgt fra gruppen bestående af mindre end 90mg, 80mg, 70mg, 60mg, 50mg, 40mg, 30mg, 29mg, 28mg, 27mg, 26mg, 25mg, 24mg, 23mg, 22mg, 21mg, 20mg, 19mg, 18mg, 17mg, 16mg, 15mg, 14mg, 13mg, 12mg, llmg, lOmg, 9mg, 8mg, 7mg, 6mg og 5mg.
3. Fast doseringsform til anvendelse ved proceduresedering og analgesi ifølge krav 1, hvori den orale transmucosale indgivelse er sublingual indgivelse.
4. Fast doseringsform til anvendelse ved proceduresedering og analgesi ifølge krav 1, hvori sederingens begyndelse sker mindre end en time efter indgivelse til subjektet.
5. Fast doseringsform til anvendelse ved proceduresedering og analgesi ifølge krav 1, hvori sederingens varighed er 4 timer eller mindre efter indgivelse.
6. Enkeltdosisapplikator (SDA) til anvendelse ved proceduresedering og analgesi, omfattende en doseringsform ifølge krav 1.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95450107P | 2007-08-07 | 2007-08-07 | |
| PCT/US2008/072445 WO2009021106A1 (en) | 2007-08-07 | 2008-08-07 | Compositions and methods for procedural sedation and analgesia using oral transmucosal dosage forms |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2182902T3 true DK2182902T3 (da) | 2015-04-13 |
Family
ID=40341735
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08797363.2T DK2182902T3 (da) | 2007-08-07 | 2008-08-07 | Sammensætninger omfattende sufentanil og triazolam til proceduresedering og analgesi under anvendelse af orale transmucosale doseringsformer |
| DK13158781.8T DK2604257T3 (da) | 2007-08-07 | 2008-08-07 | Orale transmucosale doseringsformer omfattende sufentanil og triazolam |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13158781.8T DK2604257T3 (da) | 2007-08-07 | 2008-08-07 | Orale transmucosale doseringsformer omfattende sufentanil og triazolam |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20090048237A1 (da) |
| EP (3) | EP3269346A1 (da) |
| JP (1) | JP5632284B2 (da) |
| KR (1) | KR101606944B1 (da) |
| CN (1) | CN101820838B (da) |
| CA (1) | CA2704929C (da) |
| DK (2) | DK2182902T3 (da) |
| ES (2) | ES2534433T3 (da) |
| WO (1) | WO2009021106A1 (da) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8252329B2 (en) | 2007-01-05 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
| US9066847B2 (en) | 2007-01-05 | 2015-06-30 | Aceirx Pharmaceuticals, Inc. | Storage and dispensing devices for administration of oral transmucosal dosage forms |
| US9289583B2 (en) * | 2006-01-06 | 2016-03-22 | Acelrx Pharmaceuticals, Inc. | Methods for administering small volume oral transmucosal dosage forms using a dispensing device |
| US8865743B2 (en) | 2006-01-06 | 2014-10-21 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
| US8202535B2 (en) | 2006-01-06 | 2012-06-19 | Acelrx Pharmaceuticals, Inc. | Small-volume oral transmucosal dosage forms |
| US8753308B2 (en) | 2006-01-06 | 2014-06-17 | Acelrx Pharmaceuticals, Inc. | Methods for administering small volume oral transmucosal dosage forms using a dispensing device |
| US8535714B2 (en) | 2006-01-06 | 2013-09-17 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
| US8357114B2 (en) | 2006-01-06 | 2013-01-22 | Acelrx Pharmaceuticals, Inc. | Drug dispensing device with flexible push rod |
| US20100010031A1 (en) | 2007-02-09 | 2010-01-14 | Yum Ii Su | Transoral dosage forms comprising sufentanil and naloxone |
| US8945592B2 (en) * | 2008-11-21 | 2015-02-03 | Acelrx Pharmaceuticals, Inc. | Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same |
| WO2010107761A1 (en) | 2009-03-18 | 2010-09-23 | Acelrx Pharmaceuticals, Inc. | Improved storage and dispensing devices for administration of oral transmucosal dosage forms |
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| US20110288128A1 (en) | 2010-05-21 | 2011-11-24 | Acelrx Pharmaceuticals, Inc. | Oral Transmucosal Administration of Sufentanil |
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| FR3000896B1 (fr) * | 2013-01-14 | 2016-08-26 | Philippe Perovitch | Forme galenique pour l'administration de principe(s) actif(s) permettant l'induction acceleree du sommeil et/ou le traitement des troubles du sommeil |
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| BR112017013311B1 (pt) | 2014-12-23 | 2022-05-31 | Acelrx Pharmaceuticals, Inc | Aparelho para a dispensação de formas de dosagem via oral e transmucosal |
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-
2008
- 2008-08-07 WO PCT/US2008/072445 patent/WO2009021106A1/en not_active Ceased
- 2008-08-07 DK DK08797363.2T patent/DK2182902T3/da active
- 2008-08-07 US US12/187,937 patent/US20090048237A1/en not_active Abandoned
- 2008-08-07 EP EP17178215.4A patent/EP3269346A1/en active Pending
- 2008-08-07 JP JP2010520303A patent/JP5632284B2/ja not_active Expired - Fee Related
- 2008-08-07 EP EP13158781.8A patent/EP2604257B1/en active Active
- 2008-08-07 DK DK13158781.8T patent/DK2604257T3/da active
- 2008-08-07 ES ES08797363.2T patent/ES2534433T3/es active Active
- 2008-08-07 ES ES13158781.8T patent/ES2635137T3/es active Active
- 2008-08-07 CA CA2704929A patent/CA2704929C/en active Active
- 2008-08-07 KR KR1020107004908A patent/KR101606944B1/ko active Active
- 2008-08-07 CN CN2008801103489A patent/CN101820838B/zh not_active Expired - Fee Related
- 2008-08-07 EP EP08797363.2A patent/EP2182902B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2182902A4 (en) | 2010-10-13 |
| DK2604257T3 (da) | 2017-08-28 |
| KR20100052516A (ko) | 2010-05-19 |
| CN101820838B (zh) | 2013-06-05 |
| CA2704929A1 (en) | 2009-02-12 |
| US20090048237A1 (en) | 2009-02-19 |
| CN101820838A (zh) | 2010-09-01 |
| EP3269346A1 (en) | 2018-01-17 |
| JP2010535805A (ja) | 2010-11-25 |
| EP2182902B1 (en) | 2015-01-07 |
| EP2604257A1 (en) | 2013-06-19 |
| JP5632284B2 (ja) | 2014-11-26 |
| EP2604257B1 (en) | 2017-06-28 |
| KR101606944B1 (ko) | 2016-03-28 |
| EP2182902A1 (en) | 2010-05-12 |
| WO2009021106A1 (en) | 2009-02-12 |
| CA2704929C (en) | 2018-05-15 |
| ES2635137T3 (es) | 2017-10-02 |
| ES2534433T3 (es) | 2015-04-22 |
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