DK2183268T3 - Fremgangsmåder til rensning af alpha-1-antitrypsin og apolipoprotein A-1 - Google Patents

Fremgangsmåder til rensning af alpha-1-antitrypsin og apolipoprotein A-1

Info

Publication number
DK2183268T3
DK2183268T3 DK08795338.6T DK08795338T DK2183268T3 DK 2183268 T3 DK2183268 T3 DK 2183268T3 DK 08795338 T DK08795338 T DK 08795338T DK 2183268 T3 DK2183268 T3 DK 2183268T3
Authority
DK
Denmark
Prior art keywords
antitrypsin
apolipoprotein
methods
purifying alpha
purifying
Prior art date
Application number
DK08795338.6T
Other languages
English (en)
Inventor
Nathan Brinkman
Douglas Bigler
Vreni Foertsch
Reinhard Bolli
Original Assignee
Csl Behring Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Csl Behring Gmbh filed Critical Csl Behring Gmbh
Application granted granted Critical
Publication of DK2183268T3 publication Critical patent/DK2183268T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK08795338.6T 2007-08-17 2008-08-15 Fremgangsmåder til rensning af alpha-1-antitrypsin og apolipoprotein A-1 DK2183268T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93552707P 2007-08-17 2007-08-17
PCT/US2008/009745 WO2009025754A2 (en) 2007-08-17 2008-08-15 Methods for purification of alpha-1-antitrypsin and apolipoprotein a-i

Publications (1)

Publication Number Publication Date
DK2183268T3 true DK2183268T3 (da) 2013-01-21

Family

ID=39811842

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08795338.6T DK2183268T3 (da) 2007-08-17 2008-08-15 Fremgangsmåder til rensning af alpha-1-antitrypsin og apolipoprotein A-1

Country Status (13)

Country Link
US (3) US8436152B2 (da)
EP (3) EP2183268B1 (da)
JP (1) JP5600061B2 (da)
KR (1) KR101580907B1 (da)
CN (3) CN103408658A (da)
AU (1) AU2008289543B2 (da)
CA (1) CA2694854C (da)
DK (1) DK2183268T3 (da)
ES (1) ES2397280T3 (da)
NZ (3) NZ598395A (da)
PL (1) PL2183268T3 (da)
SG (1) SG183743A1 (da)
WO (1) WO2009025754A2 (da)

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CA2694854C (en) 2007-08-17 2016-09-27 Csl Behring Gmbh Methods for purification of alpha-1-antitrypsin and apolipoprotein a-i
JP2012532919A (ja) * 2009-07-16 2012-12-20 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 治療因子を含むｈｄｌおよび治療における使用
CN102127165B (zh) * 2010-01-15 2013-09-04 上海莱士血液制品股份有限公司 一种从血浆组分四沉淀中制备高纯ApoA-I的生产工艺
ES2617977T3 (es) 2010-06-30 2017-06-20 Csl Limited Una formulación de lipoproteína de alta densidad reconstituida y método de producción de la misma
HUE042314T2 (hu) 2011-02-07 2019-06-28 Cerenis Therapeutics Holding Sa Lipoprotein komplexek és azok gyártása és alkalmazásai
CN102731642B (zh) * 2011-04-14 2014-01-29 上海莱士血液制品股份有限公司 从人血浆组分四沉淀制备高纯Apoa-I的生产工艺
US9353165B2 (en) * 2012-07-25 2016-05-31 Grifols, S.A. Purification of cell culture derived alpha1 protease inhibitor
CN102766205B (zh) * 2012-07-25 2013-10-02 深圳市宝凯仑科技有限公司 一种载脂蛋白b的快速纯化方法
US9534029B2 (en) * 2012-10-03 2017-01-03 Csl Behring Ag Method of purifying proteins
JP6370792B2 (ja) * 2012-10-03 2018-08-08 ツェー・エス・エル・ベーリング・アクチエンゲゼルシャフト タンパク質の精製方法
US9125943B2 (en) 2012-11-02 2015-09-08 Csl Limited Reconstituted HDL formulation
CN113842362A (zh) 2012-11-14 2021-12-28 格雷斯公司 含有生物活性材料与无序无机氧化物的组合物
HK1220210A1 (zh) 2013-06-05 2017-04-28 Csl Limited 制备载脂蛋白a-i (apo a-i)的方法
NZ631126A (en) 2013-08-08 2018-06-29 Csl Ltd Contaminant removal method
EP2853259A1 (en) 2013-09-30 2015-04-01 Université Pierre et Marie Curie (Paris 6) Reconstituted high density lipoproteins composition and uses thereof
CA2947127A1 (en) 2014-05-02 2015-11-19 Cerenis Therapeutics Holding Sa Hdl therapy markers
CN105646699B (zh) * 2016-01-15 2019-04-05 新乡医学院 一种利用气相二氧化硅从人血浆中提取载脂蛋白a-1的方法
EP3490579B1 (en) 2016-07-27 2025-09-10 Hartis-Pharma SA Therapeutic combinations to treat red blood cell disorders
CN107022025A (zh) * 2017-04-17 2017-08-08 深圳职业技术学院 一种纯化α1‑抗胰蛋白酶的方法
CN108239146A (zh) * 2018-03-26 2018-07-03 江苏中新医药有限公司 一种高纯度rhNGF的制备方法
CN108467429A (zh) * 2018-03-26 2018-08-31 江苏中新医药有限公司 疏水层析动态清除重组人神经生长因子前体的方法
CN117209585B (zh) * 2023-11-09 2024-04-05 南京立顶医疗科技有限公司 一种人血清天然脂蛋白(a)的高效提取方法

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EP0067293B1 (en) 1981-05-01 1986-06-25 Medical Research Institute of San Francisco Method for isolating alpha-1-antitrypsin
US4820805A (en) 1983-07-14 1989-04-11 New York Blood Center, Inc. Undenatured virus-free trialkyl phosphate treated biologically active protein derivatives
US4697003A (en) 1985-11-01 1987-09-29 Miles Laboratories, Inc. Method of preparing alpha-1-proteinase inhibitor
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US4876241A (en) 1987-05-22 1989-10-24 Armour Pharmaceutical Company Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants
CA1335077C (en) 1988-02-08 1995-04-04 Henri Isliker Process for the manufacture of apolipoproteins from human blood plasma or serum
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US6284874B1 (en) 1994-06-17 2001-09-04 Alpha Therapeutic Corporation Process for separating α1-proteinase inhibitor from cohn fraction IV1 and IV4 paste
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AT407114B (de) 1997-06-10 2000-12-27 Immuno Ag Alpha 1-antitrypsin-präparation sowie verfahren zu deren herstellung
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US6093804A (en) * 1998-09-24 2000-07-25 American National Red Cross Method for purification of alpha-1 proteinase inhibitor
US6106773A (en) 1998-09-24 2000-08-22 American National Red Cross Pathogen inactivating compositions for disinfecting biological fluids
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US7777006B2 (en) * 2002-12-31 2010-08-17 Csl Behring L.L.C. Method for purification of alpha-1-antitrypsin
PT1664123E (pt) 2003-09-22 2008-07-16 Kamada Ltd Preparação em larga escala de um inibidor da alfa-1 proteinase e sua utilização
RU2346996C2 (ru) 2004-06-29 2009-02-20 ЮРОПИЭН НИКЕЛЬ ПиЭлСи Усовершенствованное выщелачивание основных металлов
BRPI0514435B8 (pt) * 2004-08-20 2021-05-25 American Nat Red Cross isolamento sequêncial de proteínas e esquemas de purificação através de cromatografia por afinidade
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CA2694854C (en) 2007-08-17 2016-09-27 Csl Behring Gmbh Methods for purification of alpha-1-antitrypsin and apolipoprotein a-i

Also Published As

Publication number Publication date
NZ598395A (en) 2013-07-26
US20110087008A1 (en) 2011-04-14
NZ595384A (en) 2012-03-30
US20130289245A1 (en) 2013-10-31
CN101778860A (zh) 2010-07-14
EP2183268B1 (en) 2012-10-10
KR101580907B1 (ko) 2015-12-29
WO2009025754A2 (en) 2009-02-26
CA2694854C (en) 2016-09-27
EP2520583A1 (en) 2012-11-07
CN101778860B (zh) 2013-07-10
CA2694854A1 (en) 2009-02-26
CN103396479A (zh) 2013-11-20
ES2397280T3 (es) 2013-03-06
PL2183268T3 (pl) 2013-03-29
CN103408658A (zh) 2013-11-27
US8962802B2 (en) 2015-02-24
KR20100074134A (ko) 2010-07-01
WO2009025754A3 (en) 2009-04-30
US20140094591A1 (en) 2014-04-03
AU2008289543A1 (en) 2009-02-26
NZ582170A (en) 2012-02-24
SG183743A1 (en) 2012-09-27
US8436152B2 (en) 2013-05-07
AU2008289543B2 (en) 2011-11-03
US8653245B2 (en) 2014-02-18
JP5600061B2 (ja) 2014-10-01
EP2183268A2 (en) 2010-05-12
JP2010536758A (ja) 2010-12-02
EP2522674A1 (en) 2012-11-14

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