DK2200980T3 - Aminoarylsulfonamidforbindelser og deres anvendelse som 5-HT6-ligander - Google Patents
Aminoarylsulfonamidforbindelser og deres anvendelse som 5-HT6-liganderInfo
- Publication number
- DK2200980T3 DK2200980T3 DK08776656.4T DK08776656T DK2200980T3 DK 2200980 T3 DK2200980 T3 DK 2200980T3 DK 08776656 T DK08776656 T DK 08776656T DK 2200980 T3 DK2200980 T3 DK 2200980T3
- Authority
- DK
- Denmark
- Prior art keywords
- compounds
- pharmaceutically acceptable
- disorders
- stereoisomers
- derivatives
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000003446 ligand Substances 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 108091005435 5-HT6 receptors Proteins 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000030814 Eating disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 201000011529 cardiovascular cancer Diseases 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 235000014632 disordered eating Nutrition 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 208000014951 hematologic disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2433CH2007 | 2007-10-26 | ||
| PCT/IN2008/000281 WO2009053997A1 (en) | 2007-10-26 | 2008-05-02 | Amino arylsulfonamide compounds and their use as 5-ht6 ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2200980T3 true DK2200980T3 (da) | 2011-11-21 |
Family
ID=39769531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08776656.4T DK2200980T3 (da) | 2007-10-26 | 2008-05-02 | Aminoarylsulfonamidforbindelser og deres anvendelse som 5-HT6-ligander |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7964627B2 (da) |
| EP (1) | EP2200980B9 (da) |
| JP (1) | JP5236001B2 (da) |
| KR (1) | KR101268654B1 (da) |
| CN (1) | CN101835748B (da) |
| AT (1) | ATE518833T1 (da) |
| AU (1) | AU2008315309B2 (da) |
| BR (1) | BRPI0816571A2 (da) |
| CA (1) | CA2703157C (da) |
| CY (1) | CY1112181T1 (da) |
| DK (1) | DK2200980T3 (da) |
| EA (1) | EA017154B1 (da) |
| ES (1) | ES2370680T3 (da) |
| HR (1) | HRP20110780T2 (da) |
| IL (1) | IL205231A (da) |
| MX (1) | MX2010003765A (da) |
| NZ (1) | NZ585374A (da) |
| SI (1) | SI2200980T1 (da) |
| WO (1) | WO2009053997A1 (da) |
| ZA (1) | ZA201002165B (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102153884B (zh) * | 2011-02-16 | 2013-06-19 | 连云港清泰化工有限公司 | 一种墨水型染料及其制备方法与用途 |
| AU2012321345B2 (en) | 2011-10-03 | 2016-03-17 | The University Of Utah Research Foundation | Application of 5-HT6 receptor antagonists for the alleviation of cognitive deficits of down syndrome |
| US20130202581A1 (en) * | 2012-02-02 | 2013-08-08 | Curelon Llc | Enzyme compositions and use thereof for wound healing |
| CN104725295B (zh) | 2013-12-20 | 2019-05-24 | 广东东阳光药业有限公司 | 芳杂环类衍生物及其在药物上的应用 |
| EA031319B1 (ru) * | 2014-08-16 | 2018-12-28 | Сувен Лайф Сайенсиз Лимитед | Активный метаболит димезилатмоногидрата 1-[(2-бромфенил)сульфонил]-5-метокси-3-[(4-метил-1-пиперазинил)метил]-1h-индола и димезилатдигидратная соль активного метаболита |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DZ2376A1 (fr) | 1996-12-19 | 2002-12-28 | Smithkline Beecham Plc | Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant. |
| IL133870A0 (en) | 1997-07-11 | 2001-04-30 | Smithkline Beecham Plc | Sulphonamide derivatives being 5-ht6 receptor antagonists and process for their preparation |
| DK0930302T3 (da) * | 1998-01-16 | 2003-07-21 | Hoffmann La Roche | Benzosulfonderivater |
| GB9801392D0 (en) | 1998-01-22 | 1998-03-18 | Smithkline Beecham Plc | Novel compounds |
| GB9803411D0 (en) | 1998-02-18 | 1998-04-15 | Smithkline Beecham Plc | Novel compounds |
| EP1173432B9 (en) | 1999-04-21 | 2008-10-15 | NPS Allelix Corp. | Piperidine-indole compounds having 5-ht6 affinity |
| GB9926302D0 (en) | 1999-11-05 | 2000-01-12 | Smithkline Beecham Plc | Novel compounds |
| MXPA03006605A (es) | 2001-01-30 | 2003-09-22 | Lilly Co Eli | Esteres de indol-5-ilo del acido bencensulfonico como antagonistas del receptor 5-ht6. |
| BR0207302A (pt) | 2001-02-08 | 2004-02-10 | Memory Pharm Corp | Trifluorometilpurinas como inibidores da fosfodiesterase 4 |
| RU2294932C2 (ru) | 2001-06-07 | 2007-03-10 | Ф.Хоффманн-Ля Рош Аг | Новые производные индола со сродством к рецептору 5-ht6 |
| EP1472544A2 (en) | 2002-02-01 | 2004-11-03 | Bayer HealthCare AG | Diagnostics and therapeutics for diseases associated with a new human 5-ht6 receptor |
| WO2003066056A1 (en) | 2002-02-05 | 2003-08-14 | Glaxo Group Limited | Method of promoting neuronal growth |
| AR039127A1 (es) | 2002-03-27 | 2005-02-09 | Glaxo Group Ltd | Compuesto de quinolina, procedimiento para su preparacion, composicion farmaceutica que lo comprende y uso del mismo para la fabricacion de un medicamento |
| JP2006505559A (ja) * | 2002-10-18 | 2006-02-16 | エフ．ホフマン−ラ ロシュ アーゲー | ５−ｈｔ６受容体親和性を持つ４−ピペラジニルベンゼンスルホニルインドール |
| ATE401307T1 (de) | 2002-11-28 | 2008-08-15 | Suven Life Sciences Ltd | N-arylsulfonyl-2-substituierte indole mit affinität zum serotonin rezeptor, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen |
| US7507835B2 (en) | 2002-11-28 | 2009-03-24 | Suven Life Sciences Ltd. | N-arylsulfonyl-3-aminoalkoxyindoles |
| WO2004048331A1 (en) | 2002-11-28 | 2004-06-10 | Suven Life Sciences Limited | N-arylalkyl-3-aminoalkoxyindoles and their use as 5-ht ligands |
| JP4571507B2 (ja) * | 2002-12-18 | 2010-10-27 | スベン ライフ サイエンシズ リミティド | セロトニン受容体親和性を有する四環系３−置換インドール |
| US7998981B2 (en) * | 2005-08-12 | 2011-08-16 | Suven Life Sciences Limited | Aminoaryl sulphonamide derivatives as functional 5-HT6 ligands |
-
2008
- 2008-05-02 CA CA2703157A patent/CA2703157C/en not_active Expired - Fee Related
- 2008-05-02 US US12/682,596 patent/US7964627B2/en not_active Expired - Fee Related
- 2008-05-02 JP JP2010530633A patent/JP5236001B2/ja active Active
- 2008-05-02 SI SI200830420T patent/SI2200980T1/sl unknown
- 2008-05-02 WO PCT/IN2008/000281 patent/WO2009053997A1/en not_active Ceased
- 2008-05-02 AU AU2008315309A patent/AU2008315309B2/en not_active Ceased
- 2008-05-02 NZ NZ585374A patent/NZ585374A/en not_active IP Right Cessation
- 2008-05-02 MX MX2010003765A patent/MX2010003765A/es active IP Right Grant
- 2008-05-02 BR BRPI0816571A patent/BRPI0816571A2/pt active Search and Examination
- 2008-05-02 KR KR1020107010395A patent/KR101268654B1/ko not_active Expired - Fee Related
- 2008-05-02 HR HRP20110780TT patent/HRP20110780T2/hr unknown
- 2008-05-02 DK DK08776656.4T patent/DK2200980T3/da active
- 2008-05-02 AT AT08776656T patent/ATE518833T1/de active
- 2008-05-02 EP EP08776656A patent/EP2200980B9/en active Active
- 2008-05-02 CN CN2008801127356A patent/CN101835748B/zh not_active Expired - Fee Related
- 2008-05-02 ES ES08776656T patent/ES2370680T3/es active Active
- 2008-05-02 EA EA201070527A patent/EA017154B1/ru not_active IP Right Cessation
-
2010
- 2010-03-26 ZA ZA2010/02165A patent/ZA201002165B/en unknown
- 2010-04-21 IL IL205231A patent/IL205231A/en active IP Right Grant
-
2011
- 2011-11-03 CY CY20111101058T patent/CY1112181T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101835748B (zh) | 2012-11-14 |
| WO2009053997A1 (en) | 2009-04-30 |
| AU2008315309A1 (en) | 2009-04-30 |
| ES2370680T9 (es) | 2012-02-15 |
| EP2200980B9 (en) | 2011-12-28 |
| JP2011500792A (ja) | 2011-01-06 |
| CN101835748A (zh) | 2010-09-15 |
| KR101268654B1 (ko) | 2013-05-29 |
| KR20100069707A (ko) | 2010-06-24 |
| ES2370680T3 (es) | 2011-12-21 |
| CY1112181T1 (el) | 2015-12-09 |
| JP5236001B2 (ja) | 2013-07-17 |
| CA2703157C (en) | 2013-02-05 |
| CA2703157A1 (en) | 2009-04-30 |
| BRPI0816571A2 (pt) | 2015-12-22 |
| HRP20110780T1 (hr) | 2011-11-30 |
| ZA201002165B (en) | 2011-05-25 |
| EP2200980A1 (en) | 2010-06-30 |
| IL205231A (en) | 2014-03-31 |
| US20100216861A1 (en) | 2010-08-26 |
| SI2200980T1 (sl) | 2011-12-30 |
| EP2200980B1 (en) | 2011-08-03 |
| IL205231A0 (en) | 2010-12-30 |
| HRP20110780T2 (hr) | 2018-06-29 |
| ATE518833T1 (de) | 2011-08-15 |
| MX2010003765A (es) | 2010-04-30 |
| US7964627B2 (en) | 2011-06-21 |
| HK1147750A1 (en) | 2011-08-19 |
| AU2008315309B2 (en) | 2011-06-09 |
| EA017154B1 (ru) | 2012-10-30 |
| EA201070527A1 (ru) | 2010-10-29 |
| NZ585374A (en) | 2011-09-30 |
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