DK2266968T3 - Syntese af UDP-glucose: N-acylsphingosin-glucosyltransferase-hæmmere - Google Patents

Syntese af UDP-glucose: N-acylsphingosin-glucosyltransferase-hæmmere

Info

Publication number: DK2266968T3
Authority: DK; Denmark
Prior art keywords: synthesis; udp; glucose; acylsphingosine; inhibitors
Prior art date: 2001-07-16

Application number

DK10075429.0T

Other languages

English (en)

Inventor

Bradford Hirth

Craig Siegel

Original Assignee

Genzyme Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-16

Filing date

2002-07-16

Publication date

2013-04-08

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23182463&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2266968(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-07-16 Application filed by Genzyme Corp filed Critical Genzyme Corp

2013-04-08 Application granted granted Critical

2013-04-08 Publication of DK2266968T3 publication Critical patent/DK2266968T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Neurology (AREA)
Diabetes (AREA)
Hematology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Hospice & Palliative Care (AREA)
Obesity (AREA)
Psychiatry (AREA)
Gastroenterology & Hepatology (AREA)
Dermatology (AREA)
Ophthalmology & Optometry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Enzymes And Modification Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Cosmetics (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Cephalosporin Compounds (AREA)

DK10075429.0T 2001-07-16 2002-07-16 Syntese af UDP-glucose: N-acylsphingosin-glucosyltransferase-hæmmere DK2266968T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US30581401P	2001-07-16	2001-07-16
EP02750099A EP1409467B1 (en)	2001-07-16	2002-07-16	A n-acylsphingosine glucosyltransferase inhibitor

Publications (1)

Publication Number	Publication Date
DK2266968T3 true DK2266968T3 (da)	2013-04-08

Family

ID=23182463

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK10075429.0T DK2266968T3 (da)	2001-07-16	2002-07-16	Syntese af UDP-glucose: N-acylsphingosin-glucosyltransferase-hæmmere
DK02750099.0T DK1409467T3 (da)	2001-07-16	2002-07-16	N-acylsphingosinglucosyltransferase-inhibitor
DK09003291.3T DK2067775T3 (da)	2001-07-16	2002-07-16	N-acylsphingosinglucosyltransferase-inhibitor

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
DK02750099.0T DK1409467T3 (da)	2001-07-16	2002-07-16	N-acylsphingosinglucosyltransferase-inhibitor
DK09003291.3T DK2067775T3 (da)	2001-07-16	2002-07-16	N-acylsphingosinglucosyltransferase-inhibitor

Country Status (15)

Country	Link
US (11)	US6855830B2 (da)
EP (3)	EP1409467B1 (da)
JP (6)	JP5038582B2 (da)
AT (2)	ATE555102T1 (da)
BE (1)	BE2015C029I2 (da)
BR (3)	BR122015016313B8 (da)
CA (1)	CA2453978C (da)
CY (1)	CY2015028I2 (da)
DK (3)	DK2266968T3 (da)
ES (3)	ES2399323T3 (da)
FR (1)	FR15C0036I2 (da)
IL (3)	IL159905A0 (da)
LU (1)	LU92717I2 (da)
PT (3)	PT2266968E (da)
WO (1)	WO2003008399A1 (da)

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2002
- 2002-07-16 PT PT100754290T patent/PT2266968E/pt unknown
- 2002-07-16 WO PCT/US2002/022659 patent/WO2003008399A1/en not_active Ceased
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- 2002-07-16 AT AT09003291T patent/ATE555102T1/de active
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- 2002-07-16 PT PT09003291T patent/PT2067775E/pt unknown
- 2002-07-16 DK DK10075429.0T patent/DK2266968T3/da active
- 2002-07-16 AT AT02750099T patent/ATE554082T1/de active
- 2002-07-16 US US10/197,227 patent/US6855830B2/en not_active Expired - Lifetime
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- 2002-07-16 DK DK02750099.0T patent/DK1409467T3/da active
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2004
- 2004-01-16 IL IL159905A patent/IL159905A/en active Protection Beyond IP Right Term
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2008
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2012
- 2012-03-14 US US13/420,108 patent/US8779163B2/en not_active Expired - Lifetime
2013
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- 2016-12-30 US US15/395,329 patent/US20170334888A1/en not_active Abandoned
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- 2018-11-21 US US16/198,258 patent/US20190322649A1/en not_active Abandoned
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Also Published As

Publication number	Publication date
ATE554082T1 (de)	2012-05-15
EP2266968A3 (en)	2011-05-18
DK2067775T3 (da)	2012-07-16
CA2453978A1 (en)	2003-01-30
BR122015016314B8 (pt)	2021-05-25
US20050009872A1 (en)	2005-01-13
FR15C0036I1 (da)	2015-06-26
IL159905A (en)	2009-05-04
US8138353B2 (en)	2012-03-20
JP5227348B2 (ja)	2013-07-03
EP2266968A2 (en)	2010-12-29
EP2067775A1 (en)	2009-06-10
US20190322649A1 (en)	2019-10-24
BR122015016313B1 (pt)	2019-04-16
CY2015028I1 (el)	2016-07-27
US20080058514A1 (en)	2008-03-06
BRPI0211379B8 (pt)	2021-05-25
ATE555102T1 (de)	2012-05-15
US8779163B2 (en)	2014-07-15
JP4708073B2 (ja)	2011-06-22
EP1409467A1 (en)	2004-04-21
EP2266968B1 (en)	2013-01-09
JP2013136618A (ja)	2013-07-11
JP2015180656A (ja)	2015-10-15
US20120296088A1 (en)	2012-11-22
ES2399323T3 (es)	2013-03-27
JP5038582B2 (ja)	2012-10-03
CA2453978C (en)	2011-10-11
LU92717I2 (fr)	2015-11-24
PT2266968E (pt)	2013-02-25
US20150148534A1 (en)	2015-05-28
US20210171507A1 (en)	2021-06-10
US7196205B2 (en)	2007-03-27
ES2395463T3 (es)	2013-02-15
BR0211379A (pt)	2004-08-17
US9546161B2 (en)	2017-01-17
PT2067775E (pt)	2012-07-16
US7763738B2 (en)	2010-07-27
BE2015C029I2 (da)	2021-07-19
JP2005502635A (ja)	2005-01-27
BR122015016314B1 (pt)	2019-04-16
EP1409467B1 (en)	2012-04-18
US6855830B2 (en)	2005-02-15
JP2017075151A (ja)	2017-04-20
CY2015028I2 (el)	2016-07-27
ES2395122T3 (es)	2013-02-08
WO2003008399A1 (en)	2003-01-30
FR15C0036I2 (fr)	2016-05-27
US20050222244A1 (en)	2005-10-06
US20030050299A1 (en)	2003-03-13
US20070203223A1 (en)	2007-08-30
EP2067775B1 (en)	2012-04-25
US20110003987A1 (en)	2011-01-06
BR122015016313B8 (pt)	2021-05-25
IL193244A0 (en)	2009-02-11
JP6182254B2 (ja)	2017-08-16
DK1409467T3 (da)	2012-07-16
PT1409467E (pt)	2012-10-24
BRPI0211379B1 (pt)	2018-02-14
US20170334888A1 (en)	2017-11-23
HK1132267A1 (en)	2010-02-19
ES2395463T4 (es)	2013-02-12
HK1153733A1 (en)	2012-04-05
JP2005255686A (ja)	2005-09-22
US7265228B2 (en)	2007-09-04
JP2010095546A (ja)	2010-04-30
US7615573B2 (en)	2009-11-10
IL159905A0 (en)	2004-06-20

Publication	Publication Date	Title
DK1409467T3 (da)	2012-07-16	N-acylsphingosinglucosyltransferase-inhibitor
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DK1289972T3 (da)	2005-01-17	Serinproteaseinhibitorer
NO20033766L (no)	2000-02-09	4-Fenylpiperidinforbindelser
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AU2002348261A1 (en)	2003-06-10	Diastereoselective synthesis of udp-glucose : n-acylsphingosine glucosyltransferase inhibitors
IT1292377B1 (it)	1999-02-08	Composizioni farmaceutiche a base di prostaglandine
DK1385518T3 (da)	2008-10-27	Benzimidazolon-forbindelser
EE9900446A (et)	2000-04-17	Bensoksasinoonide asümmeetriline sünteesimine uute vaheühendite kaudu
DE60014043D1 (de)	2004-10-28	Flouride von 4-substituierten piperidin-derivaten
DK1209151T3 (da)	2007-08-20	4-substituerede piperidinderivativer
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HRP20030653B1 (en)	2012-06-30	Novel benzoylguanidine salt
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CY1113586T1 (el)	2016-06-22	Ενας αναστολεας ν-ακυλοσφιγγοσινο γλυκοζυλοτρανσφερασης
DK0949250T3 (da)	2006-08-28	Fremgangsmåde til fremstilling af alpha1L-adrenoceptorantagonister
NO20042160L (no)	2004-08-17	Inhibitorer av 11-betahydroksysteroid dehydrogenase type 1