DK226882A - Cholsyre-trimebutyn-forbindelser og fremgangsmaade til fremstilling deraf - Google Patents

Cholsyre-trimebutyn-forbindelser og fremgangsmaade til fremstilling deraf Download PDF

Info

Publication number: DK226882A
Authority: DK; Denmark
Prior art keywords: trimmbutyn; procedures; compounds; producing; cholic acid
Prior art date: 1981-05-21

Application number

DK226882A

Other languages

English (en)

Other versions

DK159456B (da

DK159456C (da

Inventor

A Bonaldi

E Molinari

V Springolo

Original Assignee

Erregierre Ind Chim

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-05-21

Filing date

1982-05-19

Publication date

1982-11-22

1982-05-19 Application filed by Erregierre Ind Chim filed Critical Erregierre Ind Chim

1982-11-22 Publication of DK226882A publication Critical patent/DK226882A/da

1990-10-15 Publication of DK159456B publication Critical patent/DK159456B/da

1991-03-18 Application granted granted Critical

1991-03-18 Publication of DK159456C publication Critical patent/DK159456C/da

Links

235000019416 cholic acid Nutrition 0.000 title abstract 2
BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 title 1
239000004380 Cholic acid Substances 0.000 title 1
BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 title 1
229960002471 cholic acid Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 title 1
238000000034 method Methods 0.000 title 1
RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 abstract 1
239000002812 cholic acid derivative Substances 0.000 abstract 1
150000001842 cholic acids Chemical class 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000000968 intestinal effect Effects 0.000 abstract 1
230000032297 kinesis Effects 0.000 abstract 1
238000010606 normalization Methods 0.000 abstract 1
230000000079 pharmacotherapeutic effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 abstract 1
229960001661 ursodiol Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK226882A 1981-05-21 1982-05-19 Analogifremgangsmaade til fremstilling af salte af cholsyrer, specielt chenodeoxycholsyre eller ursodeoxycholsyre, med 3,4,5-trimethoxybenzoesyreesteren af 2-phenyl-2-dimethylaminobutanol DK159456C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2186781		1981-05-21
IT21867/81A IT1136624B (it)	1981-05-21	1981-05-21	Prodotti di salificazione di acidi colici,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo

Publications (3)

Publication Number	Publication Date
DK226882A true DK226882A (da)	1982-11-22
DK159456B DK159456B (da)	1990-10-15
DK159456C DK159456C (da)	1991-03-18

Family

ID=11187975

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK226882A DK159456C (da)	1981-05-21	1982-05-19	Analogifremgangsmaade til fremstilling af salte af cholsyrer, specielt chenodeoxycholsyre eller ursodeoxycholsyre, med 3,4,5-trimethoxybenzoesyreesteren af 2-phenyl-2-dimethylaminobutanol

Country Status (13)

Country	Link
US (1)	US4404199A (da)
EP (1)	EP0065666B1 (da)
JP (1)	JPS57203098A (da)
AT (1)	ATE11528T1 (da)
CA (1)	CA1194469A (da)
DE (1)	DE3262109D1 (da)
DK (1)	DK159456C (da)
ES (1)	ES8302735A1 (da)
IE (1)	IE52917B1 (da)
IT (1)	IT1136624B (da)
NO (1)	NO158423C (da)
PT (1)	PT74864B (da)
YU (1)	YU43516B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1152801B (it) *	1982-08-17	1987-01-14	Proter Spa	Composti steroidei ad attivita' coleretica, processo per la loro preparazione e composizioni terapeutiche che li contengono come principio attivo
US5753269A (en) *	1995-12-27	1998-05-19	Bayer Corporation	Otic microbial combinations
IL139241A0 (en)	1998-05-13	2001-11-25	Novo Nordisk As	Meiosis regulating compounds
US20020119921A1 (en) *	1999-03-31	2002-08-29	Michael Streit	Thrombospondin-2 and uses thereof
AU2001231196A1 (en) *	2000-01-27	2001-08-07	The General Hospital Corporation	Delivery of therapeutic biological from implantable tissue matrices
CA3194562C (en)	2014-07-29	2026-03-17	Shenzhen Hightide Biopharmaceutical, Ltd.	Berberine-ursodeoxycholic salt, method of preparation and application therof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2369M (fr) *	1962-10-17	1964-03-02	Jouveinal Lab	Nouveau médicament contre les troubles du systeme nerveux central.
GB1532413A (en) *	1974-12-23	1978-11-15	Union International Co Ltd	Chenodeoxycholic acid
GB1431709A (en) *	1973-12-03	1976-04-14	Prodotti Antibiotici Spa	Lysozyme derivatives
FR2358144A1 (fr) *	1976-07-13	1978-02-10	Lipha	Nouvelle composition medicamenteuse pour le traitement de la lithiase biliaire
US4186143A (en) *	1977-06-20	1980-01-29	Canada Packers Limited	Chenodeoxycholic acid recovery process
JPS5529075A (en) *	1978-08-24	1980-03-01	Suzuki Motor Co Ltd	Crank room oil recoverer for 2-cycle engine
US4241047A (en) *	1979-07-18	1980-12-23	Lipha, Lyonnaise Industrielle Pharmaceutique	Novel medicinal composition for the treatment of biliary lithiasis

1981
- 1981-05-21 IT IT21867/81A patent/IT1136624B/it active
1982
- 1982-04-30 AT AT82103701T patent/ATE11528T1/de not_active IP Right Cessation
- 1982-04-30 EP EP82103701A patent/EP0065666B1/en not_active Expired
- 1982-04-30 DE DE8282103701T patent/DE3262109D1/de not_active Expired
- 1982-05-03 US US06/374,243 patent/US4404199A/en not_active Expired - Fee Related
- 1982-05-04 IE IE1056/82A patent/IE52917B1/en not_active IP Right Cessation
- 1982-05-05 CA CA000402296A patent/CA1194469A/en not_active Expired
- 1982-05-10 PT PT74864A patent/PT74864B/pt unknown
- 1982-05-19 DK DK226882A patent/DK159456C/da not_active IP Right Cessation
- 1982-05-19 YU YU1065/82A patent/YU43516B/xx unknown
- 1982-05-19 NO NO821672A patent/NO158423C/no unknown
- 1982-05-20 ES ES512391A patent/ES8302735A1/es not_active Expired
- 1982-05-21 JP JP57085079A patent/JPS57203098A/ja active Granted

Also Published As

Publication number	Publication date
YU43516B (en)	1989-08-31
EP0065666A1 (en)	1982-12-01
NO158423B (no)	1988-05-30
IE52917B1 (en)	1988-04-13
US4404199A (en)	1983-09-13
PT74864B (fr)	1983-12-07
YU106582A (en)	1984-10-31
ATE11528T1 (de)	1985-02-15
DK159456B (da)	1990-10-15
PT74864A (fr)	1982-06-01
JPS57203098A (en)	1982-12-13
NO158423C (no)	1988-09-14
DE3262109D1 (en)	1985-03-14
IE821056L (en)	1982-11-21
IT1136624B (it)	1986-09-03
CA1194469A (en)	1985-10-01
ES512391A0 (es)	1983-02-01
IT8121867A0 (it)	1981-05-21
JPS6312478B2 (da)	1988-03-18
NO821672L (no)	1982-11-22
EP0065666B1 (en)	1985-01-30
DK159456C (da)	1991-03-18
ES8302735A1 (es)	1983-02-01

Similar Documents

Publication	Publication Date	Title
DE3781730D1 (de)	1992-10-22	1-hydroxy-3-(n-methyl-n-propylamino)propan-1,1-diphosphonsaeure verfahren zu dessen herstellung und diese verbindung enthaltende arzneimittel.
ZA884919B (en)	1989-01-18	3-demethylmevalonic acid derivatives,a process for their preparation,pharmaceutical products based on these compounds,their use and intermediates
HUT50842A (en)	1990-03-28	Process for producing new diphosphonic acid derivatives and pharmaceutical compositions comprising same
DK346783A (da)	1984-01-30	Triphenylimidazolyloxyalkansyrer og derivater deraf, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende disse forbindelser
DE3751533D1 (de)	1995-10-26	Verfahren zur Herstellung von fluoroskopischen und radiographischen Röntgenbildern und ein nach diesem Verfahren arbeitender, tragbarer Diagnostikapparat.
EP0100899A3 (en)	1985-07-17	Benzisoselenazolones, process for their preparation and pharmaceutical compositions containing them
DE3873870D1 (de)	1992-09-24	Androstan-17-carbonsaeureester, verfahren zu ihrer herstellung und arzneimittel, die sie enthalten.
CS138384A1 (en)	1989-07-12	Pharmaceutical agents for asthma treatment and method of effective substance production
NO821672L (no)	1982-11-22	Fremgangsmaate for fremstilling av salter av cholinsyrer
DK218189A (da)	1989-07-03	Fumarsyrekonjugat og farmaceutisk praeparat indeholdende en saadan forbindelse
PT76196A (fr)	1983-03-01	Procede de preparation de derives d'imidazolidine et de compositions pharmaceutiques les contenant
DE3277971D1 (en)	1988-02-18	Acylamino-4-aza-1-adamantanes, process for their preparation and their therapeutic use
PT74744B (fr)	1985-01-08	Procede de preparation de derives de phenethanolamine et de compositions pharmaceutiques les contenant
ATE31022T1 (de)	1987-12-15	Verwendung von 4,5'-azo-bis-salicylsaeure zur herstellung eines arzneimittels zur behandlung entzuendlicher darmkrankheiten.
FR2552766B1 (fr)	1987-06-26	Nouveau procede de preparation de derives de la serie du 17 a-hydroxy 19-nor progesterone
YU182178A (en)	1983-02-28	Process for obtaining dibenzo(d.g.)(1,3,6)dioxazocine derivatives and acid addition salts thereof
ATE40687T1 (de)	1989-02-15	Neue pyridinderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate.
ATE13676T1 (de)	1985-06-15	Delta-1,3,5-3-chlor-11-beta,16-alpha,17-alpha,2 - tetra-(hydroxy)-pregnan-20-on-16,17acetonidderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.
ATE10635T1 (de)	1984-12-15	Alpha-substituierte ureid obenzylpenizillansaeurederivate und verfahren zu ihrer herstellung.
ATE121724T1 (de)	1995-05-15	Neue salze der 2-(2,6-dichloranilino)- phenylessigsäure, verfahren zu ihrer herstellung und ihre verwendung für topisch anwendbare pharmazeutische zubereitungen.
FR2407940A1 (fr)	1979-06-01	Nouveaux derives steroides 17 a-aryle, ou 17 a-heteroaryle, leur procede de preparation et leur application comme medicament
SU549460A1 (ru)	1977-03-05	Способ получени сернокислого эфира 1-амино-3-гидразинопропанола-2
PT80144B (de)	1987-01-16	N-bicycloheptyl- und n-bicycloheptenil-imidazole verfahren zu ihrer herstellung ihre verwendung sowie pharmazeutische praeparate
PT79897A (en)	1985-02-01	L-n-n-propylpipecolic acid-2,6-xylidide and method for preparing the same
DE3461926D1 (en)	1987-02-12	Cycloaliphatic aminosulphonic-acid derivatives, process for their production and pharmaceutical preparations for combating heart and vascular diseases

Legal Events

Date	Code	Title	Description
1994-01-24	PBP	Patent lapsed