DK2274419T3 - Fremgangsmåder til fremstilling af hårmikrofollikler og de novopapiller og anvendelse heraf til in vitro-test og in vivo-implantationer - Google Patents

Fremgangsmåder til fremstilling af hårmikrofollikler og de novopapiller og anvendelse heraf til in vitro-test og in vivo-implantationer

Info

Publication number: DK2274419T3
Authority: DK; Denmark
Prior art keywords: novo papillae; preparation; methods; vitro testing; hair microfollicles
Prior art date: 2008-03-28

Application number

DK09724502.1T

Other languages

English (en)

Inventor

Roland Lauster

Gerd Lindner

Original Assignee

Univ Berlin Tech

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-03-28

Filing date

2009-03-23

Publication date

2012-07-23

2009-03-23 Application filed by Univ Berlin Tech filed Critical Univ Berlin Tech

2012-07-23 Application granted granted Critical

2012-07-23 Publication of DK2274419T3 publication Critical patent/DK2274419T3/da

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/60—Materials for use in artificial skin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
- A61L27/3869—Epithelial tissues other than skin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
- C12N5/0627—Hair cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
- C12N5/0698—Skin equivalents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/18—Materials or treatment for tissue regeneration for hair reconstruction
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
- C12N2502/092—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells hair cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
- C12N2502/094—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells keratinocytes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1323—Adult fibroblasts
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/52—Fibronectin; Laminin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/54—Collagen; Gelatin

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Dermatology (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Oral & Maxillofacial Surgery (AREA)
Epidemiology (AREA)
Transplantation (AREA)
Cell Biology (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Botany (AREA)
Urology & Nephrology (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Vascular Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Materials For Medical Uses (AREA)
Investigating Or Analysing Biological Materials (AREA)
Compounds Of Unknown Constitution (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Steroid Compounds (AREA)

DK09724502.1T 2008-03-28 2009-03-23 Fremgangsmåder til fremstilling af hårmikrofollikler og de novopapiller og anvendelse heraf til in vitro-test og in vivo-implantationer DK2274419T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP08153596A EP2105499A1 (en)	2008-03-28	2008-03-28	Methods for producing de novo papillae and hair microfollicles and their use for in vitro tests and in vivo implantations
PCT/EP2009/053363 WO2009118283A1 (en)	2008-03-28	2009-03-23	Methods for producing hair microfollicles and de novo papillae and their use for in vitro tests and in vivo implantations

Publications (1)

Publication Number	Publication Date
DK2274419T3 true DK2274419T3 (da)	2012-07-23

Family

ID=39734907

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK09724502.1T DK2274419T3 (da)	2008-03-28	2009-03-23	Fremgangsmåder til fremstilling af hårmikrofollikler og de novopapiller og anvendelse heraf til in vitro-test og in vivo-implantationer

Country Status (17)

Country	Link
US (2)	US8841124B2 (da)
EP (3)	EP2105499A1 (da)
JP (1)	JP5600671B2 (da)
CN (1)	CN102027106B (da)
AT (1)	ATE555192T1 (da)
AU (1)	AU2009228756B2 (da)
CA (1)	CA2719769C (da)
CY (1)	CY1112945T1 (da)
DK (1)	DK2274419T3 (da)
ES (2)	ES2386109T3 (da)
HR (1)	HRP20120591T1 (da)
HU (1)	HUE026065T2 (da)
PL (2)	PL2274419T3 (da)
PT (2)	PT2447357E (da)
RU (1)	RU2507254C2 (da)
SI (1)	SI2274419T1 (da)
WO (1)	WO2009118283A1 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2483622A (en) *	2009-08-03	2012-03-21	Univ Durham	Fibroblast feeder cells
ES2727041T3 (es)	2011-02-24	2019-10-11	Organ Technologies Inc	Método de preparación de germen de folículo piloso regenerado para trasplante en el que se controla el color del pelo
JP2012205516A (ja) *	2011-03-29	2012-10-25	Osaka Univ	人工皮膚モデルの製造方法、及び人工皮膚モデル
JP6469655B2 (ja) *	2013-05-03	2019-02-13	ザヘンリーエム．ジャクソンファウンデーションフォーザアドヴァンスメントオブミリタリーメディシンインコーポレイテッド	代用皮膚および毛包新生の方法
FR3008316B1 (fr) *	2013-07-09	2020-01-31	Assistance Publique - Hopitaux De Paris	Utilisation de fibroblastes gingivaux dans le traitement de l'alopecie
WO2015066618A1 (en) *	2013-11-01	2015-05-07	The Florida International University Board Of Trustees	Context based algorithmic framework for identifying and classifying embedded images of follicle units
JP6780638B2 (ja) *	2015-03-30	2020-11-04	味の素株式会社	ヒト血清アルブミンを含む神経幹細胞増殖培地
FR3041656A1 (fr)	2015-09-29	2017-03-31	Oreal	Utilisation des cellules de la matrice pour la preparation d'un microfollicule pileux
DE102015119877B4 (de)	2015-11-17	2017-09-21	Technische Universität Berlin	Verfahren zur Herstellung eines Hautäquivalents sowie dessen Verwendung für in vitro Tests und in vivo Transplantate
DE102015119880B4 (de) *	2015-11-17	2018-05-24	Technische Universität Berlin	Verfahren zur Herstellung von Haarfollikeln und de novo Papillen sowie deren Verwendung für in vitro Tests und in vivo Implantate
CN105353114B (zh) *	2015-11-18	2017-09-26	广东博溪生物科技有限公司	一种含黑色素的体外测试皮肤模型及其制备方法
FR3054449B1 (fr) *	2016-07-29	2018-08-31	L'oreal	Equivalent de peau a compartiments dermiques juxtaposes distincts
FR3061207B1 (fr) *	2016-12-23	2023-03-10	Oreal	Utilisation des cellules germinales pour la preparation d’un microfollicule pileux
JP2018186719A (ja) *	2017-04-28	2018-11-29	株式会社バイオミメティクスシンパシーズ	頭皮投与用幹細胞
FR3072972B1 (fr) *	2017-10-30	2023-03-10	Oreal	Procede de preparation in vitro d’equivalents de papille dermique et de follicule pileux
GB201816902D0 (en) *	2018-10-17	2018-11-28	Hairclone Ltd	Hair Rejuvenation
JP7702229B2 (ja) *	2018-11-19	2025-07-03	株式会社資生堂	毛包を有するヒト皮膚組織を再構成するための組成物、ヒト皮膚組織モデル動物およびその製造方法
CN109468271A (zh) *	2018-12-28	2019-03-15	广州暨大美塑生物科技有限公司	一种皮肤组织来源成纤维细胞快速分离培养方法
US20220228113A1 (en) *	2019-05-07	2022-07-21	National University Corporation Yokohama National University	Hair Follicle Primordia and Method for Producing Same
CN114085804B (zh) *	2021-11-09	2023-12-26	南方医科大学皮肤病医院（广东省皮肤病医院、广东省皮肤性病防治中心、中国麻风防治研究中心）	一种人胚胎干细胞体外诱导分化形成的皮肤类器官及其高效培养方法与用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10162814B4 (de)	2001-12-19	2005-06-23	Henkel Kgaa	Rekonstruiertes Haarfollikelmodell
DE10327879A1 (de) *	2003-06-18	2005-01-05	Henkel Kgaa	Rekonstruierte dermale Papille
US20050233450A1 (en) *	2004-01-12	2005-10-20	Goetinck Paul F	Methods of inducing hair growth
EP1718732B1 (en)	2004-01-27	2013-10-30	The Hospital for Sick Children Research Institute	Methods of making and using skin-derived stem cells
EP1747264B1 (de)	2004-05-21	2012-09-12	Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.	Multizelluläre gewebe- und organkultursysteme

2008
- 2008-03-28 EP EP08153596A patent/EP2105499A1/en not_active Withdrawn
2009
- 2009-03-23 US US12/935,172 patent/US8841124B2/en active Active
- 2009-03-23 SI SI200930296T patent/SI2274419T1/sl unknown
- 2009-03-23 PL PL09724502T patent/PL2274419T3/pl unknown
- 2009-03-23 HU HUE12150985A patent/HUE026065T2/en unknown
- 2009-03-23 PL PL12150985T patent/PL2447357T3/pl unknown
- 2009-03-23 PT PT121509855T patent/PT2447357E/pt unknown
- 2009-03-23 EP EP09724502A patent/EP2274419B1/en active Active
- 2009-03-23 ES ES09724502T patent/ES2386109T3/es active Active
- 2009-03-23 EP EP12150985.5A patent/EP2447357B1/en active Active
- 2009-03-23 RU RU2010144183/10A patent/RU2507254C2/ru active
- 2009-03-23 WO PCT/EP2009/053363 patent/WO2009118283A1/en not_active Ceased
- 2009-03-23 JP JP2011501184A patent/JP5600671B2/ja active Active
- 2009-03-23 PT PT09724502T patent/PT2274419E/pt unknown
- 2009-03-23 HR HRP20120591AT patent/HRP20120591T1/hr unknown
- 2009-03-23 CA CA2719769A patent/CA2719769C/en not_active Expired - Fee Related
- 2009-03-23 AU AU2009228756A patent/AU2009228756B2/en not_active Ceased
- 2009-03-23 CN CN200980116851.XA patent/CN102027106B/zh active Active
- 2009-03-23 AT AT09724502T patent/ATE555192T1/de active
- 2009-03-23 ES ES12150985.5T patent/ES2549055T3/es active Active
- 2009-03-23 DK DK09724502.1T patent/DK2274419T3/da active
2012
- 2012-07-24 CY CY20121100655T patent/CY1112945T1/el unknown
2014
- 2014-08-26 US US14/468,494 patent/US9764064B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP5600671B2 (ja)	2014-10-01
CA2719769C (en)	2018-05-01
ATE555192T1 (de)	2012-05-15
PT2447357E (pt)	2015-10-23
JP2011515095A (ja)	2011-05-19
US9764064B2 (en)	2017-09-19
ES2386109T3 (es)	2012-08-09
HRP20120591T1 (hr)	2012-08-31
AU2009228756A1 (en)	2009-10-01
HUE026065T2 (en)	2016-05-30
SI2274419T1 (sl)	2012-10-30
WO2009118283A1 (en)	2009-10-01
EP2274419A1 (en)	2011-01-19
US20110086079A1 (en)	2011-04-14
PL2447357T3 (pl)	2015-12-31
RU2010144183A (ru)	2012-05-10
CN102027106B (zh)	2014-05-14
PT2274419E (pt)	2012-07-06
CA2719769A1 (en)	2009-10-01
EP2105499A1 (en)	2009-09-30
EP2274419B1 (en)	2012-04-25
HK1156976A1 (en)	2012-06-22
AU2009228756B2 (en)	2014-07-24
EP2447357A1 (en)	2012-05-02
CN102027106A (zh)	2011-04-20
RU2507254C2 (ru)	2014-02-20
CY1112945T1 (el)	2016-04-13
ES2549055T3 (es)	2015-10-22
US8841124B2 (en)	2014-09-23
EP2447357B1 (en)	2015-07-01
US20140370070A1 (en)	2014-12-18
PL2274419T3 (pl)	2012-10-31

Publication	Publication Date	Title
PL2447357T3 (pl)	2015-12-31	Sposoby wytwarzania mikromieszków włosowych i brodawek de novo i stosowanie ich w badaniach in vitro i przeszczepach in vivo
MX2009013706A (es)	2010-07-02	Celulas multipotentes/pluripotentes y metodos relacionados.
WO2007109223A3 (en)	2007-11-08	Cell co-culture for hair follicle production
WO2006050330A3 (en)	2006-08-24	Platelets from stem cells
NZ569543A (en)	2012-12-21	Means and methods for influencing the stability of antibody producing cells
MX340952B (es)	2016-07-29	Diferenciacion de celulas madre embrionarias humanas.
WO2010042669A3 (en)	2010-07-01	Co-culture compositions and methods
WO2009114702A3 (en)	2010-02-25	Recombinant production of authentic human proteins using human cell expression systems
BR112012021267A2 (pt)	2015-09-22	métodos para a preparação de melanócitos a partir de células tronco humanas pluripotentes.
IL218447A0 (en)	2012-04-30	Co-culture lymphoid tissue equivalent (lte) for an artificial immune system (ais)
MY146352A (en)	2012-08-15	Adipose derived adult stem cells in hepatic regeneration
ATE470702T1 (de)	2010-06-15	Verfahren zur herstellung von permanenten humanen zelllinien
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