DK2363488T3 - Postweaning multisystemisk wasting syndrom-virus fra grise - Google Patents

Postweaning multisystemisk wasting syndrom-virus fra grise Download PDF

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DK2363488T3
DK2363488T3 DK10012196.1T DK10012196T DK2363488T3 DK 2363488 T3 DK2363488 T3 DK 2363488T3 DK 10012196 T DK10012196 T DK 10012196T DK 2363488 T3 DK2363488 T3 DK 2363488T3
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pcvii
polypeptide
leu
arg
pro
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DK10012196.1T
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Li Wang
Lorne A Babiuk
Andrew A Potter
Philipp Willson
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Merial Sas
Univ Belfast
Univ Saskatchewan
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Application filed by Merial Sas, Univ Belfast, Univ Saskatchewan filed Critical Merial Sas
Priority claimed from EP07008633.5A external-priority patent/EP1816200B1/en
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Publication of DK2363488T3 publication Critical patent/DK2363488T3/da

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    • A—HUMAN NECESSITIES
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Claims (13)

1. Isoleret immunogenisk porcin circovirus Type II (PCVII)-polypeptid omfattende: (a) MPSKKNGRSG PQPHKRWVFT LNNPSEDERK KIRELPISLF DYFIVGEEGN EEGRTPHLQG FANFVKKQTF NKVKWYLGAR CHIEKAKGTD QQNKEYCSKE GNLLIECGAP RSQGQRSDLS TAVSTLLESG ILVTVAKQHP VTFVKNFRGL AELLKVSGKM QKRDWKTNVH FIVGPPGCGK SKWAANFANP ETTYWKPPKN KWWDGYHGEK VVVIDDFYGW LPWDDLLRLC DRYPLTVKTK GGTVPFLARS ILITSNQTPL EWYSSTAVPA VEALYRRITS LVFWKNATKQ STEEGGQFVT LSPPCPEFPY EINY (ORF1); eller (b) polypeptid afledt fra ORF1 med mindst 98% identitet med den fulde længde af ORF1; eller (c) polypeptid afledt fra ORF1 med mindst 90% identitet med den fulde længde af ORF1; hvor polypeptidet ikke er MPSKKNGRSGPQPHKRWVFTLNNPSEDERKKIRDLPISLFDYFIVGEEGNEEGRTPHLQG FANFVKKQTFNKVKWYLGARCHIEKAKGTDQQNKEYCSKEGNLLMECGAPRSQGQRSDLS TAVSTLLESGSLVTVAEQHPVTFVRNFRGLAELLKVSGKMQKRDWKTNVHVIVGPPGCGK SKWAANFADPETTYWKPPRNKWWDGYHGEEVWIDDFYGWLPWDDLLRLCDRYPLTVETK GGTVPFLARSILITSNQTPLEWYSSTAVPAVEALYRRITSLVFWKNATEQSTEEGGQFVT LSPPCPEFPYEINY, eller MPSKKNGRSGPQPHKRWVFTLNNPSEDERKKIRELPISLFDYFIVGEEGXEEXRTPHLQG FANFVKKQTFNKVKWYLGARCHIEKAKGTDQQNKEYCSKEGNLLIECGAPRSQGQRSDLS TAVSTLLESGSLVTVAEQHPVTFVRNFRGLAELLKVSGKMQKRDWKTNVHVIVGPPGCGK SKWAANFADPETTYWKPPRNKWWDGYHGEEVWIDDFYGWLPWDDLLRLCDRYPLTVETK GGTVXXXARSILITSNQTPLEWYSSTAVPAVEALYRRITSLVFWKNATEQSTEEGGQXVT LSPPCPEFPYEINY; eller (d) fusionsprotein omfattende et hvilket som helst af (a) til (c).
2. Isoleret polypeptid ifølge krav 1, hvor polypeptidet er genereret ved kemisk syntese.
3. Isoleret polypeptid ifølge et hvilket som helst af kravene 1 til 2, hvor polypeptidet er genereret ved rekombinant produktion.
4. Isoleret polypeptid ifølge krav 3, hvor polypeptidet udtrykkes under anvendelse af baculovirus.
5. Rekombinant vektor omfattende et polynukleotid der koder for et immunogent PCVII-polypeptid som beskrevet i et hvilket som helst af kravene 1 til 4.
6. Rekombinant vektor ifølge krav 5, hvor den rekombinante vektor omfatter et polynukleotid der koder for det immunogene polypeptid MPSKKNGRSG PQPHKRWVFT LNNPSEDERK KIRELPISLF DYFIVGEEGN EEGRTPHLQG FANFVKKQTF NKVKWYLGAR CHIEKAKGTD QQNKEYCSKE GNLLIECGAP RSQGQRSDLS TAVSTLLESG ILVTVAKQHP VTFVKNFRGL AELLKVSGKM QKRDWKTNVH FIVGPPGCGK SKWAANFANP ETTYWKPPKN KWWDGYHGEK VVVIDDFYGW LPWDDLLRLC DRYPLTVKTK GGTVPFLARS ILITSNQTPL EWYSSTAVPA VEALYRRITS LVFWKNATKQ STEEGGQFVT LSPPCPEFPY EINY (ORF1).
7. Rekombinant værtscelle transformeret med vektoren ifølge krav 5 eller 6.
8. Rekombinant værtscelle ifølge krav 7, hvor den rekombinante værtscelle er en pattedyrcelle.
9. Rekombinant værtscelle ifølge krav 7, hvor den rekombinante værtscelle er en bakteriecelle.
10. Rekombinant værtscelle ifølge krav 7, hvor den rekombinante værtscelle er en gærcelle.
11. Rekombinant værtscelle ifølge krav 7, hvor den rekombinante værtscelle er en insektcelle.
12. Sammensætning omfattende et immunogent PCVII-polypeptid og en farmaceutisk eller veterinært acceptabel vehikel; hvor det immunogene PCVII-polypeptid omfatter: (a) MPSKKNGRSG PQPHKRWVFT LNNPSEDERK KIRELPISLF DYFIVGEEGN EEGRTPHLQG FANFVKKQTF NKVKWYLGAR CHIEKAKGTD QQNKEYCSKE GNLLIECGAP RSQGQRSDLS TAVSTLLESG ILVTVAKQHP VTFVKNFRGL AELLKVSGKM QKRDWKTNVH FIVGPPGCGK SKWAANFANP ETTYWKPPKN KWWDGYHGEK VVVIDDFYGW LPWDDLLRLC DRYPLTVKTK GGTVPFLARS ILITSNQTPL EWYSSTAVPA VEALYRRITS LVFWKNATKQ STEEGGQFVT LSPPCPEFPY EINY (ORF1); eller (b) polypeptid afledt fra ORF1 med mindst 98% identitet med den fulde længde af ORF1; eller (c) polypeptid afledt fra ORF1 med mindst 90% identitet med den fulde længde af ORF1; hvor polypeptidet ikke er MPSKKNGRSGPQPHKRWVFTLNNPSEDERKKIRDLPISLFDYFIVGEEGNEEGRTPHLQG FANFVKKQTFNKVKWYLGARCHIEKAKGTDQQNKEYCSKEGNLLMECGAPRSQGQRSDLS TAVSTLLESGSLVTVAEQHPVTFVRNFRGLAELLKVSGKMQKRDWKTNVHVIVGPPGCGK SKWAANFADPETTYWKPPRNKWWDGYHGEEVWIDDFYGWLPWDDLLRLCDRYPLTVETK GGTVPFLARSILITSNQTPLEWYSSTAVPAVEALYRRITSLVFWKNATEQSTEEGGQFVT LSPPCPEFPYEINY, eller MPSKKNGRSGPQPHKRWVFTLNNPSEDERKKIRELPISLFDYFIVGEEGXEEXRTPHLQG FANFVKKQTFNKVKWYLGARCHIEKAKGTDQQNKEYCSKEGNLLIECGAPRSQGQRSDLS TAVSTLLESGSLVTVAEQHPVTFVRNFRGLAELLKVSGKMQKRDWKTNVHVIVGPPGCGK SKWAANFADPETTYWKPPRNKWWDGYHGEEWVIDDFYGWLPWDDLLRLCDRYPLTVETK GGTVXXXARSILITSNQTPLEWYSSTAVPAVEALYRRITSLVFWKNATEQSTEEGGQXVT LSPPCPEFPYEINY? eller (d) fusionsprotein omfattende et hvilket som helst af (a) til (c).
13. Sammensætningen ifølge krav 12, yderligere omfattende en adjuvans.
DK10012196.1T 1997-12-11 1998-12-11 Postweaning multisystemisk wasting syndrom-virus fra grise DK2363488T3 (da)

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Application Number Priority Date Filing Date Title
US6923397P 1997-12-11 1997-12-11
US6975097P 1997-12-16 1997-12-16
EP07008633.5A EP1816200B1 (en) 1997-12-11 1998-12-11 Postweaning multisystemic wasting syndrome virus for pigs

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DK2363488T3 true DK2363488T3 (da) 2014-11-24

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DK10012196.1T DK2363488T3 (da) 1997-12-11 1998-12-11 Postweaning multisystemisk wasting syndrom-virus fra grise
DK98959682T DK1037909T3 (da) 1997-12-11 1998-12-11 Postweaning multisystemisk wasting-syndromvirus (PMWS) fra svin

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US (3) US20020106639A1 (da)
EP (2) EP2363488B1 (da)
JP (5) JP3795751B2 (da)
KR (3) KR100879650B1 (da)
CN (1) CN1309708A (da)
AT (1) ATE364624T1 (da)
AU (1) AU764379B2 (da)
BR (1) BR9813485A (da)
CA (1) CA2313806A1 (da)
CY (1) CY1107720T1 (da)
DE (2) DE07008633T1 (da)
DK (2) DK2363488T3 (da)
ES (2) ES2526760T3 (da)
ID (1) ID28224A (da)
NZ (1) NZ505008A (da)
PT (2) PT2363488E (da)
RU (1) RU2000118777A (da)
WO (1) WO1999029717A2 (da)

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