DK2370112T3 - Implanterbar liposomindlejret matrixsammensætning og anvendelser deraf - Google Patents
Implanterbar liposomindlejret matrixsammensætning og anvendelser deraf Download PDFInfo
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- DK2370112T3 DK2370112T3 DK09828393.0T DK09828393T DK2370112T3 DK 2370112 T3 DK2370112 T3 DK 2370112T3 DK 09828393 T DK09828393 T DK 09828393T DK 2370112 T3 DK2370112 T3 DK 2370112T3
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/438—Antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
- A61L2300/626—Liposomes, micelles, vesicles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
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Claims (23)
- IMPLANTERE AR LIPOSOMINDLEJRET MATRIXS AMMEN SÆTNIN G OG ANVENDELSER DERAF1. Implanterbar, halvfast matrix omfattende et hydrogelmateriale og liposomer indlejret deri, hvori liposomeme indeholder mindst ét biologisk aktivt materiale, og hvori matrixen er permeabeS for infiltration af cel ler fra et implantationsmiljø og for produkter udskilt fra cellerne til miljøet, hvori det biologisk aktive materiale er udvalgt fra gruppen bestående af et protein, et peptid, et nukleotid, et DMA, et RNA, et siRNA og et cDNA, eller en kombination deraf, eller er et lille molekyle, et lægemiddel eller en kombination deraf; og hvori matrixen inkluderer en eller flere kemoattraktanter for monocytiske celler; og hvori liposomeme har en størrelse i området 25 til 400 nm.
- 2. Matrix ifølge krav 1, hvori det mindst ene biologisk aktive materiale er i stand til at fremkalde en angiogen fænotype i infiltrerende celler, der fagocyterer liposomeme efter implantation inden i et subjekt.
- 3. Matrix ifølge krav 1 eller 2, hvori liposomeme bærer det biologisk aktive materiale i den hydrofile liposomkeme, i membranen, på liposomoverfladen eller i en kombination deraf.
- 4. Matrix ifølge et hvilket som helst af kravene 1-3, hvori kemoattraktanten er monoeyt-kemotaktisk protein-1 eller granulocyt-makrofagkolonistimulerende faktor (GM-CSF).
- 5. Matrix ifølge et hvilket som helst af kravene 1-4, hvori liposomeme er forbundet med hydrogelmatrixen med en kemisk binding udvalgt fra gruppen bestående af en peptidbinding eller en ionbinding.
- 6. Matrix ifølge et hvilket søm helst af kravene 1-5, hvori hydrogelmateriaiet indeholder celler tilsat til hydrogelmateriaiet, før dets implantation i kroppen.
- 7. Matrix ifølge et hvilket som helst af de foregående krav, hvori hydrogelen omfatter polyhydroxysyrer, polyortoestere, polyanhydrider, gelatine, kollagen, cellulose, chitosan, aiginat, hyaluronan, thiol-modificeret hyaluronan og kombinationer eller copolymerer deraf.
- 8. Matrix ifølge et hvilket som helst af de foregående krav endvidere omfattende et tværbindingsmiddel.
- 9. Matrix ifølge et hvilket som helst af de foregående krav, hvori det biologisk aktive materiale indeholdt i liposomeme er et tumorantigen, eller hvori det biologisk aktive materiale indeholdt i liposomerne er et nukiemsyreniolekyle, der koder for et tumorantigen.
- 10. Matrix ifølge et hvilket som helst af kravene 1-8, hvori det biologisk aktive materiale, der er indeholdt i liposomerne, er et middel, der fremmer differentiering af monocytiske celler til dendritiske celler, udvalgt fra gruppen bestående af granulocyt-makrofagkolonistirnulerende faktor (GM-CSF), interleukin-4, TNF-alfa og interleukin-15 og kombinationer deraf.
- 11. Matrix ifølge et hvilket som helst af kravene 1 -8, hvori det biologisk aktive materiale er en ekspressionsvektor, der koder for en transskriptionsfaktor.
- 12. Matrix ifølge krav 11, hvori transskriptionsfaktoren er i stand til at differentiere cellen til en insulinproducerende celle, eller hvori transskriptionsfaktoren er udvalgt fra gruppen bestående afNGN-3, PDX- 1, MAFA, Oct4, Sox2, c-Myc, klf-4, Nanog, Polycomb-gruppe-(PcG)-proteiner, PAX6, MEIS1, QTX1, ATBF1, DLX5, HANDI, Nuklear faktor kappa-B og OENCUT1.
- 13. Matrix ifølge et hvilket som helst af de foregående krav, hvori det biologisk aktive materiale, der er indeholdt i liposomeme, er udvalgt fra gruppen bestående af adenosin, IL-4, IL-10, IL-13, en IL-1-receptorligand, PGE2, TGF-beta, TNF-alfa, mælkesyre, lipoteichoinsyre, NADH-dehydrogenase 5, subunit 1, poly-(adenosindiphosphat-ribose)-polymerase, pyruvat, kolonistimulerende faktor-1, NECA, EPS, Pam3CSK4, E. coli LPS, R848, imiquimod, ikkc-mcthylcrct CpG-DNA, ODN2006, thiorcdoxin-peroxidase, Trapidil, en TLR2-agonist, en TLR3-agonist, en TLR4-agonist, en TLR7-agonist, en TLR8-agonist, en TLR9-agonist, adenosin Al-agonister, adenosin A2-agonister, adenosin A3-agonistser, alendronat, et polypeptid-tumorantigen afledt af tumorceller eller tumorvæv og kombinationer deraf.
- 14. Matrix ifølge et hvilket som helst af kravene 1-13 til anvendelse i modulering af en monocytisk celles adfærd på eller i nærheden af implantationsstedet hos et subjekt.
- 15. Matrix ifølge krav 14, hvori adfærden er en angiogen aktivitet, en immunsuppressiv aktivitet, en inflammatorisk aktivitet, en antigen-præsenterende aktivitet, celledifferentiering eller celle-omprogrammering.
- 16. Matrix ifølge krav 34 eller 15, hvori cellen er en monocyt.
- 17. Matrix ifølge et hvilket søm helst af kravene 1-13 til anvendelse i til førsel af et udskilt produkt til et lokaliseret sted inden i et iskæmisk væv hos et subjekt.
- 18. Fremgangsmåde til programmering af den implanterbare matrix ifølge krav 1 til at modulere en infiltrerende monocytisk celles adfærd, omfattende formulering inden i liposomerne af et eller flere biologisk aktive materialer, der er i stand til at modulere cellens adfærd, og indlejring af liposomerne i en matrix, der inkluderer et eller flere midler til rekruttering af celler til matrixen.
- 19. Matrix ifølge et hvilket som helst af kravene 1-13 til anvendelse i præsentation af et tumorantigen, hvori liposomerne omfatter et tumorantigen.
- 20. Matrix ifølge et hvilket som helst af kravene 14-16, hvori adfærden er differentiering til insulinproducerende celler eller differentiering til dopaminproducerende celler.
- 21. Fremgangsmåde ifølge krav 18, hvori implantationsstedet er inden i pancreas.
- 22. Matrix ifølge et hvilket som helst af kravene 1-13 til anvendelse til fremme af insulinudskillelse på et lokaliseret sted hos et subjekt med insulinresistens eller insulinmangel, hvori liposomerne omfatter en ekspression s vektor, der koder for en transskriptionsfaktor, der er i stand til at differentiere en celle til en insulinproducerende celle.
- 23. Matrix ifølge et hvilket som helst af kravene 1-22, hvori liposomerne er sterisk beskyttede, kolcstcrol-modificcrcdc, PEGylcrcdc eller ovcrfladcmodificcrcdc.
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| US20020708P | 2008-11-24 | 2008-11-24 | |
| PCT/US2009/065797 WO2010060104A2 (en) | 2008-11-24 | 2009-11-24 | Implantable liposome embedded matrix composition, uses thereof, and polycaprolactone praticles as scaffolds for tissue regeneration |
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| US6876636B2 (en) | 2002-07-09 | 2005-04-05 | Qualcomm Inc. | Method and system for a multicast service initiation in a communication system |
| WO2011078990A1 (en) * | 2009-12-14 | 2011-06-30 | Benaroya Research Institute At Virginia Mason | Hydrogels comprising hyaluronan and at least one t cell induction agent |
| ITMI20111009A1 (it) | 2011-06-01 | 2012-12-02 | Milano Politecnico | Idrogeli di gelatina reticolata |
| TWI449546B (zh) * | 2011-09-07 | 2014-08-21 | Ind Tech Res Inst | 應用於軟硬組織修復與再生之生醫材料 |
| US20150064141A1 (en) | 2012-04-05 | 2015-03-05 | The Regents Of The University Of California | Regenerative sera cells and mesenchymal stem cells |
| SG10201701773UA (en) * | 2012-09-06 | 2017-04-27 | Univ Nanyang Tech | Hyaluronic Acid-Based Drug Delivery Systems |
| GB201301571D0 (en) * | 2012-11-27 | 2013-03-13 | Fundanci N Pedro Barri De La Maza | Product and use |
| EP3024936B1 (en) | 2013-07-25 | 2019-09-04 | Exicure, Inc. | Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use |
| EP2918262B1 (en) * | 2014-03-10 | 2023-08-09 | PLS-Design GmbH | Induction of antigen-specific tolerance by peripheral phagocytosis |
| EP3116479A1 (en) * | 2014-03-12 | 2017-01-18 | GlaxoSmithKline Biologicals S.A. | Liposomal compositions for mucosal delivery |
| TR201908550T4 (tr) * | 2014-06-04 | 2019-07-22 | Exicure Inc | Profilaktik veya terapötik uygulamalar için lipozomal sferik nükleik asitler tarafından immün modülatörlerin çok değerlikli teslimi. |
| EP3095440B1 (en) * | 2015-05-19 | 2020-01-15 | PLS-Design GmbH | Antigen-specific immunotherapy using tolerizing liposomes |
| EP3454839B1 (en) | 2016-05-12 | 2026-01-28 | Insitu Biologics, Inc. | Hydrogel-based biological delivery vehicle |
| WO2018039629A2 (en) | 2016-08-25 | 2018-03-01 | Northwestern University | Micellar spherical nucleic acids from thermoresponsive, traceless templates |
| WO2019032585A1 (en) * | 2017-08-09 | 2019-02-14 | The Regents Of The University Of Michigan | STRUCTURES IMITATING APOPTOSIS |
| CN107496348A (zh) * | 2017-08-28 | 2017-12-22 | 天津昂赛细胞基因工程有限公司 | 一种用于组织损伤修复的水凝胶及制备方法 |
| CN109337877B (zh) * | 2018-10-31 | 2021-11-12 | 安徽农业大学 | 二氯苯酚降解酶TcpA及其编码基因与生产菌的应用 |
| CN110327498B (zh) * | 2019-04-15 | 2021-02-02 | 北京大学口腔医学院 | 一种基于脂质体的活性小分子控释方法及其应用 |
| CN116603076B (zh) * | 2023-07-13 | 2023-10-10 | 四川大学华西医院 | 一种具有超疏水性能的药物结构涂层及其制备方法 |
| CN119074696A (zh) * | 2024-08-30 | 2024-12-06 | 上海市第四人民医院 | 用于穴位刺激的粘附水凝胶载药微球、制备方法和应用 |
| GB2701454A (en) * | 2024-09-15 | 2026-04-29 | Sai Ia Ltd | Antigen device |
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| CA2202511A1 (en) * | 1994-10-12 | 1996-04-25 | Laurence A. Roth | Targeted delivery via biodegradable polymers |
| US5756122A (en) * | 1995-06-07 | 1998-05-26 | Georgetown University | Liposomally encapsulated nucleic acids having high entrapment efficiencies, method of manufacturer and use thereof for transfection of targeted cells |
| US6267955B1 (en) | 1995-09-15 | 2001-07-31 | Yeda Research And Development Co. Ltd. | Mononuclear phagocytes and their use to promote axonal regeneration |
| US6132765A (en) * | 1996-04-12 | 2000-10-17 | Uroteq Inc. | Drug delivery via therapeutic hydrogels |
| US6077987A (en) * | 1997-09-04 | 2000-06-20 | North Shore-Long Island Jewish Research Institute | Genetic engineering of cells to enhance healing and tissue regeneration |
| US7427602B1 (en) * | 1998-05-13 | 2008-09-23 | The Regents Of The University Of Michigan | Sustained DNA delivery from structural matrices |
| AU2001234623A1 (en) * | 2000-01-28 | 2001-08-07 | Orthogene, Inc. | Gel-infused sponges for tissue repair and augmentation |
| US20020034501A1 (en) * | 2000-05-18 | 2002-03-21 | Robert Pawliuk | Methods and compositions for promoting angiogenesis using monocytes |
| AU2002343475A1 (en) * | 2001-10-03 | 2003-04-14 | Selective Genetics, Inc. | Traversal of nucleic acid molecules through a fluid space and expression in repair cells |
| US20040132679A1 (en) * | 2002-09-03 | 2004-07-08 | Baylor College Of Medicine | Induction of pancreatic islet formation |
| AU2003287444A1 (en) * | 2002-10-31 | 2004-05-25 | The General Hospital Corporation | Repairing or replacing tissues or organs |
| US7736636B2 (en) * | 2003-02-12 | 2010-06-15 | Shaker Mousa | Method for treating occlusive vascular diseases & wound healing |
| US10517883B2 (en) * | 2003-06-27 | 2019-12-31 | Zuli Holdings Ltd. | Method of treating acute myocardial infarction |
| GB0317999D0 (en) * | 2003-07-31 | 2003-09-03 | Univ Liege | Improvements in or relating to drug delivery systems |
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| US20050186240A1 (en) | 2004-02-23 | 2005-08-25 | Ringeisen Timothy A. | Gel suitable for implantation and delivery system |
| US20090104254A1 (en) * | 2004-12-22 | 2009-04-23 | Rutgers, The State University Of New Jersey | Controlled Release Hydrogels |
| US20060257359A1 (en) | 2005-02-28 | 2006-11-16 | Cedric Francois | Modifying macrophage phenotype for treatment of disease |
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| AU2009313875B2 (en) * | 2008-11-13 | 2013-01-10 | Baylor Research Institute | Regeneration of pancreatic islets and reversal of diabetes by islet transcription factor genes delivered in vivo |
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| EP2370112A2 (en) | 2011-10-05 |
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