DK2380568T3 - Fremgangsmåde til fremstilling og krystallisation af reduceret coenzyme Q 10 - Google Patents

Fremgangsmåde til fremstilling og krystallisation af reduceret coenzyme Q 10

Info

Publication number: DK2380568T3
Authority: DK; Denmark
Prior art keywords: crystallization; preparation; reduced coenzyme; coenzyme; reduced
Prior art date: 2001-10-10

Application number

DK11173425.7T

Other languages

English (en)

Inventor

Takahiro Ueda

Yasuyoshi Ueda

Tadao Ono

Mitsutoshi Moro

Shiro Kitamura

Original Assignee

Kaneka Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-10

Filing date

2002-10-10

Publication date

2013-10-07

2002-10-10 Application filed by Kaneka Corp filed Critical Kaneka Corp

2013-10-07 Application granted granted Critical

2013-10-07 Publication of DK2380568T3 publication Critical patent/DK2380568T3/da

Links

238000002425 crystallisation Methods 0.000 title 1
230000008025 crystallization Effects 0.000 title 1
238000000034 method Methods 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
QNTNKSLOFHEFPK-UPTCCGCDSA-N ubiquinol-10 Chemical compound COC1=C(O)C(C)=C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)C(O)=C1OC QNTNKSLOFHEFPK-UPTCCGCDSA-N 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/34—Separation; Purification; Stabilisation; Use of additives
- C07C41/40—Separation; Purification; Stabilisation; Use of additives by change of physical state, e.g. by crystallisation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/34—Separation; Purification; Stabilisation; Use of additives
- C07C41/46—Use of additives, e.g. for stabilisation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Crystallography & Structural Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Nutrition Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Obesity (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Diabetes (AREA)
Hematology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK11173425.7T 2001-10-10 2002-10-10 Fremgangsmåde til fremstilling og krystallisation af reduceret coenzyme Q 10 DK2380568T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP2001312179		2001-10-10
JP2002114879		2002-04-17
EP02775311.0A EP1452174B1 (en)	2001-10-10	2002-10-10	Stabilized composition comprising reduced coenzyme q10

Publications (1)

Publication Number	Publication Date
DK2380568T3 true DK2380568T3 (da)	2013-10-07

Family

ID=26623825

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK11173425.7T DK2380568T3 (da)	2001-10-10	2002-10-10	Fremgangsmåde til fremstilling og krystallisation af reduceret coenzyme Q 10

Country Status (10)

Country	Link
US (2)	US8703155B2 (da)
EP (3)	EP2380568B8 (da)
JP (1)	JP3790530B2 (da)
KR (3)	KR100934330B1 (da)
CN (3)	CN102381948B (da)
AU (1)	AU2002343962B2 (da)
CA (3)	CA2781766C (da)
DK (1)	DK2380568T3 (da)
TW (1)	TWI329510B (da)
WO (1)	WO2003032967A1 (da)

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JP3822479B2 (ja)	2001-10-10	2006-09-20	株式会社カネカ	還元型補酵素ｑ水溶液の安定化組成
TWI349039B (en) *	2001-12-27	2011-09-21	Kaneka Corp	Processes for producing coenzyme q10
TW200302056A (en) *	2002-01-18	2003-08-01	Kaneka Corp	Method for stabilizing reduced coenzyme Q10 and composition therefor
US7358402B2 (en)	2003-09-10	2008-04-15	Kaneka Corporation	Reduced coenzyme Q10 crystal with excellent stability and composition containing said reduced coenzyme Q10 crystal
US7707039B2 (en) *	2004-02-15	2010-04-27	Exbiblio B.V.	Automatic modification of web pages
AU2005224245A1 (en) *	2004-03-23	2005-09-29	Kaneka Corporation	Coenzyme Q composition with long-term persistence in blood
US7708990B2 (en) *	2004-03-23	2010-05-04	Kaneka Corporation	Coenzyme Q compositions persisting in blood
JP5001515B2 (ja) *	2004-09-17	2012-08-15	株式会社カネカ	還元型ビタミンｋの製造方法
US20060147542A1 (en) *	2004-12-24	2006-07-06	Tadao Ono	Solid preparation containing reduced coenzyme Q10 and method for producing the same
CN101087598B (zh) *	2004-12-24	2010-12-08	株式会社钟化	含有还原型辅酶q10的固体制剂及其制造方法
US8067217B2 (en) *	2004-12-28	2011-11-29	Kaneka Corporation	Method for preserving reduced coenzyme Q10
JPWO2006104153A1 (ja) *	2005-03-29	2008-09-11	株式会社カネカ	血液中の抗酸化活性を高める組成物
JP5015548B2 (ja) *	2005-10-31	2012-08-29	株式会社カネカ	還元型補酵素ｑ１０を安定化するための方法
US8506956B2 (en)	2005-10-31	2013-08-13	Kaneka Corporation	Method for stabilizing reduced coenzyme Q10
EP2025662A4 (en) *	2006-04-28	2011-07-27	Kaneka Corp	PROCESS FOR PURIFYING REDUCED COENZYME Q10
CA2650686C (en) *	2006-04-28	2014-12-16	Kaneka Corporation	Method for stabilization of reduced coenzyme q10
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WO2008129980A1 (ja) *	2007-04-16	2008-10-30	Kaneka Corporation	還元型補酵素ｑ１０含有粒子状組成物及びその製造方法
US20110123505A1 (en) *	2007-08-22	2011-05-26	Kaneka Corporation	Method of producing reduced coenzyme q10 and method of stabilizing the same
JP5558823B2 (ja) *	2007-10-05	2014-07-23	株式会社カネカ	還元型補酵素ｑ１０の製造方法
JP4598873B2 (ja) *	2007-10-30	2010-12-15	株式会社カネカ	含水有機溶媒を用いる還元型補酵素ｑ１０の製造方法
CN102656133B (zh)	2009-10-16	2015-04-15	株式会社钟化	还原型辅酶q10的制造方法、稳定化方法以及含有还原型辅酶q10的组合物
EP2489652B1 (en) *	2009-10-16	2018-07-25	Kaneka Corporation	Method for producing reduced coenzyme q10, method for stabilizing same, and composition comprising same
CA2837695C (en)	2011-06-24	2019-12-31	Kaneka Corporation	Reduced coenzyme q10 crystal having excellent stability
JP2015131766A (ja)	2012-04-27	2015-07-23	株式会社カネカ	還元型補酵素ｑ１０の製造方法
WO2014188861A1 (ja)	2013-05-20	2014-11-27	ユーハ味覚糖株式会社	ユビキノール高含有ゲル状組成物
RU2535928C1 (ru) *	2013-05-31	2014-12-20	Закрытое акционерное общество "Научно-производственное объединение "ДОМ ФАРМАЦИИ"	Экспрессный способ получения восстановленной формы коэнзима q10 на основе катализаторов для использования в фармацевтических и пищевых композициях
TW201613561A (en) *	2014-02-17	2016-04-16	Kaneka Corp	Composition comprising reduced coenzyme q10
GEP20197040B (en) *	2015-03-20	2019-11-11	Gnosis Spa	Solid forms of menaquinols
CN106117033B (zh) *	2016-06-23	2018-12-25	浙江大学	一种同时分离制备高纯度辅酶q10和还原型辅酶q10的工艺
CN106146278B (zh) *	2016-06-23	2018-12-25	浙江大学	一种从菌渣中提取分离辅酶q10的工艺
CN106497993B (zh) *	2016-09-05	2021-07-06	广东润和生物科技有限公司	还原型辅酶q10及化妆品
CN106222209B (zh) *	2016-09-05	2020-12-29	米涛(上海)环保科技有限公司	还原型辅酶q10的生产方法
EP3755683A1 (en) *	2018-02-23	2020-12-30	Center for Intelligent Research in Crystal Engineering, S.L.	Cocrystals of ubiquinol and compositions comprising them
US11471426B2 (en)	2019-10-16	2022-10-18	American River Nutrition, Llc	Compositions comprising quinone and/or quinol and methods of preparations and use thereof
DE102019218240A1 (de) *	2019-11-26	2021-05-27	Beiersdorf Ag	Wirkstoffkombinationen aus Ubichinol und Glycerylstearatcitrat und kosmetische oder dermatologische Zubereitungen, solche Wirkstoffkombinationen enthaltend
JP7719594B2 (ja) *	2020-08-31	2025-08-06	株式会社ファンケル	コエンザイムｑ１０含有組成物、コエンザイムｑ１０含有組成物の製造方法、還元剤
CN113024362B (zh)	2021-03-10	2022-02-15	中国科学院上海药物研究所	一种辅酶qh与烟酰胺的共晶及其制备方法和用途
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2002
- 2002-10-09 TW TW091123239A patent/TWI329510B/zh not_active IP Right Cessation
- 2002-10-10 KR KR1020047005199A patent/KR100934330B1/ko not_active Expired - Fee Related
- 2002-10-10 US US10/492,122 patent/US8703155B2/en not_active Expired - Lifetime
- 2002-10-10 WO PCT/JP2002/010515 patent/WO2003032967A1/ja not_active Ceased
- 2002-10-10 CA CA2781766A patent/CA2781766C/en not_active Expired - Lifetime
- 2002-10-10 CN CN201110217296.9A patent/CN102381948B/zh not_active Expired - Lifetime
- 2002-10-10 CN CN2008101361393A patent/CN101318889B/zh not_active Expired - Lifetime
- 2002-10-10 EP EP11173425.7A patent/EP2380568B8/en not_active Expired - Lifetime
- 2002-10-10 DK DK11173425.7T patent/DK2380568T3/da active
- 2002-10-10 KR KR1020097017987A patent/KR100959467B1/ko not_active Expired - Fee Related
- 2002-10-10 KR KR1020097017988A patent/KR100959465B1/ko not_active Expired - Fee Related
- 2002-10-10 CN CNB02824009XA patent/CN100415220C/zh not_active Expired - Lifetime
- 2002-10-10 JP JP2003535771A patent/JP3790530B2/ja not_active Expired - Fee Related
- 2002-10-10 CA CA2746795A patent/CA2746795C/en not_active Expired - Lifetime
- 2002-10-10 AU AU2002343962A patent/AU2002343962B2/en not_active Expired
- 2002-10-10 EP EP11173424A patent/EP2377524A1/en not_active Withdrawn
- 2002-10-10 CA CA2462557A patent/CA2462557C/en not_active Expired - Lifetime
- 2002-10-10 EP EP02775311.0A patent/EP1452174B1/en not_active Expired - Lifetime
2014
- 2014-03-05 US US14/197,347 patent/US9532957B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US9532957B2 (en)	2017-01-03
CN1599603A (zh)	2005-03-23
WO2003032967A1 (fr)	2003-04-24
EP2377524A1 (en)	2011-10-19
KR20090096758A (ko)	2009-09-14
EP2380568B1 (en)	2013-09-11
CA2746795A1 (en)	2003-04-24
KR100959467B1 (ko)	2010-05-25
CN102381948B (zh)	2014-10-01
KR20050035125A (ko)	2005-04-15
CN100415220C (zh)	2008-09-03
TWI329510B (en)	2010-09-01
CA2462557A1 (en)	2003-04-24
US20140212402A1 (en)	2014-07-31
KR100934330B1 (ko)	2009-12-29
US20050008630A1 (en)	2005-01-13
EP1452174B1 (en)	2013-12-18
JP3790530B2 (ja)	2006-06-28
CN102381948A (zh)	2012-03-21
CA2781766A1 (en)	2003-04-24
CA2781766C (en)	2014-09-09
AU2002343962A2 (en)	2003-04-28
CA2746795C (en)	2014-04-08
EP1452174A1 (en)	2004-09-01
KR20090096757A (ko)	2009-09-14
CN101318889B (zh)	2012-05-30
CA2462557C (en)	2012-09-11
EP2380568A1 (en)	2011-10-26
EP2380568B8 (en)	2013-10-16
EP1452174A4 (en)	2010-07-14
JPWO2003032967A1 (ja)	2005-02-03
AU2002343962B2 (en)	2008-01-24
CN101318889A (zh)	2008-12-10
US8703155B2 (en)	2014-04-22
KR100959465B1 (ko)	2010-05-25

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