DK2384761T3 - Modificeret gnaverparvovirus, som er i stand til formering og spredning i humane gliomer - Google Patents
Modificeret gnaverparvovirus, som er i stand til formering og spredning i humane gliomerInfo
- Publication number
- DK2384761T3 DK2384761T3 DK10004897.4T DK10004897T DK2384761T3 DK 2384761 T3 DK2384761 T3 DK 2384761T3 DK 10004897 T DK10004897 T DK 10004897T DK 2384761 T3 DK2384761 T3 DK 2384761T3
- Authority
- DK
- Denmark
- Prior art keywords
- propagating
- spreading
- tumor cells
- human tumor
- modified rodent
- Prior art date
Links
- 241000125945 Protoparvovirus Species 0.000 title abstract 5
- 230000001902 propagating effect Effects 0.000 title abstract 3
- 241000283984 Rodentia Species 0.000 title abstract 2
- 206010018338 Glioma Diseases 0.000 title 1
- 210000004881 tumor cell Anatomy 0.000 abstract 3
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 230000037430 deletion Effects 0.000 abstract 2
- 238000012217 deletion Methods 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000005017 glioblastoma Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14311—Parvovirus, e.g. minute virus of mice
- C12N2750/14322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14311—Parvovirus, e.g. minute virus of mice
- C12N2750/14332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14311—Parvovirus, e.g. minute virus of mice
- C12N2750/14341—Use of virus, viral particle or viral elements as a vector
- C12N2750/14343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10004897.4A EP2384761B1 (en) | 2010-05-07 | 2010-05-07 | Modified rodent parvovirus capable of propagating and spreading through human gliomas |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2384761T3 true DK2384761T3 (da) | 2013-12-09 |
Family
ID=43304705
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10004897.4T DK2384761T3 (da) | 2010-05-07 | 2010-05-07 | Modificeret gnaverparvovirus, som er i stand til formering og spredning i humane gliomer |
| DK11724119.0T DK2566491T3 (da) | 2010-05-07 | 2011-05-09 | Modificeret gnaverparvovirus, som kan formeres og spredes gennem menneskelige gliomer |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11724119.0T DK2566491T3 (da) | 2010-05-07 | 2011-05-09 | Modificeret gnaverparvovirus, som kan formeres og spredes gennem menneskelige gliomer |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9029117B2 (da) |
| EP (2) | EP2384761B1 (da) |
| JP (1) | JP5812301B2 (da) |
| AU (1) | AU2011250204B2 (da) |
| CA (1) | CA2798098C (da) |
| DK (2) | DK2384761T3 (da) |
| ES (2) | ES2436317T3 (da) |
| WO (1) | WO2011138053A2 (da) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5765790B2 (ja) * | 2010-10-21 | 2015-08-19 | ドイッチェス・クレープスフォルシュングスツェントルムＤｅｕｔｓｃｈｅｓ Ｋｒｅｂｓｆｏｒｓｃｈｕｎｇｓｚｅｎｔｒｕｍ | ラットパルボウイルスｈ−１ｐｖのそのカプシドの遺伝子操作による癌細胞への再標的化 |
| EP3321357A1 (en) * | 2016-11-09 | 2018-05-16 | Deutsches Krebsforschungszentrum | Scalable process for oncolytic rat parvovirus h-1 production and purification based on isoelectric point-based elimination of empty particles |
| JP2022542275A (ja) | 2019-07-30 | 2022-09-30 | キンドレッド バイオサイエンシズ インコーポレイテッド | 動物用パルボウイルス抗体 |
| US20220265741A1 (en) * | 2021-02-12 | 2022-08-25 | Alliance Of Cardiovascular Researchers | Novel oncolytic parvoviruses with enhanced cargo capacity, stable shRNA expression cassette and novel immunogenic properties |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7704348A (nl) | 1977-04-21 | 1978-10-24 | Philips Nv | Werkwijze voor het bereiden van een geattenueer- de transmissible gastroenteritis(tge)-virusstam voor toepassing in levende vaccins. |
| JP2681063B2 (ja) * | 1987-08-26 | 1997-11-19 | 財団法人 阪大微生物病研究会 | 腎症候性出血熱ウイルス抗原の製造方法、及び該抗原を含有するワクチン並びに腎症候性出血熱診断剤 |
| IL100386A (en) | 1990-12-24 | 1995-07-31 | Akzo Nv | Suitable free vaccine against virus |
| AU779280B2 (en) * | 1999-03-26 | 2005-01-13 | Walter Reed Army Institute Of Research | Multivalent dengue virus vaccine |
| DE69942200D1 (de) * | 1999-08-13 | 2010-05-12 | Deutsches Krebsforsch | Parvovirus NS1 Varianten |
| US7179456B2 (en) * | 2003-04-30 | 2007-02-20 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Use of parvovirus for brain tumor therapy |
| PL2657248T3 (pl) * | 2003-06-19 | 2017-09-29 | Genzyme Corporation | Wiriony AAV o zmniejszonej immunoreaktywności i ich zastosowanie |
| DE102004020762A1 (de) * | 2004-04-27 | 2005-11-24 | Arno Thaller | Onkolytische Viren und Verfahren zu ihrer Herstellung |
| WO2009108274A2 (en) * | 2008-02-26 | 2009-09-03 | The University Of North Carolina At Chapel Hill | Methods and compositions for adeno-associated virus (aav) with hi loop mutations |
-
2010
- 2010-05-07 ES ES10004897T patent/ES2436317T3/es active Active
- 2010-05-07 DK DK10004897.4T patent/DK2384761T3/da active
- 2010-05-07 EP EP10004897.4A patent/EP2384761B1/en active Active
-
2011
- 2011-05-09 US US13/696,373 patent/US9029117B2/en active Active
- 2011-05-09 DK DK11724119.0T patent/DK2566491T3/da active
- 2011-05-09 AU AU2011250204A patent/AU2011250204B2/en not_active Ceased
- 2011-05-09 WO PCT/EP2011/002306 patent/WO2011138053A2/en not_active Ceased
- 2011-05-09 ES ES11724119.0T patent/ES2548396T3/es active Active
- 2011-05-09 EP EP11724119.0A patent/EP2566491B1/en active Active
- 2011-05-09 JP JP2013508403A patent/JP5812301B2/ja not_active Expired - Fee Related
- 2011-05-09 CA CA2798098A patent/CA2798098C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2798098C (en) | 2016-12-13 |
| DK2566491T3 (da) | 2015-09-07 |
| WO2011138053A8 (en) | 2012-05-03 |
| ES2436317T3 (es) | 2013-12-30 |
| CA2798098A1 (en) | 2011-11-10 |
| JP5812301B2 (ja) | 2015-11-11 |
| JP2013527759A (ja) | 2013-07-04 |
| WO2011138053A2 (en) | 2011-11-10 |
| US20130129683A1 (en) | 2013-05-23 |
| ES2548396T3 (es) | 2015-10-16 |
| EP2384761A1 (en) | 2011-11-09 |
| WO2011138053A3 (en) | 2012-03-15 |
| EP2566491B1 (en) | 2015-07-08 |
| AU2011250204B2 (en) | 2014-05-29 |
| AU2011250204A1 (en) | 2012-11-29 |
| EP2566491A2 (en) | 2013-03-13 |
| US9029117B2 (en) | 2015-05-12 |
| EP2384761B1 (en) | 2013-09-04 |
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