DK2393477T3 - Anvendelse af en glucocorticoidsammensætning til behandling af svær og ukontrolleret astma - Google Patents
Anvendelse af en glucocorticoidsammensætning til behandling af svær og ukontrolleret astma Download PDFInfo
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- DK2393477T3 DK2393477T3 DK10705986.7T DK10705986T DK2393477T3 DK 2393477 T3 DK2393477 T3 DK 2393477T3 DK 10705986 T DK10705986 T DK 10705986T DK 2393477 T3 DK2393477 T3 DK 2393477T3
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- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
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- A—HUMAN NECESSITIES
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- Medicinal Preparation (AREA)
Claims (14)
1. Inhalerbar glucocorticoidsammensætning til anvendelse ved behandling af en patient, som har svær og ukontrolleret astma, hvor sammensætningen administreres som en forstøvet aerosol, der frembringes af en inhalationsanordning, hvilken anordning er tilpasset til (a) at udsende den forstøvede aerosol i patientens inhalationsfase ved en hastighed på ikke over ca. 20 liter pr. minut; (b) at udsende et totalvolumen pr. inhalationsfase på mindst ca. 0,4 liter gasfase, hvilken gasfase indbefatter forstøvet aerosol og eventuelt aerosolfri luft; og (c) at udsende ikke over ca. 150 milliliter aerosolfri luft pr. inhalationsfase før udsendelse af forstøvet aerosol, forudsat at sammensætningen ikke omfatter methylxanthin.
2. Inhalerbar glucocorticoidsammensætning til anvendelse ifølge krav 1, hvor glucocorticoidet er valgt blandt fluticasonpropionat, budesonid, beclomethasondipropionat, ciclesonid, flunisolid, mometasonfuroat og triamcinolonacetonid.
3. Sammensætning til anvendelse ifølge krav 1 eller 2, hvor behandlingen endvidere indbefatter oral administration af et oralt glucocorticoid i en daglig dosis, som ikke er højere end ca. 40 milligram prednisolon eller en ækvipotent dosis af et andet glucocorticoid.
4. Sammensætning til anvendelse ifølge krav 3, hvor det oralt administrerede glucocorticoid er valgt blandt hydrocortison, dexamethason, prednison, prednisolon og methylprednisolon.
5. Sammensætning til anvendelse ifølge krav 3 eller 4, hvor den daglige dosis af det oralt administrerede glucocorticoid reduceres under behandlingen med mindst 30% i forhold til den indledende daglige dosis.
6. Sammensætning til anvendelse ifølge krav 3 eller 4, hvor den daglige dosis af det oralt administrerede glucocorticoid reduceres til nul under behandlingen.
7. Sammensætning til anvendelse ifølge et hvilket som helst af de foregående krav, hvor inhalationsanordningen er tilpasset til at udsende et gasfase-totalvolumen pr. inhalationsfase i intervallet fra ca. 0,4 til ca. 2 liter, og fortrinsvis fra ca. 0,4 til ca. 1,4 liter, hvilket totalvolumen er valgt på grundlag af patientens inhalationskapacitet eller patientens faktiske og forudsagte forcerede eksspirationsvolumen på ét sekund.
8. Sammensætning til anvendelse ifølge et hvilket som helst af de foregående krav, hvor inhalationsanordningen er tilpasset til at frembringe en forstøvet aerosol med en aerodynamisk massemedian-diameter (mass median aerodynamic diameter - MMAD) fra ca. 2 til ca. 6 mikrometer, og fortrinsvis fra ca. 3 til ca. 5 mikrometer.
9. Sammensætning til anvendelse ifølge et hvilket som helst af de foregående krav, hvor inhalationsanordningen er tilpasset til at udsende den forstøvede aerosol i patientens inhalationsfase ved et overtryk på op til ca. 40 mbar.
10. Sammensætning til anvendelse ifølge krav 9, hvor overtrykket i inhalationsfasen i alt væsentligt holdes på mindst ca. 1 mbar.
11. Sammensætning til anvendelse ifølge et hvilket som helst af de foregående krav, hvor inhalationsanordningen er tilpasset til kun at udsende gasfase efter at være blevet åndedrætsaktiveret af patienten.
12. Sammensætning til anvendelse ifølge et hvilket som helst af de foregående krav, hvor inhalationsanordningen er tilpasset til at udsende fra ca. 200 til ca. 3.000 milliliter forstøvet aerosol pr. inhalationsfase.
13. Sammensætning til anvendelse ifølge et hvilket som helst af de foregående krav, hvor inhalationsanordningen er tilpasset til at udsende fra ca. 200 til ca. 500 milliliter aerosolfri luft, efter udsendelse af den forstøvede aerosol, pr. inhalationsfase.
14. Sammensætning til anvendelse ifølge et hvilket som helst af de foregående krav, hvor inhalationsanordningen er tilpasset til at udsende den forstøvede aerosol ved en hastighed på ikke over ca. 300 milliliter pr. sekund, og fortrinsvis ikke over 250 milliliter pr. sekund.
Applications Claiming Priority (2)
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| US12/365,754 US20100196483A1 (en) | 2009-02-04 | 2009-02-04 | Method for treatmentof severe and uncontrollable asthma |
| PCT/EP2010/051321 WO2010089330A1 (en) | 2009-02-04 | 2010-02-03 | Use of a glucocorticoid composition for the treatment of severe and uncontrolled asthma |
Publications (1)
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| DK2393477T3 true DK2393477T3 (da) | 2018-04-09 |
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| DK10705986.7T DK2393477T3 (da) | 2009-02-04 | 2010-02-03 | Anvendelse af en glucocorticoidsammensætning til behandling af svær og ukontrolleret astma |
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| UA (1) | UA102587C2 (da) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP2534957B1 (en) | 2007-12-14 | 2015-05-27 | AeroDesigns, Inc | Delivering aerosolizable products |
| EP2846859B1 (en) | 2012-03-09 | 2017-01-04 | Vectura GmbH | Mixing channel for an inhalation device and inhalation device |
| WO2014012954A1 (en) * | 2012-07-18 | 2014-01-23 | Takeda Gmbh | Treatment of partly controlled or uncontrolled severe asthma |
| US20140261474A1 (en) * | 2013-03-15 | 2014-09-18 | Aradigm Corporation | Methods for inhalation of smoke-free nicotine |
| US8807131B1 (en) | 2013-06-18 | 2014-08-19 | Isonea Limited | Compliance monitoring for asthma inhalers |
| JP6529012B2 (ja) | 2013-10-08 | 2019-06-12 | エイアイ・セラピューティクス・インコーポレーテッド | リンパ脈管筋腫症の処置のためのラパマイシン |
| WO2015110394A1 (en) * | 2014-01-22 | 2015-07-30 | Takeda Gmbh | Treatment of partly controlled or uncontrolled severe asthma with a pde4 inhibitor (and in combination with a leukotriene modifier) |
| NZ724756A (en) | 2014-04-04 | 2023-07-28 | Ai Therapeutics Inc | An inhalable rapamycin formulation for treating age-related conditions |
| ES3034743T3 (en) * | 2014-06-25 | 2025-08-22 | Optinose Inc | Nasal administration |
| RU2732908C2 (ru) | 2014-10-07 | 2020-09-24 | ЭйАй ТЕРАПЬЮТИКС, ИНК. | Ингаляционная лекарственная форма рапамицина для лечения легочной гипертензии |
| RU2611406C1 (ru) * | 2015-09-03 | 2017-02-21 | Общество с ограниченной ответственностью "Биосурф" (ООО "Биосурф") | Способ лечения бронхиальной астмы |
| ES2988939T3 (es) | 2016-07-08 | 2024-11-22 | Trudell Medical Int Inc | Dispositivo de presión espiratoria positiva oscilante inteligente |
| CN110049795B (zh) | 2016-12-09 | 2022-07-19 | 特鲁德尔医学国际公司 | 智能雾化器 |
| US11666801B2 (en) | 2018-01-04 | 2023-06-06 | Trudell Medical International | Smart oscillating positive expiratory pressure device |
| WO2021038467A1 (en) | 2019-08-27 | 2021-03-04 | Trudell Medical International | Smart oscillating positive expiratory pressure device |
| US11593679B2 (en) * | 2019-11-29 | 2023-02-28 | Kpn Innovations, Llc. | Method of and system for generating a longevity element and an instruction set for a longevity element plan |
| US12051492B2 (en) | 2021-01-29 | 2024-07-30 | AsthmaTek, Inc. | Systems and methods to determine a therapy regimen to treat asthma of a subject |
Family Cites Families (15)
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| DE19720701A1 (de) * | 1997-05-16 | 1998-11-19 | Gsf Forschungszentrum Umwelt | Vorrichtung zur Applikation eines Medikament-Aerosols über die Lunge |
| US6187765B1 (en) * | 1997-10-09 | 2001-02-13 | Schering Corporation | Mometasone furoate suspensions for nebulization |
| DE19851279B4 (de) * | 1998-06-17 | 2006-05-24 | GSF - Forschungszentrum für Umwelt und Gesundheit GmbH | Vorrichtung zum gesteuerten inhalatorischen Einbringen von dosierten Medikamenten in die Lunge |
| DE19912265A1 (de) * | 1999-03-18 | 2000-09-21 | Gsf Forschungszentrum Umwelt | Verfahren und Vorrichtung zur Bereitstellung einer konstanten Medikamenten-Dosis für eine inhalatorische Applikation mit niedrigem Inhalationsfluß |
| DE19912461B4 (de) * | 1999-03-19 | 2006-07-20 | GSF - Forschungszentrum für Umwelt und Gesundheit GmbH | Vorrichtung zur Flußbegrenzung bei niedrigen Differenzdrücken |
| DE10013093B4 (de) * | 2000-03-17 | 2005-12-22 | Inamed Gmbh | Vorrichtung zur kontrollierten Inhalation therapeutischer Aerosole |
| DE10029119B4 (de) * | 2000-06-14 | 2005-12-22 | Institut für Aerosol Medizin InAMed GmbH | Inhalationsvorrichtung |
| DE10123749A1 (de) * | 2001-05-16 | 2002-12-12 | Inamed Gmbh | Vorrichtung zum Verabreichen von Aerosolen |
| AU2004311478A1 (en) * | 2003-12-31 | 2005-07-21 | Cydex Pharmaceuticals, Inc. | Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid |
| US20070020299A1 (en) * | 2003-12-31 | 2007-01-25 | Pipkin James D | Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid |
| EP1700614B1 (de) * | 2005-03-08 | 2013-05-08 | Activaero GmbH | Inhalationsvorrichtung |
| ATE373498T1 (de) * | 2005-07-06 | 2007-10-15 | Activaero Gmbh | Regelbares ventil und inhalationsvorrichtung |
| KR100802292B1 (ko) * | 2006-07-21 | 2008-02-11 | 동부일렉트로닉스 주식회사 | 마스크 및 이를 이용한 마이크로 렌즈 제작 방법 |
| CN106038481A (zh) * | 2007-06-28 | 2016-10-26 | 锡德克斯药物公司 | 皮质类固醇水溶液的鼻部和眼部给药 |
| US20100092397A1 (en) * | 2008-10-14 | 2010-04-15 | Activaero Gmbh | Method For Treatment of COPD and Other Pulmonary Diseases |
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2009
- 2009-02-04 US US12/365,754 patent/US20100196483A1/en not_active Abandoned
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2010
- 2010-02-03 PT PT107059867T patent/PT2393477T/pt unknown
- 2010-02-03 NZ NZ594210A patent/NZ594210A/xx unknown
- 2010-02-03 RU RU2011135824/15A patent/RU2519344C2/ru active
- 2010-02-03 BR BRPI1008227A patent/BRPI1008227A8/pt not_active Application Discontinuation
- 2010-02-03 SG SG2011056207A patent/SG173538A1/en unknown
- 2010-02-03 EP EP10705986.7A patent/EP2393477B1/en not_active Revoked
- 2010-02-03 CA CA2751443A patent/CA2751443C/en active Active
- 2010-02-03 SI SI201031650T patent/SI2393477T1/en unknown
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- 2010-02-03 MX MX2011008200A patent/MX2011008200A/es active IP Right Grant
- 2010-02-03 HU HUE10705986A patent/HUE038553T2/hu unknown
- 2010-02-03 CN CN201080006616XA patent/CN102307567A/zh active Pending
- 2010-02-03 JP JP2011548677A patent/JP5886630B2/ja active Active
- 2010-02-03 CN CN201410371150.3A patent/CN104306360A/zh active Pending
- 2010-02-03 WO PCT/EP2010/051321 patent/WO2010089330A1/en not_active Ceased
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- 2010-02-03 UA UAA201110621A patent/UA102587C2/ru unknown
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- 2010-02-03 NO NO10705986A patent/NO2393477T3/no unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| NZ594210A (en) | 2013-09-27 |
| PL2393477T3 (pl) | 2018-06-29 |
| JP2012516873A (ja) | 2012-07-26 |
| BRPI1008227A8 (pt) | 2018-12-11 |
| PT2393477T (pt) | 2018-02-14 |
| EP2393477A1 (en) | 2011-12-14 |
| EP3338782A1 (en) | 2018-06-27 |
| RU2011135824A (ru) | 2013-03-10 |
| IL213959A0 (en) | 2011-08-31 |
| ES2659328T3 (es) | 2018-03-14 |
| MX2011008200A (es) | 2011-10-21 |
| UA102587C2 (ru) | 2013-07-25 |
| RU2519344C2 (ru) | 2014-06-10 |
| CN102307567A (zh) | 2012-01-04 |
| SG173538A1 (en) | 2011-09-29 |
| CA2751443A1 (en) | 2010-08-12 |
| CA2751443C (en) | 2018-03-20 |
| HUE038553T2 (hu) | 2018-10-29 |
| IL213959A (en) | 2015-05-31 |
| JP5886630B2 (ja) | 2016-03-16 |
| WO2010089330A1 (en) | 2010-08-12 |
| NO2393477T3 (da) | 2018-05-26 |
| EP2393477B1 (en) | 2017-12-27 |
| KR20110122671A (ko) | 2011-11-10 |
| AU2010210183B2 (en) | 2014-09-11 |
| AU2010210183A1 (en) | 2011-07-28 |
| SI2393477T1 (en) | 2018-04-30 |
| CN104306360A (zh) | 2015-01-28 |
| US20100196483A1 (en) | 2010-08-05 |
| BRPI1008227A2 (pt) | 2016-03-08 |
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