DK2397158T3 - Kombination af morphinanforbindelser og antidepressiva til behandling af pseudobulbær affekt - Google Patents
Kombination af morphinanforbindelser og antidepressiva til behandling af pseudobulbær affekt Download PDFInfo
- Publication number
- DK2397158T3 DK2397158T3 DK11180603.0T DK11180603T DK2397158T3 DK 2397158 T3 DK2397158 T3 DK 2397158T3 DK 11180603 T DK11180603 T DK 11180603T DK 2397158 T3 DK2397158 T3 DK 2397158T3
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- DK
- Denmark
- Prior art keywords
- compound
- pharmaceutically acceptable
- formula
- reuptake inhibitor
- combination
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
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- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (10)
- KOMBINATION AF MORPHINANFORBINDELSER OG ANTIDEPRESSIVA TIL BEHANDLING AF PSEUDOBULBÆR AFFEKT1. Kombination af: (a) en terapeutisk effektiv mængde af en selektiv serotoninreuptakehæmmer og (b) en terapeutisk effektiv mængde af en forbindelse med formlen II:II eller et farmaceutisk acceptabelt salt deraf, hvor: R3 er udvalgt fra -OCH2D, -OCHD2 og -OCD3; R4 er udvalgt fra -CH3, -CH2D, -CHD2 og -CD3; forudsat, når R3 er -OCD3, at R4 ikke er -CH3; til anvendelse til behandling af pseudobulbær affekt.
- 2. Kombination til anvendelse ifølge krav 1, hvor R4 er -CH3, -CHD2 eller -CD3.
- 3. Kombination til anvendelse ifølge krav 1, hvor R3 er -OCD3.
- 4. Kombination til anvendelse ifølge krav 1, hvor den selektive serotoninreuptakehæmmer er en hæmmer af et cytochrom p450 2D6-enzym.
- 5. Kombination til anvendelse ifølge et hvilket som helst af kravene 1 til 4, hvor den selektive serotoninreuptakehæmmer er udvalgt fra gruppen bestående af fluoxetin, norfluoxetin, citalopram, dapoxetin, escitalopram, fluvoxamin, paroxetin og sertralin, eller farmaceutisk acceptable salte deraf.
- 6. Kombination til anvendelse ifølge krav 5, hvor den selektive serotoninreuptakehæmmer er udvalgt fra gruppen bestående af citalopram, norfluoxetin, dapoxetin, escitalopram, fluvoxamin, paroxetin og sertralin, eller farmaceutisk acceptable salte deraf.
- 7. Kombination til anvendelse ifølge krav 6, hvor den selektive serotoninreuptakehæmmer er paroxetin, eller et farmaceutisk acceptabelt salt deraf.
- 8. Kombination til anvendelse ifølge krav 1, hvor den selektive serotoninreuptakehæmmer er udvalgt fra gruppen bestående af citalopram, fluvoxamin, norfluoxetin, fluoxetin, paroxetin og sertralin og forbindelsen med formlen II er udvalgt fra gruppen bestående af:eller farmaceutisk acceptable salte deraf.
- 9. Kombination til anvendelse ifølge krav 8, hvor den selektive serotoninreuptakehæmmer er udvalgt fra gruppen bestående af citalopram, fhivoxamin, paroxetin og sertralin, eller et farmaceutisk acceptabelt salt deraf.
- 10. Kombination til anvendelse ifølge krav 8 eller krav 9, hvor den selektive serotoninreuptakehæmmer er paroxetin, eller et farmaceutisk acceptabelt salt deraf.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10983208P | 2008-10-30 | 2008-10-30 | |
| EP09744582.9A EP2365808B1 (en) | 2008-10-30 | 2009-10-30 | Combination of morphinan compounds and antidepressant for the treatment of pseudobulbar affect, neurological diseases, intractable and chronic pain and brain injury |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2397158T3 true DK2397158T3 (da) | 2016-07-25 |
Family
ID=41346111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11180603.0T DK2397158T3 (da) | 2008-10-30 | 2009-10-30 | Kombination af morphinanforbindelser og antidepressiva til behandling af pseudobulbær affekt |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US20120083487A1 (da) |
| EP (4) | EP2365808B1 (da) |
| CY (1) | CY1117760T1 (da) |
| DK (1) | DK2397158T3 (da) |
| HK (1) | HK1225642A1 (da) |
| HR (1) | HRP20160454T1 (da) |
| HU (1) | HUE028956T2 (da) |
| PL (1) | PL2397158T3 (da) |
| PT (1) | PT2397158T (da) |
| SI (1) | SI2397158T1 (da) |
| WO (1) | WO2010062692A1 (da) |
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| FI3825306T3 (fi) | 2007-05-01 | 2023-08-23 | Concert Pharmaceuticals Inc | Morfinaaniyhdisteitä |
| US7973049B2 (en) | 2007-05-01 | 2011-07-05 | Concert Pharmaceuticals Inc. | Morphinan compounds |
| CN103044327B (zh) * | 2013-01-07 | 2014-12-17 | 苏州立新制药有限公司 | 一种右美沙芬的制备方法 |
| US11090300B2 (en) | 2013-11-05 | 2021-08-17 | Antecip Bioventures Ii Llc | Bupropion as a modulator of drug activity |
| US10813924B2 (en) | 2018-03-20 | 2020-10-27 | Antecip Bioventures Ii Llc | Bupropion and dextromethorphan for treating nicotine addiction |
| US12194006B2 (en) | 2013-11-05 | 2025-01-14 | Antecip Bioventures Ii Llc | Bupropion as a modulator of drug activity |
| US9474731B1 (en) | 2013-11-05 | 2016-10-25 | Antecip Bioventures Ii Llc | Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects |
| US11311534B2 (en) | 2013-11-05 | 2022-04-26 | Antecip Bio Ventures Ii Llc | Bupropion as a modulator of drug activity |
| US11298352B2 (en) | 2013-11-05 | 2022-04-12 | Antecip Bioventures Ii Llc | Bupropion as a modulator of drug activity |
| US9763932B2 (en) | 2013-11-05 | 2017-09-19 | Antecip Bioventures Ii Llc | Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects |
| US10512643B2 (en) | 2013-11-05 | 2019-12-24 | Antecip Bioventures Ii Llc | Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects |
| US10966974B2 (en) | 2013-11-05 | 2021-04-06 | Antecip Bioventures Ii Llc | Bupropion as a modulator of drug activity |
| US10881657B2 (en) | 2013-11-05 | 2021-01-05 | Antecip Bioventures Ii Llc | Bupropion as a modulator of drug activity |
| US11517543B2 (en) | 2013-11-05 | 2022-12-06 | Antecip Bioventures Ii Llc | Bupropion as a modulator of drug activity |
| US11576909B2 (en) | 2013-11-05 | 2023-02-14 | Antecip Bioventures Ii Llc | Bupropion as a modulator of drug activity |
| US11253492B2 (en) | 2013-11-05 | 2022-02-22 | Antecip Bioventures Ii Llc | Bupropion as a modulator of drug activity |
| US10933034B2 (en) | 2013-11-05 | 2021-03-02 | Antecip Bioventures Ii Llc | Bupropion as a modulator of drug activity |
| US20200338022A1 (en) | 2019-01-07 | 2020-10-29 | Antecip Bioventures Ii Llc | Bupropion as a modulator of drug activity |
| US10874664B2 (en) | 2013-11-05 | 2020-12-29 | Antecip Bioventures Ii Llc | Bupropion as a modulator of drug activity |
| US11534414B2 (en) | 2013-11-05 | 2022-12-27 | Antecip Bioventures Ii Llc | Bupropion as a modulator of drug activity |
| US11207281B2 (en) | 2013-11-05 | 2021-12-28 | Antecip Bioventures Ii Llc | Bupropion as a modulator of drug activity |
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| EP2365808A1 (en) | 2011-09-21 |
| EP2365808B1 (en) | 2018-01-10 |
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| US20230285387A1 (en) | 2023-09-14 |
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| EP3090760A1 (en) | 2016-11-09 |
| US20120083487A1 (en) | 2012-04-05 |
| EP2397158B1 (en) | 2016-04-13 |
| CY1117760T1 (el) | 2017-05-17 |
| HRP20160454T1 (hr) | 2016-07-01 |
| EP3603674A1 (en) | 2020-02-05 |
| EP3603674B1 (en) | 2025-02-26 |
| WO2010062692A1 (en) | 2010-06-03 |
| HK1225642A1 (en) | 2017-09-15 |
| EP2397158A3 (en) | 2012-02-22 |
| US20220023292A1 (en) | 2022-01-27 |
| US20180344727A1 (en) | 2018-12-06 |
| HUE028956T2 (en) | 2017-01-30 |
| EP2397158A2 (en) | 2011-12-21 |
| PL2397158T3 (pl) | 2016-09-30 |
| US20160143902A1 (en) | 2016-05-26 |
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