DK2415475T3 - Farmaceutisk præparat, der omfatter en protonpumpehæmmer og et præbiotikum, til behandling af ulcerøse læsioner i mavesæk og duodenum - Google Patents
Farmaceutisk præparat, der omfatter en protonpumpehæmmer og et præbiotikum, til behandling af ulcerøse læsioner i mavesæk og duodenum Download PDFInfo
- Publication number
- DK2415475T3 DK2415475T3 DK10759105.9T DK10759105T DK2415475T3 DK 2415475 T3 DK2415475 T3 DK 2415475T3 DK 10759105 T DK10759105 T DK 10759105T DK 2415475 T3 DK2415475 T3 DK 2415475T3
- Authority
- DK
- Denmark
- Prior art keywords
- pharmaceutical composition
- ppi
- treatment
- prebiotic
- composition according
- Prior art date
Links
- 235000013406 prebiotics Nutrition 0.000 title claims description 24
- 229940126409 proton pump inhibitor Drugs 0.000 title claims description 21
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 20
- 238000011282 treatment Methods 0.000 title claims description 20
- 239000000612 proton pump inhibitor Substances 0.000 title claims description 15
- 210000002784 stomach Anatomy 0.000 title description 10
- 210000001198 duodenum Anatomy 0.000 title description 9
- 208000025865 Ulcer Diseases 0.000 title description 2
- 230000003902 lesion Effects 0.000 title description 2
- 208000000718 duodenal ulcer Diseases 0.000 claims description 19
- 230000008029 eradication Effects 0.000 claims description 18
- 208000007107 Stomach Ulcer Diseases 0.000 claims description 17
- 239000000203 mixture Substances 0.000 claims description 16
- 230000002496 gastric effect Effects 0.000 claims description 15
- 201000005917 gastric ulcer Diseases 0.000 claims description 15
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 claims description 12
- 229960000381 omeprazole Drugs 0.000 claims description 11
- 229960004770 esomeprazole Drugs 0.000 claims description 8
- SUBDBMMJDZJVOS-DEOSSOPVSA-N esomeprazole Chemical compound C([S@](=O)C1=NC2=CC=C(C=C2N1)OC)C1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-DEOSSOPVSA-N 0.000 claims description 7
- 229960003174 lansoprazole Drugs 0.000 claims description 7
- MJIHNNLFOKEZEW-UHFFFAOYSA-N lansoprazole Chemical compound CC1=C(OCC(F)(F)F)C=CN=C1CS(=O)C1=NC2=CC=CC=C2N1 MJIHNNLFOKEZEW-UHFFFAOYSA-N 0.000 claims description 6
- 229960005019 pantoprazole Drugs 0.000 claims description 6
- 229960004157 rabeprazole Drugs 0.000 claims description 6
- IQPSEEYGBUAQFF-UHFFFAOYSA-N Pantoprazole Chemical compound COC1=CC=NC(CS(=O)C=2NC3=CC=C(OC(F)F)C=C3N=2)=C1OC IQPSEEYGBUAQFF-UHFFFAOYSA-N 0.000 claims description 5
- 239000003242 anti bacterial agent Substances 0.000 claims description 5
- 229940088710 antibiotic agent Drugs 0.000 claims description 5
- 239000002552 dosage form Substances 0.000 claims description 5
- YREYEVIYCVEVJK-UHFFFAOYSA-N rabeprazole Chemical compound COCCCOC1=CC=NC(CS(=O)C=2NC3=CC=CC=C3N=2)=C1C YREYEVIYCVEVJK-UHFFFAOYSA-N 0.000 claims description 5
- JCQLYHFGKNRPGE-FCVZTGTOSA-N lactulose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 JCQLYHFGKNRPGE-FCVZTGTOSA-N 0.000 claims description 4
- 229960000511 lactulose Drugs 0.000 claims description 4
- PFCRQPBOOFTZGQ-UHFFFAOYSA-N lactulose keto form Natural products OCC(=O)C(O)C(C(O)CO)OC1OC(CO)C(O)C(O)C1O PFCRQPBOOFTZGQ-UHFFFAOYSA-N 0.000 claims description 4
- 229920001202 Inulin Polymers 0.000 claims description 3
- FTSSQIKWUOOEGC-RULYVFMPSA-N fructooligosaccharide Chemical compound OC[C@H]1O[C@@](CO)(OC[C@@]2(OC[C@@]3(OC[C@@]4(OC[C@@]5(OC[C@@]6(OC[C@@]7(OC[C@@]8(OC[C@@]9(OC[C@@]%10(OC[C@@]%11(O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%12O)O[C@H](CO)[C@@H](O)[C@@H]%11O)O[C@H](CO)[C@@H](O)[C@@H]%10O)O[C@H](CO)[C@@H](O)[C@@H]9O)O[C@H](CO)[C@@H](O)[C@@H]8O)O[C@H](CO)[C@@H](O)[C@@H]7O)O[C@H](CO)[C@@H](O)[C@@H]6O)O[C@H](CO)[C@@H](O)[C@@H]5O)O[C@H](CO)[C@@H](O)[C@@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H]1O FTSSQIKWUOOEGC-RULYVFMPSA-N 0.000 claims description 3
- 229940107187 fructooligosaccharide Drugs 0.000 claims description 3
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims description 3
- 229940029339 inulin Drugs 0.000 claims description 3
- 229920001542 oligosaccharide Polymers 0.000 claims description 3
- 150000002482 oligosaccharides Chemical class 0.000 claims description 3
- -1 portion letters Substances 0.000 claims description 3
- FVVCFHXLWDDRHG-UPLOTWCNSA-N (2s,3r,4s,5r,6r)-2-[(2r,3s,4r,5r,6r)-6-[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](CO)O1 FVVCFHXLWDDRHG-UPLOTWCNSA-N 0.000 claims description 2
- SATHPVQTSSUFFW-UHFFFAOYSA-N 4-[6-[(3,5-dihydroxy-4-methoxyoxan-2-yl)oxymethyl]-3,5-dihydroxy-4-methoxyoxan-2-yl]oxy-2-(hydroxymethyl)-6-methyloxane-3,5-diol Chemical compound OC1C(OC)C(O)COC1OCC1C(O)C(OC)C(O)C(OC2C(C(CO)OC(C)C2O)O)O1 SATHPVQTSSUFFW-UHFFFAOYSA-N 0.000 claims description 2
- 229920000189 Arabinogalactan Polymers 0.000 claims description 2
- 239000001904 Arabinogalactan Substances 0.000 claims description 2
- 229920001218 Pullulan Polymers 0.000 claims description 2
- 239000004373 Pullulan Substances 0.000 claims description 2
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 claims description 2
- UQZIYBXSHAGNOE-USOSMYMVSA-N Stachyose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO[C@@H]2[C@@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O2)O1 UQZIYBXSHAGNOE-USOSMYMVSA-N 0.000 claims description 2
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 claims description 2
- FYGDTMLNYKFZSV-DZOUCCHMSA-N alpha-D-Glcp-(1->4)-alpha-D-Glcp-(1->4)-D-Glcp Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)O[C@H](O[C@@H]2[C@H](OC(O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-DZOUCCHMSA-N 0.000 claims description 2
- 235000019312 arabinogalactan Nutrition 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 claims description 2
- 230000037406 food intake Effects 0.000 claims description 2
- 235000012631 food intake Nutrition 0.000 claims description 2
- 235000021255 galacto-oligosaccharides Nutrition 0.000 claims description 2
- 150000003271 galactooligosaccharides Chemical class 0.000 claims description 2
- 150000004676 glycans Chemical class 0.000 claims description 2
- 239000008187 granular material Substances 0.000 claims description 2
- DLRVVLDZNNYCBX-RTPHMHGBSA-N isomaltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-RTPHMHGBSA-N 0.000 claims description 2
- 229920005610 lignin Polymers 0.000 claims description 2
- 239000001814 pectin Substances 0.000 claims description 2
- 229920001277 pectin Polymers 0.000 claims description 2
- 235000010987 pectin Nutrition 0.000 claims description 2
- 239000008188 pellet Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 229920001282 polysaccharide Polymers 0.000 claims description 2
- 239000005017 polysaccharide Substances 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 235000019423 pullulan Nutrition 0.000 claims description 2
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 claims description 2
- UQZIYBXSHAGNOE-XNSRJBNMSA-N stachyose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@@H]3[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O3)O)O2)O)O1 UQZIYBXSHAGNOE-XNSRJBNMSA-N 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 150000004043 trisaccharides Chemical class 0.000 claims description 2
- 239000000470 constituent Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 description 16
- 241000186660 Lactobacillus Species 0.000 description 11
- 208000008469 Peptic Ulcer Diseases 0.000 description 11
- 201000010099 disease Diseases 0.000 description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 11
- 208000011906 peptic ulcer disease Diseases 0.000 description 11
- 241000590002 Helicobacter pylori Species 0.000 description 9
- 229940037467 helicobacter pylori Drugs 0.000 description 9
- 238000000034 method Methods 0.000 description 8
- 239000004599 antimicrobial Substances 0.000 description 6
- AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 description 6
- 229960002626 clarithromycin Drugs 0.000 description 6
- 229940126534 drug product Drugs 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 229940126601 medicinal product Drugs 0.000 description 6
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 6
- 229960000282 metronidazole Drugs 0.000 description 6
- 239000003814 drug Substances 0.000 description 5
- 210000001035 gastrointestinal tract Anatomy 0.000 description 5
- 239000000825 pharmaceutical preparation Substances 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 241000186000 Bifidobacterium Species 0.000 description 4
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
- 108010046334 Urease Proteins 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- RJGYJMFQWGPBGM-UHFFFAOYSA-N 1,2,4-thiadiazinane 1,1-dioxide Chemical compound O=S1(=O)CCNCN1 RJGYJMFQWGPBGM-UHFFFAOYSA-N 0.000 description 3
- 206010019375 Helicobacter infections Diseases 0.000 description 3
- 206010061297 Mucosal erosion Diseases 0.000 description 3
- 239000003159 antacid agent Substances 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 238000001574 biopsy Methods 0.000 description 3
- 239000004202 carbamide Substances 0.000 description 3
- 210000001072 colon Anatomy 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 229940039696 lactobacillus Drugs 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 244000005706 microflora Species 0.000 description 3
- 210000004877 mucosa Anatomy 0.000 description 3
- 238000009097 single-agent therapy Methods 0.000 description 3
- AJKIRUJIDFJUKJ-UHFFFAOYSA-N taurolidine Chemical compound C1NS(=O)(=O)CCN1CN1CNS(=O)(=O)CC1 AJKIRUJIDFJUKJ-UHFFFAOYSA-N 0.000 description 3
- 229960004267 taurolidine Drugs 0.000 description 3
- 229950007343 taurultam Drugs 0.000 description 3
- 238000011269 treatment regimen Methods 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 229960003022 amoxicillin Drugs 0.000 description 2
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 description 2
- 229940069428 antacid Drugs 0.000 description 2
- 230000001458 anti-acid effect Effects 0.000 description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 description 2
- 239000001569 carbon dioxide Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000006957 competitive inhibition Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 231100000676 disease causative agent Toxicity 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 230000005713 exacerbation Effects 0.000 description 2
- 230000027119 gastric acid secretion Effects 0.000 description 2
- 208000021302 gastroesophageal reflux disease Diseases 0.000 description 2
- 230000001900 immune effect Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 239000000832 lactitol Substances 0.000 description 2
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 description 2
- 235000010448 lactitol Nutrition 0.000 description 2
- 229960003451 lactitol Drugs 0.000 description 2
- 230000002906 microbiologic effect Effects 0.000 description 2
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 2
- 238000003752 polymerase chain reaction Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000002285 radioactive effect Effects 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 210000002438 upper gastrointestinal tract Anatomy 0.000 description 2
- LGQKSQQRKHFMLI-SJYYZXOBSA-N (2s,3r,4s,5r)-2-[(3r,4r,5r,6r)-4,5,6-trihydroxyoxan-3-yl]oxyoxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)CO[C@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)OC1 LGQKSQQRKHFMLI-SJYYZXOBSA-N 0.000 description 1
- LGQKSQQRKHFMLI-UHFFFAOYSA-N 4-O-beta-D-xylopyranosyl-beta-D-xylopyranose Natural products OC1C(O)C(O)COC1OC1C(O)C(O)C(O)OC1 LGQKSQQRKHFMLI-UHFFFAOYSA-N 0.000 description 1
- 108091006112 ATPases Proteins 0.000 description 1
- 102000057290 Adenosine Triphosphatases Human genes 0.000 description 1
- 241000589876 Campylobacter Species 0.000 description 1
- OKTJSMMVPCPJKN-OUBTZVSYSA-N Carbon-13 Chemical compound [13C] OKTJSMMVPCPJKN-OUBTZVSYSA-N 0.000 description 1
- 108010053835 Catalase Proteins 0.000 description 1
- 102100035882 Catalase Human genes 0.000 description 1
- 101710112752 Cytotoxin Proteins 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- SQNRKWHRVIAKLP-UHFFFAOYSA-N D-xylobiose Natural products O=CC(O)C(O)C(CO)OC1OCC(O)C(O)C1O SQNRKWHRVIAKLP-UHFFFAOYSA-N 0.000 description 1
- 208000036649 Dysbacteriosis Diseases 0.000 description 1
- 208000027244 Dysbiosis Diseases 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 241000589989 Helicobacter Species 0.000 description 1
- 241001495142 Helicobacter heilmannii Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 208000012868 Overgrowth Diseases 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 201000008629 Zollinger-Ellison syndrome Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000001262 anti-secretory effect Effects 0.000 description 1
- 230000000767 anti-ulcer Effects 0.000 description 1
- 229940124350 antibacterial drug Drugs 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 238000011203 antimicrobial therapy Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- DLRVVLDZNNYCBX-ZZFZYMBESA-N beta-melibiose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)O1 DLRVVLDZNNYCBX-ZZFZYMBESA-N 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 230000002380 cytological effect Effects 0.000 description 1
- 231100000599 cytotoxic agent Toxicity 0.000 description 1
- 239000002619 cytotoxin Substances 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- 102000038379 digestive enzymes Human genes 0.000 description 1
- 108091007734 digestive enzymes Proteins 0.000 description 1
- 230000007140 dysbiosis Effects 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 238000002181 esophagogastroduodenoscopy Methods 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 239000005417 food ingredient Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000005714 functional activity Effects 0.000 description 1
- 210000001156 gastric mucosa Anatomy 0.000 description 1
- 201000000052 gastrinoma Diseases 0.000 description 1
- 210000003736 gastrointestinal content Anatomy 0.000 description 1
- 238000002575 gastroscopy Methods 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 238000010562 histological examination Methods 0.000 description 1
- 230000007366 host health Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 230000008991 intestinal motility Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000009630 liquid culture Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000013048 microbiological method Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 230000006740 morphological transformation Effects 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 208000000689 peptic esophagitis Diseases 0.000 description 1
- 238000001050 pharmacotherapy Methods 0.000 description 1
- 230000017363 positive regulation of growth Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 210000004203 pyloric antrum Anatomy 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 238000011301 standard therapy Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000002731 stomach secretion inhibitor Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000011885 synergistic combination Substances 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/732—Pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/733—Fructosans, e.g. inulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (10)
1. Farmaceutisk præparat til behandling af sår i mavesæk og duodenum, der inkluderer mindst én PPI og mindst ét præbiotikum, med følgende indhold af præparatbestanddele i vægt-%: - protonpumpehæmmer 0,05-25 %; - præbiotikum 40-95 %; - excipienser op til 100 %, hvor præbiotikummet er udvalgt fra en gruppe, der består af et di- eller trisaccharid, der er udvalgt fra gruppen, der består af lactulose, lactosucrose, melibiose, xylobiose, stachyose og raffinose; og/eller et oligosaccharid, der er udvalgt fra gruppen, der består af fructooligosaccharid, galactooligosaccharid, maltooligosaccharid, xylooligosaccharid, isomaltooligosaccharid og gentioligosaccharid; og/eller et polysaccharid, der er udvalgt fra gruppen, der består af arabinogalactan, pectin, pullulan, inulin og lignin.
2. Farmaceutisk præparat ifølge krav 1, der er kendetegnet ved, at det indeholder en protonpumpehæmmer fra gruppen: omeprazol, pantoprazol, lansoprazol, rabeprazol og esomeprazol.
3. Farmaceutisk præparat ifølge krav 2, der er kendetegnet ved, at det indeholder PPI'en omeprazol i en mængde på 10-120 mg.
4. Farmaceutisk præparat ifølge krav 2, der er kendetegnet ved, at det indeholder PPI'en pantoprazol i en mængde på 20-800 mg.
5. Farmaceutisk præparat ifølge krav 2, der er kendetegnet ved, at det indeholder PPI'en lansoprazol i en mængde på 10-600 mg.
6. Farmaceutisk præparat ifølge krav 2, der er kendetegnet ved, at det indeholder PPI'en rabeprazol i en mængde på 10-200 mg.
7. Farmaceutisk præparat ifølge krav 2, der er kendetegnet ved, at det indeholder PPI'en esomeprazol i en mængde på 20-240 mg.
8. Farmaceutisk præparat ifølge et hvilket som helst af kravene 1 til 7, der er kendetegnet ved, at doseringsformen af præparatet er en suspension til oral administration, en opløsning til oral administration eller kapsler, tabletter, pulvere, portionsbreve, pellets, granula til oral administration.
9. Farmaceutisk præparat ifølge et hvilket som helst af kravene 1 til 8 til anvendelse til behandling af sår i mavesæk og duodenum, når udryddelse af H. pylori er opnået under behandlingsforløbet, hos patienter (mindst én gang dagligt før fødeindtagelse, i det mindste inden for 14 dage) ved enteral administration.
10. Farmaceutisk præparat til anvendelse til behandling ifølge krav 9, der er kendetegnet ved, at udryddelse af H. pylori er opnået uden administration af antibiotika under behandlingsforløbet.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2009111362/15A RU2410100C2 (ru) | 2009-03-30 | 2009-03-30 | Фармацевтическая композиция ингибитора протонной помпы и пребиотика для лечения язвенных поражений желудка и 12-перстной кишки |
| PCT/RU2010/000197 WO2010114425A2 (ru) | 2009-03-30 | 2010-04-23 | Фармацевтическая композиция ингибитора протонной помпы и пребиотика для лечения язвенных поражений желудка и 12- перстной кишки |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2415475T3 true DK2415475T3 (da) | 2015-01-12 |
Family
ID=42828898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10759105.9T DK2415475T3 (da) | 2009-03-30 | 2010-04-23 | Farmaceutisk præparat, der omfatter en protonpumpehæmmer og et præbiotikum, til behandling af ulcerøse læsioner i mavesæk og duodenum |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20120028914A1 (da) |
| EP (1) | EP2415475B1 (da) |
| CN (1) | CN102333534B (da) |
| BR (1) | BRPI1014831A2 (da) |
| CY (1) | CY1116050T1 (da) |
| DK (1) | DK2415475T3 (da) |
| EA (1) | EA022204B1 (da) |
| ES (1) | ES2527470T3 (da) |
| HR (1) | HRP20150001T1 (da) |
| PL (1) | PL2415475T3 (da) |
| PT (1) | PT2415475E (da) |
| RU (1) | RU2410100C2 (da) |
| SI (1) | SI2415475T1 (da) |
| UA (1) | UA97078C2 (da) |
| WO (1) | WO2010114425A2 (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2449787C1 (ru) * | 2011-01-12 | 2012-05-10 | Государственное образовательное учреждение высшего профессионального образования "Пермская государственная медицинская академия имени академика Е.А. Вагнера Федерального агентства по здравоохранению и социальному развитию" | Способ лечения эрозивных и язвенных поражений слизистой оболочки желудка |
| DE102011013524A1 (de) * | 2011-03-10 | 2012-09-13 | SC "PharmVILAR" CJSC | Mittel EXPORTAL mit gastroprotektiver (antiulceröser) Wirkung |
| RU2501549C1 (ru) * | 2012-08-30 | 2013-12-20 | Авва Девелопмент Лтд | Фармацевтическая композиция для лечения гастроэзофагеальной рефлюксной болезни |
| CN108159059A (zh) * | 2017-12-15 | 2018-06-15 | 哈尔滨珍宝制药有限公司 | 一种包含埃索美拉唑钠的药物组合物及其制备方法 |
| CN108904546A (zh) * | 2018-07-10 | 2018-11-30 | 山东腾贵医药有限公司 | 一种对幽门螺旋杆菌有抑制、杀灭作用的益生菌组合制剂及其制备方法 |
| CN111166776A (zh) * | 2018-11-10 | 2020-05-19 | 湖南益优健康产业有限公司 | 一种根除幽门螺杆菌引起的慢性胃炎的配方 |
| CN109566951B (zh) * | 2018-11-26 | 2021-09-17 | 大兴安岭北天原生物科技有限责任公司 | 含黄芪或黄芪茎、叶、花的护胃咀嚼片 |
| CN109497557B (zh) * | 2019-01-06 | 2022-07-15 | 赵勤农 | 一种抗Hp感染促进胃部菌群平衡的组合物及其应用 |
| CN111903962A (zh) * | 2020-05-25 | 2020-11-10 | 上海复旦奥医医学科技有限公司 | 一种胃溃疡和十二指肠溃疡专用型临床营养配方及其制备 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4993893A (en) * | 1992-07-31 | 1994-03-03 | Neose Pharmaceuticals, Inc. | Compositions for treating and inhibiting gastric and duodenal ulcers |
| MX9304638A (es) * | 1992-07-31 | 1994-05-31 | Neose Pharm Inc | Composicion para tratar e inhibir las ulceras gastricas y duodenales. |
| WO1994018986A1 (en) * | 1993-02-26 | 1994-09-01 | Jan Staffan Normark | Use of oligosaccharide glycosides as inhibitors of bacterial adherence |
| JP2001509791A (ja) * | 1996-11-27 | 2001-07-24 | ザ、プロクター、エンド、ギャンブル、カンパニー | 胃腸障害の治療用組成物及び方法 |
| US6117868A (en) | 1998-09-16 | 2000-09-12 | Ed. Geistlich Sohne Ag Fur Chemische Industrie | Treatment of gastrointestinal ulcers or gastritis caused by microbial infection |
| RU2184558C2 (ru) * | 2000-08-07 | 2002-07-10 | Нижегородская государственная медицинская академия | Способ лечения язвенной болезни двенадцатиперстной кишки |
| FI20011403A7 (fi) * | 2001-06-29 | 2002-12-30 | Carbion Oy | Menetelmä ja koostumukset vatsan sairauksien hoitoon |
| US6685427B1 (en) * | 2002-07-23 | 2004-02-03 | General Electric Company | Brush seal for a rotary machine and method of retrofitting |
| US20050031696A1 (en) * | 2003-04-22 | 2005-02-10 | Dr. Reddy's Laboratories Limited | Oral pharmaceutical formulations of acid-labile active ingredients and process for making same |
| US7670624B2 (en) * | 2004-01-29 | 2010-03-02 | Astella Pharma Inc. | Gastrointestinal-specific multiple drug release system |
| AR049142A1 (es) * | 2004-06-07 | 2006-06-28 | Wyeth Corp | Composiciones para recubrimientos de azucar,composiciones recubiertas y metodos para la fabricacion de los mismos |
| EP2012807A4 (en) * | 2006-04-10 | 2009-07-08 | Dikovskiy Aleksander Vladimiro | PHARMACEUTICAL COMPOSITION FROM AN ENTEROSORBEN AND PREBIOTIKA, DOSAGE FORMS AND METHOD FOR THE PREVENTION AND TREATMENT OF GASTROINTESTINAL DISEASES |
| RU2325187C1 (ru) * | 2006-11-21 | 2008-05-27 | Александр Владимирович Диковский | Фармацевтическая композиция антибиотиков и пребиотиков (варианты) для профилактики и лечения дисбиозов в процессе антибактериальной терапии |
-
2009
- 2009-03-30 RU RU2009111362/15A patent/RU2410100C2/ru not_active IP Right Cessation
-
2010
- 2010-04-23 EP EP10759105.9A patent/EP2415475B1/en not_active Not-in-force
- 2010-04-23 EA EA201100857A patent/EA022204B1/ru not_active IP Right Cessation
- 2010-04-23 CN CN2010800074518A patent/CN102333534B/zh not_active Expired - Fee Related
- 2010-04-23 WO PCT/RU2010/000197 patent/WO2010114425A2/ru not_active Ceased
- 2010-04-23 BR BRPI1014831A patent/BRPI1014831A2/pt active Search and Examination
- 2010-04-23 HR HRP20150001AT patent/HRP20150001T1/hr unknown
- 2010-04-23 PL PL10759105T patent/PL2415475T3/pl unknown
- 2010-04-23 DK DK10759105.9T patent/DK2415475T3/da active
- 2010-04-23 US US13/257,361 patent/US20120028914A1/en not_active Abandoned
- 2010-04-23 ES ES10759105.9T patent/ES2527470T3/es active Active
- 2010-04-23 PT PT107591059T patent/PT2415475E/pt unknown
- 2010-04-23 UA UAA201107579A patent/UA97078C2/uk unknown
- 2010-04-23 SI SI201030845T patent/SI2415475T1/sl unknown
-
2015
- 2015-01-07 CY CY20151100010T patent/CY1116050T1/el unknown
-
2016
- 2016-01-28 US US15/008,600 patent/US20160136194A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| RU2009111362A (ru) | 2010-10-10 |
| EP2415475A2 (en) | 2012-02-08 |
| WO2010114425A3 (ru) | 2011-01-06 |
| CY1116050T1 (el) | 2017-01-25 |
| BRPI1014831A2 (pt) | 2016-04-12 |
| CN102333534A (zh) | 2012-01-25 |
| SI2415475T1 (sl) | 2015-03-31 |
| US20120028914A1 (en) | 2012-02-02 |
| HRP20150001T1 (hr) | 2015-02-27 |
| CN102333534B (zh) | 2013-01-02 |
| EA201100857A1 (ru) | 2011-12-30 |
| EP2415475B1 (en) | 2014-12-31 |
| PL2415475T3 (pl) | 2015-03-31 |
| UA97078C2 (uk) | 2011-12-26 |
| WO2010114425A8 (ru) | 2011-12-08 |
| ES2527470T3 (es) | 2015-01-26 |
| EP2415475A4 (en) | 2012-09-05 |
| PT2415475E (pt) | 2015-01-13 |
| EA022204B1 (ru) | 2015-11-30 |
| RU2410100C2 (ru) | 2011-01-27 |
| US20160136194A1 (en) | 2016-05-19 |
| WO2010114425A2 (ru) | 2010-10-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK2415475T3 (da) | Farmaceutisk præparat, der omfatter en protonpumpehæmmer og et præbiotikum, til behandling af ulcerøse læsioner i mavesæk og duodenum | |
| CN108883139B (zh) | 包含细菌菌株的组合物 | |
| JP2015512936A (ja) | プレバイオティクス組成物およびその使用方法 | |
| CN103987393A (zh) | 能够恢复在胃酸过多的药物治疗期间丧失的胃本身的屏障效应的包括与益生菌联合的n-乙酰半胱氨酸和/或微胶囊化的胃保护性溶菌酶的组合物 | |
| US20210338749A1 (en) | Methods of treatment of inflammatory conditions and associated infections | |
| WO2020063531A1 (zh) | 副干酪乳杆菌et-22及其用途 | |
| WO2024141107A1 (zh) | 柯林斯菌新菌种及其药物组合物 | |
| WO2018112740A1 (zh) | 一种加氏乳杆菌及其培养方法和应用 | |
| RU2501549C1 (ru) | Фармацевтическая композиция для лечения гастроэзофагеальной рефлюксной болезни | |
| JP6837992B2 (ja) | 非伝達性の抗生物質耐性を有し、同じ治療適応症を有する乳酸菌および／またはビフィズス菌の同時使用と組合せた、特定の治療活性を有する抗生物質の使用 | |
| CN116121136B (zh) | 一种缓解便秘的益生菌组合物及其应用 | |
| WO2021097288A1 (en) | Compositions and methods for treating neurodegenerative diseases | |
| CN111544451A (zh) | 用于抗幽门螺杆菌的组合物及其应用 | |
| CN118599710A (zh) | 一种动物双歧杆菌及其用途 | |
| CN117460515A (zh) | 包含半乳糖的用于改善肠道微生物种群的组合物 | |
| TW202444397A (zh) | 用於改善慢性腎臟病的乳酸菌菌株組成物及其應用 | |
| RU2746590C1 (ru) | Способ эрадикации бактерий Helicobacter pylori при экспериментальном хеликобактериозе у конвенциональных белых мышей и средство для его осуществления | |
| BR112020006694A2 (pt) | uma composição farmacêutica compreendendo um probiótico e um prebiótico para prevenir a aquisição de ou para tratar infecções resistentes a fármacos | |
| TW202140049A (zh) | 用於治療ｂ型肝炎（ｈｂｖ）及ｄ型肝炎（ｈｄｖ）之組合物及方法 | |
| BR112020015168A2 (pt) | Composição compreendendo novas cepas de lactobacillus salivarius e método para a prevenção e o tratamento de otite e infecções das vias aéreas superiores | |
| CN110974822B (zh) | 吡咯烷二硫代氨基甲酸铵的制药用途 | |
| CN121427738A (zh) | 一种改善婴幼儿功能性便秘的植物乳植杆菌lp-z6及其应用 | |
| RU2713154C1 (ru) | Антихеликобактерное средство и способ его применения | |
| HK40123776A (zh) | 一种防复胖的乳杆菌科菌株及其产品、组合物及其应用 | |
| CN120005775A (zh) | 复合益生菌、其制剂、后生元组合物及其在防治幽门螺旋杆菌中的应用和产品 |