DK2418211T3 - Deutererede morphinanforbindelser - Google Patents
Deutererede morphinanforbindelser Download PDFInfo
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- DK2418211T3 DK2418211T3 DK11188848.3T DK11188848T DK2418211T3 DK 2418211 T3 DK2418211 T3 DK 2418211T3 DK 11188848 T DK11188848 T DK 11188848T DK 2418211 T3 DK2418211 T3 DK 2418211T3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
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- Public Health (AREA)
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- Emergency Medicine (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (12)
- DEUTEREREDE MORPHINANFORBINDELSER E Forbindelse med formlen I:(l) eller et farmaceutisk acceptabelt salt deraf, hvor: R1 er CD3; og R2 er udvalgt fra CH3, og CD3.
- 2. Forbindelse ifølge krav 1, hvilken forbindelse er udvalgt fra en hvilken som helst af:eller et farmaceutisk acceptabelt salt deraf, hvor et hvilket som helst atom, der ikke er betegnet som deuterium, er til stede ved dets naturlige isotophyppighed.
- 3. Pyrogenfri farmaceutisk sammensætning, der omfatter: forbindelsen ifølge krav 1 eller 2 eller et farmaceutisk acceptabelt salt deraf, og en farmaceutisk acceptabel bærer.
- 4. Sammensætning ifølge krav 3, hvilken sammensætning endvidere omfatter et andet terapeutisk middel, der er anvendeligt til behandling af en patient, der lider af eller er disponeret for en sygdom eller tilstand, der er udvalgt fra emotionel labilitet; pseudobulbær affekt; autisme; neurologiske sygdomme og neurodegenerative sygdomme; hjerneskader; forstyrrelser med bevidsthedsforstyrrelser; hjerte-karsygdomme; glaukom; tardiv dyskinesi; cancer; rheumatoid arthritis; diabetisk neuropati; retinopatiske sygdomme; sygdomme eller lidelser, der er forårsaget af homocysteininduceret apoptose; sygdomme eller lidelser, der er forårsaget af forhøjede homocysteinniveauer; kronisk smerte; genstridig smerte; neuropatisk smerte, sympatetisk medieret smerte; smerte, der er forbundet med gastrointestinal dysfunktion; smerte i munden; rygsmerte; centralt smertesyndrom; komplekst regionalt smertesyndrom; epileptiske anfald; epileptisk hemiplegi; erhvervet epileptiform afasi (Landau-Kleffner-syndrom); svær myoklon epilepsi (SMEI); tidlig infantil epileptisk encefalopati; anfald efter apopleksi; feberkramper; posttraumatiske anfald; tinnitus; seksuel dysfunktion; genstridig hoste; dermatitis; afhængighedsforstyrrelser; Retts syndrom (RTT); stemmeforstyrrelser på grund af ukontrollerede spasmer i larynxmusklen; methotrexat-neurotoksicitet; og træthed, der er forårsaget af cancer.
- 5. Sammensætning ifølge krav 4, hvor det andet terapeutiske middel er udvalgt fra quinidin, quinidinsulfat, oxycodon og gabapentin.
- 6. Sammensætning ifølge et hvilket som helst af kravene 3-5 til anvendelse til behandling af en sygdom eller tilstand, der er udvalgt fra emotionel labilitet; pseudobulbær affekt; autisme; neurologiske sygdomme og neurodegenerative sygdomme; hjerneskader; forstyrrelser med bevidsthedsforstyrrelser; hjerte-kar-sygdomme; glaukom; tardiv dyskinesi; cancer; rheumatoid arthritis; diabetisk neuropati; retinopatiske sygdomme; sygdomme eller lidelser, der er forårsaget af homocysteininduceret apoptose; sygdomme eller lidelser, der er forårsaget af forhøjede homocysteinniveauer; kronisk smerte; genstridig smerte; neuropatisk smerte, sympatetisk medieret smerte; smerte, der er forbundet med gastrointestinal dysfunktion; smerte i munden; rygsmerte; centralt smertesyndrom; komplekst regionalt smertesyndrom; epileptiske anfald; epileptisk hemiplegi; erhvervet epileptiform afasi (Landau-Kleffner-syndrom); svær myoklon epilepsi (SMEI); tidlig infantil epileptisk encefalopati; anfald efter apopleksi; feberkramper; posttraumatiske anfald; tinnitus; seksuel dysfunktion; genstridig hoste; dermatitis; afhængighedsforstyrrelser; Retts syndrom (RTT); stemmeforstyrrelser på grund af ukontrollerede spasmer i larynxmusklen; methotrexat-neurotoksicitet; og træthed, der er forårsaget af cancer.
- 7. Sammensætning ifølge krav 6, hvor tilstanden er diabetisk neuropatisk smerte.
- 8. Sammensætning ifølge krav 6, hvor tilstanden er epileptiske anfald.
- 9. Sammensætning ifølge et hvilket som helst af kravene 3-5 til anvendelse til behandling af tilstande, der er relateret til eksponering for kemiske stoffer.
- 10. Sammensætning ifølge et hvilket som helst af kravene 3-5 til anvendelse til behandling af smerte.
- 11. Sammensætning ifølge krav 3, hvilken sammensætning endvidere omfatter et andet terapeutisk middel, der er anvendeligt til behandling af en patient, der lider af eller er disponeret for smerte.
- 12. Sammensætning ifølge krav 3, hvilken sammensætning endvidere omfatter et andet terapeutisk middel, der er anvendeligt til behandling af en patient, der lider af eller er disponeret for tilstande, der er relateret til eksponering for kemiske stoffer.
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| US9851108P | 2008-09-19 | 2008-09-19 | |
| EP09792714A EP2334678B1 (en) | 2008-09-19 | 2009-09-18 | Morphinan compounds |
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| DK2418211T3 true DK2418211T3 (da) | 2016-06-27 |
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- 2009-09-18 ES ES14179393.5T patent/ES2656444T3/es active Active
- 2009-09-18 WO PCT/US2009/057476 patent/WO2010033801A1/en not_active Ceased
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2011
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2013
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