DK2428574T3 - Oxidoreduktaser til stereoselektiv reduktion af ketoforbindelser - Google Patents

Oxidoreduktaser til stereoselektiv reduktion af ketoforbindelser

Info

Publication number: DK2428574T3
Authority: DK; Denmark
Prior art keywords: oxidoreductases; keto compounds; stereoselective reduction; stereoselective; reduction
Prior art date: 2005-07-27

Application number

DK11189703.9T

Other languages

English (en)

Inventor

Antje Tschentscher

Antje Gupta

Maria Dupont

Original Assignee

Cambrex Iep Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-07-27

Filing date

2006-07-20

Publication date

2014-10-27

2006-07-20 Application filed by Cambrex Iep Gmbh filed Critical Cambrex Iep Gmbh

2014-10-27 Application granted granted Critical

2014-10-27 Publication of DK2428574T3 publication Critical patent/DK2428574T3/da

Links

102000004316 Oxidoreductases Human genes 0.000 title 1
108090000854 Oxidoreductases Proteins 0.000 title 1
125000000468 ketone group Chemical group 0.000 title 1
238000011916 stereoselective reduction Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Enzymes And Modification Thereof (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK11189703.9T 2005-07-27 2006-07-20 Oxidoreduktaser til stereoselektiv reduktion af ketoforbindelser DK2428574T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
AT0126105A AT502395B1 (de)	2005-07-27	2005-07-27	Oxidoreduktasen zur stereoselektiven reduktion von ketoverbindungen
EP06776315A EP1907556A1 (de)	2005-07-27	2006-07-20	Oxidoreduktasen zur stereoselektiven reduktion von ketoverbindungen

Publications (1)

Publication Number	Publication Date
DK2428574T3 true DK2428574T3 (da)	2014-10-27

Family

ID=37216025

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK11189701.3T DK2426209T3 (da)	2005-07-27	2006-07-20	Oxidoreduktaser til stereoselektiv reduktion af ketoforbindelser
DK11189708T DK2428576T3 (da)	2005-07-27	2006-07-20	Oxidoreduktaser til stereoselektiv reduktion af ketoforbindelser
DK11189703.9T DK2428574T3 (da)	2005-07-27	2006-07-20	Oxidoreduktaser til stereoselektiv reduktion af ketoforbindelser

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
DK11189701.3T DK2426209T3 (da)	2005-07-27	2006-07-20	Oxidoreduktaser til stereoselektiv reduktion af ketoforbindelser
DK11189708T DK2428576T3 (da)	2005-07-27	2006-07-20	Oxidoreduktaser til stereoselektiv reduktion af ketoforbindelser

Country Status (16)

Country	Link
US (2)	US20090311762A1 (da)
EP (5)	EP1907556A1 (da)
JP (1)	JP2009502148A (da)
KR (2)	KR101341392B1 (da)
CN (1)	CN101273137A (da)
AT (1)	AT502395B1 (da)
AU (1)	AU2006274252B2 (da)
CA (5)	CA2821720C (da)
DK (3)	DK2426209T3 (da)
ES (3)	ES2525549T3 (da)
HU (1)	HUE024985T2 (da)
PL (3)	PL2428576T3 (da)
PT (3)	PT2428576E (da)
SI (3)	SI2428576T1 (da)
WO (1)	WO2007012428A1 (da)
ZA (1)	ZA200800732B (da)

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KR101586503B1 (ko)	2007-09-13	2016-01-18	코덱시스, 인코포레이티드	아세토페논의 환원을 위한 케토리덕타제 폴리펩티드
TWI601825B (zh)	2007-09-27	2017-10-11	Ｉｅｐ有限公司	對映異構選擇性酶催化還原中間產物之方法
CN101889081B (zh)	2007-09-28	2014-06-18	科德克希思公司	酮还原酶多肽及其用途
HUE027683T2 (en)	2007-10-01	2016-10-28	Codexis Inc	Ketoreductase polypeptides for the production of azetidinone
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WO2010025287A2 (en)	2008-08-27	2010-03-04	Codexis, Inc.	Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
SI2329014T1 (sl)	2008-08-29	2015-01-30	Codexis, Inc.	Polipeptidi ketoreduktaze za stereoselektivno produkcijo (4s)-3(5s)-5(4-fluorofenil)-5-hidroksipentanoil)-4-fenil-1,3-oksazolidin -2-ona
EP2226386A1 (de)	2009-03-05	2010-09-08	IEP GmbH	Verfahren zur stereoselektiven enzymatischen Reduktion von Ketoverbindungen
AU2009348523B2 (en)	2009-06-22	2015-02-26	Sk Biopharmaceuticals Co., Ltd.	Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester
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MX387756B (es) *	2014-08-25	2025-03-18	Hli Cellular Therapeutics Llc	Composiciones de matríces extracelulares.
CN108441433B (zh) *	2018-03-31	2021-08-20	湖南科技大学	胶红酵母nq1及在制备手性醇中的应用
CN108753851B (zh) *	2018-05-28	2022-05-20	中国科学院成都生物研究所	羰基还原酶生物催化生产手性1,2-二醇类化合物
WO2020248186A1 (zh) *	2019-06-13	2020-12-17	凯莱英医药集团（天津）股份有限公司	酮还原酶突变体及生产手性醇的方法
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CN115449527B (zh) *	2021-06-08	2025-07-04	华南理工大学	氧化还原酶作为圆柚醇脱氢酶在生物合成圆柚酮中的应用

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2005
- 2005-07-27 AT AT0126105A patent/AT502395B1/de not_active IP Right Cessation
2006
- 2006-07-20 EP EP06776315A patent/EP1907556A1/de not_active Withdrawn
- 2006-07-20 ES ES11189701.3T patent/ES2525549T3/es not_active Expired - Lifetime
- 2006-07-20 KR KR1020087004580A patent/KR101341392B1/ko not_active Expired - Fee Related
- 2006-07-20 PL PL11189708T patent/PL2428576T3/pl unknown
- 2006-07-20 PL PL11189701T patent/PL2426209T3/pl unknown
- 2006-07-20 CA CA2821720A patent/CA2821720C/en not_active Expired - Lifetime
- 2006-07-20 CA CA2869218A patent/CA2869218C/en not_active Expired - Lifetime
- 2006-07-20 DK DK11189701.3T patent/DK2426209T3/da active
- 2006-07-20 DK DK11189708T patent/DK2428576T3/da active
- 2006-07-20 CN CNA2006800356804A patent/CN101273137A/zh active Pending
- 2006-07-20 PT PT111897088T patent/PT2428576E/pt unknown
- 2006-07-20 ES ES11189703.9T patent/ES2524167T3/es not_active Expired - Lifetime
- 2006-07-20 AU AU2006274252A patent/AU2006274252B2/en not_active Ceased
- 2006-07-20 EP EP11189701.3A patent/EP2426209B1/de not_active Expired - Lifetime
- 2006-07-20 KR KR1020137022212A patent/KR101354546B1/ko not_active Expired - Fee Related
- 2006-07-20 EP EP11189703.9A patent/EP2428574B1/de not_active Expired - Lifetime
- 2006-07-20 SI SI200631899T patent/SI2428576T1/sl unknown
- 2006-07-20 EP EP11189708.8A patent/EP2428576B1/de not_active Expired - Lifetime
- 2006-07-20 EP EP11189707A patent/EP2428575A1/de not_active Withdrawn
- 2006-07-20 CA CA2821717A patent/CA2821717C/en not_active Expired - Lifetime
- 2006-07-20 WO PCT/EP2006/007150 patent/WO2007012428A1/de not_active Ceased
- 2006-07-20 PL PL11189703T patent/PL2428574T3/pl unknown
- 2006-07-20 JP JP2008523190A patent/JP2009502148A/ja active Pending
- 2006-07-20 CA CA2625834A patent/CA2625834C/en not_active Expired - Lifetime
- 2006-07-20 DK DK11189703.9T patent/DK2428574T3/da active
- 2006-07-20 SI SI200631849T patent/SI2428574T1/sl unknown
- 2006-07-20 PT PT111897039T patent/PT2428574E/pt unknown
- 2006-07-20 US US11/996,968 patent/US20090311762A1/en not_active Abandoned
- 2006-07-20 ZA ZA200800732A patent/ZA200800732B/xx unknown
- 2006-07-20 PT PT111897013T patent/PT2426209E/pt unknown
- 2006-07-20 HU HUE11189708A patent/HUE024985T2/hu unknown
- 2006-07-20 SI SI200631878T patent/SI2426209T1/sl unknown
- 2006-07-20 ES ES11189708.8T patent/ES2534657T3/es not_active Expired - Lifetime
- 2006-07-20 CA CA2821719A patent/CA2821719C/en not_active Expired - Lifetime
2011
- 2011-10-25 US US13/280,876 patent/US9040265B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1907556A1 (de)	2008-04-09
US20090311762A1 (en)	2009-12-17
SI2428574T1 (sl)	2014-12-31
ES2525549T3 (es)	2014-12-26
HUE024985T2 (hu)	2016-02-29
CN101273137A (zh)	2008-09-24
EP2428574A1 (de)	2012-03-14
EP2428576B1 (de)	2015-01-14
AT502395B1 (de)	2007-03-15
KR20080036617A (ko)	2008-04-28
US20140017743A1 (en)	2014-01-16
AT502395A4 (de)	2007-03-15
PT2428574E (pt)	2014-11-26
PT2426209E (pt)	2014-12-16
SI2428576T1 (sl)	2015-04-30
PT2428576E (pt)	2015-04-30
CA2869218A1 (en)	2007-02-01
JP2009502148A (ja)	2009-01-29
KR101354546B1 (ko)	2014-01-22
AU2006274252B2 (en)	2012-12-13
CA2869218C (en)	2017-06-27
CA2821719A1 (en)	2007-02-01
EP2428576A1 (de)	2012-03-14
PL2428576T3 (pl)	2015-07-31
EP2426209A1 (de)	2012-03-07
ES2534657T3 (es)	2015-04-27
CA2821720C (en)	2015-11-24
CA2625834C (en)	2013-08-27
WO2007012428A1 (de)	2007-02-01
AU2006274252A1 (en)	2007-02-01
PL2426209T3 (pl)	2015-04-30
US9040265B2 (en)	2015-05-26
DK2428576T3 (da)	2015-03-09
ZA200800732B (en)	2009-05-27
CA2821717C (en)	2017-06-27
EP2428575A1 (de)	2012-03-14
EP2428574B1 (de)	2014-09-24
CA2821719C (en)	2017-06-27
SI2426209T1 (sl)	2015-02-27
CA2821720A1 (en)	2007-02-01
KR101341392B1 (ko)	2013-12-20
CA2625834A1 (en)	2007-02-01
CA2821717A1 (en)	2007-02-01
KR20130110223A (ko)	2013-10-08
ES2524167T3 (es)	2014-12-04
PL2428574T3 (pl)	2015-03-31
EP2426209B1 (de)	2014-10-15
DK2426209T3 (da)	2014-11-10

Publication	Publication Date	Title
DK2426209T3 (da)	2014-11-10	Oxidoreduktaser til stereoselektiv reduktion af ketoforbindelser
DK2178863T3 (da)	2013-02-11	Fremgangsmåde til syntetisering af anvendelige forbindelser til behandling af hepatitis C
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DK1778668T3 (da)	2013-09-30	Fremgangsmåde til fremstilling af dihydropteridion
DK1720802T3 (da)	2013-09-30	Okidation af organiske forbindelser ved højt pH
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