DK2435568T3 - Samling af syntetiske antistoffer til behandling af sygdom - Google Patents

Samling af syntetiske antistoffer til behandling af sygdom

Info

Publication number
DK2435568T3
DK2435568T3 DK10722101.2T DK10722101T DK2435568T3 DK 2435568 T3 DK2435568 T3 DK 2435568T3 DK 10722101 T DK10722101 T DK 10722101T DK 2435568 T3 DK2435568 T3 DK 2435568T3
Authority
DK
Denmark
Prior art keywords
collection
treat disease
synthetic antibodies
antibodies
synthetic
Prior art date
Application number
DK10722101.2T
Other languages
English (en)
Inventor
Markus Enzelberger
Josef Prassler
Stefanie Urlinger
Tanja Herrmann
Thomas Tiller
Original Assignee
Morphosys Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphosys Ag filed Critical Morphosys Ag
Application granted granted Critical
Publication of DK2435568T3 publication Critical patent/DK2435568T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK10722101.2T 2009-05-29 2010-05-29 Samling af syntetiske antistoffer til behandling af sygdom DK2435568T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US18235009P 2009-05-29 2009-05-29
EP09162724 2009-06-15
US29940110P 2010-01-29 2010-01-29
PCT/EP2010/057507 WO2010136598A1 (en) 2009-05-29 2010-05-29 A collection and methods for its use

Publications (1)

Publication Number Publication Date
DK2435568T3 true DK2435568T3 (da) 2014-09-08

Family

ID=41210731

Family Applications (1)

Application Number Title Priority Date Filing Date
DK10722101.2T DK2435568T3 (da) 2009-05-29 2010-05-29 Samling af syntetiske antistoffer til behandling af sygdom

Country Status (17)

Country Link
US (3) US8685896B2 (da)
EP (1) EP2435568B1 (da)
JP (1) JP5804521B2 (da)
KR (1) KR101805202B1 (da)
CN (1) CN102449149B (da)
AU (1) AU2010252939B2 (da)
CA (1) CA2758356C (da)
DK (1) DK2435568T3 (da)
ES (1) ES2511051T3 (da)
IL (1) IL216536B (da)
MX (1) MX2011012696A (da)
NZ (1) NZ596603A (da)
PT (1) PT2435568E (da)
RU (1) RU2569187C2 (da)
SG (1) SG175407A1 (da)
WO (1) WO2010136598A1 (da)
ZA (1) ZA201107652B (da)

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US20130045492A1 (en) 2010-02-08 2013-02-21 Regeneron Pharmaceuticals, Inc. Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
HRP20181811T1 (hr) 2010-11-19 2018-12-28 Morphosys Ag Zbirka sljedova protutijela i njezina upotreba
EP2698431B1 (en) 2011-03-30 2020-09-09 Chugai Seiyaku Kabushiki Kaisha Retention of antigen-binding molecules in blood plasma and method for modifying immunogenicity
CA2833917C (en) * 2011-04-28 2020-04-28 The Board Of Trustees Of The Leland Stanford Junior University Identification of polynucleotides associated with a sample.
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PT3865581T (pt) 2011-08-05 2024-10-04 Regeneron Pharma Murganhos da cadeia leve universal humanizada
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CA2791109C (en) * 2011-09-26 2021-02-16 Merus B.V. Generation of binding molecules
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US20150050269A1 (en) 2011-09-30 2015-02-19 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities
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Also Published As

Publication number Publication date
MX2011012696A (es) 2012-03-29
IL216536B (en) 2018-06-28
US9624293B2 (en) 2017-04-18
EP2435568B1 (en) 2014-07-02
US20120077713A1 (en) 2012-03-29
RU2011147741A (ru) 2013-07-10
IL216536A0 (en) 2012-02-29
US10647757B2 (en) 2020-05-12
RU2569187C2 (ru) 2015-11-20
EP2435568A1 (en) 2012-04-04
JP2012527881A (ja) 2012-11-12
ZA201107652B (en) 2012-06-27
KR101805202B1 (ko) 2017-12-07
CA2758356A1 (en) 2010-12-02
SG175407A1 (en) 2011-11-28
KR20120087809A (ko) 2012-08-07
AU2010252939A1 (en) 2011-10-13
NZ596603A (en) 2013-07-26
HK1168635A1 (en) 2013-01-04
WO2010136598A1 (en) 2010-12-02
US8685896B2 (en) 2014-04-01
CA2758356C (en) 2016-07-26
US20170218048A1 (en) 2017-08-03
CN102449149A (zh) 2012-05-09
ES2511051T3 (es) 2014-10-22
US20140163208A1 (en) 2014-06-12
JP5804521B2 (ja) 2015-11-04
AU2010252939B2 (en) 2014-06-26
CN102449149B (zh) 2014-04-23
PT2435568E (pt) 2014-10-08

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